Search Results - "TSCHAN, M"

Reliable LC3 and p62 autophagy marker detection in formalin fixed paraffin embedded human tissue by immunohistochemistry by Schläfli, A M, Berezowska, S, Adams, O, Langer, R, Tschan, M P

“…Autophagy assures cellular homeostasis, and gains increasing importance in cancer, where it impacts on carcinogenesis, propagation of the malignant phenotype…”
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p62/SQSTM1 upregulation constitutes a survival mechanism that occurs during granulocytic differentiation of acute myeloid leukemia cells by Trocoli, A, Bensadoun, P, Richard, E, Labrunie, G, Merhi, F, Schläfli, A M, Brigger, D, Souquere, S, Pierron, G, Pasquet, J-M, Soubeyran, P, Reiffers, J, Ségal-Bendirdjian, E, Tschan, M P, Djavaheri-Mergny, M

“…The p62/SQSTM1 adapter protein has an important role in the regulation of several key signaling pathways and helps transport ubiquitinated proteins to the…”
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MicroRNA-29b is involved in the Src-ID1 signaling pathway and is dysregulated in human lung adenocarcinoma by Rothschild, S I, Tschan, M P, Federzoni, E A, Jaggi, R, Fey, M F, Gugger, M, Gautschi, O

“…The c-Src kinase regulates cancer cell invasion through inhibitor of DNA binding/differentiation 1 (ID1). Src and ID1 are frequently overexpressed in human…”
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WIPI-dependent autophagy during neutrophil differentiation of NB4 acute promyelocytic leukemia cells by Brigger, D, Proikas-Cezanne, T, Tschan, M P

“…Members of the WD-repeat protein interacting with phosphoinositides (WIPI) family are phosphatidylinositol 3-phosphate (PI3P) effectors that are essential for…”
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Ruthenium Metal Nanoparticles in Hydrogenation: Influence of Phosphorus-Ligands by Tschan, M. J.-L., Diebolt, O., van Leeuwen, P. W. N. M.

“…Ruthenium nanoparticles (RuNPs) attracted much attention in the last decade because of their potential applications in catalytic hydrogenation and oxidation…”
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miR-125b controls apoptosis and temozolomide resistance by targeting TNFAIP3 and NKIRAS2 in glioblastomas by Haemmig, S, Baumgartner, U, Glück, A, Zbinden, S, Tschan, M P, Kappeler, A, Mariani, L, Vajtai, I, Vassella, E

“…Diffusely infiltrating gliomas are among the most prognostically discouraging neoplasia in human. Temozolomide (TMZ) in combination with radiotherapy is…”
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p73 regulates autophagy and hepatocellular lipid metabolism through a transcriptional activation of the ATG5 gene by He, Z, Liu, H, Agostini, M, Yousefi, S, Perren, A, Tschan, M P, Mak, T W, Melino, G, Simon, H U

“…p73, a member of the p53 tumor suppressor family, is involved in neurogenesis, sensory pathways, immunity, inflammation, and tumorigenesis. How p73 is able to…”
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The role of autophagy in anticancer therapy: promises and uncertainties by Tschan, M. P., Simon, H.‐U.

“…  Tschan MP, Simon H‐U. (Department of Medical Oncology, Inselspital, Bern University Hospital; and Institute of Pharmacology, University of Bern; Bern,…”
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Activation of RARα induces autophagy in SKBR3 breast cancer cells and depletion of key autophagy genes enhances ATRA toxicity by Brigger, D, Schläfli, A M, Garattini, E, Tschan, M P

“…All- trans retinoic acid (ATRA), a pan-retinoic acid receptor (RAR) agonist, is, along with other retinoids, a promising therapeutic agent for the treatment of…”
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T-cell protection and enrichment through lentiviral CCR5 intrabody gene delivery by SWAN, C. H, BÜHLER, B, TSCHAN, M. P, BARBAS, C. F, TORBETT, B. E

“…CCR5 is the chemokine co-receptor for R5-tropic human immunodeficiency virus type 1 (HIV-1) isolates most often associated with primary infection. We have…”
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Impact of p53 Status on Radiosensitization of Tumor Cells by MET Inhibition-Associated Checkpoint Abrogation by Mikami, K, Medová, M, Nisa, L, Francica, P, Glück, A A, Tschan, M P, Blaukat, A, Bladt, F, Aebersold, D M, Zimmer, Y

“…Signaling via the MET receptor tyrosine kinase has been implicated in crosstalk with cellular responses to DNA damage. Our group previously demonstrated that…”
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Nondestructive room-temperature adsorption of 2,4,6-tri(2'-thienyl)-1,3,5-triazine on a Si-B interface: high-resolution STM imaging and molecular modeling by Makoudi, Y, Palmino, F, Duverger, E, Arab, M, Chérioux, F, Ramseyer, C, Therrien, B, Tschan, M J-L, Süss-Fink, G

“…Organic nanostructures on semiconductors are currently investigated but the surfaces are known to interact strongly with molecules. To reduce the…”
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The anti-apoptotic gene BCL2A1 is a novel transcriptional target of PU.1 by Jenal, M, Batliner, J, Reddy, V A, Haferlach, T, Tobler, A, Fey, M F, Torbett, B E, Tschan, M P

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DAPK2 is a novel E2F1/KLF6 target gene involved in their proapoptotic function by Britschgi, A, Trinh, E, Rizzi, M, Jenal, M, Ress, A, Tobler, A, Fey, M F, Helin, K, Tschan, M P

“…Death-associated protein kinase 2 (DAPK2) belongs to a family of proapoptotic Ca 2+ /calmodulin-regulated serine/threonine kinases. We recently identified…”
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WIPI-dependent autophagy during neutrophil differentiation of NB4 acute promyelocytic leukemia cells by Brigger, D, Proikas-Cezanne, T, Tschan, M P

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Thiazolides promote apoptosis in colorectal tumor cells via MAP kinase-induced Bim and Puma activation by Brockmann, A, Bluwstein, A, Kögel, A, May, S, Marx, A, Tschan, M P, Brunner, T

“…While many anticancer therapies aim to target the death of tumor cells, sophisticated resistance mechanisms in the tumor cells prevent cell death induction. In…”
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Synergistic induction of cell death in liver tumor cells by TRAIL and chemotherapeutic drugs via the BH3-only proteins Bim and Bid by Schneider-Jakob, S, Corazza, N, Badmann, A, Sidler, D, Stuber-Roos, R, Keogh, A, Frese, S, Tschan, M, Brunner, T

“…Although death receptors and chemotherapeutic drugs activate distinct apoptosis signaling cascades, crosstalk between the extrinsic and intrinsic apoptosis…”
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518: miR-125b confers NF-κB activity and temozolomide resistance by targeting TNFAIP3 and NKIRAS2 in glioblastomas by Haemmig, S, Baumgartner, U, Zbinden, S, Glück, A, Tschan, M, Kappeler, A, Vajtai, I, Vassella, E

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Identification of the p53 family-responsive element in the promoter region of the tumor suppressor gene hypermethylated in cancer 1 by BRITSCHGI, C, RIZZI, M, GROB, T. J, TSCHAN, M. P, HÜGLI, B, REDDY, V. A, ANDRES, A.-C, TORBETT, B. E, TOBLER, A, FEY, M. F

“…The tumor suppressor gene hypermethylated in cancer 1 (HIC1), located on human chromosome 17p13.3, is frequently silenced in cancer by epigenetic mechanisms…”
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PU.1 binding to the p53 family of tumor suppressors impairs their transcriptional activity by Tschan, M P, Reddy, V A, Ress, A, Arvidsson, G, Fey, M F, Torbett, B E

“…The transcription factor PU.1 is essential for terminal myeloid differentiation, B- and T-cell development, erythropoiesis and hematopoietic stem cell…”
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