Search Results - "TRUSHIN, Sergey A"

Human Immunodeficiency Virus Type 1 Protease Cleaves Procaspase 8 In Vivo by ZILIN NIE, BREN, Gary D, DOUEK, Daniel C, BADLEY, Andrew D, VLAHAKIS, Stacey R, SCHIMNICH, Alicia Algeciras, BRENCHLEY, Jason M, TRUSHIN, Sergey A, WARREN, Sarah, SCHNEPPLE, David J, KOVACS, Colin M, LOUTFY, Mona R

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Human Immunodeficiency Virus Reactivation by Phorbol Esters or T-Cell Receptor Ligation Requires both PKCα and PKCθ by TRUSHIN, Sergey A, BREN, Gary D, ASIN, Susana, PENNINGTON, Kevin N, PAYA, Carlos V, BADLEY, Andrew D

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Immunological and Mass Spectrometric Assays of SHBG: Consistent and Inconsistent Metabolic Associations in Healthy Men by Veldhuis, Johannes D, Bondar, Olga P, Dyer, Roy B, Trushin, Sergey A, Klee, Eric W, Singh, Ravinder J, Klee, George G

“…Context: SHBG concentrations correlate inconsistently with metabolic parameters. Hypothesis: SHBG assay platforms contribute to nonuniformities according to…”
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Interleukins 6 and 8 and abdominal fat depots are distinct correlates of lipid moieties in healthy pre- and postmenopausal women by Veldhuis, Johannes D., Dyer, Roy B., Trushin, Sergey A., Bondar, Olga P., Singh, Ravinder J., Klee, George G.

“…Available data associate lipids concentrations in men with body mass index, anabolic steroids, age, and certain cytokines. Data were less clear in women,…”
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Mass spectrometry measurements of prostate-specific antigen (PSA) peptides derived from immune-extracted PSA provide a potential strategy for harmonizing immunoassay differences by Klee, Eric W, Bondar, Olga P, Goodmanson, Marcia K, Trushin, Sergey A, Singh, Ravinder J, Anderson, N Leigh, Klee, George G

“…Harmonization of prostate-specific antigen (PSA) immunoassays is important for good patient care. The specificity of the antibodies used to detect circulating…”
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Immunologic and mass-spectrometric estimates of SHBG concentrations in healthy women by Veldhuis, Johannes D, Dyer, Roy B, Trushin, Sergey A, Bondar, Olga P, Singh, Ravinder J, Klee, George G

“…Abstract Objective Sex-hormone binding globulin (SHBG) concentrations across the adult female lifespan are not well defined. To address this knowledge gap,…”
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Serum concentrations of prostate-specific antigen measured using immune extraction, trypsin digestion, and tandem mass spectrometry quantification of LSEPAELTDAVK peptide by Klee, Eric W, Bondar, Olga P, Goodmanson, Marcia K, Trushin, Sergey A, Bergstralh, Eric J, Singh, Ravinder J, Anderson, N Leigh, Klee, George G

“…Prostate-specific antigen (PSA) is a 34-kDa glycoprotein with chymotrypsin-like enzyme activity that circulates both in free forms and complexed to various…”
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SDF-1α degrades whereas glycoprotein 120 upregulates Bcl-2 interacting mediator of death extralong isoform: implications for the development of T cell memory by Trushin, Sergey A, Carena, Alberto A, Bren, Gary D, Rizza, Stacey A, Dong, Xiangyang, Abraham, Roshini S, Badley, Andrew D

“…After a primary immune response, T cell memory occurs when a subset of Ag-specific T cells resists peripheral selection by acquiring resistance to TCR-induced…”
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Protein Kinase Cα (PKCα) Acts Upstream of PKCθ To Activate IκB Kinase and NF-κB in T Lymphocytes by Trushin, Sergey A., Pennington, Kevin N., Carmona, Eva M., Asin, Susana, Savoy, Doris N., Billadeau, Daniel D., Paya, Carlos V.

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HIV gp120 Induces, NF-κB Dependent, HIV Replication that Requires Procaspase 8 by Bren, Gary D., Trushin, Sergey A., Whitman, Joe, Shepard, Brett, Badley, Andrew D.

“…Background HIV envelope glycoprotein gp120 causes cellular activation resulting in anergy, apoptosis, proinflammatory cytokine production, and through an…”
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Glycoprotein 120 Binding to CXCR4 Causes p38-Dependent Primary T Cell Death That Is Facilitated by, but Does Not Require Cell-Associated CD4 by Trushin, Sergey A, Algeciras-Schimnich, Alicia, Vlahakis, Stacey R, Bren, Gary D, Warren, Sarah, Schnepple, David J, Badley, Andrew D

“…HIV-1 infection causes the depletion of host CD4 T cells through direct and indirect (bystander) mechanisms. Although HIV Env has been implicated in apoptosis…”
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Infected Cell Killing by HIV-1 Protease Promotes NF-κB Dependent HIV-1 Replication by Bren, Gary D., Whitman, Joe, Cummins, Nathan, Shepard, Brett, Rizza, Stacey A., Trushin, Sergey A., Badley, Andrew D.

“…Acute HIV-1 infection of CD4 T cells often results in apoptotic death of infected cells, yet it is unclear what evolutionary advantage this offers to HIV-1…”
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Protein Kinase Cβ Modulates Ligand-induced Cell Surface Death Receptor Accumulation: A MECHANISTIC BASIS FOR ENZASTAURIN-DEATH LIGAND SYNERGY by Meng, Xue Wei, Heldebrant, Michael P, Flatten, Karen S, Loegering, David A, Dai, Haiming, Schneider, Paula A, Gomez, Timothy S, Peterson, Kevin L, Trushin, Sergey A, Hess, Allan D, Smith, B. Douglas, Karp, Judith E, Billadeau, Daniel D, Kaufmann, Scott H

“…Although treatment with the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) is known to protect a subset of cells from induction of…”
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CXCR4 Tropic HIV-1 gp120 Inhibition of SDF-1α-Induced Chemotaxis Requires Lck and is Associated with Cofilin Phosphorylation by Trushin, Sergey A, Bren, Gary D, Badley, Andrew D

“…HIV gp120 is a pleiotropic protein present in the plasma and tissues of HIV-infected patients, which affects a variety of homeostatic functions. In this…”
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CD4 T Cells Treated with gp120 Acquire a CD45R0+/CD45RA+ Phenotype by Trushin, Sergey A, Bren, Gary D, Badley, Andrew D

“…HIV-infected patients exhibit quantitative and qualitative defects in CD4 T cells, including having increased numbers of CD4+CD45R0+/CD45RA+ T cells, although…”
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HIV gp120 induces, NF-kappaB dependent, HIV replication that requires procaspase 8 by Bren, Gary D, Trushin, Sergey A, Whitman, Joe, Shepard, Brett, Badley, Andrew D

“…HIV envelope glycoprotein gp120 causes cellular activation resulting in anergy, apoptosis, proinflammatory cytokine production, and through an unknown…”
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Serine 32 and serine 36 of IκBα are directly phosphorylated by protein kinase CKII in Vitro by Taylor, Julie A, Bren, Gary D, Pennington, Kevin N, Trushin, Sergey A, Asin, Susana, Paya, Carlos V

“…IκBα is an inherently unstable protein which binds to and retains the ubiquitous transcription factor NFκB in the cytoplasm of resting cells. A continuous low…”
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Infected cell killing by HIV-1 protease promotes NF-kappaB dependent HIV-1 replication by Bren, Gary D, Whitman, Joe, Cummins, Nathan, Shepard, Brett, Rizza, Stacey A, Trushin, Sergey A, Badley, Andrew D

“…Acute HIV-1 infection of CD4 T cells often results in apoptotic death of infected cells, yet it is unclear what evolutionary advantage this offers to HIV-1…”
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SDF-1α degrades, while gp120 upregulates BimEL: implications for the development of T cell memory by Trushin, Sergey A., Carena, Alberto A., Bren, Gary D., Rizza, Stacey A., Dong, Xiangyang, Abraham, Roshini S., Badley, Andrew D.

“…Following a primary immune response, T cell memory occurs when a subset of antigen specific T cells resist peripheral selection by acquiring resistance to TCR…”
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Protein Kinase C and Calcineurin Synergize to Activate IκB Kinase and NF-κB in T Lymphocytes by Trushin, Sergey A., Pennington, Kevin N., Algeciras-Schimnich, Alicia, Paya, Carlos V.

“…The nuclear factor of κB (NF-κB) is a ubiquitous transcription factor that is key in the regulation of the immune response and inflammation. T cell receptor…”
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