Search Results - "TROWSDALE, John"

Genetics of antigen processing and presentation by Kelly, Adrian, Trowsdale, John

“…Immune response to disease requires coordinated expression of an army of molecules. The highly polymorphic MHC class I and class II molecules are key to…”
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Major Histocompatibility Complex Genomics and Human Disease by Trowsdale, John, Knight, Julian C

“…Over several decades, various forms of genomic analysis of the human major histocompatibility complex (MHC) have been extremely successful in picking up many…”
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Regulation of Immunity by Butyrophilins by Rhodes, David A, Reith, Walter, Trowsdale, John

“…Butyrophilin molecules (commonly contracted to BTN), collectively take their name from the eponymous protein in cow's milk. They are considered to be members…”
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Genetic and Functional Relationships between MHC and NK Receptor Genes by Trowsdale, John

“…HLA class I and NK receptors are encoded within dense clusters of immune loci. The MHC, at 6p21.3, and the complex containing the KIR loci, at 19q13.4, both…”
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Mother's little helpers: mechanisms of maternal-fetal tolerance by Betz, Alexander G, Trowsdale, John

“…The evolutionary adaptation in mammals that allows implantation of their embryos in the mother's womb creates an immunological problem. Although it ensures…”
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NK cell responses to cytomegalovirus infection lead to stable imprints in the human KIR repertoire and involve activating KIRs by Béziat, Vivien, Liu, Lisa L., Malmberg, Jenny-Ann, Ivarsson, Martin A., Sohlberg, Ebba, Björklund, Andreas T., Retière, Christelle, Sverremark-Ekström, Eva, Traherne, James, Ljungman, Per, Schaffer, Marie, Price, David A., Trowsdale, John, Michaëlsson, Jakob, Ljunggren, Hans-Gustaf, Malmberg, Karl-Johan

“…Human natural killer (NK) cells are functionally regulated by killer cell immunoglobulin-like receptors (KIRs) and their interactions with HLA class I…”
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extended human leukocyte receptor complex: diverse ways of modulating immune responses by Barrow, Alexander David, Trowsdale, John

“…The leukocyte receptor complex (LRC) and its extended region comprise a large set of genes encoding immunoglobulin superfamily (IgSF) receptors, interspersed…”
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KIR B centromeric region present in Africans but not Europeans protects pregnant women from pre-eclampsia by Nakimuli, Annettee, Chazara, Olympe, Hiby, Susan E, Farrell, Lydia, Tukwasibwe, Stephen, Jayaraman, Jyothi, Traherne, James A, Trowsdale, John, Colucci, Francesco, Lougee, Emma, Vaughan, Robert W, Elliott, Alison M, Byamugisha, Josaphat, Kaleebu, Pontiano, Mirembe, Florence, Nemat-Gorgani, Neda, Parham, Peter, Norman, Paul J, Moffett, Ashley

“…In sub-Saharan Africans, maternal mortality is unacceptably high, with >400 deaths per 100,000 births compared with <10 deaths per 100,000 births in Europeans…”
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Structural basis for PRYSPRY-mediated tripartite motif (TRIM) protein function by James, Leo C, Keeble, Anthony H, Khan, Zahra, Rhodes, David A, Trowsdale, John

“…The human tripartite motif (TRIM) family comprises 70 members, including HIV restriction factor TRIM5α and disease-associated proteins TRIM20 (pyrin) and…”
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Critical Role of CD2 Co-stimulation in Adaptive Natural Killer Cell Responses Revealed in NKG2C-Deficient Humans by Liu, Lisa L., Landskron, Johannes, Ask, Eivind H., Enqvist, Monika, Sohlberg, Ebba, Traherne, James A., Hammer, Quirin, Goodridge, Jodie P., Larsson, Stella, Jayaraman, Jyothi, Oei, Vincent Y.S., Schaffer, Marie, Taskén, Kjetil, Ljunggren, Hans-Gustaf, Romagnani, Chiara, Trowsdale, John, Malmberg, Karl-Johan, Béziat, Vivien

“…Infection by human cytomegalovirus (HCMV) leads to NKG2C-driven expansion of adaptive natural killer (NK) cells, contributing to host defense. However,…”
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Comparative genomics of major histocompatibility complexes by Kelley, James, Walter, Lutz, Trowsdale, John

“…The major histocompatibility complex (MHC) is a gene dense region found in all jawed vertebrates examined to date. The MHC contains a high percentage of immune…”
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Combinations of maternal KIR and fetal HLA-C genes influence the risk of preeclampsia and reproductive success by Hiby, Susan E, Walker, James J, O'shaughnessy, Kevin M, Redman, Christopher W G, Carrington, Mary, Trowsdale, John, Moffett, Ashley

“…Preeclampsia is a serious complication of pregnancy in which the fetus receives an inadequate supply of blood due to failure of trophoblast invasion. There is…”
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Comparative genomics of natural killer cell receptor gene clusters by Kelley, James, Walter, Lutz, Trowsdale, John

“…Many receptors on natural killer (NK) cells recognize major histocompatibility complex class I molecules in order to monitor unhealthy tissues, such as cells…”
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NKG2D Ligand Expression in Human Colorectal Cancer Reveals Associations with Prognosis and Evidence for Immunoediting by McGilvray, Roger W, Eagle, Robert A, Watson, Nicholas F S, Al-Attar, Ahmad, Ball, Graham, Jafferji, Insiya, Trowsdale, John, Durrant, Lindy G

“…Purpose: NKG2D (natural killer group 2, member D) binds to cellular ligands of the MIC and ULBP/RAET family. These ligands have restricted expression in normal…”
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Interactions between Human NK Cells and Macrophages in Response to Salmonella Infection by Lapaque, Nicolas, Walzer, Thierry, Meresse, Stephane, Vivier, Eric, Trowsdale, John

“…NK cells play a key role in host resistance to a range of pathogenic microorganisms, particularly during the initial stages of infection. NK cell interactions…”
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Imputation of KIR Types from SNP Variation Data by Vukcevic, Damjan, Traherne, James A., Næss, Sigrid, Ellinghaus, Eva, Kamatani, Yoichiro, Dilthey, Alexander, Lathrop, Mark, Karlsen, Tom H., Franke, Andre, Moffatt, Miriam, Cookson, William, Trowsdale, John, McVean, Gil, Sawcer, Stephen, Leslie, Stephen

“…Large population studies of immune system genes are essential for characterizing their role in diseases, including autoimmune conditions. Of key interest are a…”
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HLA class I allelic sequence and conformation regulate leukocyte Ig-like receptor binding by Jones, Des C, Kosmoliaptsis, Vasilis, Apps, Richard, Lapaque, Nicolas, Smith, Isobel, Kono, Azumi, Chang, Chiwen, Boyle, Louise H, Taylor, Craig J, Trowsdale, John, Allen, Rachel L

“…Leukocyte Ig-like receptors (LILRs) are a family of innate immune receptors predominantly expressed by myeloid cells that can alter the Ag presentation…”
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KIR in Allogeneic Hematopoietic Stem Cell Transplantation: Need for a Unified Paradigm for Donor Selection by Dhuyser, Adèle, Aarnink, Alice, Pérès, Michaël, Jayaraman, Jyothi, Nemat-Gorgani, Neda, Rubio, Marie Thérèse, Trowsdale, John, Traherne, James

“…Allogeneic hematopoietic stem cell transplantation (aHSCT) is a lifesaving therapy for hematological malignancies. For years, a fully matched HLA donor was a…”
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Estimating KIR Haplotype Frequencies on a Cohort of 10,000 Individuals: A Comprehensive Study on Population Variations, Typing Resolutions, and Reference Haplotypes by Vierra-Green, Cynthia, Roe, David, Jayaraman, Jyothi, Trowsdale, John, Traherne, James, Kuang, Rui, Spellman, Stephen, Maiers, Martin

“…The killer cell immunoglobulin-like receptors (KIR) mediate human natural killer (NK) cell cytotoxicity via activating or inhibiting signals. Although…”
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NKG2D Ligand MICA Is Retained in the cis-Golgi Apparatus by Human Cytomegalovirus Protein UL142 by ASHIRU, Omodele, BENNETT, Neil J, BOYLE, Louise H, THOMAS, Mair, TROWSDALE, John, WILLS, Mark R

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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