Search Results - "TSUJI, Moriya"

A mechanism for glycoconjugate vaccine activation of the adaptive immune system and its implications for vaccine design by Avci, Fikri Y, Li, Xiangming, Tsuji, Moriya, Kasper, Dennis L

“…Glycoconjugate vaccines—such as those targeting some bacteria—couple a glycan to a protein to provide T cell help to B cells and induce polysaccharide-specific…”
Get full text

Comment on "γδ T Cells Are Required for the Induction of Sterile Immunity during Irradiated Sporozoite Vaccinations" by McKenna, Kyle C, Tsuji, Moriya

Get full text

Editorial: Development of Humanized Mouse Models for Infectious Diseases and Cancer by Tsuji, Moriya, Akkina, Ramesh

Get full text

Molecular Mechanism behind the Safe Immunostimulatory Effect of Withania somnifera by Kalpana, Kriti, Yap, Shen, Tsuji, Moriya, Kawamura, Akira

“…(L.) Dunal (family ) is a medicinal plant known for, among many pharmacological properties, an immune boosting effect. Our recent study revealed that its key…”
Get full text

SARS-CoV-2 RNA Shedding in Semen and Oligozoospermia of Patient with Severe Coronavirus Disease 11 Weeks after Infection by Purpura, Lawrence J, Alukal, Joseph, Chong, Alexander M, Liu, Lihong, Cantos, Anyelina, Shah, Jayesh, Medrano, Nicola, Chang, Jennifer Y, Tsuji, Moriya, Mohri, Hiroshi, Uhlemann, Anne Catrin, Ho, David, Yin, Michael T

“…We report severe acute respiratory syndrome coronavirus 2 in semen by using quantitative reverse transcription PCR during the late convalescent phase. Virus…”
Get full text

An immunostimulatory glycolipid that blocks SARS-CoV-2, RSV, and influenza infections in vivo by Tsuji, Moriya, Nair, Manoj S., Masuda, Kazuya, Castagna, Candace, Chong, Zhenlu, Darling, Tamarand L., Seehra, Kuljeet, Hwang, Youngmin, Ribeiro, Ágata Lopes, Ferreira, Geovane Marques, Corredor, Laura, Coelho-dos-Reis, Jordana Grazziela Alves, Tsuji, Yukiko, Mori, Munemasa, Boon, Adrianus C. M., Diamond, Michael S., Huang, Yaoxing, Ho, David D.

“…Prophylactic vaccines for SARS-CoV-2 have lowered the incidence of severe COVID-19, but emergence of viral variants that are antigenically distinct from the…”
Get full text

Design of a potent CD1d-binding NKT cell ligand as a vaccine adjuvant by Li, Xiangming, Fujio, Masakazu, Imamura, Masakazu, Wu, Douglass, Vasan, Sandhya, Wong, Chi-Huey, Ho, David D., Tsuji, Moriya

“…The glycolipid α-galactosylceramide (α-GalCer) has been shown to bind CD1d molecules to activate invariant natural killer T (iNKT) cells, and subsequently…”
Get full text

Model for In Vivo Assessment of Humoral Protection against Malaria Sporozoite Challenge by Passive Transfer of Monoclonal Antibodies and Immune Serum by Sack, Brandon K, Miller, Jessica L, Vaughan, Ashley M, Douglass, Alyse, Kaushansky, Alexis, Mikolajczak, Sebastian, Coppi, Alida, Gonzalez-Aseguinolaza, Gloria, Tsuji, Moriya, Zavala, Fidel, Sinnis, Photini, Kappe, Stefan H I

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Ultra-low volume intradermal administration of radiation-attenuated sporozoites with the glycolipid adjuvant 7DW8-5 completely protects mice against malaria by Watson, Felicia N., Shears, Melanie J., Kalata, Anya C., Duncombe, Caroline J., Seilie, A. Mariko, Chavtur, Chris, Conrad, Ethan, Cruz Talavera, Irene, Raappana, Andrew, Sather, D. Noah, Chakravarty, Sumana, Sim, B. Kim Lee, Hoffman, Stephen L., Tsuji, Moriya, Murphy, Sean C.

“…Radiation-attenuated sporozoite (RAS) vaccines can completely prevent blood stage Plasmodium infection by inducing liver-resident memory CD8 + T cells to…”
Get full text

Targeted Co-delivery of Tumor Antigen and α-Galactosylceramide to CD141 + Dendritic Cells Induces a Potent Tumor Antigen-Specific Human CD8 + T Cell Response in Human Immune System Mice by Huang, Jing, Zhou, Jing, Ghinnagow, Reem, Seki, Toshiyuki, Iketani, Sho, Soulard, Daphnée, Paczkowski, Patrick, Tsuji, Yukiko, MacKay, Sean, Cruz, Luis Javier, Trottein, François, Tsuji, Moriya

“…Active co-delivery of tumor antigens (Ag) and α-galactosylceramide (α-GalCer), a potent agonist for invariant Natural Killer T ( NKT) cells, to cross-priming…”
Get full text

Human Immune System Mice for the Study of Human Immunodeficiency Virus-Type 1 Infection of the Central Nervous System by Evering, Teresa H, Tsuji, Moriya

“…Immunodeficient mice transplanted with human cell populations or tissues, also known as human immune system (HIS) mice, have emerged as an important and…”
Get full text

Layer-by-Layer Delivery of Multiple Antigens Using Trimethyl Chitosan Nanoparticles as a Malaria Vaccine Candidate by Xu, Yang, Zhou, Ziyou, Brooks, Brad, Ferguson, Tammy, Obliosca, Judy, Huang, Jing, Kaneko, Izumi, Iwanaga, Shiroh, Yuda, Masao, Tsuji, Yukiko, Zhang, Huitang, Luo, Christina C., Jiang, Xunqing, Kong, Xiang-Peng, Tsuji, Moriya, Tison, Christopher K.

“…Developing a safe and effective malaria vaccine is critical to reducing the spread and resurgence of this deadly disease, especially in children. In recent…”
Get full text

Microfluidic Synthesis of Scalable Layer-by-Layer Multiple Antigen Nano-Delivery Platform for SARS-CoV-2 Vaccines by Xu, Yang, Masuda, Kazuya, Groso, Christine, Hassan, Rick, Zhou, Ziyou, Broderick, Kelsey, Tsuji, Moriya, Tison, Christopher

“…The COVID-19 outbreak was a global pandemic with wide-ranging healthcare implications. Although several mRNA-based vaccines delivered using lipid nanoparticles…”
Get full text

Mechanisms for Glycolipid Antigen-Driven Cytokine Polarization by Vα14 i NKT Cells by Sullivan, Barbara A., Nagarajan, Niranjana A., Wingender, Gerhard, Wang, Jing, Scott, Iain, Tsuji, Moriya, Franck, Richard W., Porcelli, Steven A., Zajonc, Dirk M., Kronenberg, Mitchell

“…Abstract Certain glycolipid Ags for Vα14i NKT cells can direct the overall cytokine balance of the immune response. Th2-biasing OCH has a lower TCR avidity…”
Get full text

Surveillance of SARS-CoV-2 immunogenicity: loss of immunodominant HLA-A02-restricted epitopes that activate CD8 + T cells by Lopes-Ribeiro, Ágata, Oliveira, Patrícia de Melo, Retes, Henrique Morais, Barbosa-Stancioli, Edel Figueiredo, da Fonseca, Flávio Guimarães, Tsuji, Moriya, Coelho-Dos-Reis, Jordana Grazziela Alves

“…In this present work, coronavirus subfamilies and SARS-CoV-2 Variants of Concern (VOCs) were investigated for the presence of MHC-I immunodominant viral…”
Get full text

A potent adjuvant effect of a CD1d-binding NKT cell ligand in human immune system mice by Li, Xiangming, Huang, Jing, Kaneko, Izumi, Zhang, Min, Iwanaga, Shiroh, Yuda, Masao, Tsuji, Moriya

“…A CD1d-binding invariant natural killer T (iNKT)-cell stimulatory glycolipid, namely 7DW8-5, is shown to enhance the efficacy of radiation-attenuated…”
Get full text

Development of a novel mechanism-based glycolipid adjuvant for vaccination by Coelho-Dos-Reis, Jordana Grazziela, Li, Xiangming, Tsuji, Moriya

“…The inability to elicit strong and durable cellular responses is a major obstacle in the development of successful vaccines, in particular those against…”
Get full text

Novel Peptide-Based PD1 Immunomodulators Demonstrate Efficacy in Infectious Disease Vaccines and Therapeutics by Kotraiah, Vinayaka, Phares, Timothy W, Browne, Cecille D, Pannucci, James, Mansour, Marc, Noe, Amy R, Tucker, Kenneth D, Christen, Jayne M, Reed, Charles, MacKay, Alecia, Weir, Genevieve M, Rajagopalan, Rajkannan, Stanford, Marianne M, Chung, Chun-Shiang, Ayala, Alfred, Huang, Jing, Tsuji, Moriya, Gutierrez, Gabriel M

“…Many pathogens use the same immune evasion mechanisms as cancer cells. Patients with chronic infections have elevated levels of checkpoint receptors (e.g.,…”
Get full text

Molecular Identification of GD3 as a Suppressor of the Innate Immune Response in Ovarian Cancer by WEBB, Tonya J, XIANGMING LI, GIUNTOLI, Robert L, LOPEZ, Pablo H. H, HEUSER, Christoph, SCHNAAR, Ronald L, TSUJI, Moriya, KURTS, Christian, OELKE, Mathias, SCHNECK, Jonathan P

“…Tumors often display mechanisms to avoid or suppress immune recognition. One such mechanism is the shedding of gangliosides into the local tumor…”
Get full text

KLRG⁺ invariant natural killer T cells are long-lived effectors by Shimizu, Kanako, Sato, Yusuke, Shinga, Jun, Watanabe, Takashi, Endo, Takaho, Asakura, Miki, Yamasaki, Satoru, Kawahara, Kazuyoshi, Kinjo, Yuki, Kitamura, Hiroshi, Watarai, Hiroshi, Ishii, Yasuyuki, Tsuji, Moriya, Taniguchi, Masaru, Ohara, Osamu, Fujii, Shin-ichiro

“…Immunological memory has been regarded as a unique feature of the adaptive immune response mediated in an antigen-specific manner by T and B lymphocytes…”
Get full text