Search Results - "TREPICCHIO, W. L"

Hematopoietic, immunomodulatory and epithelial effects of interleukin-11 by SCHWERTSCHLAG, U. S, TREPICCHIO, W. L, DYKSTRA, K. H, KEITH, J. C, TURNER, K. J, DORNER, A. J

“…Interleukin 11 (IL-11) is a pleiotropic cytokine with biological activities on many different cell types. Recombinant human IL-11 (rhIL-11) is produced by…”
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Recombinant human IL-11 attenuates the inflammatory response through down-regulation of proinflammatory cytokine release and nitric oxide production by Trepicchio, WL, Bozza, M, Pedneault, G, Dorner, AJ

“…To elucidate the molecular mechanisms regulating the anti-inflammatory activities of recombinant human (rh)IL-11, the ability of rhIL-11 to reduce serum levels…”
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Increased expression of interleukin 23 p19 and p40 in lesional skin of patients with psoriasis vulgaris by Lee, Edmund, Trepicchio, William L, Oestreicher, Judith L, Pittman, Debra, Wang, Frank, Chamian, Francesca, Dhodapkar, Madhav, Krueger, James G

“…Psoriasis is a type I-deviated disease characterized by the presence of interferon (IFN)-gamma and multiple IFN-related inflammatory genes in lesions. Because…”
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Interleukin‐11 reduces T‐cell–dependent experimental liver injury in mice by Bozza, Mary, Bliss, Judith L., Maylor, Richard, Erickson, Jamie, Donnelly, Lori, Bouchard, Page, Dorner, Andrew J., Trepicchio, William L.

“…Recombinant human interleukin‐11 (rhIL‐11) is a multifunctional cytokine that can reduce inflammation through the downregulation of multiple pro‐inflammatory…”
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Interleukin-11 modulates Th1/Th2 cytokine production from activated CD4+ T cells by Bozza, M, Bliss, J L, Dorner, A J, Trepicchio, W L

“…Recombinant human interleukin-11 (rHuIL-11) is a pleiotropic cytokine with effects on multiple cell types. rHuIL-11 reduces activated macrophage activity and…”
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Designing prospective clinical pharmacogenomic (PG) trials: meeting report on drug development strategies to enhance therapeutic decision making by Trepicchio, W L, Essayan, D, Hall, S T, Schechter, G, Tezak, Z, Wang, S J, Weinreich, D, Simon, R

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Developmental regulation of the human embryonic beta-like globin gene is mediated by synergistic interactions among multiple tissue- and stage-specific elements by TREPICCHIO, W. L, DYER, M. A, BARON, M. H

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Interleukin-11 therapy selectively downregulates type I cytokine proinflammatory pathways in psoriasis lesions by Trepicchio, W L, Ozawa, M, Walters, I B, Kikuchi, T, Gilleaudeau, P, Bliss, J L, Schwertschlag, U, Dorner, A J, Krueger, J G

“…Psoriasis is a chronic inflammatory skin disease in which epidermal hyperplasia results from skin infiltration by type I T lymphocytes and release of…”
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Molecular classification of psoriasis disease-associated genes through pharmacogenomic expression profiling by OESTREICHER, J. L, WALTERS, I. B, KIKUCHI, T, GILLEAUDEAU, P, SURETTE, J, SCHWERTSCHLAG, U, DORNER, A. J, KRUEGER, J. G, TREPICCHIO, W. L

“…Psoriasis is recognized as the most common T cell-mediated inflammatory disease in humans. Genetic linkage to as many as six distinct disease loci has been…”
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IL-11 regulates macrophage effector function through the inhibition of nuclear factor- Kappa B by Trepicchio, W L, Wang, LiLi, Bozza, M, Dorner, A J

“…Recombinant human IL-11 (rhIL-11) is an anti-inflammatory cytokine that can reduce the production of inflammatory mediators such as TNF- alpha , IL-1 beta ,…”
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IL-11 regulates macrophage effector function through the inhibition of nuclear factor-kappaB by Trepicchio, WL, Wang, L, Bozza, M, Dorner, AJ

“…Recombinant human IL-11 (rhIL-11) is an anti-inflammatory cytokine that can reduce the production of inflammatory mediators such as TNF-alpha, IL-1beta, IL-12,…”
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A novel developmental regulatory motif required for stage-specific activation of the epsilon-globin gene and nuclear factor binding in embryonic erythroid cells by Trepicchio, W L, Dyer, M A, Baron, M H

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Clinical pharmacogenomics and transcriptional profiling in early phase oncology clinical trials by Burczynski, Michael E, Oestreicher, Judith L, Cahilly, Monica J, Mounts, Deborah P, Whitley, Maryann Z, Speicher, Lisa A, Trepicchio, William L

“…Microarray-based expression profiling studies in the field of oncology have demonstrated encouraging correlations between tumor transcriptional profiles and…”
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Interleukin-11: A gp130 Cytokine by TREPICCHIO, WILLIAM L., DORNER, ANDREW J.

“…Interleukin (IL)‐11 is a member of the gp130 family of cytokines. Comparison of IL‐11 with another gp130 family member, IL‐6, indicates that these two…”
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Members of the rel/NF-kappa B family of transcriptional regulatory proteins bind the HRAS1 minisatellite DNA sequence by Trepicchio, W L, Krontiris, T G

“…The 28 base pair repeat unit of a minisatellite 1000 bp downstream from the human HRAS1 gene (VTRHRAS1) bound four proteins (p45, p50, p72 and p85) in nuclear…”
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Protective Effect of rhIL-11 in a Murine Model of Acetaminophen-Induced Hepatotoxicity by Trepicchio, William L., Bozza, Mary, Bouchard, Page, Dorner, Andrew J.

“…Acetaminophen intoxication results in hepatotoxicity associated with increased serum concentrations of hepatocellular leakage enzymes such as aspartate…”
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IGH minisatellite suppression of USF-binding-site- and Eμ-mediated transcriptional activation of the adenovirus major late promoter by Trepicchio, William L., Krontiris, Theodore G.

“…The 50bp repeat unit of the minisatellite within the DH JH interval of the human immunoglobulin heavy chain locus binds a nuclear factor present in a wide…”
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Autocrine regulation of IL-12 receptor expression is independent of secondary IFN-gamma secretion and not restricted to T and NK cells by Thibodeaux, D K, Hunter, S E, Waldburger, K E, Bliss, J L, Trepicchio, W L, Sypek, J P, Dunussi-Joannopoulos, K, Goldman, S J, Leonard, J P

“…The biological response to IL-12 is mediated through specific binding to a high affinity receptor complex composed of at least two subunits (designated…”
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EXPLORATORY BIOMARKER ANALYSIS IN THE PH 3 ECHELON‐1 STUDY: WORSE OUTCOME WITH ABVD IN PATIENTS WITH ELEVATED BASELINE LEVELS OF SCD30 AND TARC by Radford, J., Connors, J.M., Younes, A., Gallamini, A., Ansell, S.M., Kim, W.S., Cheong, J., Flinn, I., Kalakonda, N., Kaminski, M., Pettengell, R., Onsum, M., Josephson, N., Kuroda, S., Liu, R., Miao, H., Gautam, A., Trepicchio, W.L., Sureda, A.

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Recombinant human interleukin-11 does not affect functions of purified human neutrophils in vitro by Bozza, M, Kyvelos, D, Trepicchio, W L, Collins, M, Klempner, M S, Dorner, A J

“…Recombinant human interleukin-11 (rHu-IL-11) is a multifunctional cytokine with thrombopoietic activity and demonstrated clinical efficacy in treating…”
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