Search Results - "TRUDEL, Suzanne"

Circulating tumour DNA sequence analysis as an alternative to multiple myeloma bone marrow aspirates by Kis, Olena, Kaedbey, Rayan, Chow, Signy, Danesh, Arnavaz, Dowar, Mark, Li, Tiantian, Li, Zhihua, Liu, Jessica, Mansour, Mark, Masih-Khan, Esther, Zhang, Tong, Bratman, Scott V., Oza, Amit M., Kamel-Reid, Suzanne, Trudel, Suzanne, Pugh, Trevor J.

“…The requirement for bone-marrow aspirates for genomic profiling of multiple myeloma poses an obstacle to enrolment and retention of patients in clinical…”
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Antibody–drug conjugate, GSK2857916, in relapsed/refractory multiple myeloma: an update on safety and efficacy from dose expansion phase I study by Trudel, Suzanne, Lendvai, Nikoletta, Popat, Rakesh, Voorhees, Peter M., Reeves, Brandi, Libby, Edward N., Richardson, Paul G., Hoos, Axel, Gupta, Ira, Bragulat, Veronique, He, Zangdong, Opalinska, Joanna B., Cohen, Adam D.

“…Interim analyses of a phase I study with GSK2857916, an antibody–drug conjugate against B cell maturation antigen, have previously reported a 60% overall…”
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Longitudinal single-cell analysis of a myeloma mouse model identifies subclonal molecular programs associated with progression by Croucher, Danielle C., Richards, Laura M., Tsofack, Serges P., Waller, Daniel, Li, Zhihua, Wei, Ellen Nong, Huang, Xian Fang, Chesi, Marta, Bergsagel, P. Leif, Sebag, Michael, Pugh, Trevor J., Trudel, Suzanne

“…Molecular programs that underlie precursor progression in multiple myeloma are incompletely understood. Here, we report a disease spectrum-spanning,…”
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Single-Agent Lenalidomide in the Treatment of Previously Untreated Chronic Lymphocytic Leukemia by CHEN, Christine I, LEIF BERGSAGEL, P, BRANDWEIN, Joseph, PANTOJA, Mariela, JOHNSTON, James, GIBSON, Spencer, HERNANDEZ, Tiffany, SPANER, David, TRUDEL, Suzanne, PAUL, Harminder, WEI XU, LAU, Anthea, DAVE, Nimisha, KUKRETI, Vishal, WEI, Ellen, LEUNG-HAGESTEIJN, Chungyee, ZHI HUA LI

“…Lenalidomide is an oral immunomodulatory drug with multiple effects on the immune system and tumor cell microenvironment leading to inhibition of malignant…”
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Preclinical studies of the pan-Bcl inhibitor obatoclax (GX015-070) in multiple myeloma by Trudel, Suzanne, Li, Zhi Hua, Rauw, Jennifer, Tiedemann, Rodger E., Wen, Xiao Yan, Stewart, A. Keith

“…Bcl family members Bcl-2, Bcl-xL, and Mcl-1, are frequently expressed and implicated in the survival of myeloma cells. Obatoclax (GX015-070) is a novel,…”
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Belantamab mafodotin, pomalidomide, and dexamethasone for triple class exposed/refractory relapsed multiple myeloma: a subgroup analysis of the ALGONQUIN trial by McCurdy, Arleigh, Reece, Donna, Louzada, Martha L., White, Darrell, Parkin, Stephen, Chu, Michael P., Kotb, Rami, Mian, Hira, Othman, Ibraheem, Su, Jiandong, Khan, Aniba, Gul, Engin, Trudel, Suzanne

“…Given the early use of triplet and quadruplet regimens, most patients with multiple myeloma (MM) will be exposed and/or refractory to PIs, IMiDs, and anti-CD38…”
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Exploiting the mevalonate pathway to distinguish statin-sensitive multiple myeloma by Clendening, James W., Pandyra, Aleksandra, Li, Zhihua, Boutros, Paul C., Martirosyan, Anna, Lehner, Richard, Jurisica, Igor, Trudel, Suzanne, Penn, Linda Z.

“…Statin inhibitors, used to control hypercholesterolemia, trigger apoptosis of hematologic tumor cells and therefore have immediate potential as anticancer…”
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D(T)PACE as salvage therapy for aggressive or refractory multiple myeloma by Gerrie, Alina S., Mikhael, Joseph R., Cheng, Lu, Jiang, Haiyan, Kukreti, Vishal, Panzarella, Tony, Reece, Donna, Stewart, Keith A., Trieu, Young, Trudel, Suzanne, Chen, Christine I.

“…Summary Dexamethasone ± thalidomide with infusion of cisplatin, doxorubicin, cyclophosphamide, and etoposide [D(T)PACE] is generally reserved as salvage…”
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Phase I-II Trial of Bortezomib Plus Oral Cyclophosphamide and Prednisone in Relapsed and Refractory Multiple Myeloma by REECE, Donna E, PIZA RODRIGUEZ, Giovanni, CHEN, Christine, TRUDEL, Suzanne, KUKRETI, Vishal, MIKHAEL, Joseph, PANTOJA, Mariela, WEI XU, STEWART, A. Keith

“…The combination of oral weekly cyclophosphamide and alternate day prednisone is a convenient regimen for relapsed/refractory multiple myeloma (MM), and we…”
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P902: ISATUXIMAB, WEEKLY CARFILZOMIB AND DEXAMETHASONE AS SALVAGE THERAPY FOR RRMM; INTERIM RESULTS FROM A PHASE 2 TRIAL by Vesole, David H., Berdeja, Jesus, Matous, Jeffrey, Trudel, Suzanne, Schade, Henning, Munster, Pamela, Berkeley, Savannah, Sun, Benjamin, Martin, Tom

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The tricyclic antidepressant amitriptyline inhibits D-cyclin transactivation and induces myeloma cell apoptosis by inhibiting histone deacetylases: in vitro and in silico evidence by Mao, Xinliang, Hou, Tingjun, Cao, Biyin, Wang, Wenjie, Li, Zhihua, Chen, Suning, Fei, Min, Hurren, Rose, Gronda, Marcela, Wu, Depei, Trudel, Suzanne, Schimmer, Aaron D

“…Amitriptyline is a classic tricyclic antidepressant (TCA) and has been used to treat the depression and anxiety of patients with cancer, but its relevance to…”
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P946: TOCILIZUMAB PRE‐TREATMENT SIGNIFICANTLY REDUCES THE INCIDENCE OF CYTOKINE RELEASE SYNDROME IN PATIENTS WITH RELAPSED/REFRACTORY MULTIPLE MYELOMA (RRMM) WHO RECEIVE CEVOSTAMAB by Mateos, Maria‐Victoria, Bahlis, Nizar J, Spencer, Andrew, Kaedbey, Rayan, Rodríguez‐Otero, Paula, Harrison, Simon, Wong, Chihunt, Goodman, Grant, Nakamura, Rin, Choeurng, Voleak, Cooper, James, Trudel, Suzanne

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The Bcl-2 Family Protein Inhibitor, ABT-737, Has Substantial Antimyeloma Activity and Shows Synergistic Effect with Dexamethasone and Melphalan by TRUDEL, Suzanne, STEWART, A. Keith, ZHIHUA LI, YANJUN SHU, LIANG, Sheng-Ben, TRIEU, Young, REECE, Donna, PATERSON, Josh, DINGYAN WANG, WEN, Xiao-Yan

“…Purpose: The aim of this study is to investigate the antimyeloma activity of a novel Bcl-2 family inhibitor, ABT-737, in preclinical treatment of multiple…”
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Measurement of Protein Phosphorylation Stoichiometry by Selected Reaction Monitoring Mass Spectrometry by Jin, Lily L, Tong, Jiefei, Prakash, Amol, Peterman, Scott M, St-Germain, Jonathan R, Taylor, Paul, Trudel, Suzanne, Moran, Michael F

“…The stoichiometry of protein phosphorylation at specific amino acid sites may be used to infer on the significance of the modification, and its biological…”
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P868: MEZIGDOMIDE (MEZI) PLUS DEXAMETHASONE (DEX) IN PATIENTS (PTS) WITH RELAPSED/REFRACTORY MULTIPLE MYELOMA (RRMM): RESULTS FROM THE DOSE‐EXPANSION PHASE OF THE CC‐92480‐MM‐001 TRIAL by Bahlis, Nizar J, Trudel, Suzanne, Quach, Hang, Popat, Rakesh, Lonial, Sagar, Orlowski, Robert Z, Kim, Kihyun, Mateos, Maria‐Victoria, Pawlyn, Charlotte, Ramasamy, Karthik, Martinez‐Lopez, Joaquín, Casas‐Avilés, Ignacio, Spirli, Alessia, Gong, Jing, Amatangelo, Michael, Katz, Jessica, Maciag, Paulo, Peluso, Teresa, Richardson, Paul

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Light chain deposition disease affecting the gastrointestinal tract in the setting of post-living donor kidney transplantation by Jimenez-Zepeda, Victor H., Vajpeyi, Rajkumar, John, Rohan, Trudel, Suzanne

“…Light chain deposition disease (LCDD) is an uncommon, clonal plasma cell proliferative disorder, in which monoclonal immunoglobulin light chains deposit in…”
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Multiple myeloma phosphotyrosine proteomic profile associated with FGFR3 expression, ligand activation, and drug inhibition by St-Germain, Jonathan R, Taylor, Paul, Tong, Jiefei, Jin, Lily L, Nikolic, Ana, Stewart, Ian I, Ewing, Robert M, Dharsee, Moyez, Li, Zhihua, Trudel, Suzanne, Moran, Michael F

“…Signaling by growth factor receptor tyrosine kinases is manifest through networks of proteins that are substrates and/or bind to the activated receptors. FGF…”
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Incorporating isatuximab in the treatment of multiple myeloma by Trudel, Suzanne

“…Isatuximab is a novel monoclonal antibody that binds selectively to CD38, which is widely expressed on plasma cells, and kills myeloma cells via multimodal…”
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Clinical Outcomes in t(4;14) Multiple Myeloma: A Chemotherapy-Sensitive Disease Characterized by Rapid Relapse and Alkylating Agent Resistance by Jaksic, Wilfrid, Trudel, Suzanne, Chang, Hong, Trieu, Young, Qi, Xi, Mikhael, Joseph, Reece, Donna, Chen, Christine, Stewart, A Keith

“…To determine whether primary drug resistance or rapid relapse explains the poor prognosis seen in t(4;14)-positive multiple myeloma (MM). A total of 131…”
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Autologous stem cell transplant for light chain deposition disease: Incorporating bortezomib to the induction therapy by Jimenez-Zepeda, Victor H., Trudel, Suzanne, Winter, Andrew, Reece, Donna E., Chen, Christine, Kukreti, Vishal

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