Search Results - "TROMBERG, Bruce"

Characterization of Cholesterol Crystals in Atherosclerotic Plaques Using Stimulated Raman Scattering and Second-Harmonic Generation Microscopy by Suhalim, Jeffrey L., Chung, Chao-Yu, Lilledahl, Magnus B., Lim, Ryan S., Levi, Moshe, Tromberg, Bruce J., Potma, Eric O.

“…Cholesterol crystals (ChCs) have been identified as a major factor of plaque vulnerability and as a potential biomarker for atherosclerosis. Yet, due to the…”
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Rapid Scaling Up of Covid-19 Diagnostic Testing in the United States — The NIH RADx Initiative by Tromberg, Bruce J, Schwetz, Tara A, Pérez-Stable, Eliseo J, Hodes, Richard J, Woychik, Richard P, Bright, Rick A, Fleurence, Rachael L, Collins, Francis S

“…In April 2020, Congress appropriated $1.5 billion to the NIH to increase national testing capacity for SARS-CoV-2. The NIH established the Rapid Acceleration…”
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CDCP1 drives triple-negative breast cancer metastasis through reduction of lipid-droplet abundance and stimulation of fatty acid oxidation by Wright, Heather J., Hou, Jue, Xu, Binzhi, Cortez, Marvin, Potma, Eric O., Tromberg, Bruce J., Razorenova, Olga V.

“…Triple-negative breast cancer (TNBC) is notoriously aggressive with high metastatic potential, which has recently been linked to high rates of fatty acid…”
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In Vivo Multiphoton NADH Fluorescence Reveals Depth-Dependent Keratinocyte Metabolism in Human Skin by Balu, Mihaela, Mazhar, Amaan, Hayakawa, Carole K., Mittal, Richa, Krasieva, Tatiana B., König, Karsten, Venugopalan, Vasan, Tromberg, Bruce J.

“…We employ a clinical multiphoton microscope to monitor in vivo and noninvasively the changes in reduced nicotinamide adenine dinucleotide (NADH) fluorescence…”
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Review of short-wave infrared spectroscopy and imaging methods for biological tissue characterization by Wilson, Robert H, Nadeau, Kyle P, Jaworski, Frank B, Tromberg, Bruce J, Durkin, Anthony J

“…We present a review of short-wave infrared (SWIR, defined here as ∼1000 to 2000 nm) spectroscopy and imaging techniques for biological tissue optical property…”
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Quantitation and mapping of tissue optical properties using modulated imaging by Cuccia, David J, Bevilacqua, Frederic, Durkin, Anthony J, Ayers, Frederick R, Tromberg, Bruce J

“…We describe the development of a rapid, noncontact imaging method, modulated imaging (MI), for quantitative, wide-field characterization of optical absorption…”
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Diffuse optical imaging using spatially and temporally modulated light by O'Sullivan, Thomas D, Cerussi, Albert E, Cuccia, David J, Tromberg, Bruce J

“…The authors describe the development of diffuse optical imaging (DOI) technologies, specifically the use of spatial and temporal modulation to control near…”
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PTEN Deficiency and AMPK Activation Promote Nutrient Scavenging and Anabolism in Prostate Cancer Cells by Kim, Seong M, Nguyen, Tricia T, Ravi, Archna, Kubiniok, Peter, Finicle, Brendan T, Jayashankar, Vaishali, Malacrida, Leonel, Hou, Jue, Robertson, Jane, Gao, Dong, Chernoff, Jonathan, Digman, Michelle A, Potma, Eric O, Tromberg, Bruce J, Thibault, Pierre, Edinger, Aimee L

“…We report that PTEN-deficient prostate cancer cells use macropinocytosis to survive and proliferate under nutrient stress. PTEN loss increased macropinocytosis…”
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Quantitative real-time optical imaging of the tissue metabolic rate of oxygen consumption by Ghijsen, Michael, Lentsch, Griffin R, Gioux, Sylvain, Brenner, Matthew, Durkin, Anthony J, Choi, Bernard, Tromberg, Bruce J

“…The tissue metabolic rate of oxygen consumption (tMRO2) is a clinically relevant marker for a number of pathologies including cancer and arterial occlusive…”
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Real-time, wide-field, and quantitative oxygenation imaging using spatiotemporal modulation of light by Schmidt, Manon, Aguénounon, Enagnon, Nahas, Amir, Torregrossa, Murielle, Tromberg, Bruce J, Uhring, Wilfried, Gioux, Sylvain

“…Quantitative diffuse optical imaging has the potential to provide valuable functional information about tissue status, such as oxygen saturation or blood…”
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Noninvasive assessment of skin structure by combined photothermal radiometry and optical spectroscopy: coregistration with multiphoton microscopy by Verdel, Nina, Lentsch, Griffin, Balu, Mihaela, Tromberg, Bruce J, Majaron, Boris

“…We are combining two optical techniques, pulsed photothermal radiometry (PPTR) and diffuse reflectance spectroscopy (DRS), for noninvasive assessment of the…”
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In Vivo Multiphoton Microscopy of Basal Cell Carcinoma by Balu, Mihaela, Zachary, Christopher B, Harris, Ronald M, Krasieva, Tatiana B, König, Karsten, Tromberg, Bruce J, Kelly, Kristen M

“…Basal cell carcinomas (BCCs) are diagnosed by clinical evaluation, which can include dermoscopic evaluation, biopsy, and histopathologic examination. Recent…”
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Predicting Responses to Neoadjuvant Chemotherapy in Breast Cancer: ACRIN 6691 Trial of Diffuse Optical Spectroscopic Imaging by Tromberg, Bruce J, Zhang, Zheng, Leproux, Anaïs, O'Sullivan, Thomas D, Cerussi, Albert E, Carpenter, Philip M, Mehta, Rita S, Roblyer, Darren, Yang, Wei, Paulsen, Keith D, Pogue, Brian W, Jiang, Shudong, Kaufman, Peter A, Yodh, Arjun G, Chung, So Hyun, Schnall, Mitchell, Snyder, Bradley S, Hylton, Nola, Boas, David A, Carp, Stefan A, Isakoff, Steven J, Mankoff, David

“…The prospective multicenter ACRIN 6691 trial was designed to evaluate whether changes from baseline to mid-therapy in a diffuse optical spectroscopic imaging…”
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Kinetic Analysis of Lipid Metabolism in Breast Cancer Cells via Nonlinear Optical Microscopy by Hou, Jue, Reid, Nellone E., Tromberg, Bruce J., Potma, Eric O.

“…Investigating the behavior of breast cancer cells via reaction kinetics may help unravel the mechanisms that underlie metabolic changes in tumors. However,…”
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Imaging Cells and Extracellular Matrix in vivo by Using Second-Harmonic Generation and Two-Photon Excited Fluorescence by Zoumi, Aikaterini, Yeh, Alvin, Tromberg, Bruce J.

“…Multiphoton microscopy relies on nonlinear light-matter interactions to provide contrast and optical sectioning capability for high-resolution imaging. Most…”
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Diffuse optical spectroscopic imaging reveals distinct early breast tumor hemodynamic responses to metronomic and maximum tolerated dose regimens by Tank, Anup, Peterson, Hannah M, Pera, Vivian, Tabassum, Syeda, Leproux, Anais, O'Sullivan, Thomas, Jones, Eric, Cabral, Howard, Ko, Naomi, Mehta, Rita S, Tromberg, Bruce J, Roblyer, Darren

“…Breast cancer patients with early-stage disease are increasingly administered neoadjuvant chemotherapy (NAC) to downstage their tumors prior to surgery. In…”
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Visualization of Breast Cancer Metabolism Using Multimodal Nonlinear Optical Microscopy of Cellular Lipids and Redox State by Hou, Jue, Williams, Joshua, Botvinick, Elliot L, Potma, Eric O, Tromberg, Bruce J

“…Label-free nonlinear optical microscopy (NLOM) based on two-photon excited fluorescence (TPEF) from cofactors nicotinamide adenine dinucleotide (NADH) and…”
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Effect of Blood Flow Restriction on Tissue Oxygenation during Knee Extension by Ganesan, Goutham, Cotter, Joshua A, Reuland, Warren, Cerussi, Albert E, Tromberg, Bruce J, Galassetti, Pietro

“…PURPOSETime-resolved near-infrared spectroscopy was used to quantify tissue oxy- and deoxyhemoglobin concentrations ([HbO2] and [HbR]) and O2 saturation (stO2)…”
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Three-dimensional speckle suppression in Optical Coherence Tomography based on the curvelet transform by Jian, Zhongping, Yu, Lingfeng, Rao, Bin, Tromberg, Bruce J, Chen, Zhongping

“…Optical coherence tomography is an emerging non-invasive technology that provides high resolution, cross-sectional tomographic images of internal structures of…”
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A comparison of Doppler optical coherence tomography methods by Liu, Gangjun, Lin, Alexander J, Tromberg, Bruce J, Chen, Zhongping

“…We compare, in detail, the phase-resolved color Doppler (PRCD), phase-resolved Doppler variance (PRDV) and intensity-based Doppler variance (IBDV) methods. All…”
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