Search Results - "TOWNSLEY, MARY I."

Role of MMP2 and MMP9 in TRPV4-induced lung injury by Villalta, Patricia C, Rocic, Petra, Townsley, Mary I

“…Ca(2+) entry through transient receptor potential vanilloid 4 (TRPV4) results in swelling, blebbing, and detachment of the epithelium and capillary endothelium…”
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TRPV4 channels augment macrophage activation and ventilator-induced lung injury by Hamanaka, Kazutoshi, Jian, Ming-Yuan, Townsley, Mary I, King, Judy A, Liedtke, Wolfgang, Weber, David S, Eyal, Fabien G, Clapp, Mary M, Parker, James C

“…We have previously implicated transient receptor potential vanilloid 4 (TRPV4) channels and alveolar macrophages in initiating the permeability increase in…”
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Endothelial SK3 channel-associated Ca2+ microdomains modulate blood pressure by Yap, Fui C, Weber, David S, Taylor, Mark S, Townsley, Mary I, Comer, Brian S, Maylie, James, Adelman, John P, Lin, Mike T

“…Activation of vascular endothelial small- (KCa2.3, SK3) or intermediate- (KCa3.1, IK1) conductance Ca(2+)-activated potassium channels induces vasorelaxation…”
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Permeability and calcium signaling in lung endothelium: unpack the box by Townsley, Mary I.

“…This brief review assesses the role of Ca2+ signaling in lung endothelium in regulation of endothelial permeability. The disconnect between experimental and…”
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Evaluation of lung injury in rats and mice by Parker, James C, Townsley, Mary I

“…Lung injury is a broad descriptor that can be applied to conditions ranging from mild interstitial edema without cellular injury to massive and fatal…”
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TRPV4 initiates the acute calcium-dependent permeability increase during ventilator-induced lung injury in isolated mouse lungs by Hamanaka, Kazutoshi, Jian, Ming-Yuan, Weber, David S, Alvarez, Diego F, Townsley, Mary I, Al-Mehdi, Abu B, King, Judy A, Liedtke, Wolfgang, Parker, James C

“…We have previously implicated calcium entry through stretch-activated cation channels in initiating the acute pulmonary vascular permeability increase in…”
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Structure and composition of pulmonary arteries, capillaries, and veins by Townsley, Mary I

“…The pulmonary vasculature comprises three anatomic compartments connected in series: the arterial tree, an extensive capillary bed, and the venular tree…”
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Transient receptor potential channels and regulation of lung endothelial permeability by Villalta, Patricia C., Townsley, Mary I.

“…This review highlights our current knowledge regarding expression of transient receptor potential (TRP) cation channels in lung endothelium and evidence for…”
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Endothelial hyperpermeability in severe pulmonary arterial hypertension: role of store-operated calcium entry by Zhou, Chun, Townsley, Mary I, Alexeyev, Mikhail, Voelkel, Norbert F, Stevens, Troy

“…Here, we tested the hypothesis that animals with severe pulmonary arterial hypertension (PAH) display increased sensitivity to vascular permeability induced by…”
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Transient Receptor Potential Vanilloid 4–Mediated Disruption of the Alveolar Septal Barrier: A Novel Mechanism of Acute Lung Injury by Alvarez, Diego F, King, Judy A, Weber, David, Addison, Emile, Liedtke, Wolfgang, Townsley, Mary I

“…Disruption of the alveolar septal barrier leads to acute lung injury, patchy alveolar flooding, and hypoxemia. Although calcium entry into endothelial cells is…”
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An orally active TRPV4 channel blocker prevents and resolves pulmonary edema induced by heart failure by Thorneloe, Kevin S, Cheung, Mui, Bao, Weike, Alsaid, Hasan, Lenhard, Stephen, Jian, Ming-Yuan, Costell, Melissa, Maniscalco-Hauk, Kristeen, Krawiec, John A, Olzinski, Alan, Gordon, Earl, Lozinskaya, Irina, Elefante, Lou, Qin, Pu, Matasic, Daniel S, James, Chris, Tunstead, James, Donovan, Brian, Kallal, Lorena, Waszkiewicz, Anna, Vaidya, Kalindi, Davenport, Elizabeth A, Larkin, Jonathan, Burgert, Mark, Casillas, Linda N, Marquis, Robert W, Ye, Guosen, Eidam, Hilary S, Goodman, Krista B, Toomey, John R, Roethke, Theresa J, Jucker, Beat M, Schnackenberg, Christine G, Townsley, Mary I, Lepore, John J, Willette, Robert N

“…Pulmonary edema resulting from high pulmonary venous pressure (PVP) is a major cause of morbidity and mortality in heart failure (HF) patients, but current…”
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Role of EETs in regulation of endothelial permeability in rat lung by Alvarez, Diego F, Gjerde, Eli-Anne B, Townsley, Mary I

“…This study tested the hypothesis that epoxyeicosatrienoic acids (EETs) derived from arachidonic acid via P-450 epoxygenases are soluble factors linking…”
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High Vascular Pressure-Induced Lung Injury Requires P450 Epoxygenase-Dependent Activation of TRPV4 by Jian, Ming-Yuan, King, Judy A, Al-Mehdi, Abu-Bakr, Liedtke, Wolfgang, Townsley, Mary I

“…High vascular pressure targets the lung septal network, causing acute lung injury. While calcium entry in septal endothelium has been implicated, the channel…”
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Disruptive effects of anion secretion inhibitors on airway mucus morphology in isolated perfused pig lung by Trout, Laura, Townsley, Mary I., Bowden, Amy L., Ballard, Stephen T.

“…Since anion secretion inhibitors reproduce important aspects of cystic fibrosis (CF) lung disease, the effects of these antagonists on airway mucus morphology…”
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The effects of mitochondrial complex I blockade on ATP and permeability in rat pulmonary microvascular endothelial cells in culture (PMVEC) are overcome by coenzyme Q1 (CoQ1) by Bongard, Robert D., Townsley, Mary I., Merker, Marilyn P.

“…In isolated rat lung perfused with a physiological saline solution (5.5mM glucose), complex I inhibitors decrease lung tissue ATP and increase endothelial…”
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Functional coupling of TRPV4, IK, and SK channels contributes to Ca(2+)-dependent endothelial injury in rodent lung by Lin, Mike T, Jian, Ming-Yuan, Taylor, Mark S, Cioffi, Donna L, Yap, Fui C, Liedtke, Wolfgang, Townsley, Mary I

“…Our previous work has shown that the increased lung endothelial permeability response to 14,15-epoxyeicosatrienoic acid (14,15-EET) in rat lung requires Ca(2+)…”
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Physiological determinants of the pulmonary filtration coefficient by Parker, James C, Townsley, Mary I

“…Current emphasis on translational application of genetic models of lung disease has renewed interest in the measurement of the gravimetric filtration…”
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Functional coupling of TRPV4, IK, and SK channels contributes to Ca2+-dependent endothelial injury in rodent lung by Lin, Mike T., Jian, Ming-Yuan, Taylor, Mark S., Cioffi, Donna L., Yap, Fui C., Liedtke, Wolfgang, Townsley, Mary I.

“…Our previous work has shown that the increased lung endothelial permeability response to 14,15-epoxyeicosatrienoic acid (14,15-EET) in rat lung requires Ca2+…”
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Depleted energy charge and increased pulmonary endothelial permeability induced by mitochondrial complex I inhibition are mitigated by coenzyme Q₁ in the isolated perfused rat lung by Bongard, Robert D, Yan, Ke, Hoffmann, Raymond G, Audi, Said H, Zhang, Xiao, Lindemer, Brian J, Townsley, Mary I, Merker, Marilyn P

“…Mitochondrial dysfunction is associated with various forms of lung injury and disease that also involve alterations in pulmonary endothelial permeability, but…”
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Resistance to Store Depletion-induced Endothelial Injury in Rat Lung after Chronic Heart Failure by Alvarez, Diego F, King, Judy A, Townsley, Mary I

“…In chronic heart failure, the lung endothelial permeability response to angiotensin II or thapsigargin-induced store depletion is ablated, although the…”
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