Search Results - "TSATSAKIS, Aristidis"

Human exposure to chemical mixtures: Challenges for the integration of toxicology with epidemiology data in risk assessment by Hernández, Antonio F., Tsatsakis, Aristidis M.

“…Little is known about the potential adverse effects from longterm exposure to complex mixtures at low doses, close to health-based reference values…”
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Akt inhibitors in cancer treatment: The long journey from drug discovery to clinical use (Review) by NITULESCU, GEORGE MIHAI, MARGINA, DENISA, JUZENAS, PETRAS, PENG, QIAN, OLARU, OCTAVIAN TUDOREL, SALOUSTROS, EMMANOUIL, FENGA, CONCETTINA, SPANDIDOS, DEMETRIOS A, LIBRA, MASSIMO, TSATSAKIS, ARISTIDIS M

“…Targeted cancer therapies are used to inhibit the growth, progression, and metastasis of the tumor by interfering with specific molecular targets and are…”
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Overview of Cadmium Thyroid Disrupting Effects and Mechanisms by Buha, Aleksandra, Matovic, Vesna, Antonijevic, Biljana, Bulat, Zorica, Curcic, Marijana, Renieri, Elisavet A, Tsatsakis, Aristidis M, Schweitzer, Amie, Wallace, David

“…Humans are exposed to a significant number of chemicals that are suspected to produce disturbances in hormone homeostasis. Hence, in recent decades, there has…”
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New challenges in risk assessment of chemicals when simulating real exposure scenarios; simultaneous multi-chemicals' low dose exposure by Tsatsakis, Aristidis M., Docea, Anca Oana, Tsitsimpikou, Christina

“…The general population experiences uncontrolled multi-chemicals exposure from many different sources at doses around or well below regulatory limits…”
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A global assessment of phthalates burden and related links to health effects by Katsikantami, Ioanna, Sifakis, Stavros, Tzatzarakis, Manolis N., Vakonaki, Elena, Kalantzi, Olga-Ioanna, Tsatsakis, Aristidis M., Rizos, Apostolos K.

“…Phthalates are ubiquitous environmental contaminants which are used in industry as plasticizers and additives in cosmetics. They are classified as Endocrine…”
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Proposing new approaches for the risk characterisation of single chemicals and chemical mixtures: The source related Hazard Quotient (HQS) and Hazard Index (HIS) and the adversity specific Hazard Index (HIA) by Goumenou, Marina, Tsatsakis, Aristidis

“…A hazard quotient (HQ) for a single chemical and the hazard index (HI) for a mixture of chemicals were first described as approaches for risk characterisation…”
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Current and innovative methods for the diagnosis of COVID‑19 infection (Review) by Falzone, Luca, Gattuso, Giuseppe, Tsatsakis, Aristidis, Spandidos, Demetrios A, Libra, Massimo

“…The Coronavirus Disease 2019 (COVID‑19) pandemic has forced the scientific community to rapidly develop highly reliable diagnostic methods in order to…”
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Cytochrome P450 CYP1A1: wider roles in cancer progression and prevention by Androutsopoulos, Vasilis P, Tsatsakis, Aristidis M, Spandidos, Demetrios A

“…CYP1A1 is one of the main cytochrome P450 enzymes, examined extensively for its capacity to activate compounds with carcinogenic properties. Continuous…”
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Polycystic Ovary Syndrome: A Comprehensive Review of Pathogenesis, Management, and Drug Repurposing by Sadeghi, Hosna Mohammad, Adeli, Ida, Calina, Daniela, Docea, Anca Oana, Mousavi, Taraneh, Daniali, Marzieh, Nikfar, Shekoufeh, Tsatsakis, Aristidis, Abdollahi, Mohammad

“…Polycystic ovary syndrome (PCOS) is an endocrine-gynecology disorder affecting many women of childbearing age. Although a part of the involved mechanism in…”
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Cardiotoxicity of nano-particles by Bostan, Hasan Badie, Rezaee, Ramin, Valokala, Mahmoud Gorji, Tsarouhas, Konstantinos, Golokhvast, Kirill, Tsatsakis, Aristidis M., Karimi, Gholamreza

“…Nano-particles (NPs) are used in industrial and biomedical fields such as cosmetics, food additives and biosensors. Beside their favorable properties,…”
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Systematic review of biomonitoring studies to determine the association between exposure to organophosphorus and pyrethroid insecticides and human health outcomes by Koureas, Michalis, Tsakalof, Andreas, Tsatsakis, Aristidis, Hadjichristodoulou, Christos

“…► Epidemiological studies of health effects of human exposure to pesticides are reviewed. ► Studies focused on exposure to organophosphorus and pyrethroid…”
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Pesticides exposure as etiological factors of Parkinson's disease and other neurodegenerative diseases—A mechanistic approach by Baltazar, Maria Teresa, Dinis-Oliveira, Ricardo Jorge, de Lourdes Bastos, Maria, Tsatsakis, Aristidis M., Duarte, José Alberto, Carvalho, Félix

“…•The review provides new information regarding the neurotoxicity mechanisms of herbicides and pesticides.•New perspectives concerning chronic pesticide…”
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Persistent organochlorinated pesticides and mechanisms of their toxicity by Mrema, Ezra J, Rubino, Federico M, Brambilla, Gabri, Moretto, Angelo, Tsatsakis, Aristidis M, Colosio, Claudio

“…Highlights ► Diet is a major source of OCP exposure for the general population. ► OCPs exposure can induce enzymes for hormones and toxicants metabolisms. ►…”
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Hormetic Neurobehavioral effects of low dose toxic chemical mixtures in real-life risk simulation (RLRS) in rats by Tsatsakis, Aristidis M., Docea, Anca Oana, Calina, Daniela, Buga, Ana Maria, Zlatian, Ovidiu, Gutnikov, Sergei, Kostoff, Ronald N., Aschner, Michael

“…The current study aims to assess the long-term effects of very low dose exposures to a complex chemical mixture on motor performance and behavioural changes in…”
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Mechanistic understanding of nanoparticles' interactions with extracellular matrix: the cell and immune system by Engin, Ayse Basak, Nikitovic, Dragana, Neagu, Monica, Henrich-Noack, Petra, Docea, Anca Oana, Shtilman, Mikhail I, Golokhvast, Kirill, Tsatsakis, Aristidis M

“…Extracellular matrix (ECM) is an extraordinarily complex and unique meshwork composed of structural proteins and glycosaminoglycans. The ECM provides essential…”
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Toxic effects of pesticide mixtures at a molecular level: Their relevance to human health by Hernández, Antonio F, Parrón, Tesifón, Tsatsakis, Aristidis M, Requena, Mar, Alarcón, Raquel, López-Guarnido, Olga

“…Highlights ► Toxic effects of pesticide mixtures can be independent, dose addition or interaction. ► Metabolic interactions involve inhibition or induction of…”
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Resveratrol as MDR reversion molecule in breast cancer: An overview by Alamolhodaei, Nafiseh Sadat, Tsatsakis, Aristidis M., Ramezani, Mohammad, Hayes, A. Wallace, Karimi, Gholamreza

“…Breast cancer is the most common cause of cancer mortality among women worldwide; therefore, a strategy to defeat breast cancer is an extremely important…”
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Safety of COVID-19 vaccines administered in the EU: Should we be concerned? by Hernández, Antonio F., Calina, Daniela, Poulas, Konstantinos, Docea, Anca Oana, Tsatsakis, Aristidis M.

“…[Display omitted] •mRNA and viral vector vaccines are currently used in the EU for COVID-19 prophylaxis.•EMA has assessed the safety of the three vaccines…”
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Selenium neurotoxicity in humans: Bridging laboratory and epidemiologic studies by Vinceti, Marco, Mandrioli, Jessica, Borella, Paola, Michalke, Bernhard, Tsatsakis, Aristidis, Finkelstein, Yoram

“…•Acute overexposure to the metalloid selenium (Se) is neurotoxic in the human.•Neurotoxicity of chronic Se overexposure needs to be better…”
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Obesity ‑ a risk factor for increased COVID‑19 prevalence, severity and lethality (Review) by Petrakis, Demetrios, Margină, Denisa, Tsarouhas, Konstantinos, Tekos, Fotios, Stan, Miriana, Nikitovic, Dragana, Kouretas, Demetrios, Spandidos, Demetrios A, Tsatsakis, Aristidis

“…Coronaviruses (CoVs), enveloped positive-sense RNA viruses, are a group of viruses that cause infections in the human respiratory tract, which can be…”
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