Search Results - "TSUDA, MITSUHIRO"

Comparative toxicokinetic/toxicodynamic study of rubber antioxidants, 2-mercaptobenzimidazole and its methyl substituted derivatives, by repeated oral administration in rats by SAKEMI, Kazue, ITO, Rieno, UMEMURA, Takashi, OHNO, Yasuo, TSUDA, Mitsuhiro

“…2-Mercaptobenzimidazole (MBI), a rubber antioxidant, is known to exhibit potent thyroid toxicity in rats, whereas its methylated derivatives are much less…”
Get full text

TOXICITY STUDY OF A RUBBER ANTIOXIDANT, 2-MERCAPTOBENZIMIDAZOLE, BY REPEATED ORAL ADMINISTRATION TO RATS by KAWASAKI, Yasushi, UMEMURA, Takashi, SAITO, Minoru, MOMMA, Junko, MATSUSHIMA, Yuko, SEKIGUCHI, Hiromi, MATSUMOTO, Mami, SAKEMI, Kazue, ISAMA, Kazuo, INOUE, Tohru, KUROKAWA, Yuji, TSUDA, Mitsuhiro

“…The chemical structure of 2-mercaptobenzimidazole (2-MBI), which is widely used as a rubber antioxidant, is partially similar to those of thiourea (TU) and…”
Get full text

A new protocol and criteria for quantitative determination of sensitization potencies of chemicals by guinea pig maximization test by Nakamura, A, Momma, J, Sekiguchi, H, Noda, T, Yamano, T, Kaniwa, M, Kojima, S, Tsuda, M, Kurokawa, Y

“…This paper presents precise sensitization test data of 15 chemicals with a wide spectrum of sensitization potencies, and proposes a new protocol and criteria…”
Get more information

COMPARATIVE TOXICOKINETIC STUDY OF RUBBER ANTIOXIDANTS, 2-MERCAPTOBENZIMIDAZOLE AND 2-MERCAPTOMETHYLBENZIMIDAZOLE, BY SINGLE ORAL ADMINISTRATION IN RATS by SAKEMI, Kazue, USAMI, Makoto, MITSUNAGA, Katsuyoshi, OHNO, Yasuo, TSUDA, Mitsuhiro

“…Toxicokinetics of 2-mercaptobenzimidazole (MBI) and 2-mercaptomethylbenzimidazole (MMBI), rubber antioxidants with thioureylene structure, were compared after…”
Get full text

Marked formation of thiazolidine-4-carboxylic acid, an effective nitrite trapping agent in vivo, on boiling of dried shiitake mushroom (Lentinus edodes) by Kurashima, Yukiko, Tsuda, Mitsuhiro, Sugimura, Takashi

Get full text

Future prospects for toxicokinetics: its ability to predict drug adverse events in humans by Sugiyama, Y, Ito, K, Tsuda, M, Horii, I

Get full text

Cross-sectional Epidemiologic Study for Assessing Cancer Risks at the Population Level: II. Baseline Data and Correlation Analysis by Tsugane, Shoichiro, Gey, Fred, Ichinowatari, Yoshimi, Miyajima, Yoshimichi, Ishibashi, Teruo, Matsushima, Shosui, Hirota, Yoko, Inami, Tsuneo, Yamaguchi, Momoko, Karita, Kanae, Kabuto, Michinori, Takashima, Yutaka, Todoriki, Hidemi, Tsuda, Mitsuhiro, Akabane, Masayuki, Furuichi, Yasuhiro, Hamada, Gerson, Watanabe, Shaw

“…A cross-sectional study on associations between lifestyle factors and cancer risks was conducted in five areas of Japan. The study design and participation…”
Get full text

Cross-sectional Epidemiologic Study for Assessing Cancer Risks at the Population Level: I. Study Design and Participation Rate by Tsugane, Shoichiro, Gey, Fred, Ichinowatari, Yoshimi, Miyajima, Yoshimichi, Ishibashi, Teruo, Matsushima, Shosui, Hirota, Yoko, Inami, Tsuneo, Yamaguchi, Momoko, Karita, Kanae, Kabuto, Michinori, Takashima, Yutaka, Todoriki, Hidemi, Tsuda, Mitsuhiro, Akabane, Masayuki, Furuichi, Yasuhiro, Hamada, Gerson, Watanabe, Shaw

“…A cross-sectional study to assess the associations between lifestyle factors and cancer risk was conducted in five areas of Japan (Ninohe in Iwate, Yokote in…”
Get full text

Cross-sectional Epidemiologic Study for Assessing Cancer Risks at the Population Level by Tsugane, Shoichiro, Gey, Fred, Ichinowatari, Yoshimi, Miyajima, Yoshimichi, Ishibashi, Teruo, Matsushima, Shosui, Hirota, Yoko, Inami, Tsuneo, Yamaguchi, Momoko, Karita, Kanae, Kabuto, Michinori, Takashima, Yutaka, Todoriki, Hidemi, Tsuda, Mitsuhiro, Akabane, Masayuki, Furuichi, Yasuhiro, Hamada, Gerson, Watanabe, Shaw

Get full text

Liver fluke infection and cholangiocarcinoma: model of endogenous nitric oxide and extragastric nitrosation in human carcinogenesis by Haswell-Elkins, M R, Satarug, S, Tsuda, M, Mairiang, E, Esumi, H, Sithithaworn, P, Mairiang, P, Saitoh, M, Yongvanit, P, Elkins, D B

“…Cancers arising during bacterial, viral and parasitic infection provide useful models to investigate the link between inflammation and carcinogenesis. Because…”
Get more information

Effect of Systemic L-Arginine Administration on Hemodynamics and Nitric Oxide Release in Man by HISHIKAWA, Keiichi, NAKAKI, Toshio, TSUDA, Mitsuhiro, ESUMI, Hiroyasu, OHSHIMA, Hiroshi, SUZUKI, Hiromichi, SARUTA, Takao, KATO, Ryuichi

“…The effects of L-arginine administration on systemic hemodynamics and plasma concentrations of neuro-endocrine hormones and amino acids were investigated in 10…”
Get full text

Catalytic Hydrogenation of Dimethylpyridine Methiodides and Stereochemistry of Hydrogenation Products by TSUDA, MITSUHIRO, KAWAZOE, YUTAKA

“…Catalytic hydrogenation of six kinds of N-methylpyridinium iodides gave pairs of geometrical isomers in a certain ratio for each methiodide. ortho-Dimethyl…”
Get full text

Effects of an inhibitor of microsomal Ca2+ ATPase, 2,5-di(tert-butyl)-1,4-hydroquinone on intracellular free Ca2+ level and histamine secretion in rat basophilic leukemia cells by Kitajima, Satoshi, Momma, Junto, Tsuda, Mitsuhiro, Kurokawa, Yuji, Teshima, Reiko, Sawada, Jun-ichi

“…We examined the effect of the inhibitor of microsomal Ca2+ ATPase, 2,5-di(tert-butyl)-1,4-hydroquinone (DtBHQ) on intracellular free Ca2+ level (「Ca2+ 」_i )…”
Get full text

Stereochemistry in Solution. IV. Conformational Preference of the Non-bonded Electron Pair of Nitrogen in Piperidine Derivatives. Effective Size of the Lone Paired Electrons by TSUDA, MITSUHIRO, KAWAZOE, YUTAKA

“…From the IR spectrum in C-D stretching region of 2, 6-dideuterated piperidine, N-methylpiperidine, and N-isopropylpiperidine, quantitative evaluation was made…”
Get full text

PRESENCE OF N-NITROSO-L-THIOPROLINE AND N-NITROSO-L-METHYLTHIOPROLINES IN HUMAN URINE AS MAJOR N-NITROSO COMPOUNDS by TSUDA, Mitsuhiro, HIRAYAMA, Takeshi, SUGIMURA, Takashi

“…Unknown N-nitroso compounds were found in human urine of healthy volunteers by gas chromatography-thermal energy analysis. These compounds were identified as…”
Get full text

Formation of thiazolidine-4-carboxylic acid (thioproline), an effective nitrite-trapping agent in human body, in Parkia speciosa seeds and other edible leguminous seeds in Thailand by SUVACHITTANONT, W, KURASHIMA, Y, ESUMI, H, TSUDA, M

Get full text

Formation of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in a model system by heating creatinine, glycine and glucose by Jägerstad, M, Olsson, K, Grivas, S, Negishi, C, Wakabayashi, K, Tsuda, M, Sato, S, Sugimura, T

“…A mixture of creatinine, glucose and glycine was heated in diethylene glycol containing 14% water for 2 h at 128 degrees C, and the mutagens formed were…”
Get more information

On the Relationship between C-13 Nuclear Magnetic Resonance Chemical Shift and Stability of Molecule in Methyl-Substituted N, N-Dimethylpiperidinium Salts by TSUDA, MITSUHIRO, ICHIKAWA, HIROSHI, OGATA, MICHIHIKO, KAWAZOE, YUTAKA

“…Among positional and conformational isomers of mono-and di-methyl derivatives of N, N-dimethylpiperidinium ions, a linear relationship was found between the…”
Get full text

Solvent-and Concentration-Dependent Shifts in Proton Magnetic Resonance of Quaternary Ammonium Salts by TSUDA, MITSUHIRO, TSUDA, MASAKO, KAWAZOE, YUTAKA, CASY, ALANF, HASSAN, MAHMOUDM.A.

“…Proton magnetic resonance spectra of some methylpiperidinium salts were taken in various solvents and at various concentrations. Chemical shifts of the…”
Get full text

Relationships between the synthesis of N-nitrosodimethylamine and immune responses to chronic infection with the carcinogenic parasite, Opisthorchis viverrini, in men by SATARUG, S, HASWELL-ELKINS, M. R, ELKINS, D. B, SITHITHAWORN, P, BARTSCH, H, OHSHIMA, H, TSUDA, M, MAIRIANG, P, MAIRIANG, E, YONGVANIT, P, ESUMI, H

“…This study investigated the relationship between immune responses to infection with the liver fluke, Opisthorchis viverrini, and the synthesis of the…”
Get full text