Search Results - "TSUKITA, S"

Tight junction-based epithelial microenvironment and cell proliferation by Tsukita, S, Yamazaki, Y, Katsuno, T, Tamura, A, Tsukita, S

“…Belt-like tight junctions (TJs), referred to as zonula occludens, have long been regarded as a specialized differentiation of epithelial cell membranes. They…”
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Epithelial transport and barrier function in occludin-deficient mice by Schulzke, J.D., Gitter, A.H., Mankertz, J., Spiegel, S., Seidler, U., Amasheh, S., Saitou, M., Tsukita, S., Fromm, M.

“…This study aimed at functional characterization of the tight junction protein occludin using the occludin-deficient mouse model. Epithelial transport and…”
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Tight junction-associated proteins (occludin, ZO-1, claudin-1, claudin-4) in squamous cell carcinoma and Bowen's disease by Morita, K., Tsukita, S., Miyachi, Y.

“…Summary Background  The epidermis, which is a typical stratified epithelium, has tight junctions (TJs) in the granular layer, as do simple epithelia. So far,…”
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Complex phenotype of mice lacking occludin, a component of tight junction strands by Saitou, M, Furuse, M, Sasaki, H, Schulzke, J D, Fromm, M, Takano, H, Noda, T, Tsukita, S

“…Occludin is an integral membrane protein with four transmembrane domains that is exclusively localized at tight junction (TJ) strands. Here, we describe the…”
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Fer tyrosine kinase oligomer mediates and amplifies Src-induced tumor progression by Oneyama, C, Yoshikawa, Y, Ninomiya, Y, Iino, T, Tsukita, S, Okada, M

“…c-Src is upregulated in various human cancers, suggesting its role in malignant progression. However, the molecular circuits of c-Src oncogenic signaling…”
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Outer dense fiber 2 is a widespread centrosome scaffold component preferentially associated with mother centrioles: its identification from isolated centrosomes by Nakagawa, Y, Yamane, Y, Okanoue, T, Tsukita, S

“…Because centrosomes were enriched in the bile canaliculi fraction from the chicken liver through their association with apical membranes, we developed a…”
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Occludin: A Novel Integral Membrane Protein Localizing at Tight Junctions by Furuse, Mikio, Hirase, Tetsuaki, Itoh, Masahiko, Nagafuchi, Akira, Yonemura, Shigenobu, Tsukita, Sachiko, Tsukita, Shoichiro

“…Recently, we found that ZO-1, a tight junction-associated protein, was concentrated in the so called isolated adherens junction fraction from the liver. Using…”
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The Roles of Catenins in the Cadherin-Mediated Cell Adhesion: Functional Analysis of E-Cadherin-α Catenin Fusion Molecules by Nagafuchi, Akira, Ishihara, Satoru, Tsukita, Shoichiro

“…The carboxyl terminus-truncated cadherin (nonfunctional cadherin) has no cell adhesion activity probably because of its failure to associate with cytoplasmic…”
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Regulation Mechanism of ERM (Ezrin/Radixin/Moesin) Protein/Plasma Membrane Association: Possible Involvement of Phosphatidylinositol Turnover and Rho-Dependent Signaling Pathway by Hirao, Motohiro, Sato, Naruki, Kondo, Takahisa, Yonemura, Shigenobu, Monden, Morito, Sasaki, Takuya, Takai, Yoshimi, Tsukita, Shoichiro, Tsukita, Sachiko

“…The ERM proteins, ezrin, radixin, and moesin, are involved in the actin filament/plasma membrane interaction as cross-linkers. CD44 has been identified as one…”
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ERM Family Members as Molecular Linkers between the Cell Surface Glycoprotein CD44 and Actin-Based Cytoskeletons by Tsukita, Sachiko, Oishi, Kumiko, Sato, Naruki, Sagara, Junji, Kawai, Akihiko, Tsukita, Shoichiro

“…The ERM family members, ezrin, radixin, and moesin, localizing just beneath the plasma membranes, are thought to be involved in the actin filament/plasma…”
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Induction of Polarized Cell-Cell Association and Retardation of Growth by Activation of the E-Cadherin-Catenin Adhesion System in a Dispersed Carcinoma Line by Watabe, Mitsuko, Nagafuchi, Akira, Tsukita, Sachiko, Takeichi, Masatoshi

“…PC9 lung carcinoma cells cannot tightly associate with one another, and therefore grow singly, despite their expression of E-cadherin, because of their lack of…”
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Involvement of claudin-1 in the beta-catenin/Tcf signaling pathway and its frequent upregulation in human colorectal cancers by Miwa, N, Furuse, M, Tsukita, S, Niikawa, N, Nakamura, Y, Furukawa, Y

“…Accumulation of beta-catenin in cytoplasm and nuclei is frequently observed in a wide variety of tumors arising, for example, in the colon, liver, uterus, or…”
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Interspecies Diversity of the Occludin Sequence: cDNA Cloning of Human, Mouse, Dog, and Rat-Kangaroo Homologues by Ando-Akatsuka, Yuhko, Saitou, Mitinori, Hirase, Tetsuaki, Kishi, Masashi, Sakakibara, Akira, Itoh, Masahiko, Yonemura, Shigenobu, Furuse, Mikio, Tsukita, Shoichiro

“…Occludin has been identified from chick liver as a novel integral membrane protein localizing at tight junctions. To analyze and modulate the functions of…”
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Perturbation of Cell Adhesion and Microvilli Formation by Antisense Oligonucleotides to ERM Family Members by Takeuchi, Kosei, Sato, Naruki, Kasahara, Hideko, Funayama, Noriko, Nagafuchi, Akira, Yonemura, Shigenobu, Tsukita, Sachiko, Tsukita, Shoichiro

“…To examine the functions of ERM family members (ezrin, radixin, and moesin), mouse epithelial cells (MTD-1A cells) and thymoma cells (L5178Y), which coexpress…”
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Cadherin-Mediated Cell-Cell Adhesion Is Perturbed by v-src Tyrosine Phosphorylation in Metastatic Fibroblasts by Matsuyoshi, Norihisa, Hamaguchi, Michinari, Taniguchi, Shun'ichiro, Nagafuchi, Akira, Tsukita, Shoichiro, Takeichi, Masatoshi

“…Rat 3Y1 cells acquire metastatic potential when transformed with v-src, and this potential is enhanced by double transformation with v-src and v-fos…”
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A New 82-kD Barbed End-Capping Protein (Radixin) Localized in the Cell-to-Cell Adherens Junction: Purification and Characterization by Tsukita, Sachiko, Hieda, Yohki, Tsukita, Shoichiro

“…An 82-kD protein has been purified from the undercoat of the adherens junction isolated from the rat liver. The purification scheme includes low salt…”
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Subcellular Distribution of Tight Junction-Associated Proteins (Occludin, ZO-1, ZO-2) in Rodent Skin by Morita, Kazumasa, Itoh, Masahiko, Saitou, Mitinori, Ando-Akatsuka, Yuhko, Furuse, Mikio, Yoneda, Kozo, Imamura, Sadao, Fujimoto, Kazushi, Tsukita, Shoichiro

“…Occludin is an integral membrane protein that is concentrated at tight junctions (zonulae occludentes) in simple epithelial cells. ZO-1 and ZO-2 are peripheral…”
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Expression of occludin, tight-junction-associated protein, in human digestive tract by Kimura, Y, Shiozaki, H, Hirao, M, Maeno, Y, Doki, Y, Inoue, M, Monden, T, Ando- Akatsuka, Y, Furuse, M, Tsukita, S, Monden, M

“…The tight junction seals cells together at a subapical location and functionally separates the plasma membrane into an apical and a basolateral domain. This…”
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A 220-kD Undercoat-Constitutive Protein: Its Specific Localization at Cadherin-Based Cell-Cell Adhesion Sites by Itoh, Masahiko, Yonemura, Shigenobu, Nagafuchi, Akira, Tsukita, Sachiko, Tsukita, Shoichiro

“…Recently we developed an isolation procedure for the cell-to-cell adherens junctions (AJ; cadherin-based junctions) from rat liver. In this study, using the…”
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Isolation of Cell-to-Cell Adherens Junctions from Rat Liver by Tsukita, Shoichiro, Tsukita, Sachiko

“…A new isolation procedure for cell-to-cell adherens junctions has been developed using rat liver. From the bile canaliculi-enriched fraction obtained by…”
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