Search Results - "TRAN, Scott B"

The synthesis of [1‐14C]2‐(1H‐tetrazol‐5‐yl)acetic acid by Maxwell, Brad D., Tran, Scott B.

“…Tetrazoles are a common heterocyclic functionality in many biologically active molecules. [1‐14C]2‐(1H‐Tetrazol‐5‐yl)acetic acid was required as an…”
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The syntheses of isotopically labelled CB-1 antagonists for the treatment of obesity by Tran, Scott B., Maxwell, Brad D., Burrell, Richard, Bonacorsi Jr, Samuel J.

“…BMS‐725519, BMS‐811064, and BMS‐812204 are potent and selective central cannabinoid receptor antagonists that have been investigated for the treatment of human…”
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The syntheses of [14C]BMS-823778 for use in a human ADME clinical study and of [13CD3 13CD2]BMT-094817, a stable-isotope labeled standard of a newly detected human metabolite by Maxwell, Brad D., Tran, Scott B., Lago, Michael, Li, Jun, Bonacorsi Jr, Samuel J.

“…Type 2 diabetes is a significant worldwide health problem. To support the development of BMS‐823778 as an inhibitor of 11β‐hydroxysteroid dehydrogenase type 1…”
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Metabolism and Disposition of [14 C]Brivanib Alaninate after Oral Administration to Rats, Monkeys, and Humans by JIACHANG GONG, JINPING GAN, TRAN, Scott B, LYER, Ramaswamy A, CACERES-CORTES, Janet, CHRISTOPHER, Lisa J, ARORA, Vinod, MASSON, Eric, WILLIAMS, Daphne, PURSLEY, Janice, ALLENTOFF, Alban, LAGO, Michael

“…Brivanib [(R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[1,2,4]triazin-6-yloxy)propan-2-ol, BMS-540215] is a potent and selective dual inhibitor…”
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The synthesis of 14C-labeled, 13CD2-labeled saxagliptin, and its 13CD2-labeled 5-hydroxy metabolite by Tran, Scott B., Maxwell, Brad D., Cao, Kai, Bonacorsi, Samuel J.

“…14C‐labeled saxagliptin, 13CD2‐labeled saxagliptin, and its 13CD2‐labeled 5‐hydroxy metabolite were synthesized to further support development of the compound…”
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Disposition of [1'-14C]Stavudine after Oral Administration to Humans by LIAN ZHOU, KAUL, Sanjeev, LIU-KREYCHE, Peggy, TRAN, Scott B, ESPINA, Robert R, WARRACK, Bethanne M, ROONGTA, Vikram A, LYER, Ramaswamy A

“…The disposition of stavudine, a potent and orally active nucleoside reverse transcriptase inhibitor, was investigated in six healthy human subjects. Before…”
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An improved synthesis of [2-14C]2, 5-dichloropyrimidine by Cao, Kai, Tran, Scott B., Maxwell, Brad D., Bonacorsi Jr, Samuel J.

“…A previously described, five‐step synthesis of [2‐14C]2, 5‐dichloropyrimidine was based on condensation of [14C]urea with an acetal, followed by bromination,…”
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A novel synthesis of [2-14C]2,5-dichloropyrimidine by Tran, Scott B., Maxwell, Brad D., Wu, Hong, Bonacorsi Jr, Samuel J.

“…[2‐14 C]2,5‐dichloropyrimidine is a useful reagent for labeling biologically active compounds for use in hepatocyte transport studies, protein covalent…”
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Synthesis of [13C4]Baraclude® (entecavir) by Tran, Scott B., Ekhato, Ihoezo V., Rinehart, J. Kent

“…Entecavir, labeled as 1H‐[13C4]purin‐6(9H)‐one, was prepared from commercially available [13C]guanidine HCl, 1 and diethyl [1,2,3‐13C3]malonate, 2. The…”
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The syntheses and in vitro biotransformation studies of [14C]apixaban, a highly potent, selective, efficacious and orally bioavailable inhibitor of blood coagulation Factor Xa by Maxwell, Brad D., Tran, Scott B., Chen, Shiang-Yuan, Zhang, Donglu, Chen, Bang-Chi, Zhang, Huiping, Bonacorsi Jr, Samuel J.

“…Apixaban is a potent inhibitor of blood coagulation Factor Xa in the late stages of development. [14C]apixaban was synthesized with the 14C label in the two…”
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Synthesis of lead LFA-1 antagonist [14C]spyrocyclic hydantoin by Tran, Scott B., Maxwell, Brad D., Chen, Shiang-Yuan, Bonacorsi, Samuel J., Leith, Leslie, Ogan, Marc, Rinehart, J. Kent, Balasubramanian, Balu

“…Radiolabelled drug lead candidate leukocyte function‐associated antigen 1 antagonist [14C]spyrocyclic hydantoin:…”
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The 14C, 13C, and 15N syntheses of a potent VEGFR-2 kinase inhibitor, Brivanib, and its prodrug, Brivanib Alaninate by Tran, Scott B., Lago, Michael W., Tian, Yuan, Gong, Sharon X., Batra, Indu, Allentoff, Alban J., Maxwell, Brad D., Bonacorsi, Samuel J., Ogan, Marc, Rinehart, J. Kent, Balasubramanian, Balu

“…The interruption of tyrosine kinase vascular endothelial growth factor receptor‐2 (VEGFR‐2) signaling by the binding of a small molecule inhibitor, for…”
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The synthesis of 14 C-labeled, 13 CD 2 -labeled saxagliptin, and its 13 CD 2 -labeled 5-hydroxy metabolite: 14C-saxagliptin, 13CD2-saxagliptin and 13CD2-5-hydroxy metabolite by Tran, Scott B., Maxwell, Brad D., Cao, Kai, Bonacorsi, Samuel J.

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The synthesis of (14)C-labeled, (13)CD2-labeled saxagliptin, and its (13)CD2-labeled 5-hydroxy metabolite by Tran, Scott B, Maxwell, Brad D, Cao, Kai, Bonacorsi, Samuel J

“…(14)C-labeled saxagliptin, (13) CD2-labeled saxagliptin, and its (13) CD2-labeled 5-hydroxy metabolite were synthesized to further support development of the…”
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The 14 C, 13 C, and 15 N syntheses of a potent VEGFR‐2 kinase inhibitor, Brivanib, and its prodrug, Brivanib Alaninate by Tran, Scott B., Lago, Michael W., Tian, Yuan, Gong, Sharon X., Batra, Indu, Allentoff, Alban J., Maxwell, Brad D., Bonacorsi, Samuel J., Ogan, Marc, Rinehart, J. Kent, Balasubramanian, Balu

“…Abstract The interruption of tyrosine kinase vascular endothelial growth factor receptor‐2 (VEGFR‐2) signaling by the binding of a small molecule inhibitor,…”
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GPI 6607, A WATER-SOLUBLE POLY(ADP-RIBOSE) POLYMERASE INHIBITOR PROTECTS AGAINST SPLANCHNIC ARTERY OCCLUSION AND REPERFUSION INJURY IN RATS: 143 by Mooney, Maria L., Shea-Donohue, Terez, Tran, Scott B., Xiao, Ge, Li, Jia-He, Lautar, Susan, Zhang, Jie, Wu, Qi Yi

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