Search Results - "TSUBAMOTO, YOSHIHARU"

Inhibition of gastric inhibitory polypeptide signaling prevents obesity by Seino, Yutaka, Miyawaki, Kazumasa, Yamada, Yuichiro, Ban, Nobuhiro, Ihara, Yu, Tsukiyama, Katsushi, Zhou, Heying, Fujimoto, Shimpei, Oku, Akira, Tsuda, Kinsuke, Toyokuni, Shinya, Hiai, Hiroshi, Mizunoya, Wataru, Fushiki, Tohru, Holst, Jens Juul, Makino, Mitsuhiro, Tashita, Akira, Kobara, Yukari, Tsubamoto, Yoshiharu, Jinnouchi, Takayoshi, Jomori, Takahito

“…Secretion of gastric inhibitory polypeptide (GIP), a duodenal hormone, is primarily induced by absorption of ingested fat. Here we describe a novel pathway of…”
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Role of NADH Shuttle System in Glucose-Induced Activation of Mitochondrial Metabolism and Insulin Secretion by Eto, Kazuhiro, Tsubamoto, Yoshiharu, Terauchi, Yasuo, Sugiyama, Takuya, Kishimoto, Takuya, Takahashi, Noriko, Yamauchi, Naoko, Kubota, Naoto, Murayama, Shigeo, Aizawa, Toru, Akanuma, Yasuo, Aizawa, Shinichi, Kasai, Haruo, Yazaki, Yoshio, Kadowaki, Takashi

“…Glucose metabolism in glycolysis and in mitochondria is pivotal to glucose-induced insulin secretion from pancreatic β cells. One or more factors derived from…”
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Phosphatidylinositol 3-Kinase Suppresses Glucose-Stimulated Insulin Secretion by Affecting Post-Cytosolic [Ca2+] Elevation Signals by ETO, Kazuhiro, YAMASHITA, Tokuyuki, TOBE, Kazuyuki, IINO, Masamitsu, NODA, Mitsuhiko, KIMURA, Satoshi, KADOWAKI, Takashi, TSUBAMOTO, Yoshiharu, TERAUCHI, Yasuo, HIROSE, Kenzo, KUBOTA, Naoto, YAMASHITA, Shigeo, TAKA, Junko, SATOH, Shinobu, SEKIHARA, Hisahiko

“…Phosphatidylinositol 3-Kinase Suppresses Glucose-Stimulated Insulin Secretion by Affecting Post-Cytosolic [Ca 2+ ] Elevation Signals Kazuhiro Eto 1 , Tokuyuki…”
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GIP Receptor Antagonist, SKL-14959 Indicated Alteration of the Lipids Metabolism to Catabolism by the Inhibition of Plasma LPL Activity, Resulting in the Suppression of Weight Gain on DietsInduced Obesity Mice by Nakamura, Takashi, Tanimoto, Hitomi, Okamoto, Masayuki, Takeuchi, Mitsuaki, Tsubamoto, Yoshiharu, Noda, Hitoshi

“…Introduction: Glucose-dependent insulinotropic polypeptide (GIP) plays a crucial role in the regulation of lipid metabolism via lipoprotein lipase (LPL). GIP…”
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Glucokinase and IRS-2 are required for compensatory beta cell hyperplasia in response to high-fat diet-induced insulin resistance by Terauchi, Yasuo, Takamoto, Iseki, Kubota, Naoto, Matsui, Junji, Suzuki, Ryo, Komeda, Kajuro, Hara, Akemi, Toyoda, Yukiyasu, Miwa, Ichitomo, Aizawa, Shinichi, Tsutsumi, Shuichi, Tsubamoto, Yoshiharu, Hashimoto, Shinji, Eto, Kazuhiro, Nakamura, Akinobu, Noda, Mitsuhiko, Tobe, Kazuyuki, Aburatani, Hiroyuki, Nagai, Ryozo, Kadowaki, Takashi

“…Glucokinase (Gck) functions as a glucose sensor for insulin secretion, and in mice fed standard chow, haploinsufficiency of beta cell-specific Gck (Gck(+/-))…”
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Hexamminecobalt(III) Chloride Inhibits Glucose-induced Insulin Secretion at the Exocytotic Process by Tsubamoto, Yoshiharu, Eto, Kazuhiro, Noda, Mitsuhiko, Daniel, Samira, Suga, Sechiko, Yamashita, Shigeo, Kasai, Haruo, Wakui, Makoto, Sharp, Geoffrey W.G., Kimura, Satoshi, Kadowaki, Takashi

“…Hexamminecobalt(III) (HAC) chloride was found to have a potent inhibitory effect on glucose-induced insulin secretion from pancreatic islets. HAC at 2…”
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Preclinical and clinical aspects of the dipeptidyl peptidase-4 inhibitor anagliptin by Tsubamoto, Yoshiharu, Goto, Moritaka

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GIP Receptor Antagonist, SKL-14959 Indicated Alteration of the Lipids Metabolism to Catabolism by the Inhibition of Plasma LPL Activity, Resulting in the Suppression of Weight Gain on Diets-Induced Obesity Mice by Nakamura, Takashi, Tanimoto, Hitomi, Okamoto, Masayuki, Takeuchi, Mitsuaki, Tsubamoto, Yoshiharu, Noda, Hitoshi

“…Glucose-dependent insulinotropic polypeptide (GIP) plays a crucial role in the regulation of lipid metabolism via lipoprotein lipase (LPL). GIP receptor…”
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PPARγ Mediates High-Fat Diet–Induced Adipocyte Hypertrophy and Insulin Resistance by Kubota, Naoto, Terauchi, Yasuo, Miki, Hiroshi, Tamemoto, Hiroyuki, Yamauchi, Toshimasa, Komeda, Kajuro, Satoh, Shinobu, Nakano, Ryosuke, Ishii, Chikara, Sugiyama, Takuya, Eto, Kazuhiro, Tsubamoto, Yoshiharu, Okuno, Akira, Murakami, Koji, Sekihara, Hisahiko, Hasegawa, Go, Naito, Makoto, Toyoshima, Yasushi, Tanaka, Satoshi, Shiota, Kunio, Kitamura, Toshio, Fujita, Toshiro, Ezaki, Osamu, Aizawa, Shinichi, Nagai, Ryozo, Tobe, Kazuyuki, Kimura, Satoshi, Kadowaki, Takashi

“…Agonist-induced activation of peroxisome proliferator-activated receptor γ (PPARγ) is known to cause adipocyte differentiation and insulin sensitivity. The…”
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Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia by KUBOTA, Naoto, TOBE, Kazuyuki, SATOH, Shinobu, SEKIHARA, Hisahiko, SCIACCHITANO, Salvatore, LESNIAK, Maxine, AIZAWA, Shinichi, NAGAI, Ryozo, KIMURA, Satoshi, AKANUMA, Yasuo, TAYLOR, Simeon I, KADOWAKI, Takashi, TERAUCHI, Yasuo, ETO, Kazuhiro, YAMAUCHI, Toshimasa, SUZUKI, Ryo, TSUBAMOTO, Yoshiharu, KOMEDA, Kajuro, NAKANO, Ryosuke, MIKI, Hiroshi

“…Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia. N Kubota…”
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NADH Shuttle System Regulates KATPChannel-dependent Pathway and Steps Distal to Cytosolic Ca2+ Concentration Elevation in Glucose-induced Insulin Secretion by Eto, Kazuhiro, Suga, Sechiko, Wakui, Makoto, Tsubamoto, Yoshiharu, Terauchi, Yasuo, Taka, Junko, Aizawa, Shinichi, Noda, Mitsuhiko, Kimura, Satoshi, Kasai, Haruo, Kadowaki, Takashi

“…The NADH shuttle system is composed of the glycerol phosphate and malate-aspartate shuttles. We generated mice that lack mitochondrial glycerol-3-phosphate…”
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Switch to Anaerobic Glucose Metabolism with NADH Accumulation in the β-Cell Model of Mitochondrial Diabetes by Noda, Mitsuhiko, Yamashita, Shigeo, Takahashi, Noriko, Eto, Kazuhiro, Shen, Lin-Ming, Izumi, Kazuo, Daniel, Samira, Tsubamoto, Yoshiharu, Nemoto, Tomomi, Iino, Masamitsu, Kasai, Haruo, Sharp, Geoffrey W.G., Kadowaki, Takashi

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Protozoan myoglobin from Paramecium caudatum by TSUBAMOTO, Yoshiharu, MATSUOKA, Ariki, YUSA, Keisuke, SHIKAMA, Keiji

“…Native oxymyoglobin (MbO2) was isolated directly from the cells of Paramecium caudatum with complete separation from metmyoglobin (metMb) on a DEAE‐cellulose…”
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Glucose metabolism and glutamate analog acutely alkalinize pH of insulin secretory vesicles of pancreatic beta-cells by Eto, Kazuhiro, Yamashita, Tokuyuki, Hirose, Kenzo, Tsubamoto, Yoshiharu, Ainscow, Edward K, Rutter, Guy A, Kimura, Satoshi, Noda, Mitsuhiko, Iino, Masamitsu, Kadowaki, Takashi

“…We studied acute changes of secretory vesicle pH in pancreatic beta-cells with a fluorescent pH indicator, lysosensor green DND-189. Fluorescence was decreased…”
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NADH shuttle system regulates K(ATP) channel-dependent pathway and steps distal to cytosolic Ca(2+) concentration elevation in glucose-induced insulin secretion by Eto, K, Suga, S, Wakui, M, Tsubamoto, Y, Terauchi, Y, Taka, J, Aizawa, S, Noda, M, Kimura, S, Kasai, H, Kadowaki, T

“…The NADH shuttle system is composed of the glycerol phosphate and malate-aspartate shuttles. We generated mice that lack mitochondrial glycerol-3-phosphate…”
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Failure of Compensatory [Beta]-Cell Hyperplasia in Heterozygous Glucokinase-Deficient Mice under a High-Fat Diet by TERAUCHI, YASUO, KOMEDA, KAJURO, KUBOTA, NAOTO, ETO, KAZUHIRO, TSUBAMOTO, YOSHIHARU, AKANUMA, YASUO, KADOWAKI, TAKASHI

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Switch to anaerobic glucose metabolism with NADH accumulation in the beta-cell model of mitochondrial diabetes. Characteristics of betaHC9 cells deficient in mitochondrial DNA transcription by Noda, Mitsuhiko, Yamashita, Shigeo, Takahashi, Noriko, Eto, Kazuhiro, Shen, Lin-Ming, Izumi, Kazuo, Daniel, Samira, Tsubamoto, Yoshiharu, Nemoto, Tomomi, Iino, Masamitsu, Kasai, Haruo, Sharp, Geoffrey W G, Kadowaki, Takashi

“…To elucidate the mechanism underlying diabetes caused by mitochondrial gene mutations, we created a model by applying 0.4 microg/ml ethidium bromide (EtBr) to…”
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Switch to Anaerobic Glucose Metabolism with NADH Accumulation in the β-Cell Model of Mitochondrial Diabetes by Mitsuhiko Noda, Shigeo Yamashita, Noriko Takahashi, Kazuhiro Eto, Lin-Ming Shen, Kazuo Izumi, Samira Daniel, Yoshiharu Tsubamoto, Tomomi Nemoto, Masamitsu Iino, Haruo Kasai, Geoffrey W. G. Sharp, Takashi Kadowaki

“…To elucidate the mechanism underlying diabetes caused by mitochondrial gene mutations, we created a model by applying 0.4 μg/ml ethidium bromide (EtBr) to the…”
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Role of IRS-1/2 and PI-3 Kinase Pathway in the Regulation of [Beta]-Cell Mass and Glucose-Stimulated Insulin Secretion.(insulin receptor substrate; phosphatidylinositol-3 kinase) by ETO, KAZUHIRO, TSUBAMOTO, YOSHIHARU, TERAUCHI, YASUO, WAKI, KAYO, KUBOTA, NAOTO, TAKA, JUNKO, TAMEMOTO, HIROYUKI, TOBE, KAZUYUKI, NODA, MITSUHIKO, KADOWAKI, TAKASHI

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Essential Role of the NADH Shuttle System for Activating both the [K.sub.ATP] Channel-Dependent and -Independent Pathways of Glucose-Induced Insulin Secretion by ETO, KAZUHIRO, TSUBAMOTO, YOSHIHARU, SUGA, SECHIKO, TERAUCHI, YASUO, TAKA, JUNKO, NODA, MITSUHIKO, WAKUI, MAKOTO, KADOWAKI, TAKASHI

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