TRANSFER OF CS-807 INTO SEXUAL ORGAN TISSUES AND ITS CLINICAL EVALUATION IN THE TOCOGYNECOLOGICAL FIELD
1) The blood level of CS-807 and its transfer over time into the uterus, ovaries and uterine adnexa were determined. Results revealed that the blood level rose gradually from the point of emergence 65 min after administration and reached a peak at 5h, but no firm conclusions could be reached as ther...
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| Published in: | CHEMOTHERAPY Vol. 36; no. Supplement1; pp. 918 - 922 |
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| Main Authors: | , , , |
| Format: | Journal Article |
| Language: | Japanese |
| Published: |
Japanese Society of Chemotherapy
20-05-1988
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| Online Access: | Get full text |
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| Summary: | 1) The blood level of CS-807 and its transfer over time into the uterus, ovaries and uterine adnexa were determined. Results revealed that the blood level rose gradually from the point of emergence 65 min after administration and reached a peak at 5h, but no firm conclusions could be reached as there were only alimited number of cases available for evaluation. 2) CS-807, an oral cephalosporin with a broad antibacterial spectrum and activated bioavailability through oral administration, was evaluated in seven cases of infection in the field of tocogynecology. It was effective in six cases and ineffective in one. 3) Neither side-effects nor abnormalities in clinical laboratory tests were observed. 4) From our results, we consider CS-807 a safe and effective antibiotic against tocogynecological infections manageable on an out-patient basis and its generally applicable dose to be 100mg twice daily with follow-up. |
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| ISSN: | 0009-3165 1884-5894 |
| DOI: | 10.11250/chemotherapy1953.36.Supplement1_918 |