Search Results - "TSIKARIS, V."

Molecular requirements involving the human platelet protease-activated receptor-4 mechanism of activation by peptide analogues of its tethered-ligand by Moschonas, I. C., Kellici, T. F., Mavromoustakos, T., Stathopoulos, P., Tsikaris, V., Magafa, V., Tzakos, A. G., Tselepis, A. D.

“…Thrombin is the most potent agonist of human platelets and its effects are primarily mediated through the protease-activated receptors (PARs)-1 and -4…”
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The administration of the synthetic peptide YMESRADR with a low aspirin dose significantly augments its antiplatelet effect, in contrast to the highly constrained peptide (S,S) PSRCDCR-NH2. An experimental study by Englezopoulos, K.V., Stathopoulou, E.M., Moussis, V., Chantzichristos, V.G., Papamichael, N.D., Tatsidou, P.T., Roussa, V.D., Tsoumani, M.E., Lakkas, L., Rammos, A., Katsouras, C.S., Fotou, E., Tsikaris, V., Tselepis, A.D., Michalis, L.K.

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Cyclic antithrombotic agents with non-RGD like activity by Trypou, P, Moussis, V, Malissiova, E, Chantzichristos, V.G, Tselepis, A.D, Tsikaris, V

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853: Development of a novel tumor homing compound targeting glioblastoma cells by Giannopoulou, E, Siatis, K, Lampropoulou, A, Papadopoulos, C, Christoforidis, S, Papas, S, Briasoulis, E, Tzakos, A, Tsikaris, V, Kalofonos, H.P

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Inhibition of human platelet aggregation using AIIB derived peptides that maintain AIIBB3 in its low affinity state by Trypou, P, Lee, W.H, Schaffner-Reckinger, E, Tsoukatos, D.C, Aylward, K, Moussis, V, Tsikaris, V, Malisiova, E, Gkourogianni, A, Papadaki, S, Egot, M, Baruch, D, Kieffer, N, Bachelot-Loza, C

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Highly constrained cyclic (S,S) ‐CXaaC‐ peptides as inhibitors of fibrinogen binding to platelets by KOUKI, A., MITSIOS, J. V., SAKARELLOS‐DAITSIOTIS, M., SAKARELLOS, C., TSELEPIS, A. D., TSIKARIS, V., TSOUKATOS, D. C.

“…The Arg‐Gly‐Asp RGD motif of adhesive proteins is recognized by the activated platelet integrin αIIbβ3. Binding of fibrinogen (Fg) to activated αIIbβ3 causes…”
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Design, synthesis and biological evaluation of antipicornaviral pyrrole-containing peptidomimetics by Minchev, I, Vladimirova, S, Vezenkova, L, Bijeva, A, Moussis, V, Nikolaeva-Glomb, L, Tsikaris, V, Czeuz, M, Galabov, A

“…A series of new peptidomimetics based on the tripeptide sequence Z-Leu-Phe-Gln-OH were synthesized, with ten of these including the alpha-nitrogen atom of the…”
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The value of synthetic linear epitope analogues of La/SSB for the detection of autoantibodies to La/SSB; specificity, sensitivity and comparison of methods by YIANNAKI, E. E, TZIOUFAS, A. G, BACHMANN, M, HANTOUMI, J, TSIKARIS, V, SAKARELLOS-DAITSIOTIS, M, SAKARELLOS, C, MOUTSOPOULOS, H. M

“…In a previous study it was shown that La/SSB contains four linear epitopes, p147–154, p291–302, p301–318 and p349–364. The aim of the present study was to…”
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A three-residue cyclic scaffold of non-RGD containing peptide analogues as platelet aggregation inhibitors: Design, synthesis, and structure-function relationships by Stavrakoudis, Athanassios, Bizos, George, Eleftheriadis, Damianos, Kouki, Aggeliki, Panou-Pomonis, Eugenia, Sakarellos-Daitsiotis, Maria, Sakarellos, Constantinos, Tsoukatos, Demokritos, Tsikaris, Vassilios

“…Antagonists of fibrinogen at the GPIIb/IIIa receptor, which is the most abundant membrane protein on the platelet surface, are under active investigation as…”
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The Ser-Arg-Tyr-Asp region of the major surface glycoprotein of Leishmania mimics the Arg-Gly-Asp-Ser cell attachment region of fibronectin by SOTERIADOU, K. P, REMOUNDOS, M. S, KATSIKAS, M. C, TZINIA, A. K, TSIKARIS, V, SAKARELLOS, C, TZARTOS, S. J

“…The major surface glycoprotein of Leishmania, gp63, a fibronectin-like molecule, plays a key role in parasite-macrophage interaction. Binding of gp63 to…”
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No Evidence of Epitope Spreading After Immunization with the Major Sm Epitope P-P-G-M-R-P-P Anchored to Sequential Oligopeptide Carriers (SOCs) by Vlachoyiannopoulos, P.G, Petrovas, C, Tzioufas, A.G, Alexopoulos, Ch, Tsikaris, V, Guialis, A, Nakopoulou, L, Sakarellos-Daitsiotis, M, Sakarellos, C, Davaris, P, Moutsopoulos, H.M

“…The sequence Pro-Pro-Gly-Meth-Arg-Pro-Pro (PPGMRPP) is the major B-cell epitope of the Sm autoantigen. The aim of the present study was to evaluate the immune…”
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The third-dimensional structure of the complex between an Fv antibody fragment and an analogue of the main immunogenic region of the acetylcholine receptor: A combined two-dimensional NMR, homology, and molecular modeling approach by Kleinjung, Jens, Petit, Marie-Christine, Orlewski, Piotr, Mamalaki, Avgi, Tzartos, Socrates J., Tsikaris, Vassilios, Sakarellos-Daitsiotis, Maria, Sakarellos, Constantinos, Marraud, Michel, Cung, Manh-Thong

“…Binding of autoantibodies to the acetylcholine receptor (AChR) plays a major role in the autoimmune disease Myasthenia gravis (MG). In this paper, we propose a…”
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Structural, Molecular and Immunological Properties of Linear B‐Cell Epitopes of Ro60KD Autoantigen by Routsias, Sakarellos‐Daitsiotis, Tsikaris, Sakarellos, Moutsopoulos, Tzioufas

“…Antibodies to Ro60KD protein are found with high frequency in sera from patients with systemic lupus erythematosus (SLE) and primary Sjögren's syndrome (pSS)…”
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The administration of the synthetic peptide YMESRADR with a low aspirin dose significantly augments its antiplatelet effect, in contrast to the highly constrained peptide (S,S) PSRCDCR-NH 2 . An experimental study by Englezopoulos, K V, Stathopoulou, E M, Moussis, V, Chantzichristos, V G, Papamichael, N D, Tatsidou, P T, Roussa, V D, Tsoumani, M E, Lakkas, L, Rammos, A, Katsouras, C S, Fotou, E, Tsikaris, V, Tselepis, A D, Michalis, L K

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Multiple anchoring of myelopeptides on sequential oligopeptide carriers (SOCn): synthesis, conformation and studies in human leukemia cells by Keramisanou, D., Tsikaris, V., Sakarellos-Daitsiotis, M., Sakarellos, C., Mikhailova, A. A., Strelkov, L. A.

“…: Myelopeptides, MP‐6 (Val‐Asp‐Pro‐Pro) and MP‐4 (Phe‐Arg‐Pro‐Arg‐Ile‐Met‐Thr‐Pro), induce metabolic changes in human leukemia cells, HL‐60, characteristic of…”
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The main immunogenic region (MIR) of the nicotinic acetylcholine receptor and the anti-MIR antibodies by Tzartos, S J, Cung, M T, Demange, P, Loutrari, H, Mamalaki, A, Marraud, M, Papadouli, I, Sakarellos, C, Tsikaris, V

“…Myasthenia gravis (MG) is caused by autoantibodies against the nicotinic acetylcholine receptor (AChR) of the neuromuscular junction. The anti-AChR antibodies…”
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Antigenic role of single residues within the main immunogenic region of the nicotinic acetylcholine receptor by Papadouli, I, Potamianos, S, Hadjidakis, I, Bairaktari, E, Tsikaris, V, Sakarellos, C, Cung, M T, Marraud, M, Tzartos, S J

“…The target of most of the autoantibodies against the acetylcholine receptor (AChR) in myasthenic sera is the main immunogenic region (MIR) on the extracellular…”
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Conformational properties of the Arg-Leu-Gly tripeptide--DMSO--water clusters with the combined use of molecular dynamics and energy minimization studies by Demetropoulos, I, Tsibiris, A, Tsikaris, V, Sakarellos-Daitsiotis, M, Sakarellos, C

“…The Arg-Leu-Gly tripeptide is the repeating fragment of sequential arginine-rich polypeptides capable of interacting with DNA. The conformational influence of…”
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The main immunogenic region of the acetylcholine receptor. Structure and role in myasthenia gravis by Tzartos, S J, Barkas, T, Cung, M T, Kordossi, A, Loutrari, H, Marraud, M, Papadouli, I, Sakarellos, C, Sophianos, D, Tsikaris, V

“…Auto-antibodies to the nicotine acetylcholine receptor (AChR) cause the disease myasthenia gravis (MG). Animals immunized with AChR or receiving anti-AChR…”
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Changes in the c.d. spectra of calf thymus DNA induced by sequential polypeptides in aqueous solutions. Part I by Tsikaris, V, Panou-Pomonis, E, Sakarellos, C, Sakarellos-Daitsiotis, M, Marraud, M

“…Interactions of calf thymus DNA with sequential polypeptides were studied using c.d. spectroscopy in aqueous solutions. It was found that DNA structural…”
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