Search Results - "TSUJIO, ICHIRO"
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Tau protein is a potential biological marker for normal pressure hydrocephalus
Published in Psychiatry and clinical neurosciences (01-04-2000)“…A biological marker for normal pressure hydrocephalus (NPH) is beneficial for evaluation of its severity and of indications for shunt operation. Tau protein…”
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Quantitative analysis of neurofilament proteins in Alzheimer brain by enzyme linked immunosorbent assay system
Published in Psychiatry and clinical neurosciences (01-10-1999)“…The abnormality of cytoskeletal proteins is related to Alzheimer’s disease. Because neurofilament proteins (NF) are major cytoskeletal components of neurones,…”
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Presenilin-2 mutation and polymorphism in Japanese Alzheimer disease patients
Published in Clinica chimica acta (01-05-1999)“…The Asn141Ile mutation of the presenilin 2 gene is responsible for familial early-onset Alzheimer disease found in Volga-German kindreds. However, the genetic…”
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Novel Therapeutic Strategies for Delirium in Patients With Cancer: A Preliminary Study
Published in American journal of hospice & palliative medicine (01-06-2016)“…To compare the efficacy of antipsychotics (APs) for delirium treatment in patients with cancer, 27 patients treated with 1 of the 4 APs, haloperidol (HPD),…”
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Inhibitors of protein phosphatase-2A from human brain structures, immunocytological localization and activities towards dephosphorylation of the Alzheimer type hyperphosphorylated tau
Published in FEBS letters (17-01-2005)“…Protein phosphatase (PP)-2A, which regulates the phosphorylation of tau, is regulated by two endogenous inhibitor proteins, I1PP2A and I2PP2A, in mammalian…”
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Role of protein kinase B in Alzheimer's neurofibrillary pathology
Published in Acta neuropathologica (01-04-2003)“…Protein kinase B (PKB) is an important intermediate in the phosphatidylinositol-3 kinase signaling cascade that acts to phosphorylate glycogen synthase…”
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Dantrolene sodium reverses the increase in cAMP response element and TPA responsive element DNA‐binding activity in the rabbit brain following haloperidol administration and heat stress
Published in Psychiatry and clinical neurosciences (01-12-1997)“…Using electrophoretic mobility‐shift assay (EMSA), we examined DNA‐binding activity of cAMP response element (CRE), onto its responsive element CRE, as well as…”
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Inactivation of glycogen synthase kinase-3 by protein kinase C δ: implications for regulation of τ phosphorylation
Published in FEBS letters (03-03-2000)“…The role of the phosphatidylinositol 3-kinase (PI3K) pathway in the hyperphosphorylation of τ was investigated in SY5Y human neuroblastoma cells. Wortmannin,…”
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Dephosphorylation of tau protein induced by neuropsychiatric drugs
Published in Neurobiology of aging (01-05-2000)Get full text
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Significance and mechanism of Alzheimer neurofibrillary degeneration and therapeutic targets to inhibit this lesion
Published in Journal of molecular neuroscience (01-08-2002)“…Abnormally hyperphosphorylated tau which is the major protein subunit of paired helical filaments (PHF)/neurofibrillary tangles is the pivotal lesion in…”
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Alzheimer neurofibrillary degeneration: therapeutic targets and high-throughput assays
Published in Journal of molecular neuroscience (2003)“…Neurofibrillary degeneration has primary and pivotal involvement in the pathogenesis of Alzheimer disease (AD) and other tauopathies. The inhibition of this…”
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Alzheimer neurofibrillary degeneration
Published in Journal of molecular neuroscience (01-08-2003)“…Neurofibrillary degeneration has primary and pivotal involvement in the pathogenesis of Alzheimer disease (AD) and other tauopathies. The inhibition of this…”
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Significance of tau phosphorylation and protein kinase regulation in the pathogenesis of Alzheimer disease
Published in Alzheimer disease and associated disorders (2000)“…The role of the phosphatidylinositol-3 kinase pathway in the hyperphosphorylation of tau protein was investigated in cultured cells. Human kidney 293T-cells…”
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