Search Results - "TRON, Victor"

The microRNA-200 family is upregulated in endometrial carcinoma by Snowdon, Jaime, Zhang, Xiao, Childs, Tim, Tron, Victor A, Feilotter, Harriet

“…MicroRNAs (miRNAs, miRs) are small non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. MicroRNAs are dysregulated in…”
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Clinical, Morphologic, and Molecular Features of Benign and Intermediate-grade Melanocytic Tumors With Activating Mutations in MAP2K1 by Fumero-Velázquez, Mónica, Hagstrom, Michael, Dhillon, Soneet, Geraminejad, Tara, Olivares, Shantel, Donati, Michele, Nosek, Daniel, Waldenbäck, Pia, Kazakov, Dmitry, Sheffield, Brandon S., Tron, Victor A., Gerami, Pedram

“…Activating mutations in MAP2K1 can be seen in benign and intermediate-grade melanocytic neoplasms with spitzoid morphology. We analyzed the clinical,…”
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MicroRNA-193b Represses Cell Proliferation and Regulates Cyclin D1 in Melanoma by Chen, Jiamin, Feilotter, Harriet E, Paré, Geneviève C, Zhang, Xiao, Pemberton, Joshua G.W, Garady, Cherif, Lai, Dulcie, Yang, Xiaolong, Tron, Victor A

“…Cutaneous melanoma is an aggressive form of human skin cancer characterized by high metastatic potential and poor prognosis. To better understand the role of…”
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RNA silencing of Mcl-1 enhances ABT-737-mediated apoptosis in melanoma: role for a caspase-8-dependent pathway by Keuling, Angela M, Felton, Kathleen E A, Parker, Arabesque A M, Akbari, Majid, Andrew, Susan E, Tron, Victor A

“…Malignant melanoma is resistant to almost all conventional forms of chemotherapy. Recent evidence suggests that anti-apoptotic proteins of the Bcl-2 family are…”
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Roles for miR-375 in Neuroendocrine Differentiation and Tumor Suppression via Notch Pathway Suppression in Merkel Cell Carcinoma by Abraham, Karan J, Zhang, Xiao, Vidal, Ricardo, Paré, Geneviève C, Feilotter, Harriet E, Tron, Victor A

“…Dysfunction of key miRNA pathways regulating basic cellular processes is a common driver of many cancers. However, the biological roles and/or clinical…”
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miR-193b Regulates Mcl-1 in Melanoma by Chen, Jiamin, Zhang, Xiao, Lentz, Cindy, Abi-Daoud, Marie, Paré, Geneviève C, Yang, Xiaolong, Feilotter, Harriet E, Tron, Victor A

“…MicroRNAs play important roles in gene regulation, and their expression is frequently dysregulated in cancer cells. In a previous study, we reported that…”
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Interleukin-21 Has Activity in Patients With Metastatic Melanoma: A Phase II Study by PETRELLA, Teresa M, TOZER, Richard, HAGERMAN, Linda, WALSH, Wendy, EISENHAUER, Elizabeth A, BELANGER, Karl, SAVAGE, Kerry J, WONG, Ralph, SMYLIE, Michael, KAMEL-REID, Suzanne, TRON, Victor, CHEN, Bingshu E, HUNDER, Naomi N

“…We report a multicenter phase II study of patients with metastatic melanoma (MM), evaluating the efficacy, toxicity, progression-free survival (PFS),…”
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Impact of Next-generation Sequencing on Interobserver Agreement and Diagnosis of Spitzoid Neoplasms by Benton, Sarah, Zhao, Jeffrey, Zhang, Bin, Bahrami, Armita, Barnhill, Raymond L., Busam, Klaus, Cerroni, Lorenzo, Cook, Martin G., de la Fouchardière, Arnaud, Elder, David E., Johansson, Iva, Landman, Gilles, Lazar, Alexander, LeBoit, Philip, Lowe, Lori, Massi, Daniela, Duncan, Lyn M., Messina, Jane, Mihic-Probst, Daniela, Mihm, Martin C., Piepkorn, Michael W., Schmidt, Birgitta, Scolyer, Richard A., Shea, Christopher R., Tetzlaff, Michael T., Tron, Victor A., Xu, Xiaowei, Yeh, Iwei, Yun, Sook Jung, Zembowicz, Artur, Gerami, Pedram

“…Atypical Spitzoid melanocytic tumors are diagnostically challenging. Many studies have suggested various genomic markers to improve classification and…”
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Fit-For-Purpose PD-L1 Biomarker Testing For Patient Selection in Immuno-Oncology: Guidelines For Clinical Laboratories From the Canadian Association of Pathologists-Association Canadienne Des Pathologistes (CAP-ACP) by Cheung, Carol C, Barnes, Penny, Bigras, Gilbert, Boerner, Scott, Butany, Jagdish, Calabrese, Fiorella, Couture, Christian, Deschenes, Jean, El-Zimaity, Hala, Fischer, Gabor, Fiset, Pierre O, Garratt, John, Geldenhuys, Laurette, Gilks, C Blake, Ilie, Marius, Ionescu, Diana, Lim, Hyun J, Manning, Lisa, Mansoor, Adnan, Riddell, Robert, Ross, Catherine, Roy-Chowdhuri, Sinchita, Spatz, Alan, Swanson, Paul E, Tron, Victor A, Tsao, Ming-Sound, Wang, Hangjun, Xu, Zhaolin, Torlakovic, Emina E

“…Since 2014, programmed cell death protein 1 (PD-1)/programmed cell death ligand 1 (PD-L1) checkpoint inhibitors have been approved by various regulatory…”
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UBE4B promotes Hdm2-mediated degradation of the tumor suppressor p53 by Leng, Roger P, Wu, Hong, Pomeroy, Scott L, Ferreira, Manuel, Teider, Natalia, Mariani, Juliana, Nakayama, Keiichi I, Hatakeyama, Shigetsugu, Tron, Victor A, Saltibus, Linda F, Spyracopoulos, Leo

“…Polyubiquitination of the tumor suppressor p53 (encoded by TP53 ) regulates its stability by targeting it for degradation. Wu et al . now report that UBE4B, an…”
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Multicolor microRNA FISH effectively differentiates tumor types by Renwick, Neil, Cekan, Pavol, Masry, Paul A, McGeary, Sean E, Miller, Jason B, Hafner, Markus, Li, Zhen, Mihailovic, Aleksandra, Morozov, Pavel, Brown, Miguel, Gogakos, Tasos, Mobin, Mehrpouya B, Snorrason, Einar L, Feilotter, Harriet E, Zhang, Xiao, Perlis, Clifford S, Wu, Hong, Suárez-Fariñas, Mayte, Feng, Huichen, Shuda, Masahiro, Moore, Patrick S, Tron, Victor A, Chang, Yuan, Tuschl, Thomas

“…MicroRNAs (miRNAs) are excellent tumor biomarkers because of their cell-type specificity and abundance. However, many miRNA detection methods, such as…”
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An Array-Based Analysis of MicroRNA Expression Comparing Matched Frozen and Formalin-Fixed Paraffin-Embedded Human Tissue Samples by Zhang, Xiao, Chen, Jiamin, Radcliffe, Tom, LeBrun, Dave P, Tron, Victor A, Feilotter, Harriet

“…MicroRNAs (miRNAs) are small, noncoding RNAs that suppress gene expression at the posttranscriptional level via an antisense RNA-RNA interaction. miRNAs used…”
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miR-138-5p induces aggressive traits by targeting Trp53 expression in murine melanoma cells, and correlates with poor prognosis of melanoma patients by da Cruz, Adriana Taveira, Hunger, Aline, de Melo, Fabiana Henriques Machado, Monteiro, Ana Carolina, Paré, Geneviève Catherine, Lai, Dulce, Alves-Fernandes, Débora Kristina, Ayub, Ana Luisa Pedroso, Cordero, Esteban Mauricio, Filho, José Franco da Silveira, Schneider-Stock, Regine, Strauss, Bryan Eric, Tron, Victor, Jasiulionis, Miriam Galvonas

“…Deregulation of miRNAs contributes to the development of distinct cancer types, including melanoma, an aggressive form of skin cancer characterized by high…”
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Towards new therapeutic approaches for malignant melanoma by Pacheco, Ivan, Buzea, Cristina, Tron, Victor

“…Recent progress in understanding the molecular mechanisms of the initiation and progression of melanoma has created new opportunities for developing novel…”
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Pemphigoid Gestationis: A Case Presentation by Warshafsky, Chelsie, Tron, Victor A., Robertson, Deborah, Kives, Sari

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Inhibition of p38 MAPK enhances ABT-737-induced cell death in melanoma cell lines: novel regulation of PUMA by Keuling, Angela M., Andrew, Susan E., Tron, Victor A.

“…Summary The mitogen‐activated protein kinase (MAPK) pathway is constitutively activated in the majority of melanomas, promoting cell survival, proliferation…”
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Defining the DNA mismatch repair-dependent apoptotic pathway in primary cells: Evidence for p53-independence and involvement of centrosomal caspase 2 by Narine, Kelly A.D., Keuling, Angela M., Gombos, Randi, Tron, Victor A., Andrew, Susan E., Young, Leah C.

“…Many studies have shown that DNA mismatch repair (MMR) has a role beyond that of repair in response to several types of DNA damage, including ultraviolet…”
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The associated contributions of p53 and the DNA mismatch repair protein Msh6 to spontaneous tumorigenesis by Young, Leah C., Keuling, Angela M., Lai, Raymond, Nation, Patrick N., Tron, Victor A., Andrew, Susan E.

“…DNA mismatch repair (MMR) is a highly conserved system that repairs DNA adducts acquired during replication, as well as some forms of exogenous/endogenous DNA…”
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GADD45 Regulates G2/M Arrest, DNA Repair, and Cell Death in Keratinocytes Following Ultraviolet Exposure by Maeda, Tomoko, Hanna, Atef N., Sim, Adrian B., Chua, Prescillia P., Chong, Michelle T., Tron, Victor A.

“…GADD45 is a multifunctional protein that is regulated by p53. p53 plays an important role in regulating DNA repair and in the response to ultraviolet light in…”
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DNA Mismatch Repair Proteins: Potential Guardians Against Genomic Instability and Tumorigenesis Induced by Ultraviolet Photoproducts by Young, Leah C., Hays, John B., Tron, Victor A., Andrew, Susan E.

“…In addition to their established role in repairing post-replicative DNA errors, DNA mismatch repair proteins contribute to cell cycle arrest and apoptosis in…”
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