Search Results - "TRIMMER, J. S"

Deletion of the Kv2.1 delayed rectifier potassium channel leads to neuronal and behavioral hyperexcitability by Speca, D. J., Ogata, G., Mandikian, D., Bishop, H. I., Wiler, S. W., Eum, K., Wenzel, H. Jürgen, Doisy, E. T., Matt, L., Campi, K. L., Golub, M. S., Nerbonne, J. M., Hell, J. W., Trainor, B. C., Sack, J. T., Schwartzkroin, P. A., Trimmer, J. S.

“…The Kv2.1 delayed rectifier potassium channel exhibits high‐level expression in both principal and inhibitory neurons throughout the central nervous system,…”
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Localization of voltage-gated ion channels in mammalian brain by Trimmer, James S, Rhodes, Kenneth J

“…The intrinsic electrical properties of neurons are shaped in large part by the action of voltage-gated ion channels. Molecular cloning studies have revealed a…”
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Dendritic A-type potassium channel subunit expression in CA1 hippocampal interneurons by Menegola, M, Misonou, H, Vacher, H, Trimmer, J.S

“…Abstract Voltage-gated potassium (Kv) channels are important and diverse determinants of neuronal excitability and exhibit specific expression patterns…”
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Modulation of A-type potassium channels by a family of calcium sensors by Rhodes, Kenneth J, An, W. Frank, Bowlby, Mark R, Betty, Maria, Cao, Jie, Ling, Huai-Ping, Mendoza, Grace, Hinson, Joseph W, Mattsson, Karen I, Strassle, Brian W, Trimmer, James S

“…In the brain and heart, rapidly inactivating (A-type) voltage-gated potassium (Kv) currents operate at subthreshold membrane potentials to control the…”
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Dynamic localization and clustering of dendritic Kv2.1 voltage-dependent potassium channels in developing hippocampal neurons by Antonucci, D.E., Lim, S.T., Vassanelli, S., Trimmer, J.S.

“…Dendritic excitability is modulated by the highly variable spatial and temporal expression pattern of voltage-dependent potassium channels. Somatodendritic…”
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Immunological Identification and Characterization of a Delayed Rectifier K+Channel Polypeptide in Rat Brain by Trimmer, James S.

“…Antibodies specific for the drk1 polypeptide were used to characterize the corresponding protein in rat brain. Recombinant and synthetic immunogens containing…”
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Outward K+ current densities and Kv1.5 expression are reduced in Chronic human atrial fibrillation by VAN WAGONER, D. R, POND, A. L, MCCARTHY, P. M, TRIMMER, J. S, NERBONNE, J. M

“…Chronic atrial fibrillation is associated with a shortening of the atrial action potential duration and atrial refractory period. To test the hypothesis that…”
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Distinct Potassium Channels on Pain-Sensing Neurons by Rasband, Matthew N., Park, Eunice W., Vanderah, Todd W., Lai, Josephine, Porreca, Frank, Trimmer, James S.

“…Differential expression of ion channels contributes functional diversity to sensory neuron signaling. We find nerve injury induced by the Chung model of…”
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A novel cyclic nucleotide-gated ion channel enriched in synaptic terminals of isotocin neurons in zebrafish brain and pituitary by Khan, S, Perry, C, Tetreault, M.L, Henry, D, Trimmer, J.S, Zimmerman, A.L, Matthews, G

“…Abstract Cyclic nucleotide-gated (CNG) channels are nonselective cation channels opened by binding of intracellular cyclic GMP or cyclic AMP. CNG channels…”
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Differential spatiotemporal expression of K+ channel polypeptides in rat hippocampal neurons developing in situ and in vitro by Maletic-Savatic, M, Lenn, NJ, Trimmer, JS

“…Hippocampal neurons are highly plastic in their excitable properties, both during development and in the adult brain. As voltage-sensitive K+ channels are…”
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Differential asparagine-linked glycosylation of voltage-gated K+ channels in mammalian brain and in transfected cells by Shi, G, Trimmer, J S

“…Glycosylation of ion channel proteins dramatically impacts channel function. Here we characterize the asparagine (N)-linked glycosylation of voltage-gated K+…”
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Association and colocalization of K+ channel alpha- and beta-subunit polypeptides in rat brain by Rhodes, KJ, Keilbaugh, SA, Barrezueta, NX, Lopez, KL, Trimmer, JS

“…Recent cloning of auxiliary subunits associated with voltage-gated ion channels and their subsequent coexpression with the channel forming alpha-subunits has…”
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Generation and characterization of subtype-specific monoclonal antibodies to K+ channel α- and β-subunit polypeptides by BEKELE-ARCURI, Z, MATOS, M. F, MANGANAS, L, STRASSLE, B. W, MONAGHAN, M. M, RHODES, K. J, TRIMMER, J. S

“…Molecular characterization of mammalian voltage-sensitive K+ channel genes and their expression became possible with the cloning of the Shaker locus of…”
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Identification of a Cytoplasmic Domain Important in the Polarized Expression and Clustering of the Kv2.1 K+Channel by Scannevin, Robert H., Murakoshi, Hideyuki, Rhodes, Kenneth J., Trimmer, James S.

“…The voltage-sensitive K+channel Kv2.1 has a polarized and clustered distribution in neurons. To investigate the basis for this localization, we expressed…”
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Altered expression and localization of hippocampal A-type potassium channel subunits in the pilocarpine-induced model of temporal lobe epilepsy by Monaghan, M.M, Menegola, M, Vacher, H, Rhodes, K.J, Trimmer, J.S

“…Abstract Altered ion channel expression and/or function may contribute to the development of certain human epilepsies. In rats, systemic administration of…”
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Dynamic regulation of the voltage-gated Kv2.1 potassium channel by multisite phosphorylation by Mohapatra, D P, Park, K-S, Trimmer, J S

“…Voltage-gated K(+) channels are key regulators of neuronal excitability. The Kv2.1 voltage-gated K(+) channel is the major delayed rectifier K(+) channel…”
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Developmental analysis reveals mismatches in the expression of K+ channel alpha subunits and voltage-gated K+ channel currents in rat ventricular myocytes by Xu, H, Dixon, J E, Barry, D M, Trimmer, J S, Merlie, J P, McKinnon, D, Nerbonne, J M

“…In the experiments here, the developmental expression of the functional Ca(2+)-independent, depolarization-activated K+ channel currents, Ito and IK, and of…”
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Nerve Growth Factor Regulates the Abundance and Distribution of K+ Channels in PC12 Cells by Sharma, Nutan, D'Arcangelo, Gabriella, Kleinklaus, Amy, Halegoua, Simon, Trimmer, James S.

“…We examined the effect of nerve growth factor (NGF) treatment on expression of a neuronal delayed rectifier K+ channel subtype, Kv2.1 (drk1), in PC12 cells…”
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Properties of Kv2.1 K+ channels expressed in transfected mammalian cells by Shi, G, Kleinklaus, A K, Marrion, N V, Trimmer, J S

“…We have transiently expressed the rat Kv2.1 K+ channel polypeptide (pKv2.1) at high levels by transfection of mammalian COS-1 cells. Kv2.1-transfected cells…”
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Functional Specialization of the Axon Initial Segment by Isoform-Specific Sodium Channel Targeting by Boiko, Tatiana, Van Wart, Audra, Caldwell, John H, Levinson, S. Rock, Trimmer, James S, Matthews, Gary

“…Voltage-dependent sodium channels cluster at high density at axon initial segments, where propagating action potentials are thought to arise, and at nodes of…”
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