Search Results - "TROILO, P. J"

Detection of integration of plasmid DNA into host genomic DNA following intramuscular injection and electroporation by WANG, Z, TROILO, P. J, FOLLMER, T. T, RIZZUTO, G, CILIBERTO, G, FATTORI, E, MONICA, N. L, MANAM, S, LEDWITH, B. J, WANG, X, GRIFFITHS, T. G, PACCHIONE, S. J, BARNUM, A. B, HARPER, L. B, PAULEY, C. J, NIU, Z, DENISOVA, L

“…Plasmid vectors have been widely used for DNA vaccines and gene therapy. Following intramuscular injection, the plasmid that persists is extrachromosomal and…”
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Tumorigenicity assessments of Per.C6 cells and of an Ad5-vectored HIV-1 vaccine produced on this continuous cell line by Ledwith, B J, Lanning, C L, Gumprecht, L A, Anderson, C A, Coleman, J B, Gatto, N T, Balasubramanian, G, Farris, G M, Kemp, R K, Harper, L B, Barnum, A B, Pacchione, S J, Mauer, K L, Troilo, P F J, Brown, E R, Wolf, J J, Lebronl, J A, Lewis, J A, Nichols, W W

“…PER.C6, a cell line derived from human embryonic retinal cells transformed with the Adenovirus Type 5 (Ad5) E1A and E1B genes, is used to produce E1-deleted…”
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Adaptation of the WHO guideline for residual DNA in parenteral vaccines produced on continuous cell lines to a limit for oral vaccines by Lebron, J A, Troilol, P J, Pacchione, S, Griffiths, T G, Harper, L B, Mixson, L A, Jackson, B E, Michna, L, Barnum, A B, Denisova, L, Johnson, C N, Maurer, K L, Morgan-Hoffman, S, Niu, Z, Roden, D F, Wang, Z, Wolf, J J, Hamilton, T R, Laux, K M, Soper, K A, Ledwith, B J

“…Although there is a WHO guidance for a limit on residual DNA for parenterally administered vaccines produced on continuous cell lines, there is no…”
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Plasmid DNA vaccines: investigation of integration into host cellular DNA following intramuscular injection in mice by Ledwith, B J, Manam, S, Troilo, P J, Barnum, A B, Pauley, C J, Griffiths , 2nd, T G, Harper, L B, Beare, C M, Bagdon, W J, Nichols, W W

“…The primary safety concern for DNA vaccines is their potential to integrate into the host cell genome. We describe an integration assay based on purification…”
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Plasmid DNA vaccines: assay for integration into host genomic DNA by Ledwith, B J, Manam, S, Troilo, P J, Barnum, A B, Pauley, C J, Griffiths, 2nd, T G, Harper, L B, Schock, H B, Zhang, H, Faris, J E, Way, P A, Beare, C M, Bagdon, W J, Nichols, W W

“…The primary safety concern for DNA vaccines is their potential to integrate into host cellular DNA. We describe a sensitive and quantitative assay for…”
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Plasmid DNA vaccines: tissue distribution and effects of DNA sequence, adjuvants and delivery method on integration into host DNA by Manam, S, Ledwith, B J, Barnum, A B, Troilo, P J, Pauley, C J, Harper, L B, Griffiths , 2nd, T G, Niu, Z, Denisova, L, Follmer, T T, Pacchione, S J, Wang, Z, Beare, C M, Bagdon, W J, Nichols, W W

“…A variety of factors could affect the frequency of integration of plasmid DNA vaccines into host cellular DNA, including DNA sequences within the plasmid, the…”
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Potential DNA vaccine integration into host cell genome by Nichols, W W, Ledwith, B J, Manam, S V, Troilo, P J

“…Studies have been designed to examine the potential integration of DNA vaccines into the host cell genome. This is of concern because of the possibility of…”
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Femtosecond laser: a new intradermal DNA delivery method for efficient, long-term gene expression and genetic immunization by Zeira, Evelyne, Manevitch, Alexandra, Manevitch, Zakharia, Kedar, Eli, Gropp, Michal, Daudi, Nili, Barsuk, Rimma, Harati, Menahem, Yotvat, Hagit, Troilo, Philip J, Griffiths, Thomas G. II, Pacchione, Stephen J, Roden, Dana F, Niu, Zhutian, Nussbaum, Ofer, Zamir, Gideon, Papo, Orit, Hemo, Izhack, Lewis, Aaron, Galun, Eithan

“…A femtosecond laser beam gene transduction (SG-LBGT) system is described as a novel and efficient method of intradermal (i.d.) nonviral gene delivery in mice…”
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