Search Results - "TRONO, Didier"

KRAB zinc finger proteins by Ecco, Gabriela, Imbeault, Michael, Trono, Didier

“…Krüppel-associated box domain zinc finger proteins (KRAB-ZFPs) are the largest family of transcriptional regulators in higher vertebrates. Characterized by an…”
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The Developmental Control of Transposable Elements and the Evolution of Higher Species by Friedli, Marc, Trono, Didier

“…Transposable elements (TEs) account for at least 50% of the human genome. They constitute essential motors of evolution through their ability to modify genomic…”
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DUX-family transcription factors regulate zygotic genome activation in placental mammals by De Iaco, Alberto, Planet, Evarist, Coluccio, Andrea, Verp, Sonia, Duc, Julien, Trono, Didier

“…Didier Trono and colleagues show that both human DUX4 and mouse Dux are expressed before zygotic genome activation (ZGA) and lead to activation of…”
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KRAB zinc-finger proteins contribute to the evolution of gene regulatory networks by Imbeault, Michaël, Helleboid, Pierre-Yves, Trono, Didier

“…Genomic analyses of KRAB-containing zinc-finger proteins and the transposable elements to which they bind show that a co-evolutionary arms race was not the…”
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DPPA2 and DPPA4 are necessary to establish a 2C‐like state in mouse embryonic stem cells by De Iaco, Alberto, Coudray, Alexandre, Duc, Julien, Trono, Didier

“…After fertilization of the transcriptionally silent oocyte, expression from both parental chromosomes is launched through zygotic genome activation (ZGA),…”
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Integrated proteogenomic deep sequencing and analytics accurately identify non-canonical peptides in tumor immunopeptidomes by Chong, Chloe, Müller, Markus, Pak, HuiSong, Harnett, Dermot, Huber, Florian, Grun, Delphine, Leleu, Marion, Auger, Aymeric, Arnaud, Marion, Stevenson, Brian J., Michaux, Justine, Bilic, Ilija, Hirsekorn, Antje, Calviello, Lorenzo, Simó-Riudalbas, Laia, Planet, Evarist, Lubiński, Jan, Bryśkiewicz, Marta, Wiznerowicz, Maciej, Xenarios, Ioannis, Zhang, Lin, Trono, Didier, Harari, Alexandre, Ohler, Uwe, Coukos, George, Bassani-Sternberg, Michal

“…Efforts to precisely identify tumor human leukocyte antigen (HLA) bound peptides capable of mediating T cell-based tumor rejection still face important…”
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Hominoid-Specific Transposable Elements and KZFPs Facilitate Human Embryonic Genome Activation and Control Transcription in Naive Human ESCs by Pontis, Julien, Planet, Evarist, Offner, Sandra, Turelli, Priscilla, Duc, Julien, Coudray, Alexandre, Theunissen, Thorold W., Jaenisch, Rudolf, Trono, Didier

“…Expansion of transposable elements (TEs) coincides with evolutionary shifts in gene expression. TEs frequently harbor binding sites for transcriptional…”
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Dynamic control of endogenous retroviruses during development by Rowe, Helen M, Trono, Didier

“…Abstract Close to half of the human genome encompasses mobile genetic elements, most of which are retrotransposons. These genetic invaders are formidable…”
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DUX is a non-essential synchronizer of zygotic genome activation by De Iaco, Alberto, Verp, Sonia, Offner, Sandra, Grun, Delphine, Trono, Didier

“…Some of the earliest transcripts produced in fertilized human and mouse oocytes code for DUX, a double homeodomain protein that promotes embryonic genome…”
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Seroprevalence of anti-SARS-CoV-2 IgG antibodies in Geneva, Switzerland (SEROCoV-POP): a population-based study by Stringhini, Silvia, Wisniak, Ania, Piumatti, Giovanni, Azman, Andrew S, Lauer, Stephen A, Baysson, Hélène, De Ridder, David, Petrovic, Dusan, Schrempft, Stephanie, Marcus, Kailing, Yerly, Sabine, Arm Vernez, Isabelle, Keiser, Olivia, Hurst, Samia, Posfay-Barbe, Klara M, Trono, Didier, Pittet, Didier, Gétaz, Laurent, Chappuis, François, Eckerle, Isabella, Vuilleumier, Nicolas, Meyer, Benjamin, Flahault, Antoine, Kaiser, Laurent, Guessous, Idris

“…Assessing the burden of COVID-19 on the basis of medically attended case numbers is suboptimal given its reliance on testing strategy, changing case…”
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Switzerland and the Digital Health Revolution by Trono, Didier

“…New technologies in life sciences are helping to revolutionize health management with the objective to move towards personalized healthcare. The Swiss Federal…”
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KRAB-zinc finger protein gene expansion in response to active retrotransposons in the murine lineage by Wolf, Gernot, de Iaco, Alberto, Sun, Ming-An, Bruno, Melania, Tinkham, Matthew, Hoang, Don, Mitra, Apratim, Ralls, Sherry, Trono, Didier, Macfarlan, Todd S

“…The Krüppel-associated box zinc finger protein (KRAB-ZFP) family diversified in mammals. The majority of human KRAB-ZFPs bind transposable elements (TEs),…”
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ZNF445 is a primary regulator of genomic imprinting by Takahashi, Nozomi, Coluccio, Andrea, Thorball, Christian W, Planet, Evarist, Shi, Hui, Offner, Sandra, Turelli, Priscilla, Imbeault, Michael, Ferguson-Smith, Anne C, Trono, Didier

“…Genomic imprinting is an epigenetic process regulated by germline-derived DNA methylation, causing parental origin-specific monoallelic gene expression. Zinc…”
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Human reproduction is regulated by retrotransposons derived from ancient Hominidae-specific viral infections by Xiang, Xinyu, Tao, Yu, DiRusso, Jonathan, Hsu, Fei-Man, Zhang, Jinchun, Xue, Ziwei, Pontis, Julien, Trono, Didier, Liu, Wanlu, Clark, Amander T.

“…Germ cells are essential to pass DNA from one generation to the next. In human reproduction, germ cell development begins with the specification of primordial…”
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Interplay of TRIM28 and DNA methylation in controlling human endogenous retroelements by Turelli, Priscilla, Castro-Diaz, Nathaly, Marzetta, Flavia, Kapopoulou, Adamandia, Raclot, Charlène, Duc, Julien, Tieng, Vannary, Quenneville, Simon, Trono, Didier

“…Reverse transcription-derived sequences account for at least half of the human genome. Although these retroelements are formidable motors of evolution, they…”
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Release of human cytomegalovirus from latency by a KAP1/TRIM28 phosphorylation switch by Rauwel, Benjamin, Jang, Suk Min, Cassano, Marco, Kapopoulou, Adamandia, Barde, Isabelle, Trono, Didier

“…Human cytomegalovirus (HCMV) is a highly prevalent pathogen that induces life-long infections notably through the establishment of latency in hematopoietic…”
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Molecular Criteria for Defining the Naive Human Pluripotent State by Theunissen, Thorold W., Friedli, Marc, He, Yupeng, Planet, Evarist, O’Neil, Ryan C., Markoulaki, Styliani, Pontis, Julien, Wang, Haoyi, Iouranova, Alexandra, Imbeault, Michaël, Duc, Julien, Cohen, Malkiel A., Wert, Katherine J., Castanon, Rosa, Zhang, Zhuzhu, Huang, Yanmei, Nery, Joseph R., Drotar, Jesse, Lungjangwa, Tenzin, Trono, Didier, Ecker, Joseph R., Jaenisch, Rudolf

“…Recent studies have aimed to convert cultured human pluripotent cells to a naive state, but it remains unclear to what extent the resulting cells recapitulate…”
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In Embryonic Stem Cells, ZFP57/KAP1 Recognize a Methylated Hexanucleotide to Affect Chromatin and DNA Methylation of Imprinting Control Regions by Quenneville, Simon, Verde, Gaetano, Corsinotti, Andrea, Kapopoulou, Adamandia, Jakobsson, Johan, Offner, Sandra, Baglivo, Ilaria, Pedone, Paolo V., Grimaldi, Giovanna, Riccio, Andrea, Trono, Didier

“…The maintenance of H3K9 and DNA methylation at imprinting control regions (ICRs) during early embryogenesis is key to the regulation of imprinted genes. Here,…”
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Conditional Suppression of Cellular Genes: Lentivirus Vector-Mediated Drug-Inducible RNA Interference by Wiznerowicz, Maciej, Trono, Didier

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Evolutionally dynamic L1 regulation in embryonic stem cells by Castro-Diaz, Nathaly, Ecco, Gabriela, Coluccio, Andrea, Kapopoulou, Adamandia, Yazdanpanah, Benyamin, Friedli, Marc, Duc, Julien, Jang, Suk Min, Turelli, Priscilla, Trono, Didier

“…Mobile elements are important evolutionary forces that challenge genomic integrity. Long interspersed element-1 (L1, also known as LINE-1) is the only…”
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