Search Results - "TRESOLDI, Eleonora"
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T cell receptor recognition of hybrid insulin peptides bound to HLA-DQ8
Published in Nature communications (25-08-2021)“…HLA-DQ8, a genetic risk factor in type I diabetes (T1D), presents hybrid insulin peptides (HIPs) to autoreactive CD4+ T cells. The abundance of spliced…”
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A minority of proliferating human CD4+ T cells in antigen-driven proliferation assays are antigen specific
Published in Frontiers in immunology (28-10-2024)“…Antigen-driven T-cell proliferation is often measured using fluorescent dye dilution assays, such as the CFSE-based proliferation assay. Dye dilution assays…”
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Stability of human rapamycin-expanded CD4+CD25+ T regulatory cells
Published in Haematologica (Roma) (01-09-2011)“…The clinical use of ex vivo-expanded T-regulatory cells for the treatment of T-cell-mediated diseases has gained increasing momentum. However, the recent…”
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Glutamine deamidation does not increase the immunogenicity of C-peptide in people with type 1 diabetes
Published in Journal of translational autoimmunity (Online) (01-01-2023)“…Type 1 diabetes (T1D) is a T-cell mediated autoimmune disease in which the insulin-producing beta cells are destroyed. While it is clear that full-length…”
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5
In vivo evolution of HIV-1 co-receptor usage and sensitivity to chemokine-mediated suppression
Published in Nature medicine (01-11-1997)“…Following the identification of the C-C chemokines RANTES, MIP-1alpha and MIP-1beta as major human immunodeficiency virus (HIV)-suppressive factors produced by…”
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Reply to Comment on "Stability of human rapamycin-expanded CD4+CD25+ T-regulatory cells" Haematologica 2011;96(9):1357-65
Published in Haematologica (Roma) (01-05-2012)Get full text
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Generation of donor-specific Tr1 cells to be used after kidney transplantation and definition of the timing of their in vivo infusion in the presence of immunosuppression
Published in Journal of translational medicine (21-02-2017)“…Operational tolerance is an alternative to lifelong immunosuppression after transplantation. One strategy to achieve tolerance is by T regulatory cells. Safety…”
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Proinsulin C-peptide is an autoantigen in people with type 1 diabetes
Published in Proceedings of the National Academy of Sciences - PNAS (16-10-2018)“…Type 1 diabetes (T1D) is an autoimmune disease in which insulin-producing beta cells, found within the islets of Langerhans in the pancreas, are destroyed by…”
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Generation of Donor-specific T Regulatory Type 1 Cells From Patients on Dialysis for Cell Therapy After Kidney Transplantation
Published in Transplantation (01-08-2015)“…T regulatory type 1 (Tr1) cell-mediated induction of tolerance in preclinical models of transplantation is remarkably effective. The clinical application of…”
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Differentiation of Tr1 cells by immature dendritic cells requires IL-10 but not CD25+CD4+ Tr cells
Published in Blood (01-02-2005)“…Dendritic cells (DCs) are specialized antigen-presenting cells that monitor the antigenic environment and activate naive T cells. The role of DCs is not only…”
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Preventing Bacterial Infections with Pilus-Based Vaccines: the Group B Streptococcus Paradigm
Published in The Journal of infectious diseases (01-01-2009)“…We recently described the presence of 3 pilus variants in the human pathogen group B streptococcus (GBS; also known as Streptococcus agalactiae), each encoded…”
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Proinsulin C-peptide is a major source of HLA-DQ8 restricted hybrid insulin peptides recognized by human islet-infiltrating CD4+ T cells
Published in PNAS nexus (01-11-2024)“…Abstract Type 1 diabetes (T1D) is an autoimmune disease that develops when T cells destroy the insulin-producing beta cells that reside in the pancreatic…”
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Expanding human T regulatory cells with the mTOR-inhibitor rapamycin
Published in Methods in molecular biology (Clifton, N.J.) (01-01-2012)“…CD4(+)CD25(+)FOXP3(+) T regulatory (Treg) cells are pivotal for the induction and maintenance of peripheral tolerance in both mice and humans. The possibility…”
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An anti-CD45RO/RB monoclonal antibody modulates T cell responses via induction of apoptosis and generation of regulatory T cells
Published in The Journal of experimental medicine (18-04-2005)“…The effects of a chimeric monoclonal antibody (chA6 mAb) that recognizes both the RO and RB isoforms of the transmembrane protein tyrosine phosphatase CD45 on…”
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Cutting Edge: CXCR4 Is a Functional Coreceptor for Infection of Human Macrophages by CXCR4-Dependent Primary HIV-1 Isolates
Published in The Journal of immunology (1950) (01-09-1998)“…Abstract The identification of HIV-1 coreceptors has provided a molecular basis for the tropism of different HIV-1 strains. CXC chemokine receptor-4 (CXCR4)…”
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Nonproductive Human Immunodeficiency Virus Type 1 Infection of Human Fetal Astrocytes: Independence from CD4 and Major Chemokine Receptors
Published in Virology (New York, N.Y.) (25-11-1999)“…Human immunodeficiency virus type 1 (HIV-1) infection of the brain is associated with neurological manifestations both in adults and in children. The primary…”
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C-C chemokines released by lipopolysaccharide (LPS)-stimulated human macrophages suppress HIV-1 infection in both macrophages and T cells
Published in The Journal of experimental medicine (03-03-1997)“…Human immunodeficiency virus-1 (HIV-1) expression in monocyte-derived macrophages (MDM) infected in vitro is known to be inhibited by lipopolysaccharide (LPS)…”
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Prognostic value of the stromal cell-derived factor 1 3'A mutation in pediatric human immunodeficiency virus type 1 infection
Published in The Journal of infectious diseases (01-03-2002)“…A mutation of the stromal cell-derived factor 1 gene (SDF-1 3'A) was shown to protect adults exposed to human immunodeficiency virus type 1 (HIV-1) from…”
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Prognostic Value of the Stromal Cell-Derived Factor 1 3′A Mutation in Pediatric Human Immunodeficiency Virus Type 1 Infection
Published in The Journal of infectious diseases (01-03-2002)“…A mutation of the stromal cell-derived factor 1 gene (SDF-1 3′A) was shown to protect adults exposed to human immunodeficiency virus type 1 (HIV-1) from…”
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Human recombinant antibody fragments specific for a rye-grass pollen allergen: Characterization and potential applications
Published in Molecular immunology (01-09-1996)“…One of the major allergens from the pollen of perennial rye grass ( Lolium perenne), Lol pII, was used to isolate specific antibody fragments from a random…”
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