Search Results - "TSUDA, HITOSHI"

Novel approach to HER2 quantification using phosphor-integrated dots in human breast invasive cancer microarray by Saito, Naoya, Matsuo, Tsukasa, Tsuda, Hitoshi, Yokota, Hiroyuki, Okada, Hisatake

“…HER2 expression in breast cancer is evaluated to select patients for anti-HER2 therapy. With the advent of newly approved HER2-targeted drugs for low HER2…”
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MicroRNA-21 expression in cancer cells is an independent biomarker of progression-free survival of endometrioid endometrial carcinoma by Sato, Kimiya, Miyamoto, Morikazu, Takano, Masashi, Tsuda, Hitoshi

“…Endometrial carcinoma is one of the most common gynecological cancers. MicroRNA-21 (miR-21) is the most consistently overexpressed miRNA in almost all human…”
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Identification of PDHX as a metabolic target for esophageal squamous cell carcinoma by Inoue, Jun, Kishikawa, Masahiro, Tsuda, Hitoshi, Nakajima, Yasuaki, Asakage, Takahiro, Inazawa, Johji

“…The metabolism in tumors is reprogrammed to meet its energetic and substrate demands. However, this metabolic reprogramming creates metabolic vulnerabilities,…”
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Gene expression microarray analysis of adult testicular germ cell tumor: a comparison between pure-type seminomas and seminoma components in mixed tumors by Miyai, Kosuke, Yonekura, Yuiko, Ito, Keiichi, Matsukuma, Susumu, Tsuda, Hitoshi

“…We previously demonstrated a genetic evidence of the progression from seminoma to embryonal carcinoma in mixed testicular germ cell tumors (TGCTs). This…”
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ARID1A expression in gastric adenocarcinoma:Clinicopathological significance and correlation with DNA mismatch repair status by Inada, Ryo, Sekine, Shigeki, Taniguchi, Hirokazu, Tsuda, Hitoshi, Katai, Hitoshi, Fujiwara, Toshiyoshi, Kushima, Ryoji

“…AIM:To analyze the mismatch repair(MMR)status and the ARID1A expression as well as their clinicopathological significance in gastric adenocarcinomas.METHODS:We…”
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The first Japanese nationwide multicenter study of BRCA mutation testing in ovarian cancer: CHARacterizing the cross-sectionaL approach to Ovarian cancer geneTic TEsting of BRCA (CHARLOTTE) by Enomoto, Takayuki, Aoki, Daisuke, Hattori, Kana, Jinushi, Masahisa, Kigawa, Junzo, Takeshima, Nobuhiro, Tsuda, Hitoshi, Watanabe, Yoh, Yoshihara, Kosuke, Sugiyama, Toru

“…gene mutations are associated with hereditary ovarian cancer. plays a key role in genome integrity, and mutations result in an increased risk for ovarian…”
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Prognostic impact of stromal periostin expression in upper urinary tract urothelial carcinoma by Miyai, Kosuke, Kawamura, Kazuki, Ito, Keiichi, Matsukuma, Susumu, Tsuda, Hitoshi

“…Background Periostin is an extracellular matrix protein that has been known to be implicated in fibrillogenesis and cell migration, including cancer…”
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Histological differences in cancer cells, stroma, and luminal spaces strongly correlate with in vivo MRI-detectability of prostate cancer by Miyai, Kosuke, Mikoshi, Ayako, Hamabe, Fumiko, Nakanishi, Kuniaki, Ito, Keiichi, Tsuda, Hitoshi, Shinmoto, Hiroshi

“…The current study aimed to investigate the plausible histopathological factors that affect the detectability of prostate cancers on multiparametric magnetic…”
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Frequent GNAS and KRAS mutations in pyloric gland adenoma of the stomach and duodenum by Matsubara, Akiko, Sekine, Shigeki, Kushima, Ryoji, Ogawa, Reiko, Taniguchi, Hirokazu, Tsuda, Hitoshi, Kanai, Yae

“…Gastric and duodenal adenomas exhibit a significant morphological and phenotypical diversity and are classified into intestinal‐type, foveolar‐type and pyloric…”
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NKX2.2 is a useful immunohistochemical marker for Ewing sarcoma by Yoshida, Akihiko, Sekine, Shigeki, Tsuta, Koji, Fukayama, Masashi, Furuta, Koh, Tsuda, Hitoshi

“…Ewing sarcoma is a high-grade round cell sarcoma that affects bones and soft tissues in children and young adults. Its diagnosis can be challenging, and the…”
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Japanese nationwide observational multicenter study of tumor BRCA1/2 variant testing in advanced ovarian cancer by Oda, Katsutoshi, Aoki, Daisuke, Tsuda, Hitoshi, Nishihara, Hiroshi, Aoyama, Hisanori, Inomata, Hyoe, Shimada, Muneaki, Enomoto, Takayuki

“…The association between germline BRCA1 and BRCA2 pathogenic variants (mutations: gBRCAm) and ovarian cancer risk is well established. Germline testing alone…”
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Correlation of high LAT1 expression with the prognosis of endometrioid carcinoma of the uterine corpus by Sato, Kimiya, Miyamoto, Morikazu, Takano, Masashi, Tsuda, Hitoshi

“…The expression of L-type amino acid transporter 1 (LAT1) has been described to play essential roles in cancer cell growth and survival. To determine the…”
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KIF5B-RET fusions in lung adenocarcinoma by Kohno, Takashi, Ichikawa, Hitoshi, Totoki, Yasushi, Yasuda, Kazuki, Hiramoto, Masaki, Nammo, Takao, Sakamoto, Hiromi, Tsuta, Koji, Furuta, Koh, Shimada, Yoko, Iwakawa, Reika, Ogiwara, Hideaki, Oike, Takahiro, Enari, Masato, Schetter, Aaron J, Okayama, Hirokazu, Haugen, Aage, Skaug, Vidar, Chiku, Suenori, Yamanaka, Itaru, Arai, Yasuhito, Watanabe, Shun-ichi, Sekine, Ikuo, Ogawa, Seishi, Harris, Curtis C, Tsuda, Hitoshi, Yoshida, Teruhiko, Yokota, Jun, Shibata, Tatsuhiro

“…The authors report a new type of genetic alteration in lung adenocarcinoma. Fusions of KIF5B with RET kinase are found in 1–2% of lung cancer patients,…”
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The utility of the proposed IASLC/ATS/ERS lung adenocarcinoma subtypes for disease prognosis and correlation of driver gene alterations by Tsuta, Koji, Kawago, Mitsumasa, Inoue, Eisuke, Yoshida, Akihiko, Takahashi, Fumiaki, Sakurai, Hiroyuki, Watanabe, Shun-ichi, Takeuchi, Masahiro, Furuta, Koh, Asamura, Hisao, Tsuda, Hitoshi

“…Abstract Background The present study aimed to determine the ability of the revised International Association for the Study of Lung Cancer (IASLC)/American…”
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Significant relationship between the LAT1 expression pattern and chemoresistance in ovarian clear cell carcinoma by Sato, Kimiya, Miyamoto, Morikazu, Takano, Masashi, Furuya, Kenichi, Tsuda, Hitoshi

“…L-type amino acid transporter 1 (LAT1) is a Na + -independent neutral amino acid transporter that plays a key role in cancer cell growth and survival. To…”
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PIK3CA mutation is an early event in the development of endometriosis-associated ovarian clear cell adenocarcinoma by Yamamoto, Sohei, Tsuda, Hitoshi, Takano, Masashi, Iwaya, Keichi, Tamai, Seiichi, Matsubara, Osamu

“…Clear cell adenocarcinoma (CCA), a highly lethal histological subtype of ovarian carcinoma, is a type of human cancer with a high frequency of activating…”
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Prognostic significance of mesothelin expression in colorectal cancer disclosed by area-specific four-point tissue microarrays by Shiraishi, Takehiro, Shinto, Eiji, Nearchou, Ines P., Tsuda, Hitoshi, Kajiwara, Yoshiki, Einama, Takahiro, Caie, Peter D., Kishi, Yoji, Ueno, Hideki

“…Mesothelin (MSLN) is a cell surface glycoprotein present in many cancer types. Its expression is generally associated with an unfavorable prognosis. This study…”
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Pilot Study of Prostate Cancer Angiogenesis Imaging Using a Photoacoustic Imaging System by Horiguchi, Akio, Shinchi, Masayuki, Nakamura, Akiko, Wada, Takatsugu, Ito, Keiichi, Asano, Tomohiko, Shinmoto, Hiroshi, Tsuda, Hitoshi, Ishihara, Miya

“…To investigate a link between the appearance of photoacoustic imaging (PAI) and microvasculature in prostate cancer and to assess the feasibility of PAI for…”
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Clinical Significance of a Gene Signature Generated from Tumor Budding Grade in Colon Cancer by Shinto, Eiji, Yoshida, Yuichiro, Kajiwara, Yoshiki, Okamoto, Koichi, Mochizuki, Satsuki, Yamadera, Masato, Shiraishi, Takehiro, Nagata, Ken, Tsuda, Hitoshi, Hase, Kazuo, Kishi, Yoji, Ueno, Hideki

“…Background Tumor budding, a microscopic finding of dedifferentiation at the invasive margin, has been reported as a definite prognostic marker in colon cancer…”
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Immunohistochemical analysis of MDM2 and CDK4 distinguishes low-grade osteosarcoma from benign mimics by Yoshida, Akihiko, Ushiku, Tetsuo, Motoi, Toru, Shibata, Tatsuhiro, Beppu, Yasuo, Fukayama, Masashi, Tsuda, Hitoshi

“…Parosteal osteosarcoma and low-grade central osteosarcoma are two types of low-grade osteosarcoma that show similar clinical behaviors, histological features,…”
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