Search Results - "TRACHSEL, Eveline"

Paclitaxel Enhances Therapeutic Efficacy of the F8-IL2 Immunocytokine to EDA-Fibronectin―Positive Metastatic Human Melanoma Xenografts by MOSCHETTA, Michele, PRETTO, Francesca, KASPAR, Manuela, TRACHSEL, Eveline, KOSMEHL, Hartwig, ROSA BANI, Maria, NERI, Dario, GIAVAZZI, Raffaella, BERNDT, Alexander, GALLER, Kerstin, RICHTER, Petra, BASSI, Andrea, OLIVA, Paolo, MICOTTI, Edoardo, VALBUSA, Giovanni, SCHWAGER, Kathrin

“…The selective delivery of bioactive agents to tumors reduces toxicity and enhances the efficacy of anticancer therapies. In this study, we show that the…”
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Antibody-Mediated Delivery of Interleukin-2 to the Stroma of Breast Cancer Strongly Enhances the Potency of Chemotherapy by MARLIND, Jessica, KASPAR, Manuela, TRACHSEL, Eveline, SOMMAVILLA, Roberto, HINDLE, Stuart, BACCI, Camilla, GIOVANNONI, Leonardo, NERI, Dario

“…Purpose: There is an interest in the discovery of biopharmaceuticals, which are well tolerated and which potentiate the action of anthracyclines and taxanes in…”
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Preclinical characterization of DEKAVIL (F8-IL10), a novel clinical-stage immunocytokine which inhibits the progression of collagen-induced arthritis by Schwager, Kathrin, Kaspar, Manuela, Bootz, Frank, Marcolongo, Roberto, Paresce, Erberto, Neri, Dario, Trachsel, Eveline

“…In this article, we present a comparative immunohistochemical evaluation of four clinical-stage antibodies (L19, F16, G11 and F8) directed against splice…”
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In vivo Imaging of Inflammation- and Tumor-Induced Lymph Node Lymphangiogenesis by Immuno―Positron Emission Tomography by MUMPRECHT, Viviane, HONER, Michael, VIGL, Benjamin, PROULX, Steven T, TRACHSEL, Eveline, KASPAR, Manuela, BANZIGER-TOBLER, Nadja E, SCHIBLI, Roger, NERI, Dario, DETMAR, Michael

“…Metastasis to regional lymph nodes (LN) is a prognostic indicator for cancer progression. There is a great demand for sensitive and noninvasive methods to…”
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Selective occlusion of tumor blood vessels by targeted delivery of an antibody‐photosensitizer conjugate by Fabbrini, Monica, Trachsel, Eveline, Soldani, Patrizia, Bindi, Stefano, Alessi, Patrizia, Bracci, Luisa, Kosmehl, Hartwig, Zardi, Luciano, Neri, Dario, Neri, Paolo

“…The irregular vasculature and high interstitial pressure of solid tumors hinder the delivery of cytotoxic agents to cancer cells. As a consequence, the doses…”
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Portable Albumin Binder from a DNA-Encoded Chemical Library by Dumelin, Christoph E, Trüssel, Sabrina, Buller, Fabian, Trachsel, Eveline, Bootz, Frank, Zhang, Yixin, Mannocci, Luca, Beck, Susanne C, Drumea-Mirancea, Mihaela, Seeliger, Mathias W, Baltes, Christof, Müggler, Thomas, Kranz, Felicitas, Rudin, Markus, Melkko, Samu, Scheuermann, Jörg, Neri, Dario

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The antibody-mediated targeted delivery of interleukin-15 and GM-CSF to the tumor neovasculature inhibits tumor growth and metastasis by Kaspar, Manuela, Trachsel, Eveline, Neri, Dario

“…Tumor-targeting immunocytokines represent a new class of anticancer pharmaceutical agents, which often display a superior therapeutic index compared with the…”
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An engineered antibody–interleukin‐12 fusion protein with enhanced tumor vascular targeting properties by Gafner, Verena, Trachsel, Eveline, Neri, Dario

“…The antibody‐mediated targeted delivery of interleukin‐12 (IL12) to the EDB domain of fibronectin, a marker of angiogenesis, is a promising avenue for…”
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The antibody-mediated targeted delivery of interleukin-10 inhibits endometriosis in a syngeneic mouse model by Schwager, Kathrin, Bootz, Frank, Imesch, Patrick, Kaspar, Manuela, Trachsel, Eveline, Neri, Dario

“…BACKGROUND Endometriosis is still a highly underdiagnosed disease, and the current medical and surgical treatment of endometriosis is associated with a high…”
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A high‐affinity human monoclonal antibody specific to the alternatively spliced EDA domain of fibronectin efficiently targets tumor neo‐vasculature in vivo by Villa, Alessandra, Trachsel, Eveline, Kaspar, Manuela, Schliemann, Christoph, Sommavilla, Roberto, Rybak, Jascha‐N., Rösli, Christoph, Borsi, Laura, Neri, Dario

“…The alternatively spliced extra‐domain B of fibronectin is one of the best characterized markers of tumor angiogenesis. Similarly, the extra‐domain A (EDA),…”
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Complete eradication of human B-cell lymphoma xenografts using rituximab in combination with the immunocytokine L19-IL2 by Schliemann, Christoph, Palumbo, Alessandro, Zuberbühler, Kathrin, Villa, Alessandra, Kaspar, Manuela, Trachsel, Eveline, Klapper, Wolfram, Menssen, Hans Dietrich, Neri, Dario

“…The antibody-mediated delivery of therapeutic agents to sites of angiogenesis is an attractive strategy for anticancer therapy, but is largely unexplored in…”
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A Dose-Escalation and Signal-Generating Study of the Immunocytokine L19-IL2 in Combination with Dacarbazine for the Therapy of Patients with Metastatic Melanoma by EIGENTLER, Thomas K, WEIDE, Benjamin, LOVATO, Valeria, KASPAR, Manuela, TRACHSEL, Eveline, MENSSEN, Hans D, NERI, Dario, GARBE, Claus, DE BRAUD, Filippo, SPITALERI, Gianluca, ROMANINI, Antonella, PFLUGFELDER, Annette, GONZALEZ-LGLESIAS, Reinerio, TASCIOTTI, Annaelisa, GIOVANNONI, Leonardo, SCHWAGER, Kathrin

“…L19-IL2 is an immunocytokine composed of an antibody fragment specific to the EDB domain of fibronectin, a tumor angiogenesis marker, and of human…”
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Antibodies for angiogenesis inhibition, vascular targeting and endothelial cell transcytosis by Trachsel, Eveline, Neri, Dario

“…The endothelium is increasingly recognized as a target for biomedical intervention, not only for its accessibility to molecular agents coming from the…”
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The tumour-targeting human L19-IL2 immunocytokine: Preclinical safety studies, phase I clinical trial in patients with solid tumours and expansion into patients with advanced renal cell carcinoma by Johannsen, Manfred, Spitaleri, Gianluca, Curigliano, Giuseppe, Roigas, Jan, Weikert, Steffen, Kempkensteffen, Carsten, Roemer, Andreas, Kloeters, Christian, Rogalla, Patrik, Pecher, Gabriele, Miller, Kurt, Berndt, Alexander, Kosmehl, Hartwig, Trachsel, Eveline, Kaspar, Manuela, Lovato, Valeria, González-Iglesias, Reinerio, Giovannoni, Leonardo, Menssen, Hans D, Neri, Dario, de Braud, Filippo

“…Abstract Background L19-IL2, a tumour-targeting immunocytokine composed of the recombinant human antibody fragment L19 (specific to the alternatively-spliced…”
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Radretumab radioimmunotherapy in patients with brain metastasis: a 124I-L19SIP dosimetric PET study by Poli, Gian Luca, Bianchi, Claudia, Virotta, Giorgio, Bettini, Anna, Moretti, Renzo, Trachsel, Eveline, Elia, Giuliano, Giovannoni, Leonardo, Neri, Dario, Bruno, Andrea

“…Radioimmunotherapy (RIT) with (131)I-labeled L19SIP (radretumab; a small immunoprotein format antibody directed against the ED-B domain of fibronectin; ∼ 80…”
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Antibody-mediated delivery of IL-10 inhibits the progression of established collagen-induced arthritis by Trachsel, Eveline, Bootz, Frank, Silacci, Michela, Kaspar, Manuela, Kosmehl, Hartwig, Neri, Dario

“…The antibody-mediated targeted delivery of cytokines to sites of disease is a promising avenue for cancer therapy, but it is largely unexplored for the…”
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Expression, engineering and characterization of the tumor-targeting heterodimeric immunocytokine F8-IL12 by Sommavilla, Roberto, Pasche, Nadine, Trachsel, Eveline, Giovannoni, Leonardo, Roesli, Christoph, Villa, Alessandra, Neri, Dario, Kaspar, Manuela

“…Proinflammatory cytokines have been used for several years in patients with advanced cancer but their administration is typically associated with severe…”
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A Human mAb Specific to Oncofetal Fibronectin Selectively Targets Chronic Skin Inflammation In Vivo by Trachsel, Eveline, Kaspar, Manuela, Bootz, Frank, Detmar, Michael, Neri, Dario

“…The antibody-based targeted delivery of bioactive agents to sites of angiogenesis is an attractive therapeutic strategy for cancer treatment, but is largely…”
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Targeting the extradomain A of fibronectin allows identification of vascular resistance to antiangiogenic therapy in experimental glioma by Acker, Güliz, Piper, Sophie Käthe, Datwyler, Anna Lena, Broggini, Thomas, Kremenetskaia, Irina, Nieminen-Kelhä, Melina, Lips, Janet, Harms, Ulrike, Mueller, Susanne, Lättig-Tünnemann, Gilla, Trachsel, Eveline, Palumbo, Alessandro, Neri, Dario, Klohs, Jan, Endres, Matthias, Vajkoczy, Peter, Harms, Christoph, Czabanka, Marcus

“…Clinical application of antiangiogenic therapy lacks direct visualization of therapy efficacy and vascular resistance. We aimed to establish molecular imaging…”
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Antibodies for angiogenesis inhibition, vascular targeting and endothelial cell transcytosis: Engineered antibody therapeutics by TRACHSEL, Eveline, NERI, Dario

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