Search Results - "TSUJI, Daisuke"

Oxidative Stress Impairs Autophagy via Inhibition of Lysosomal Transport of VAMP8 by Ohnishi, Yukiya, Tsuji, Daisuke, Itoh, Kohji

“…Autophagy is a highly conserved intracellular degrading system and its dysfunction is considered related to the cause of neurodegenerative disorders. A…”
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Protective effects of farnesyltransferase inhibitor on sepsis-induced morphological aberrations of mitochondria in muscle and increased circulating mitochondrial DNA levels in mice by Tsuji, Daisuke, Nakazawa, Harumasa, Yorozu, Tomoko, Kaneki, Masao

“…Sepsis remains a leading cause of mortality in critically ill patients and is characterized by multi-organ dysfunction. Mitochondrial damage has been proposed…”
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Relaxation Dynamics of a Granular Pile on a Vertically Vibrating Plate by Tsuji, Daisuke, Otsuki, Michio, Katsuragi, Hiroaki

“…Nonlinear relaxation dynamics of a vertically vibrated granular pile is experimentally studied. In the experiment, the flux and slope on the relaxing pile are…”
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Temporal analysis of acoustic emission from a plunged granular bed by Tsuji, Daisuke, Katsuragi, Hiroaki

“…The statistical property of acoustic emission (AE) events from a plunged granular bed is analyzed by means of actual-time and natural-time analyses. These…”
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Formohyperins G–L, polycyclic prenylated benzoylphloroglucinols from the flowers of Hypericum formosanum by Takizawa, Rena, Shimomoto, Yusei, Tsuji, Daisuke, Imabayashi, Kiyoshi, Itoh, Kohji, Akagi, Reiko, Kashiwada, Yoshiki, Tanaka, Naonobu

“…Phytochemical study on the flowers of Hypericum formosanum Maxim. (Hypericaceae) led to the isolation of formohyperins G–L ( 1–6 ), whose structures were…”
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Sarcaglabrin A, a conjugate of C15 and C10 terpenes from the aerial parts of Sarcandra glabra by Yang, Xue-Rong, Tanaka, Naonobu, Tsuji, Daisuke, Lu, Feng-Lai, Yan, Xiao-Jie, Itoh, Kohji, Li, Dian-Peng, Kashiwada, Yoshiki

“…[Display omitted] •Investigation of a medicinal plant Sarcandra glabra gave sarcaglabrins A-C.•Their structures were assigned by spectroscopic analyses…”
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Communiferulins, farnesylated coumarins from the roots of Ferula communis and their anti-neuroinflammatory activity by Yoshino, Yuki, Tanaka, Naonobu, Tsuji, Daisuke, Itoh, Kohji, Kashiwada, Yoshiki

“…Three new farnesylated coumarins, communiferulins A–C ( 1 – 3 ), and a farnesylated chromone, ferchromone ( 4 ), were isolated from the roots of an Apiaceous…”
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Formation conditions and mechanical properties of aggregates produced in tephra–water–snow flows by Niiya, Hirofumi, Oda, Kenichi, Tsuji, Daisuke, Katsuragi, Hiroaki

“…The formation of aggregates consisting of snow, water, and tephra has been reported in small-scale experiments on three-phase flows containing tephra, water,…”
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Generation of human induced pluripotent stem cells from oral mucosa by Miyoshi, Keiko, Tsuji, Daisuke, Kudoh, Keiko, Satomura, Kazuhito, Muto, Taro, Itoh, Kohji, Noma, Takafumi

“…Induced pluripotent stem (iPS) cells are one of the most promising sources for cell therapy in regenerative medicine. Using a patient's own genetically…”
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Limonoids from the aerial parts of Munronia pinnata by Yang, Xue-Rong, Tanaka, Naonobu, Tsuji, Daisuke, Lu, Feng-Lai, Yan, Xiao-Jie, Itoh, Kohji, Li, Dian-Peng, Kashiwada, Yoshiki

“…Six new limonoids, munropins A−F (1–6), were isolated from the aerial parts of a Chinese medicinal plant, Munronia pinnata (Meliaceae). The structures of 1–6…”
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3-layer modelling method to improve the cyber resilience in Industrial Control Systems by Tsuji, Daisuke, Fujita, Junya, Matsumoto, Noritaka, Tamura, Yu, Doenhoff, Jens, Shigemoto, Tomohiro

“…Cyberattacks against Industrial Control Systems (ICS), which play a crucial role in many industrial domains, could bring environmental and safety damages as…”
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Hyperdioxanes, dibenzo-1,4-dioxane derivatives from the roots of Hypericum ascyron by Niwa, Kanji, Tanaka, Naonobu, Shimomoto, Yusei, Tsuji, Daisuke, Kim, Sang-Yong, Kojoma, Mareshige, Itoh, Kohji, Chen, Chin-Ho, Lee, Kuo-Hsiung, Kashiwada, Yoshiki

“…Six dibenzo-1,4-dioxane derivatives ( 1 – 6 ) were isolated from the roots of a Hypericaceous plant Hypericum ascyron . Spectroscopic analyses revealed 2 and 4…”
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Agesasines A and B, Bromopyrrole Alkaloids from Marine Sponges Agelas spp by Lee, Sanghoon, Tanaka, Naonobu, Takahashi, Sakura, Tsuji, Daisuke, Kim, Sang-Yong, Kojoma, Mareshige, Itoh, Kohji, Kobayashi, Jun'ichi, Kashiwada, Yoshiki

“…Exploration for specialized metabolites of Okinawan marine sponges spp. resulted in the isolation of five new bromopyrrole alkaloids, agesasines A ( ) and B (…”
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Highly phosphomannosylated enzyme replacement therapy for GM2 gangliosidosis by Tsuji, Daisuke, Akeboshi, Hiromi, Matsuoka, Kazuhiko, Yasuoka, Hiroko, Miyasaki, Eri, Kasahara, Yoshiko, Kawashima, Ikuo, Chiba, Yasunori, Jigami, Yoshifumi, Taki, Takao, Sakuraba, Hitoshi, Itoh, Kohji

“…Objective: Novel recombinant human lysosomal β‐hexosaminidase A (HexA) was developed for enzyme replacement therapy (ERT) for Tay‐Sachs and Sandhoff diseases,…”
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Glycolysis inhibition inactivates ABC transporters to restore drug sensitivity in malignant cells by Nakano, Ayako, Tsuji, Daisuke, Miki, Hirokazu, Cui, Qu, El Sayed, Salah Mohamed, Ikegame, Akishige, Oda, Asuka, Amou, Hiroe, Nakamura, Shingen, Harada, Takeshi, Fujii, Shiro, Kagawa, Kumiko, Takeuchi, Kyoko, Sakai, Akira, Ozaki, Shuji, Okano, Kazuma, Nakamura, Takahiro, Itoh, Kohji, Matsumoto, Toshio, Abe, Masahiro

“…Cancer cells eventually acquire drug resistance largely via the aberrant expression of ATP-binding cassette (ABC) transporters, ATP-dependent efflux pumps…”
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1,3a,6a-Triazapentalene derivatives as photo-induced cytotoxic small fluorescent dyes by Tsuji, Daisuke, Nakayama, Atsushi, Yamamoto, Riko, Nagano, Shuji, Taniguchi, Takashi, Sato, Ryota, Karanjit, Sangita, Muguruma, Naoki, Takayama, Tetsuji, Itoh, Kohji, Namba, Kosuke

“…1,3a,6a-Triazapentalene (TAP) is a compact fluorescent chromophore whose fluorescence properties vary greatly depending on the substituents on the TAP ring…”
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Reversal of neuroinflammation in novel GS model mice by single i.c.v. administration of CHO-derived rhCTSA precursor protein by Horii, Yuto, Iniwa, Toshiki, Onitsuka, Masayoshi, Tsukimoto, Jun, Tanaka, Yuki, Ike, Hironobu, Fukushi, Yuri, Ando, Haruna, Takeuchi, Yoshie, Nishioka, So-ichiro, Tsuji, Daisuke, Ikuo, Mariko, Yamazaki, Naoshi, Takiguchi, Yoshiharu, Ishimaru, Naozumi, Itoh, Kohji

“…Galactosialidosis (GS) is a lysosomal cathepsin A (CTSA) deficiency. It associates with a simultaneous decrease of neuraminidase 1 (NEU1) activity and…”
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Combination with a defucosylated anti-HM1.24 monoclonal antibody plus lenalidomide induces marked ADCC against myeloma cells and their progenitors by Harada, Takeshi, Ozaki, Shuji, Oda, Asuka, Tsuji, Daisuke, Ikegame, Akishige, Iwasa, Masami, Udaka, Kengo, Fujii, Shiro, Nakamura, Shingen, Miki, Hirokazu, Kagawa, Kumiko, Kuroda, Yoshiaki, Kawai, Shigeto, Itoh, Kohji, Yamada-Okabe, Hisafumi, Matsumoto, Toshio, Abe, Masahiro

“…The immunomodulatory drug lenalidomide (Len) has drawn attention to potentiate antibody-dependent cellular cytotoxicity (ADCC)-mediated immunotherapies. We…”
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Mechanism of abnormal growth in astrocytes derived from a mouse model of GM2 gangliosidosis by Kawashima, Nagako, Tsuji, Daisuke, Okuda, Tetsuya, Itoh, Kohji, Nakayama, Ken-ichi

“…Sandhoff disease is a progressive neurodegenerative disorder caused by mutations in the HEXB gene which encodes the β-subunit of N-acetyl-β-hexosaminidase A…”
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Development of a 1,3a,6a-triazapentalene derivative as a compact and thiol-specific fluorescent labeling reagent by Nakayama, Atsushi, Otani, Akira, Inokuma, Tsubasa, Tsuji, Daisuke, Mukaiyama, Haruka, Nakayama, Akira, Itoh, Kohji, Otaka, Akira, Tanino, Keiji, Namba, Kosuke

“…For the fluorescence imaging of biologically active small compounds, the development of compact fluorophores that do not perturb bioactivity is required. Here…”
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