Search Results - "TSUZUKI Teruhisa"

Resveratrol and its Related Polyphenols Contribute to the Maintenance of Genome Stability by Matsuno, Yusuke, Atsumi, Yuko, Alauddin, Md, Rana, Md. Masud, Fujimori, Haruka, Hyodo, Mai, Shimizu, Atsuhiro, Ikuta, Tomoki, Tani, Hiroko, Torigoe, Hidetaka, Nakatsu, Yoshimichi, Tsuzuki, Teruhisa, Komai, Michio, Shirakawa, Hitoshi, Yoshioka, Ken-ichi

“…Genomic destabilisation is associated with the induction of mutations, including those in cancer-driver genes, and subsequent clonal evolution of cells with…”
Get full text

Replication stress triggers microsatellite destabilization and hypermutation leading to clonal expansion in vitro by Matsuno, Yusuke, Atsumi, Yuko, Shimizu, Atsuhiro, Katayama, Kotoe, Fujimori, Haruka, Hyodo, Mai, Minakawa, Yusuke, Nakatsu, Yoshimichi, Kaneko, Syuzo, Hamamoto, Ryuji, Shimamura, Teppei, Miyano, Satoru, Tsuzuki, Teruhisa, Hanaoka, Fumio, Yoshioka, Ken-ichi

“…Mismatch repair (MMR)-deficient cancers are characterized by microsatellite instability (MSI) and hypermutation. However, it remains unclear how MSI and…”
Get full text

Celecoxib and 2,5‐dimethylcelecoxib inhibit intestinal cancer growth by suppressing the Wnt/β‐catenin signaling pathway by Egashira, Issei, Takahashi‐Yanaga, Fumi, Nishida, Risa, Arioka, Masaki, Igawa, Kazunobu, Tomooka, Katsuhiko, Nakatsu, Yoshimichi, Tsuzuki, Teruhisa, Nakabeppu, Yusaku, Kitazono, Takanari, Sasaguri, Toshiyuki

“…We previously reported that celecoxib, a selective COX‐2 inhibitor, strongly inhibited human colon cancer cell proliferation by suppressing the Wnt/β‐catenin…”
Get full text

Significance of error‐avoiding mechanisms for oxidative DNA damage in carcinogenesis by Tsuzuki, Teruhisa, Nakatsu, Yoshimichi, Nakabeppu, Yusaku

“…Reactive oxygen species (ROS) are produced through normal cellular metabolism, and their formation is further enhanced by exposure to ionizing radiation and…”
Get full text

Effects of mismatches distant from the target position on gene correction with a 5′-tailed duplex by Suzuki, Tetsuya, Yanai, Yuri, Nishigaki, Natsuki, Nakatsu, Yoshimichi, Tsuzuki, Teruhisa, Kamiya, Hiroyuki

“…The introduction of a 5′-tailed duplex (5′-TD) fragment into cells corrects a base-substitution mutation in a target DNA. We previously reported that the gene…”
Get full text

Endogenous ROS production in early differentiation state suppresses endoderm differentiation via transient FOXC1 expression by Oka, Sugako, Tsuzuki, Teruhisa, Hidaka, Masumi, Ohno, Mizuki, Nakatsu, Yoshimichi, Sekiguchi, Mutsuo

“…Oxidative stress plays a pivotal role in the differentiation and proliferation of cells and programmed cell death. However, studies on the role of oxidative…”
Get full text

Oxidative nucleotide damage: consequences and prevention by Sekiguchi, Mutsuo, Tsuzuki, Teruhisa

“…8-Oxoguanine (8-oxo-7,8-dihydroguanine) is produced in DNA, as well as in nucleotide pools of cells, by reactive oxygen species normally formed during cellular…”
Get full text

Characteristic mutations induced in the small intestine of Msh2-knockout gpt delta mice by Aoki, Yasunobu, Ohno, Mizuki, Matsumoto, Michiyo, Matsumoto, Michi, Masumura, Kenichi, Nohmi, Takehiko, Tsuzuki, Teruhisa

“…Base pair mismatches in genomic DNA can result in mutagenesis, and consequently in tumorigenesis. To investigate how mismatch repair deficiency increases…”
Get full text

MUTYH-null mice are susceptible to spontaneous and oxidative stress-induced intestinal tumorigenesis by SAKAMOTO, Katsumi, TOMINAGA, Yohei, MAKI, Hisaji, NAKABEPPU, Yusaku, TSUZUKI, Teruhisa, YAMAUCHI, Kazumi, NAKATSU, Yoshimichi, SAKUMI, Kunihiko, YOSHIYAMA, Kaoru, EGASHIRA, Akinori, KURA, Shinobu, YAO, Takashi, TSUNEYOSHI, Masazumi

“…MUTYH is a mammalian DNA glycosylase that initiates base excision repair by excising adenine opposite 8-oxoguanine and 2-hydroxyadenine opposite guanine,…”
Get full text

Differentiation-inducing factor-3 inhibits intestinal tumor growth in vitro and in vivo by Kubokura, Naoya, Takahashi-Yanaga, Fumi, Arioka, Masaki, Yoshihara, Tatsuya, Igawa, Kazunobu, Tomooka, Katsuhiko, Morimoto, Sachio, Nakatsu, Yoshimichi, Tsuzuki, Teruhisa, Nakabeppu, Yusaku, Matsumoto, Takayuki, Kitazono, Takanari, Sasaguri, Toshiyuki

“…Differentiation-inducing factor-1 (DIF-1) produced by Dictyostelium discoideum strongly inhibits the proliferation of various types of cancer cells by…”
Get full text

BubR1 Insufficiency Inhibits Neointimal Hyperplasia Through Impaired Vascular Smooth Muscle Cell Proliferation in Mice by Kyuragi, Ryoichi, Matsumoto, Takuya, Harada, Yui, Saito, Satoru, Onimaru, Mitsuho, Nakatsu, Yoshimichi, Tsuzuki, Teruhisa, Nomura, Masatoshi, Yonemitsu, Yoshikazu, Maehara, Yoshihiko

“…OBJECTIVE—BubR1, a cell cycle–related protein, is an essential component of the spindle checkpoint that regulates cell division. Mice with BubR1 expression…”
Get full text

Mismatch repair deficient mice show susceptibility to oxidative stress-induced intestinal carcinogenesis by Piao, Jingshu, Nakatsu, Yoshimichi, Ohno, Mizuki, Taguchi, Ken-ichi, Tsuzuki, Teruhisa

“…We have previously established an experimental system for oxidative DNA damage-induced tumorigenesis in the small intestine of mice. To elucidate the roles of…”
Get full text

Critical Role of Monocyte Chemoattractant Protein-1 Receptor CCR2 on Monocytes in Hypertension-Induced Vascular Inflammation and Remodeling by Ishibashi, Minako, Hiasa, Ken-ichi, Zhao, Qingwei, Inoue, Shujiro, Ohtani, Kisho, Kitamoto, Shiro, Tsuchihashi, Miyuki, Sugaya, Takeshi, Charo, Israel F, Kura, Shinobu, Tsuzuki, Teruhisa, Ishibashi, Tatsuro, Takeshita, Akira, Egashira, Kensuke

“…Activated monocytes are present in the arterial walls of hypertensive patients and animals. Monocyte chemoattractant protein-1 (MCP-1), which controls monocyte…”
Get full text

Structural and Dynamic Features of the MutT Protein in the Recognition of Nucleotides with the Mutagenic 8-Oxoguanine Base by Nakamura, Teruya, Meshitsuka, Sachiko, Kitagawa, Seiju, Abe, Nanase, Yamada, Junichi, Ishino, Tetsuya, Nakano, Hiroaki, Tsuzuki, Teruhisa, Doi, Takefumi, Kobayashi, Yuji, Fujii, Satoshi, Sekiguchi, Mutsuo, Yamagata, Yuriko

“…Escherichia coli MutT hydrolyzes 8-oxo-dGTP to 8-oxo-dGMP, an event that can prevent the misincorporation of 8-oxoguanine opposite adenine in DNA. Of the…”
Get full text

Measles Virus Infection of SLAM (CD150) Knockin Mice Reproduces Tropism and Immunosuppression in Human Infection by OHNO, Shinji, ONO, Nobuyuki, SEKI, Fumio, TAKEDA, Makoto, KURA, Shinobu, TSUZUKI, Teruhisa, YANAGI, Yusuke

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Mismatch repair dependence of replication stress-associated DSB recognition and repair by Fujimori, Haruka, Hyodo, Mai, Matsuno, Yusuke, Shimizu, Atsuhiro, Minakawa, Yusuke, Atsumi, Yuko, Nakatsu, Yoshimichi, Tsuzuki, Teruhisa, Murakami, Yasufumi, Yoshioka, Ken-ichi

“…Most cancers develop with one of two types of genomic instability, namely, chromosomal instability (CIN) or microsatellite instability (MSI). Both are induced…”
Get full text

Bone Marrow–Derived Monocyte Chemoattractant Protein-1 Receptor CCR2 Is Critical in Angiotensin II–Induced Acceleration of Atherosclerosis and Aneurysm Formation in Hypercholesterolemic Mice by Ishibashi, Minako, Egashira, Kensuke, Zhao, Qingwei, Hiasa, Ken-ichi, Ohtani, Kisho, Ihara, Yoshiko, Charo, Israel F, Kura, Shinobu, Tsuzuki, Teruhisa, Takeshita, Akira, Sunagawa, Kenji

“…ABSTRACT—Angiotensin II (Ang II) is implicated in atherogenesis by activating inflammatory responses in arterial wall cells. Ang II accelerates the…”
Get full text

Spontaneous Tumorigenesis in Mice Defective in the MTH1 Gene Encoding 8-Oxo-dGTPase by Tsuzuki, Teruhisa, Egashira, Akinori, Igarashi, Hisato, Iwakuma, Tomoo, Nakatsuru, Yoko, Tominaga, Yohei, Kawate, Hisaya, Nakao, Kazuki, Nakamura, Kenji, Ide, Fumio, Kura, Shinobu, Nakabeppu, Yusaku, Katsuki, Motoya, Ishikawa, Takatoshi, Sekiguchi, Mutsuo

“…Oxygen radicals, which can be produced through normal cellular metabolism, are thought to play an important role in mutagenesis and tumorigenesis. Among…”
Get full text

Activation of AMP-activated protein kinase by MAPO1 and FLCN induces apoptosis triggered by alkylated base mismatch in DNA by Lim, Teik How, Fujikane, Ryosuke, Sano, Shiori, Sakagami, Ryuji, Nakatsu, Yoshimichi, Tsuzuki, Teruhisa, Sekiguchi, Mutsuo, Hidaka, Masumi

“…► MAPO1 is required for the induction of apoptosis triggered by O6-methylguanine. ► Flag-tagged MAPO1 interacts with AMPK and FLCN. ► AMPK and FLCN are also…”
Get full text

PSMC5, a 19S Proteasomal ATPase, Regulates Cocaine Action in the Nucleus Accumbens by Ohnishi, Yoko H, Ohnishi, Yoshinori N, Nakamura, Takanori, Ohno, Mizuki, Kennedy, Pamela J, Ohkawa, Yasuyuki, Yasuyuki, Ohkawa, Nishi, Akinori, Neve, Rachael, Tsuzuki, Teruhisa, Nestler, Eric J

“…ΔFosB is a stable transcription factor which accumulates in the nucleus accumbens (NAc), a key part of the brain's reward circuitry, in response to chronic…”
Get full text