Search Results - "TRIMMER, Jeff"

Branched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing efficiency of fatty acid oxidation and acyl-glycine export by White, Phillip J, Lapworth, Amanda L, An, Jie, Wang, Liping, McGarrah, Robert W, Stevens, Robert D, Ilkayeva, Olga, George, Tabitha, Muehlbauer, Michael J, Bain, James R, Trimmer, Jeff K, Brosnan, M. Julia, Rolph, Timothy P, Newgard, Christopher B

“…Abstract Objective A branched-chain amino acid (BCAA)-related metabolic signature is strongly associated with insulin resistance and predictive of incident…”
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Impact of combined resistance and aerobic exercise training on branched-chain amino acid turnover, glycine metabolism and insulin sensitivity in overweight humans by Glynn, Erin L., Piner, Lucy W., Huffman, Kim M., Slentz, Cris A., Elliot-Penry, Lorraine, AbouAssi, Hiba, White, Phillip J., Bain, James R., Muehlbauer, Michael J., Ilkayeva, Olga R., Stevens, Robert D., Porter Starr, Kathryn N., Bales, Connie W., Volpi, Elena, Brosnan, M. Julia, Trimmer, Jeff K., Rolph, Timothy P., Newgard, Christopher B., Kraus, William E.

“…Aims/hypotheses Obesity is associated with decreased insulin sensitivity (IS) and elevated plasma branched-chain amino acids (BCAAs). The purpose of this study…”
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Biomarkers for Type 2 Diabetes and Impaired Fasting Glucose Using a Nontargeted Metabolomics Approach by MENNI, Cristina, FAUMAN, Eric, WEI YUAN, MILBURN, Mike, PALMER, Colin N. A, FRAYLING, Timothy M, TRIMMER, Jeff, BELL, Jordana T, GIEGER, Christian, MOHNEY, Rob P, BROSNAN, Mary Julia, SUHRE, Karsten, ERTE, Idil, SORANZO, Nicole, SPECTOR, Tim D, PERRY, John R. B, KASTENMÜLLER, Gabi, SHIN, So-Youn, PETERSEN, Ann-Kristin, HYDE, Craig, PSATHA, Maria, WARD, Kirsten J

“…Using a nontargeted metabolomics approach of 447 fasting plasma metabolites, we searched for novel molecular markers that arise before and after hyperglycemia…”
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Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional β cells by Ferdaoussi, Mourad, Dai, Xiaoqing, Jensen, Mette V, Wang, Runsheng, Peterson, Brett S, Huang, Chao, Ilkayeva, Olga, Smith, Nancy, Miller, Nathanael, Hajmrle, Catherine, Spigelman, Aliya F, Wright, Robert C, Plummer, Gregory, Suzuki, Kunimasa, Mackay, James P, van de Bunt, Martijn, Gloyn, Anna L, Ryan, Terence E, Norquay, Lisa D, Brosnan, M Julia, Trimmer, Jeff K, Rolph, Timothy P, Kibbey, Richard G, Manning Fox, Jocelyn E, Colmers, William F, Shirihai, Orian S, Neufer, P Darrell, Yeh, Edward T H, Newgard, Christopher B, MacDonald, Patrick E

“…Insulin secretion from β cells of the pancreatic islets of Langerhans controls metabolic homeostasis and is impaired in individuals with type 2 diabetes (T2D)…”
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Metabolomic Identification of a Novel Pathway of Blood Pressure Regulation Involving Hexadecanedioate by Menni, Cristina, Graham, Delyth, Kastenmüller, Gabi, Alharbi, Nora H.J, Alsanosi, Safaa Md, McBride, Martin, Mangino, Massimo, Titcombe, Philip, Shin, So-Youn, Psatha, Maria, Geisendorfer, Thomas, Huber, Anja, Peters, Annette, Wang-Sattler, Rui, Xu, Tao, Brosnan, Mary Julia, Trimmer, Jeff, Reichel, Christian, Mohney, Robert P, Soranzo, Nicole, Edwards, Mark H, Cooper, Cyrus, Church, Alistair C, Suhre, Karsten, Gieger, Christian, Dominiczak, Anna F, Spector, Tim D, Padmanabhan, Sandosh, Valdes, Ana M

“…High blood pressure is a major contributor to the global burden of disease and discovering novel causal pathways of blood pressure regulation has been…”
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The hepatoselective glucokinase activator PF-04991532 ameliorates hyperglycemia without causing hepatic steatosis in diabetic rats by Erion, Derek M, Lapworth, Amanda, Amor, Paul A, Bai, Guoyun, Vera, Nicholas B, Clark, Ronald W, Yan, Qingyun, Zhu, Yimin, Ross, Trenton T, Purkal, Julie, Gorgoglione, Matthew, Zhang, Guodong, Bonato, Vinicius, Baker, Levenia, Barucci, Nicole, D'Aquila, Theresa, Robertson, Alan, Aiello, Robert J, Yan, Jiangli, Trimmer, Jeff, Rolph, Timothy P, Pfefferkorn, Jeffrey A

“…Hyperglycemia resulting from type 2 diabetes mellitus (T2DM) is the main cause of diabetic complications such as retinopathy and neuropathy. A reduction in…”
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Assessing the phenotypic effects in the general population of rare variants in genes for a dominant Mendelian form of diabetes by Flannick, Jason, Beer, Nicola L, Bick, Alexander G, Agarwala, Vineeta, Molnes, Janne, Gupta, Namrata, Burtt, Noël P, Florez, Jose C, Meigs, James B, Taylor, Herman, Lyssenko, Valeriya, Irgens, Henrik, Fox, Ervin, Burslem, Frank, Johansson, Stefan, Brosnan, M Julia, Trimmer, Jeff K, Newton-Cheh, Christopher, Tuomi, Tiinamaija, Molven, Anders, Wilson, James G, O'Donnell, Christopher J, Kathiresan, Sekar, Hirschhorn, Joel N, Njølstad, Pål R, Rolph, Tim, Seidman, J G, Gabriel, Stacey, Cox, David R, Seidman, Christine E, Groop, Leif, Altshuler, David

“…David Altshuler and colleagues sequenced seven genes for maturity-onset diabetes of the young (MODY), a dominant Mendelian disorder, in 4,003 individuals drawn…”
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Direct assessment of hepatic mitochondrial oxidative and anaplerotic fluxes in humans using dynamic 13C magnetic resonance spectroscopy by Befroy, Douglas E, Perry, Rachel J, Jain, Nimit, Dufour, Sylvie, Cline, Gary W, Trimmer, Jeff K, Brosnan, Julia, Rothman, Douglas L, Petersen, Kitt Falk, Shulman, Gerald I

“…There are currently a paucity of approaches for the direct in vivo assessment of rates of hepatic mitochondrial oxidation and anaplerotic flux in humans. With…”
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Measurement of gluconeogenesis in exercising men by mass isotopomer distribution analysis by Trimmer, Jeff K, Schwarz, Jean-Marc, Casazza, Gretchen A, Horning, Michael A, Rodriguez, Nestor, Brooks, George A

“…Departments of 1  Integrative Biology and 2  Nutritional Sciences, University of California, Berkeley, California 94720 We evaluated the hypothesis that…”
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An atlas of genetic influences on human blood metabolites by Shin, So-Youn, Fauman, Eric B, Petersen, Ann-Kristin, Krumsiek, Jan, Santos, Rita, Huang, Jie, Arnold, Matthias, Erte, Idil, Forgetta, Vincenzo, Yang, Tsun-Po, Walter, Klaudia, Menni, Cristina, Chen, Lu, Vasquez, Louella, Valdes, Ana M, Hyde, Craig L, Wang, Vicky, Ziemek, Daniel, Roberts, Phoebe, Xi, Li, Grundberg, Elin, Waldenberger, Melanie, Richards, J Brent, Mohney, Robert P, Milburn, Michael V, John, Sally L, Trimmer, Jeff, Theis, Fabian J, Overington, John P, Suhre, Karsten, Brosnan, M Julia, Gieger, Christian, Kastenmüller, Gabi, Spector, Tim D, Soranzo, Nicole

“…Nicole Soranzo, Tim Spector, Gabi Kastenmüller and colleagues report a large-scale analysis of genetic variants influencing human blood metabolite levels. They…”
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CARDINALS: A Phase 2, Randomized, Double-blind, Placebo-controlled, Parallel-group Study to Evaluate the Efficacy and Safety of Utreloxastat (PTC857) in Patients with Amyotrophic Lateral Sclerosis (P5-11.010) by Katz, Jonathan S., Vu, Tuan, Chio, Adriano, McDermott, Christopher, Devos, David, Johnston, Mayzie, Sierra, Rafael, Tansy, Aaron, Trimmer, Jeff, Shefner, Jeremy M.

“…Abstract only…”
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Autoregulation of glucose production in men with a glycerol load during rest and exercise by Trimmer, J K, Casazza, G A, Horning, M A, Brooks, G A

“…Related to hepatic autoregulation we evaluated hypotheses that 1) glucose production would be altered as a result of a glycerol load, 2) decreased glucose…”
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Metabolomic study of carotid-femoral pulse-wave velocity in women by Menni, Cristina, Mangino, Massimo, Cecelja, Marina, Psatha, Maria, Brosnan, Mary J, Trimmer, Jeff, Mohney, Robert P, Chowienczyk, Phil, Padmanabhan, Sandosh, Spector, Tim D, Valdes, Ana M

“…Carotid-femoral pulse-wave velocity (PWV) is a measure of aortic stiffness that is strongly associated with increased risk of cardiovascular morbidity and…”
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Direct assessment of hepatic mitochondrial oxidative and anaplerotic fluxes in humans using dynamic .sup.13C magnetic resonance spectroscopy by Befroy, Douglas E, Perry, Rachel J, Jain, Nimit, Dufour, Sylvie, Cline, Gary W, Trimmer, Jeff K, Brosnan, Julia

“…There are currently a paucity of approaches for the direct in vivo assessment of rates of hepatic mitochondrial oxidation and anaplerotic flux in humans. With…”
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Direct assessment of hepatic mitochondrial oxidative and anaplerotic fluxes in humans using dynamic [.sup.13]C magnetic resonance spectroscopy by Befroy, Douglas E, Perry, Rachel J, Jain, Nimit, Dufour, Sylvie, Cline, Gary W, Trimmer, Jeff K, Brosnan, Julia, Rothman, Douglas L, Petersen, Kitt Falk, Shulman, Gerald I

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Leucine metabolism is not altered with improved insulin sensitivity following a 6‐month exercise program in pre‐diabetics (LB447) by Glynn, Erin, Piner, Lucy, Slentz, Cris, Huffman, Kim, Elliot‐Penry, Lorraine, AbouAssi, Hiba, Bain, James, Muehlbauer, Michael, Ilkayeva, Olga, Stevens, Robert, Brosnan, M. Julia, Trimmer, Jeff, Newgard, Christopher, Kraus, William

“…Obesity is associated with decreased insulin sensitivity (IS), elevated plasma levels of branched‐chain amino acids (BCAAs), and accumulation of medium to long…”
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Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional [Beta] cells by Ferdaoussi, Mourad, Dai, Xiaoqing, Jensen, Mette V, Wang, Runsheng, Peterson, Brett S, Huang, Chao, Ilkayeva, Olga, Smith, Nancy, Miller, Nathanael, Hajmrle, Catherine, Spigelman, Aliya F, Wright, Robert C, Plummer, Gregory, Suzuki, Kunimasa, Mackay, James P, van de Bunt, Martijn, Gloyn, Anna L, Ryan, Terence E, Norquay, Lisa D, Brosnan, M Julia, Trimmer, Jeff K, Rolph, Timothy P, Kibbey, Richard G, Fox, Jocelyn E Manning, Colmers, William F, Shirihai, Orian S, Neufer, P Darrell, Yeh, Edward T H, Newgard, Christopher B, MacDonald, Patrick E

“…Insulin secretion from β cells of the pancreatic islets of Langerhans controls metabolic homeostasis and is impaired in individuals with type 2 diabetes (T2D)…”
Get full text