Search Results - "TSUKAMOTO, Osamu"

Direct Sarcomere Modulators Are Promising New Treatments for Cardiomyopathies by Tsukamoto, Osamu

“…Mutations in sarcomere genes can cause both hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM). However, the complex genotype-phenotype…”
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Ablation of C/EBP Homologous Protein Attenuates Endoplasmic Reticulum-Mediated Apoptosis and Cardiac Dysfunction Induced by Pressure Overload by HAI YING FU, OKADA, Ken-Ichiro, ASANUMA, Hiroshi, ASAKURA, Masanori, TAKASHIMA, Seiji, KOMURO, Issei, KITAKAZE, Masafumi, MINAMINO, Tetsuo, YULIN LIAO, TSUKAMOTO, Osamu, ISOMURA, Tadashi, ASAI, Mitsutoshi, SAWADA, Tamaki, OKUDA, Keiji, ASANO, Yoshihiro, SANADA, Shoji

“…Apoptosis may contribute to the development of heart failure, but the role of apoptotic signaling initiated by the endoplasmic reticulum in this condition has…”
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Higd1a is a positive regulator of cytochrome c oxidase by Hayashi, Takaharu, Asano, Yoshihiro, Shintani, Yasunori, Aoyama, Hiroshi, Kioka, Hidetaka, Tsukamoto, Osamu, Hikita, Masahide, Shinzawa-Itoh, Kyoko, Takafuji, Kazuaki, Higo, Shuichiro, Kato, Hisakazu, Yamazaki, Satoru, Matsuoka, Ken, Nakano, Atsushi, Asanuma, Hiroshi, Asakura, Masanori, Minamino, Tetsuo, Goto, Yu-ichi, Ogura, Takashi, Kitakaze, Masafumi, Komuro, Issei, Sakata, Yasushi, Tsukihara, Tomitake, Yoshikawa, Shinya, Takashima, Seiji

“…Cytochrome c oxidase (CcO) is the only enzyme that uses oxygen to produce a proton gradient for ATP production during mitochondrial oxidative phosphorylation…”
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Biochemical and Physiological Regulation of Cardiac Myocyte Contraction by Cardiac-Specific Myosin Light Chain Kinase by Tsukamoto, Osamu, Kitakaze, Masafumi

“…Cardiac-specific myosin light chain kinase (cMLCK) is the kinase predominantly responsible for the maintenance of the basal level of phosphorylation of cardiac…”
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Differential Regulation of Proteasome Function in Isoproterenol-Induced Cardiac Hypertrophy by Drews, Oliver, Tsukamoto, Osamu, Liem, David, Streicher, John, Wang, Yibin, Ping, Peipei

“…RATIONALE:Proteasomal degradation is altered in many disease phenotypes including cardiac hypertrophy, a prevalent condition leading to heart failure. Our…”
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Restoration of Cardiac Myosin Light Chain Kinase Ameliorates Systolic Dysfunction by Reducing Superrelaxed Myosin by Hitsumoto, Tatsuro, Tsukamoto, Osamu, Matsuoka, Ken, Li, Junjun, Liu, Li, Kuramoto, Yuki, Higo, Shuichiro, Ogawa, Shou, Fujino, Noboru, Yoshida, Shohei, Kioka, Hidetaka, Kato, Hisakazu, Hakui, Hideyuki, Saito, Yuki, Okamoto, Chisato, Inoue, Hijiri, Hyejin, Jo, Ueda, Kyoko, Segawa, Takatsugu, Nishimura, Shunsuke, Asano, Yoshihiro, Asanuma, Hiroshi, Tani, Akiyoshi, Imamura, Riyo, Komagawa, Shinsuke, Kanai, Toshio, Takamura, Masayuki, Sakata, Yasushi, Kitakaze, Masafumi, Haruta, Jun-ichi, Takashima, Seiji

“…Cardiac-specific myosin light chain kinase (cMLCK), encoded by , regulates cardiac contractility through phosphorylation of ventricular myosin regulatory light…”
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AMPK regulates cell shape of cardiomyocytes by modulating turnover of microtubules through CLIP-170 by Yashirogi, Shohei, Nagao, Takemasa, Nishida, Yuya, Takahashi, Yusuke, Qaqorh, Tasneem, Yazawa, Issei, Katayama, Toru, Kioka, Hidetaka, Matsui, Tsubasa S, Saito, Shigeyoshi, Masumura, Yuki, Tsukamoto, Osamu, Kato, Hisakazu, Ueda, Hiromichi, Yamaguchi, Osamu, Yashiro, Kenta, Yamazaki, Satoru, Takashima, Seiji, Shintani, Yasunori

“…AMP-activated protein kinase (AMPK) is a multifunctional kinase that regulates microtubule (MT) dynamic instability through CLIP-170 phosphorylation; however,…”
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A molecular triage process mediated by RING finger protein 126 and BCL2-associated athanogene 6 regulates degradation of G0/G1 switch gene 2 by Kamikubo, Kenta, Kato, Hisakazu, Kioka, Hidetaka, Yamazaki, Satoru, Tsukamoto, Osamu, Nishida, Yuya, Asano, Yoshihiro, Imamura, Hiromi, Kawahara, Hiroyuki, Shintani, Yasunori, Takashima, Seiji

“…Oxidative phosphorylation generates most of the ATP in respiring cells. ATP is an essential energy source, especially in cardiomyocytes because of their…”
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Gene Transfer of Skeletal Muscle-Type Myosin Light Chain Kinase via Adeno-Associated Virus 6 Improves Muscle Functions in an Amyotrophic Lateral Sclerosis Mouse Model by Oya, Ryohei, Tsukamoto, Osamu, Hitsumoto, Tatsuro, Nakahara, Naoya, Okamoto, Chisato, Matsuoka, Ken, Kato, Hisakazu, Inohara, Hidenori, Takashima, Seiji

“…Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that shows progressive muscle weakness. A few treatments exist including symptomatic…”
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Augmented AMPK activity inhibits cell migration by phosphorylating the novel substrate Pdlim5 by Yan, Yi, Tsukamoto, Osamu, Nakano, Atsushi, Kato, Hisakazu, Kioka, Hidetaka, Ito, Noriaki, Higo, Shuichiro, Yamazaki, Satoru, Shintani, Yasunori, Matsuoka, Ken, Liao, Yulin, Asanuma, Hiroshi, Asakura, Masanori, Takafuji, Kazuaki, Minamino, Tetsuo, Asano, Yoshihiro, Kitakaze, Masafumi, Takashima, Seiji

“…Augmented AMP-activated protein kinase (AMPK) activity inhibits cell migration, possibly contributing to the clinical benefits of chemical AMPK activators in…”
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Plasma indoxyl sulfate levels predict cardiovascular events in patients with mild chronic heart failure by Imazu, Miki, Fukuda, Hiroki, Kanzaki, Hideaki, Amaki, Makoto, Hasegawa, Takuya, Takahama, Hiroyuki, Hitsumoto, Tatsuro, Tsukamoto, Osamu, Morita, Toshisuke, Ito, Shin, Kitakaze, Masafumi

“…Indoxyl sulfate (IS) is associated with either chronic kidney disease or renal failure, which may predict cardiovascular events via cardiorenal syndrome. The…”
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Aberrant accumulation of TMEM43 accompanied by perturbed transmural gene expression in arrhythmogenic cardiomyopathy by Shinomiya, Haruki, Kato, Hisakazu, Kuramoto, Yuki, Watanabe, Nozomi, Tsuruda, Toshihiro, Arimura, Tadaaki, Miyashita, Yohei, Miyasaka, Yoshiki, Mashimo, Tomoji, Takuwa, Ayako, Motooka, Daisuke, Okuzaki, Daisuke, Matsuoka, Ken, Tsukamoto, Osamu, Hakui, Hideyuki, Yamada, Noriaki, Lee, Jong‐Kook, Kioka, Hidetaka, Kitakaze, Masafumi, Takashima, Seiji, Sakata, Yasushi, Asano, Yoshihiro

“…Arrhythmogenic cardiomyopathy (ACM) caused by TMEM43 p.S358L is a fully penetrant heart disease that results in impaired cardiac function or fatal arrhythmia…”
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In vivo real‐time ATP imaging in zebrafish hearts reveals G0s2 induces ischemic tolerance by Kioka, Hidetaka, Kato, Hisakazu, Fujita, Takeshi, Asano, Yoshihiro, Shintani, Yasunori, Yamazaki, Satoru, Tsukamoto, Osamu, Imamura, Hiromi, Kogo, Mikihiko, Kitakaze, Masafumi, Sakata, Yasushi, Takashima, Seiji

“…Most eukaryotic cells generate adenosine triphosphate (ATP) through the oxidative phosphorylation system (OXPHOS) to support cellular activities. In cultured…”
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Evaluation of intramitochondrial ATP levels identifies G0/G1 switch gene 2 as a positive regulator of oxidative phosphorylation by Kioka, Hidetaka, Kato, Hisakazu, Fujikawa, Makoto, Tsukamoto, Osamu, Suzuki, Toshiharu, Imamura, Hiromi, Nakano, Atsushi, Higo, Shuichiro, Yamazaki, Satoru, Matsuzaki, Takashi, Takafuji, Kazuaki, Asanuma, Hiroshi, Asakura, Masanori, Minamino, Tetsuo, Shintani, Yasunori, Yoshida, Masasuke, Noji, Hiroyuki, Kitakaze, Masafumi, Komuro, Issei, Asano, Yoshihiro, Takashima, Seiji

“…The oxidative phosphorylation (OXPHOS) system generates most of the ATP in respiring cells. ATP-depleting conditions, such as hypoxia, trigger responses that…”
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Different Implications of Functional Tricuspid Regurgitation Between Heart Failure (HF) With Reduced Ejection Fraction (EF) and HF With Preserved EF by Tsukamoto, Osamu, Kitakaze, Masafumi

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Natriuretic Peptides Enhance the Production of Adiponectin in Human Adipocytes and in Patients With Chronic Heart Failure by Tsukamoto, Osamu, MD, PhD, Fujita, Masashi, MD, PhD, Kato, Mahoto, MD, Yamazaki, Satoru, PhD, Asano, Yoshihiro, MD, PhD, Ogai, Akiko, PhD, Okazaki, Hidetoshi, MD, PhD, Asai, Mitsutoshi, MD, Nagamachi, Yoko, BS, Maeda, Norikazu, MD, PhD, Shintani, Yasunori, MD, PhD, Minamino, Tetsuo, MD, PhD, Asakura, Masanori, MD, PhD, Kishimoto, Ichiro, MD, PhD, Funahashi, Tohru, MD, PhD, Tomoike, Hitonobu, MD, PhD, Kitakaze, Masafumi, MD, PhD

“…Objectives We investigated the functional relationship between natriuretic peptides and adiponectin by performing both experimental and clinical studies…”
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Phosphorylation of MYL12 by Myosin Light Chain Kinase Regulates Cellular Shape Changes in Cochlear Hair Cells by Oya, Ryohei, Tsukamoto, Osamu, Sato, Takashi, Kato, Hisakazu, Matsuoka, Ken, Oshima, Kazuo, Kamakura, Takefumi, Ohta, Yumi, Imai, Takao, Takashima, Seiji, Inohara, Hidenori

“…The organ of Corti is an auditory organ located in the cochlea, comprising hair cells (HCs) and other supporting cells. Cellular shape changes of HCs are…”
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Association Between B-Type Natriuretic Peptide Deficiency and Left Ventricular Concentric Hypertrophy in Subclinical Individuals by Okamoto, Chisato, Tsukamoto, Osamu, Hasegawa, Takuya, Matsuoka, Ken, Amaki, Makoto, Kanzaki, Hideaki, Izumi, Chisato, Takashima, Seiji, Ito, Shin, Kitakaze, Masafumi

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Experimental evaluation of water vapour cross-sensitivity for accurate eddy covariance measurement of CO2 flux using open-path CO2/H2O gas analysers by Kondo, Fumiyoshi, Ono, Keisuke, Mano, Masayoshi, Miyata, Akira, Tsukamoto, Osamu

“…Non-dispersive infrared CO 2 /H 2 O gas analysers produce erroneous CO 2 outputs when CO 2 is measured in humid air, unless a correction for water vapour…”
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Btg2 is a Negative Regulator of Cardiomyocyte Hypertrophy through a Decrease in Cytosolic RNA by Masumura, Yuki, Higo, Shuichiro, Asano, Yoshihiro, Kato, Hisakazu, Yan, Yi, Ishino, Saki, Tsukamoto, Osamu, Kioka, Hidetaka, Hayashi, Takaharu, Shintani, Yasunori, Yamazaki, Satoru, Minamino, Tetsuo, Kitakaze, Masafumi, Komuro, Issei, Takashima, Seiji, Sakata, Yasushi

“…Under hypertrophic stimulation, cardiomyocytes enter a hypermetabolic state and accelerate biomass accumulation. Although the molecular pathways that regulate…”
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