Search Results - "TREMBLAY, Kimberly D"

MCRS1 is essential for epiblast development during early mouse embryogenesis by Cui, Wei, Cheong, Agnes, Wang, Yongsheng, Tsuchida, Yuran, Liu, Yong, Tremblay, Kimberly D, Mager, Jesse

“…Microspherule protein 1 (MCRS1, also known as MSP58) is an evolutionarily conserved protein that has been implicated in various biological processes. Although…”
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Patterning of the hepato‐pancreatobiliary boundary by BMP reveals heterogeneity within the murine liver bud by Palaria, Amrita, Angelo, Jesse R., Guertin, Taylor M., Mager, Jesse, Tremblay, Kimberly D.

“…During development, the endoderm initiates organ‐restricted gene expression patterns in a spatiotemporally controlled manner. This process, termed induction,…”
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DIGIT Is a Conserved Long Noncoding RNA that Regulates GSC Expression to Control Definitive Endoderm Differentiation of Embryonic Stem Cells by Daneshvar, Kaveh, Pondick, Joshua V., Kim, Byeong-Moo, Zhou, Chan, York, Samuel R., Macklin, Jillian A., Abualteen, Ameed, Tan, Bo, Sigova, Alla A., Marcho, Chelsea, Tremblay, Kimberly D., Mager, Jesse, Choi, Michael Y., Mullen, Alan C.

“…Long noncoding RNAs (lncRNAs) exhibit diverse functions, including regulation of development. Here, we combine genome-wide mapping of SMAD3 occupancy with…”
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Distinct populations of endoderm cells converge to generate the embryonic liver bud and ventral foregut tissues by Tremblay, Kimberly D., Zaret, Kenneth S.

“…The location and movement of mammalian gut tissue progenitors, prior to the expression of tissue-specific genes, has been unknown, but this knowledge is…”
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The elongation factor Elof1 is required for mammalian gastrulation by Tellier, Adam P, Archambault, Danielle, Tremblay, Kimberly D, Mager, Jesse

“…Despite having been sequenced over a decade ago, the functional significance of much of the mammalian genome remains unknown. The mouse has become the…”
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Single-cell murine genetic fate mapping reveals bipotential hepatoblasts and novel multi-organ endoderm progenitors by El Sebae, Gabriel K, Malatos, Joseph M, Cone, Mary-Kate E, Rhee, Siyeon, Angelo, Jesse R, Mager, Jesse, Tremblay, Kimberly D

“…The definitive endoderm (DE) is the embryonic germ layer that forms the gut tube and associated organs, including thymus, lungs, liver and pancreas. To…”
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A fate map of the murine pancreas buds reveals a multipotent ventral foregut organ progenitor by Angelo, Jesse R, Guerrero-Zayas, Mara-Isel, Tremblay, Kimberly D

“…The definitive endoderm is the embryonic germ layer that gives rise to the budding endodermal organs including the thyroid, lung, liver and pancreas as well as…”
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Mechanism of a Genetically Encoded Dark-to-Bright Reporter for Caspase Activity by Nicholls, Samantha B., Chu, Jun, Abbruzzese, Genevieve, Tremblay, Kimberly D., Hardy, Jeanne A.

“…Fluorescent proteins have revolutionized modern biology with their ability to report the presence of tagged proteins in living systems. Although several…”
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Arf4 is required for Mammalian development but dispensable for ciliary assembly by Follit, John A, San Agustin, Jovenal T, Jonassen, Julie A, Huang, Tingting, Rivera-Perez, Jaime A, Tremblay, Kimberly D, Pazour, Gregory J

“…The primary cilium is a sensory organelle, defects in which cause a wide range of human diseases including retinal degeneration, polycystic kidney disease and…”
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Visceral endoderm expression of Yin-Yang1 (YY1) is required for VEGFA maintenance and yolk sac development by Rhee, Siyeon, Guerrero-Zayas, Mara-Isel, Wallingford, Mary C, Ortiz-Pineda, Pablo, Mager, Jesse, Tremblay, Kimberly D

“…Mouse embryos lacking the polycomb group gene member Yin-Yang1 (YY1) die during the peri-implantation stage. To assess the post-gastrulation role of YY1, a…”
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Nuclear-encoded mitochondrial ribosomal proteins are required to initiate gastrulation by Cheong, Agnes, Archambault, Danielle, Degani, Rinat, Iverson, Elizabeth, Tremblay, Kimberly D, Mager, Jesse

“…Mitochondria are essential for energy production and although they have their own genome, many nuclear-encoded mitochondrial ribosomal proteins (MRPs) are…”
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TATA-binding associated factors have distinct roles during early mammalian development by He, Xinjian Doris, Phillips, Shelby, Hioki, Kaito, Majhi, Prabin Dhangada, Babbitt, Courtney, Tremblay, Kimberly D., Pobezinsky, Leonid A., Mager, Jesse

“…Early embryonic development is a finely orchestrated process that requires precise regulation of gene expression coordinated with morphogenetic events…”
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Borcs6 is required for endo‐lysosomal degradation during early development by Bell, Charlotte J., Gupta, Neha, Tremblay, Kimberly D., Mager, Jesse

“…Early development and differentiation require precise control of cellular functions. Lysosomal degradation is a critical component of normal cellular…”
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Protein phosphatase 1 regulatory subunit 35 is required for ciliogenesis, notochord morphogenesis, and cell-cycle progression during murine development by Archambault, Danielle, Cheong, Agnes, Iverson, Elizabeth, Tremblay, Kimberly D., Mager, Jesse

“…Protein phosphatases regulate a wide array of proteins through post-translational modification and are required for a plethora of intracellular events in…”
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A null allele of Dnaaf2 displays embryonic lethality and mimics human ciliary dyskinesia by Cheong, Agnes, Degani, Rinat, Tremblay, Kimberly D, Mager, Jesse

“…The dynein axonemal assembly factor (Dnaaf) protein family is involved in preassembly and stability of dynein arms before they are transported into the cilia…”
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Identification and fate mapping of the pancreatic mesenchyme by Angelo, Jesse R., Tremblay, Kimberly D.

“…The murine pancreas buds from the ventral embryonic endoderm at approximately 8.75 dpc and a second pancreas bud emerges from the dorsal endoderm by 9.0 dpc…”
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Overlapping peri-implantation phenotypes of ZNHIT1 and ZNHIT2 despite distinct functions during early mouse development by He, Xinjian Doris, Taylor, Louis F, Miao, Xiaosu, Shi, Yingchao, Lin, Xinhua, Yang, Zhongzhou, Liu, Xin, Miao, Yi-Liang, Alfandari, Dominique, Cui, Wei, Tremblay, Kimberly D, Mager, Jesse

“…Mammalian preimplantation development culminates in the formation of a blastocyst which undergoes extensive gene expression regulation to successfully implant…”
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Deciphering the role of retinoic acid in hepatic patterning and induction in the mouse by Guertin, Taylor M., Palaria, Amrita, Mager, Jesse, Sandell, Lisa L., Trainor, Paul A., Tremblay, Kimberly D.

“…Retinoic acid (RA), a metabolite of vitamin A, is a small molecule and morphogen that is required for embryonic development. While normal RA signals are…”
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FGF signaling is required for anterior but not posterior specification of the murine liver bud by Wang, Jikui, Rhee, Siyeon, Palaria, Amrita, Tremblay, Kimberly D.

“…Background: The definitive endoderm arises as a naive epithelial sheet that produces the entire gut tube and associated organs including the liver, pancreas…”
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Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos by Cui, Wei, Dai, Xiangpeng, Marcho, Chelsea, Han, Zhengbin, Zhang, Kun, Tremblay, Kimberly D., Mager, Jesse

“…With readily available transcriptome-wide data, understanding the role of each expressed gene is an essential next step. Although RNAi technologies allow for…”
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