Search Results - "TSUBOTA, KAZUO"

Short Tear Film Breakup Time-Type Dry Eye by Tsubota, Kazuo

“…Measurement of tear film breakup time (TBUT) has become a standard diagnostic procedure in the dry eye clinic. Short TBUT-type dry eye is characterized by TBUT…”
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Potential Role of Oxidative Stress in Ocular Surface Inflammation and Dry Eye Disease by Dogru, Murat, Kojima, Takashi, Simsek, Cem, Tsubota, Kazuo

“…Reactive oxygen species (ROS) are produced as a by-product during the mitochondrial respiration of the oxygen and potentially able to damage the tissues…”
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A review on the epidemiology of myopia in school children worldwide by Grzybowski, Andrzej, Kanclerz, Piotr, Tsubota, Kazuo, Lanca, Carla, Saw, Seang-Mei

“…Due to high prevalence myopia has gained importance in epidemiological studies. Children with early onset are at particular risk of complications associated…”
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Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men by Irie, Junichiro, Inagaki, Emi, Fujita, Masataka, Nakaya, Hideaki, Mitsuishi, Masanori, Yamaguchi, Shintaro, Yamashita, Kazuya, Shigaki, Shuhei, Ono, Takashi, Yukioka, Hideo, Okano, Hideyuki, Nabeshima, Yo-ichi, Imai, Shin-ichiro, Yasui, Masato, Tsubota, Kazuo, Itoh, Hiroshi

“…Recent studies have revealed that decline in cellular nicotinamide adenine dinucleotide (NAD+) levels causes aging-related disorders and therapeutic approaches…”
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Cascade of Inflammatory, Fibrotic Processes, and Stress-Induced Senescence in Chronic GVHD-Related Dry Eye Disease by Ogawa, Yoko, Kawakami, Yutaka, Tsubota, Kazuo

“…Ocular graft-versus-host disease (GVHD) is a major complication after allogeneic hematopoietic stem cell transplantation. Ocular GVHD affects recipients’…”
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Decreased sleep quality in high myopia children by Ayaki, Masahiko, Torii, Hidemasa, Tsubota, Kazuo, Negishi, Kazuno

“…The aim of the present study was to evaluate sleep quality in myopic children and adults. This cross sectional study surveyed 486 participants aged from 10 to…”
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Efficacy and safety of 0.01% atropine for prevention of childhood myopia in a 2-year randomized placebo-controlled study by Hieda, Osamu, Hiraoka, Takahiro, Fujikado, Takashi, Ishiko, Satoshi, Hasebe, Satoshi, Torii, Hidemasa, Takahashi, Hiroshi, Nakamura, Yo, Sotozono, Chie, Oshika, Tetsuro, Morimoto, Takeshi, Nishida, Kohji, Nishikawa, Noriko, Song, Young-Seok, Tokutake, Tomoki, Nishi, Yasuyo, Shigeno, Yuta, Kurihara, Toshihide, Negishi, Kazuno, Tsubota, Kazuo, Ono, Masafumi, Nakai, Tomoko, Tan, Donald, Tanaka, Shiro, Kinoshita, Shigeru

“…Purpose Atropine eye drops prevent the progression of myopia, but their use has not been tested in the Japanese schoolchildren population. Here, we evaluate…”
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TFOS DEWS II Definition and Classification Report by Craig, Jennifer P., Nichols, Kelly K., Akpek, Esen K., Caffery, Barbara, Dua, Harminder S., Joo, Choun-Ki, Liu, Zuguo, Nelson, J. Daniel, Nichols, Jason J., Tsubota, Kazuo, Stapleton, Fiona

“…The goals of the TFOS DEWS II Definition and Classification Subcommittee were to create an evidence-based definition and a contemporary classification system…”
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Real frontier in clinical applications of regenerative medicine by Tsubota, Kazuo

“…Dr. Kuroda from Kyoto University reviewed the clinical application of injectable growth factor for bone regeneration, and his review describes the progress of…”
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Violet Light Transmission is Related to Myopia Progression in Adult High Myopia by Torii, Hidemasa, Ohnuma, Kazuhiko, Kurihara, Toshihide, Tsubota, Kazuo, Negishi, Kazuno

“…Myopia is increasing worldwide. Although the exact etiology of myopia is unknown, outdoor activity is one of the most important environmental factors for…”
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Sleep and subjective happiness between the ages 40 and 59 in relation to presbyopia and dry eye by Negishi, Kazuno, Ayaki, Masahiko, Kawashima, Motoko, Tsubota, Kazuo

“…The aim of this study was to explore the status of quality of life between the ages 40-59 in relation to presbyopia and dry eye. Near add power and preferred…”
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Autoimmune Epithelitis and Chronic Inflammation in Sjögren's Syndrome-Related Dry Eye Disease by Ogawa, Yoko, Takeuchi, Tsutomu, Tsubota, Kazuo

“…Autoimmune epithelitis and chronic inflammation are one of the characteristic features of the immune pathogenesis of Sjögren's syndrome (SS)-related dry eye…”
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Violet light suppresses lens-induced myopia via neuropsin (OPN5) in mice by Jiang, Xiaoyan, Pardue, Machelle T., Mori, Kiwako, Ikeda, Shin-ichi, Torii, Hidemasa, D’Souza, Shane, Lang, Richard A., Kurihara, Toshihide, Tsubota, Kazuo

“…Myopia has become a major public health concern, particularly across much of Asia. It has been shown in multiple studies that outdoor activity has a protective…”
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New Perspectives on Dry Eye Definition and Diagnosis: A Consensus Report by the Asia Dry Eye Society by Tsubota, Kazuo, MD, Yokoi, Norihiko, MD, PhD, Shimazaki, Jun, MD, PhD, Watanabe, Hitoshi, MD, PhD, Dogru, Murat, MD, PhD, Yamada, Masakazu, MD, PhD, Kinoshita, Shigeru, MD, PhD, Kim, Hyo-Myung, MD, PhD, Tchah, Hung-Won, MD, PhD, Hyon, Joon Young, MD, PhD, Yoon, Kyung-Chul, MD, PhD, Seo, Kyoung Yul, MD, PhD, Sun, Xuguang, MD, PhD, Chen, Wei, MD, PhD, Liang, Lingyi, MD, PhD, Mingwu, Li, MD, PhD, Liu, Zuguo, MD, PhD

“…Abstract For the last 20 years, a great amount of evidence has accumulated through epidemiological studies that most of the dry eye disease encountered in…”
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Loss of epigenetic information as a cause of mammalian aging by Yang, Jae-Hyun, Hayano, Motoshi, Griffin, Patrick T., Amorim, João A., Bonkowski, Michael S., Apostolides, John K., Salfati, Elias L., Blanchette, Marco, Munding, Elizabeth M., Bhakta, Mital, Chew, Yap Ching, Guo, Wei, Yang, Xiaojing, Maybury-Lewis, Sun, Tian, Xiao, Ross, Jaime M., Coppotelli, Giuseppe, Meer, Margarita V., Rogers-Hammond, Ryan, Vera, Daniel L., Lu, Yuancheng Ryan, Pippin, Jeffrey W., Creswell, Michael L., Dou, Zhixun, Xu, Caiyue, Mitchell, Sarah J., Das, Abhirup, O’Connell, Brendan L., Thakur, Sachin, Kane, Alice E., Su, Qiao, Mohri, Yasuaki, Nishimura, Emi K., Schaevitz, Laura, Garg, Neha, Balta, Ana-Maria, Rego, Meghan A., Gregory-Ksander, Meredith, Jakobs, Tatjana C., Zhong, Lei, Wakimoto, Hiroko, El Andari, Jihad, Grimm, Dirk, Mostoslavsky, Raul, Wagers, Amy J., Tsubota, Kazuo, Bonasera, Stephen J., Palmeira, Carlos M., Seidman, Jonathan G., Seidman, Christine E., Wolf, Norman S., Kreiling, Jill A., Sedivy, John M., Murphy, George F., Green, Richard E., Garcia, Benjamin A., Berger, Shelley L., Oberdoerffer, Philipp, Shankland, Stuart J., Gladyshev, Vadim N., Ksander, Bruce R., Pfenning, Andreas R., Rajman, Luis A., Sinclair, David A.

“…All living things experience an increase in entropy, manifested as a loss of genetic and epigenetic information. In yeast, epigenetic information is lost over…”
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Alterations of Murine Subbasal Corneal Nerves After Environmental Dry Eye Stress by Simsek, Cem, Kojima, Takashi, Dogru, Murat, Tsubota, Kazuo

“…To investigate the morphologic changes in the corneal subbasal nerve (CSN) plexus in wild-type mice after exposure to environmental dry eye stress (EDES) using…”
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The international workshop on meibomian gland dysfunction: report of the subcommittee on management and treatment of meibomian gland dysfunction by Geerling, Gerd, Tauber, Joseph, Baudouin, Christophe, Goto, Eiki, Matsumoto, Yukihiro, O'Brien, Terrence, Rolando, Maurizio, Tsubota, Kazuo, Nichols, Kelly K

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Defining Dry Eye from a Clinical Perspective by Tsubota, Kazuo, Pflugfelder, Stephen C, Liu, Zuguo, Baudouin, Christophe, Kim, Hyo Myung, Messmer, Elisabeth M, Kruse, Friedrich, Liang, Lingyi, Carreno-Galeano, Jimena Tatiana, Rolando, Maurizio, Yokoi, Norihiko, Kinoshita, Shigeru, Dana, Reza

“…Over the past decades, the number of patients with dry eye disease (DED) has increased dramatically. The incidence of DED is higher in Asia than in Europe and…”
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Associations between problematic Internet use and psychiatric symptoms among university students in Japan by Kitazawa, Momoko, Yoshimura, Michitaka, Murata, Mayu, Sato‐Fujimoto, Yuka, Hitokoto, Hidefumi, Mimura, Masaru, Tsubota, Kazuo, Kishimoto, Taishiro

“…Aim Research on the adverse effects of Internet use has gained importance recently. However, there is currently insufficient data on Japanese young adults’…”
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Japan as the front‐runner of super‐aged societies: Perspectives from medicine and medical care in Japan by Arai, Hidenori, Ouchi, Yasuyoshi, Toba, Kenji, Endo, Tamao, Shimokado, Kentaro, Tsubota, Kazuo, Matsuo, Seiichi, Mori, Hidezo, Yumura, Wako, Yokode, Masayuki, Rakugi, Hiromi, Ohshima, Shinichi

“…Background The demographic structure of a country changes dramatically with increasing trends toward general population aging and declining birth rates. In…”
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