Search Results - "TSUJIO, I"

Significance and mechanism of Alzheimer neurofibrillary degeneration and therapeutic targets to inhibit this lesion by Iqbal, Khalid, Alonso, Alejandra del C, El-Akkad, Ezzat, Gong, Cheng-Xin, Haque, Niloufar, Khatoon, Sabiha, Pei, Jin-Jing, Tsujio, Ichiro, Wang, Jian-Zhi, Grundke-Iqbal, Inge

“…Abnormally hyperphosphorylated tau which is the major protein subunit of paired helical filaments (PHF)/neurofibrillary tangles is the pivotal lesion in…”
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Pharmacological targets to inhibit Alzheimer neurofibrillary degeneration by Iqbal, K, Alonso, A del C, El-Akkad, E, Gong, C X, Haque, N, Khatoon, S, Tsujio, I, Grundke-Iqbal, I

“…Neurofibrillary degeneration appears to be required for the clinical expression of Alzheimer disease (AD) and related tauopathies. Given the polyetiology of…”
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Role of protein kinase B in Alzheimer's neurofibrillary pathology by PEI, Jin-Jing, KHATOON, Sabiha, COWBURN, Richard F, GRUNDKE-IQBAL, Inge, IQBAL, Khalid, AN, Wen-Lin, NORDLINDER, Maria, TANAKA, Toshihisa, BRAAK, Heiko, TSUJIO, Ichiro, TAKEDA, Masatoshi, ALAFUZOFF, Irina, WINBLAD, Bengt

“…Protein kinase B (PKB) is an important intermediate in the phosphatidylinositol-3 kinase signaling cascade that acts to phosphorylate glycogen synthase…”
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Inactivation of glycogen synthase kinase-3 by protein kinase C δ: implications for regulation of τ phosphorylation by Tsujio, Ichiro, Tanaka, Toshihisa, Kudo, Takashi, Nishikawa, Takashi, Shinozaki, Kazuhiro, Grundke-Iqbal, Inge, Iqbal, Khalid, Takeda, Masatoshi

“…The role of the phosphatidylinositol 3-kinase (PI3K) pathway in the hyperphosphorylation of τ was investigated in SY5Y human neuroblastoma cells. Wortmannin,…”
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Alzheimer neurofibrillary degeneration: therapeutic targets and high-throughput assays by Iqbal, Khalid, Alonso, Alejandra del C, El-Akkad, Ezzat, Gong, Cheng-Xin, Haque, Niloufar, Khatoon, Sabiha, Pei, Jin-Jing, Tanimukai, Hitoshi, Tsujio, Ichiro, Wang, Jian-Zhi, Grundke-Iqba, Inge

“…Neurofibrillary degeneration has primary and pivotal involvement in the pathogenesis of Alzheimer disease (AD) and other tauopathies. The inhibition of this…”
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Tau protein is a potential biological marker for normal pressure hydrocephalus by Kudo, Takashi, Mima, Tatsuo, Hashimoto, Ryouta, Nakao, Kazuhisa, Morihara, Takashi, Tanimukai, Hitoshi, Tsujio, Ichiro, Koike, Yuko, Tagami, Shinji, Mori, Hiroshi, Nakamura, Yu, Tanaka, Toshihisa, Mori, Koreaki, Takeda, Masatoshi

“…A biological marker for normal pressure hydrocephalus (NPH) is beneficial for evaluation of its severity and of indications for shunt operation. Tau protein…”
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Significance of tau phosphorylation and protein kinase regulation in the pathogenesis of Alzheimer disease by TANAKA, T, TSUJIO, I, NISHIKAWA, T, SHINOSAKI, K, KUDO, T, TAKEDA, M

“…The role of the phosphatidylinositol-3 kinase pathway in the hyperphosphorylation of tau protein was investigated in cultured cells. Human kidney 293T-cells…”
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Quantitative analysis of neurofilament proteins in Alzheimer brain by enzyme linked immunosorbent assay system by Hashimoto, Ryota, Nakamura, Yu, Tsujio, Ichiro, Tanimukai, Hitoshi, Kudo, Takashi, Takeda, Masatoshi

“…The abnormality of cytoskeletal proteins is related to Alzheimer’s disease. Because neurofilament proteins (NF) are major cytoskeletal components of neurones,…”
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Presenilin-2 mutation and polymorphism in Japanese Alzheimer disease patients by Tanimukai, Hitoshi, Tsujio, Ichiro, Hashimoto, Ryota, Kudo, Takashi, Kamino, Koujin, Kamino, Koujn, Takeda, Masatoshi

“…The Asn141Ile mutation of the presenilin 2 gene is responsible for familial early-onset Alzheimer disease found in Volga-German kindreds. However, the genetic…”
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Dantrolene sodium reverses the increase in cAMP response element and TPA responsive element DNA‐binding activity in the rabbit brain following haloperidol administration and heat stress by TANII, HISASHI, TANIGUCHI, NORIO, TSUJIO, ICHIRO, ASANUMA, MASATO, IWATA, EMI, KUDO, TAKASHI, OGAWA, NORIO, TAKEDA, MASATOSHI

“…Using electrophoretic mobility‐shift assay (EMSA), we examined DNA‐binding activity of cAMP response element (CRE), onto its responsive element CRE, as well as…”
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