Search Results - "TREE, Timothy I"

Regulatory T cell dysfunction in type 1 diabetes: what’s broken and how can we fix it? by Hull, Caroline M., Peakman, Mark, Tree, Timothy I. M.

“…Type 1 diabetes is an autoimmune disease characterised by the destruction of insulin producing beta cells in the pancreas. Whilst it remains unclear what the…”
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Low-dose IL-2 reduces IL-21+ T cell frequency and induces anti-inflammatory gene expression in type 1 diabetes by Zhang, Jia-Yuan, Hamey, Fiona, Trzupek, Dominik, Mickunas, Marius, Lee, Mercede, Godfrey, Leila, Yang, Jennie H. M., Pekalski, Marcin L., Kennet, Jane, Waldron-Lynch, Frank, Evans, Mark L., Tree, Timothy I. M., Wicker, Linda S., Todd, John A., Ferreira, Ricardo C.

“…Despite early clinical successes, the mechanisms of action of low-dose interleukin-2 (LD-IL-2) immunotherapy remain only partly understood. Here we examine the…”
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Phenotypic Complexity of the Human Regulatory T Cell Compartment Revealed by Mass Cytometry by Mason, Gavin M, Lowe, Katie, Melchiotti, Rossella, Ellis, Richard, de Rinaldis, Emanuele, Peakman, Mark, Heck, Susanne, Lombardi, Giovanna, Tree, Timothy I M

“…Regulatory T cells (Tregs) are an essential component of the cellular immune response, occupying a key role in maintaining immunological tolerance and present…”
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Type 1 diabetes can present before the age of 6 months and is characterised by autoimmunity and rapid loss of beta cells by Johnson, Matthew B., Patel, Kashyap A., De Franco, Elisa, Hagopian, William, Killian, Michael, McDonald, Timothy J., Tree, Timothy I. M., Domingo-Vila, Clara, Hudson, Michelle, Hammersley, Suzanne, Dobbs, Rebecca, Ellard, Sian, Flanagan, Sarah E., Hattersley, Andrew T., Oram, Richard A.

“…Aims/hypothesis Diabetes diagnosed at <6 months of age is usually monogenic. However, 10–15% of affected infants do not have a pathogenic variant in one of the…”
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Ustekinumab for type 1 diabetes in adolescents: a multicenter, double-blind, randomized phase 2 trial by Tatovic, Danijela, Marwaha, Ashish, Taylor, Peter, Hanna, Stephanie J., Carter, Kym, Cheung, W. Y., Luzio, Steve, Dunseath, Gareth, Hutchings, Hayley A., Holland, Gail, Hiles, Steve, Fegan, Greg, Williams, Evangelia, Yang, Jennie H. M., Domingo-Vila, Clara, Pollock, Emily, Wadud, Muntaha, Ward-Hartstonge, Kirsten, Marques-Jones, Susie, Bowen-Morris, Jane, Stenson, Rachel, Levings, Megan K., Gregory, John W., Tree, Timothy I. M., Dayan, Colin

“…Immunotherapy targeting the autoimmune process in type 1 diabetes (T1D) can delay the loss of β-cells but needs to have minimal adverse effects to be an…”
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Naturally Arising Human CD4 T-Cells That Recognize Islet Autoantigens and Secrete Interleukin-10 Regulate Proinflammatory T-Cell Responses via Linked Suppression by TREE, Timothy I. M, LAWSON, Jennifer, EDWARDS, Hannah, SKOWERA, Ania, ARIF, Sefina, ROEP, Bart O, PEAKMAN, Mark

“…Regulatory T-cells (Tregs) recognizing islet autoantigens are proposed as a key mechanism in the maintenance of self-tolerance and protection from type 1…”
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Type 1 diabetes-associated IL2RA variation lowers IL-2 signaling and contributes to diminished CD4+CD25+ regulatory T cell function by Garg, Garima, Tyler, Jennifer R, Yang, Jennie H M, Cutler, Antony J, Downes, Kate, Pekalski, Marcin, Bell, Gwynneth L, Nutland, Sarah, Peakman, Mark, Todd, John A, Wicker, Linda S, Tree, Timothy I M

“…Numerous reports have demonstrated that CD4(+)CD25(+) regulatory T cells (Tregs) from individuals with a range of human autoimmune diseases, including type 1…”
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Monitoring islet specific immune responses in type 1 diabetes clinical immunotherapy trials by Arif, Sefina, Domingo-Vila, Clara, Pollock, Emily, Christakou, Eleni, Williams, Evangelia, Tree, Timothy I M

“…The number of immunotherapeutic clinical trials in type 1 diabetes currently being conducted is expanding, and thus there is a need for robust…”
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Clinical-grade multipotent adult progenitor cells durably control pathogenic T cell responses in human models of transplantation and autoimmunity by Reading, James L, Yang, Jennie H M, Sabbah, Shereen, Skowera, Ania, Knight, Robin R, Pinxteren, Jef, Vaes, Bart, Allsopp, Timothy, Ting, Anthony E, Busch, Sarah, Raber, Amy, Deans, Robert, Tree, Timothy I M

“…A major goal of immunotherapy remains the control of pathogenic T cell responses that drive autoimmunity and allograft rejection. Adherent progenitor cells,…”
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Single-cell RNAseq identifies clonally expanded antigen-specific T-cells following intradermal injection of gold nanoparticles loaded with diabetes autoantigen in humans by Hanna, Stephanie J, Thayer, Terri C, Robinson, Emma J S, Vinh, Ngoc-Nga, Williams, Nigel, Landry, Laurie G, Andrews, Robert, Siah, Qi Zhuang, Leete, Pia, Wyatt, Rebecca, McAteer, Martina A, Nakayama, Maki, Wong, F Susan, Yang, Jennie H M, Tree, Timothy I M, Ludvigsson, Johnny, Dayan, Colin M, Tatovic, Danijela

“…Gold nanoparticles (GNPs) have been used in the development of novel therapies as a way of delivery of both stimulatory and tolerogenic peptide cargoes. Here…”
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Postthymic expansion in human CD4 naive T cells defined by expression of functional high-affinity IL-2 receptors by Pekalski, Marcin L, Ferreira, Ricardo C, Coulson, Richard M R, Cutler, Antony J, Guo, Hui, Smyth, Deborah J, Downes, Kate, Dendrou, Calliope A, Castro Dopico, Xaquin, Esposito, Laura, Coleman, Gillian, Stevens, Helen E, Nutland, Sarah, Walker, Neil M, Guy, Catherine, Dunger, David B, Wallace, Chris, Tree, Timothy I M, Todd, John A, Wicker, Linda S

“…As the thymus involutes with age, the maintenance of peripheral naive T cells in humans becomes strongly dependent on peripheral cell division. However,…”
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Phenotypic Analysis of Human Lymph Nodes in Subjects With New-Onset Type 1 Diabetes and Healthy Individuals by Flow Cytometry by Yang, Jennie H M, Khatri, Leena, Mickunas, Marius, Williams, Evangelia, Tatovic, Danijela, Alhadj Ali, Mohammad, Young, Philippa, Moyle, Penelope, Sahni, Vishal, Wang, Ryan, Kaur, Rejbinder, Tannahill, Gillian M, Beaton, Andrew R, Gerlag, Danielle M, Savage, Caroline O S, Napolitano Rosen, Antonella, Waldron-Lynch, Frank, Dayan, Colin M, Tree, Timothy I M

“…Ultrasound guided sampling of human lymph node (LN) combined with advanced flow cytometry allows phenotypic analysis of multiple immune cell subsets. These may…”
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Multipotent Adult Progenitor Cells Suppress T Cell Activation in In Vivo Models of Homeostatic Proliferation in a Prostaglandin E2-Dependent Manner by Carty, Fiona, Corbett, Jennifer M, Cunha, João Paulo M C M, Reading, James L, Tree, Timothy I M, Ting, Anthony E, Stubblefield, Samantha R, English, Karen

“…Lymphodepletion strategies are used in the setting of transplantation (including bone marrow, hematopoietic cell, and solid organ) to create space or to…”
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Immune modulation in humans: implications for type 1 diabetes mellitus by Roep, Bart O., Tree, Timothy I. M.

“…Key Points Reduced immune regulation seems to be a feature of a subgroup of individuals with type 1 diabetes mellitus (T1DM) Several genetic risk factors for…”
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Studies of insulin and proinsulin in pancreas and serum support the existence of aetiopathological endotypes of type 1 diabetes associated with age at diagnosis by Leete, Pia, Oram, Richard A., McDonald, Timothy J., Shields, Beverley M., Ziller, Clemens, Hattersley, Andrew T., Richardson, Sarah J., Morgan, Noel G.

“…Aims/hypothesis It is unclear whether type 1 diabetes is a single disease or if endotypes exist. Our aim was to use a unique collection of pancreas samples…”
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IL-2 therapy restores regulatory T-cell dysfunction induced by calcineurin inhibitors by Whitehouse, Gavin, Gray, Elizabeth, Mastoridis, Sotiris, Merritt, Elliot, Kodela, Elisavet, Yang, Jennie H. M., Danger, Richard, Mairal, Marta, Christakoudi, Sofia, Lozano, Juan J., Macdougall, Iain C., Tree, Timothy I. M., Sanchez-Fueyo, Alberto, Martinez-Llordella, Marc

“…CD4⁺CD25⁺FOXP3⁺ Tregs constitute a heterogeneous lymphocyte subpopulation essential for curtailing effector T cells and establishing peripheral tolerance…”
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Generation of human islet-specific regulatory T cells by TCR gene transfer by Hull, Caroline M, Nickolay, Lauren E, Estorninho, Megan, Richardson, Max W, Riley, James L, Peakman, Mark, Maher, John, Tree, Timothy I.M

“…Abstract Based on the success in animal models of type 1 diabetes (T1D), clinical trials of adoptive regulatory T cell (Treg) therapy are underway using…”
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Metabolic and immune effects of immunotherapy with proinsulin peptide in human new-onset type 1 diabetes by Alhadj Ali, Mohammad, Liu, Yuk-Fun, Arif, Sefina, Tatovic, Danijela, Shariff, Hina, Gibson, Vivienne B, Yusuf, Norkhairin, Baptista, Roman, Eichmann, Martin, Petrov, Nedyalko, Heck, Susanne, Yang, Jennie H M, Tree, Timothy I M, Pujol-Autonell, Irma, Yeo, Lorraine, Baumard, Lucas, Stenson, Rachel, Howell, Alex, Clark, Alison, Boult, Zoe, Powrie, Jake, Adams, Laura, Wong, Florence S, Luzio, Stephen, Dunseath, Gareth, Green, Kate, O'Keefe, Alison, Bayly, Graham, Thorogood, Natasha, Andrews, Robert, Leech, Nicola, Joseph, Frank, Nair, Sunil, Seal, Susan, Cheung, HoYee, Beam, Craig, Hills, Robert, Peakman, Mark, Dayan, Colin M

“…Immunotherapy using short immunogenic peptides of disease-related autoantigens restores immune tolerance in preclinical disease models. We studied safety and…”
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CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope by Skowera, Ania, Ellis, Richard J, Varela-Calviño, Ruben, Arif, Sefina, Huang, Guo Cai, Van-Krinks, Cassie, Zaremba, Anna, Rackham, Chloe, Allen, Jennifer S, Tree, Timothy I M, Zhao, Min, Dayan, Colin M, Sewell, Andrew K, Unger, Wendy W, Unger, Wendy, Drijfhout, Jan W, Ossendorp, Ferry, Roep, Bart O, Peakman, Mark

“…The final pathway of beta cell destruction leading to insulin deficiency, hyperglycemia, and clinical type 1 diabetes is unknown. Here we show that circulating…”
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Defective Suppressor Function in CD4+CD25+ T-Cells From Patients With Type 1 Diabetes by LINDLEY, Shelley, DAYAN, Colin M, BISHOP, Amanda, ROEP, Bart O, PEAKMAN, Mark, TREE, Timothy I. M

“…Defective Suppressor Function in CD4 + CD25 + T-Cells From Patients With Type 1 Diabetes Shelley Lindley 1 , Colin M. Dayan 2 , Amanda Bishop 2 , Bart O. Roep…”
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