Search Results - "TRESSLER, ROBERT J."

Antitumor and Antimetastatic Activity of Ribozymes Targeting the Messenger RNA of Vascular Endothelial Growth Factor Receptors by Pavco, P A, Bouhana, K S, Gallegos, A M, Agrawal, A, Blanchard, K S, Grimm, S L, Jensen, K L, Andrews, L E, Wincott, F E, Pitot, P A, Tressler, R J, Cushman, C, Reynolds, M A, Parry, T J

“…Chemically stabilized hammerhead ribozymes are nuclease-resistant, RNA-based oligonucleotides that selectively bind and cleave specific target RNAs. Due to…”
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Anti-tumor activity of mycophenolate mofetil against human and mouse tumors in vivo by Tressler, R J, Garvin, L J, Slate, D L

“…Cultured tumor cell lines, tumor xenografts grown in athymic nude mice, and a murine experimental metastasis model were used to assess the in vitro and in vivo…”
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Ex Vivo Expanded Megakaryocyte Progenitors Generated From Human Mobilized Peripheral Blood CD34+ Stem Cells Can Be Cryopreserved and Transplanted Into NSG Mice to Generate Functional Platelets by Karsunky, Holger, Tressler, Robert J., Chananukul, Joy

“…Abstract 482 Thrombocytopenia is a common side effect of high-dose chemotherapy that can compromise cancer treatment by requiring treatment delay and/or dose…”
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Abstract 662: Generation and characterization of antibodies specific for IL1RAP antigen to target quiescent and proliferating AML leukemic stem cells by Jiang, Ping, Roy, Sharmili, Huang, Jen, Dao-Pick, Trang, Lu, Jennifer, Mishra, Madhavi, Lin, Jeffrey, Hsi, Eric D., Tressler, Robert J., Karsunky, Holger

“…Abstract We have isolated and characterized blast cells and leukemic stem cells (LSCs) enriched from AML patients and identified cell surface targets…”
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Abstract 4291: Imetelstat, a telomerase inhibitor in phase I trials in solid tumor and hematological malignancies, has broad activity against multiple types of cancer stem cells by Joseph, Immanual, Matsui, William, LaPorta, Caterina A M, Tabori, Uri, Kornblum, Harley, Herbert, Brittney-Shea, Harley, Calvin, Tressler, Robert J.

“…Abstract Numerous studies show that multiple tumor types have rare subpopulations of cells that are initiators of tumor growth, recurrence, and are implicated…”
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GRN163L, a Potent and Specific Inhibitor of Telomerase: Integrated Pharmacokinetic, Pharmacodynamic, and Safety Data Guides Design of Practical Treatment Regimens for Targeting Inhibitory Levels in Patients by Tressler, Robert J., Chin, Allison C., Feldman, Eric J., Rai, Kanti R., Kornbrust, Doug, Harley, Calvin B., Behrs, Melissa A. Kelly, Elias, Laurence

“…GRN163L is a lipidated thiophosphoramidate oligonucleotide that binds with nanomolar affinity to the template region of human telomerase RNA, causing direct…”
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Modulation of matrilysin levels in colon carcinoma cell lines affects tumorigenicity in vivo by WITTY, J. P, MCDONNELL, S, NEWELL, K. J, CANNON, P, NAVRE, M, TRESSLER, R. J, MATRISIAN, L. M

“…The expression of the metalloproteinase matrilysin in the human colon carcinoma cell lines SW480 and SW620 correlates with the ability of the SW620 cells to…”
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Chemical modifications of heparin that diminish its anticoagulant but preserve its heparanase-inhibitory, angiostatic, anti-tumor and anti-metastatic properties by Lapierre, France, Holme, Kevin, Lam, Lun, Tressler, Robert J., Storm, Neil, Wee, Jennifer, Stack, Robert J., Castellot, John, Tyrrell, David J.

“…Structural features of heparin potentially important for heparanase-inhibitory activity were examined by measuring the ability of heparin derivatives to affect…”
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Expression of galectins on microvessel endothelial cells and their involvement in tumour cell adhesion by Lotan, R, Belloni, P N, Tressler, R J, Lotan, D, Xu, X C, Nicolson, G L

“…Lactoside-binding lectins (galectins) with molecular weights of about 14.5 kDa (galectin-1) and 29-35 kDa (galectin-3) bind preferentially to…”
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Extracellular annexin II is associated with divalent cation-dependent tumor cell-endothelial cell adhesion of metastatic RAW117 large-cell lymphoma cells by Tressler, R J, Updyke, T V, Yeatman, T, Nicolson, G L

“…Using fixed microvessel endothelial cell monolayers the molecules involved in the adhesion of liver-preferring murine RAW117 large cell lymphoma cells to…”
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Urokinase receptor antagonists: discovery and application to in vivo models of tumor growth by TRESSLER, ROBERT J., PITOT, PATRICE A., STRATTON, JENNIFER R., FORREST, LOUISE D., ZHUO, SHAOQIU, DRUMMOND, ROBERT J., FONG, SUSAN, DOYLE, MICHAEL V., DOYLE, LAURA V., MIN, HYE YEONG, ROSENBERG, STEVEN

“…Urokinase receptor antagonists based on the growth factor domains of both human and murine urokinase which show sub‐nanomolar affinities for their homologous…”
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Microvascular endothelial cell heterogeneity : interactions with leukocytes and tumor cells by BELLONI, P. N, TRESSLER, R. J

“…Endothelium constitutes a highly specialized organ that lines the vascular system and lymphatic channels. This organ is a complex network of arteries, veins,…”
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Extracellular annexin VI expression is associated with divalent cation-dependent endothelial cell adhesion of metastatic RAW117 large-cell lymphoma cells by Tressler, R J, Yeatman, T, Nicolson, G L

“…We previously found that cell surface molecules of approximately 70, approximately 35, approximately 32, approximately 22, and approximately 14 kDa from…”
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Butanol-extractable and detergent-solubilized cell surface components from murine large cell lymphoma cells associated with adhesion to organ microvessel endothelial cells by Tressler, R J, Nicolson, G L

“…Metastatic variant cell lines of the murine RAW117 large cell lymphoma were used to study the cell surface components involved in syngeneic tumor…”
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Sialoglycoproteins of murine RAW117 large cell lymphoma/lymphosarcoma sublines of various metastatic colonization properties by Irimura, T, Tressler, R J, Nicolson, G L

“…A metastatic model for large-cell lymphoma/lymphosarcoma has been developed by sequential selection in vivo of the murine RAW117 cell line for enhanced liver…”
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Differential expression of metastasis-associated cell surface glycoproteins and mRNA in a murine large cell lymphoma by Nicolson, G L, LaBiche, R A, Frazier, M L, Blick, M, Tressler, R J, Reading, C L, Irimura, T, Rotter, V

“…A metastatic variant cell subline of the Abelson virus-transformed murine large lymphoma/lymphosarcoma RAW117 has been selected in vivo ten times for liver…”
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Correlation of inhibition of adhesion of large cell lymphoma and hepatic sinusoidal endothelial cells by RGD-containing peptide polymers with metastatic potential: role of integrin-dependent and -independent adhesion mechanisms by Tressler, R J, Belloni, P N, Nicolson, G L

“…Murine RAW117 large-cell lymphoma cells that show organ preferences of metastatic colonization were selected. We examined the role of adhesive systems in…”
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