Search Results - "TOUYZ, R. M"

Hope for resistant hypertension through BrigHTN and PRECISION by Touyz, R. M., Harrison, D. G.

“…An estimated 10–15% of individuals with hypertension are resistant to available antihypertensive therapies. Findings from two new clinical trials — BrigHTN and…”
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Critical role of Nox4-based NADPH oxidase in glucose-induced oxidative stress in the kidney: implications in type 2 diabetic nephropathy by Sedeek, M, Callera, G, Montezano, A, Gutsol, A, Heitz, F, Szyndralewiez, C, Page, P, Kennedy, C R J, Burns, K D, Touyz, R M, Hébert, R L

“…Molecular mechanisms underlying renal complications of diabetes remain unclear. We tested whether renal NADPH oxidase (Nox) 4 contributes to increased reactive…”
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Pharmacological inhibition of NOX reduces atherosclerotic lesions, vascular ROS and immune–inflammatory responses in diabetic Apoe−/− mice by Di Marco, E., Gray, S. P., Chew, P., Koulis, C., Ziegler, A., Szyndralewiez, C., Touyz, R. M., Schmidt, H. H. H. W., Cooper, M. E., Slattery, R., Jandeleit-Dahm, K. A.

“…Aims/hypothesis Enhanced vascular inflammation, immune cell infiltration and elevated production of reactive oxygen species (ROS) contribute significantly to…”
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Reactive oxygen species and angiotensin II signaling in vascular cells -- implications in cardiovascular disease by Touyz, R M

“…Diseases such as hypertension, atherosclerosis, hyperlipidemia, and diabetes are associated with vascular functional and structural changes including…”
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c-Src Induces Phosphorylation and Translocation of p47phox: Role in Superoxide Generation by Angiotensin II in Human Vascular Smooth Muscle Cells by Touyz, R M, Yao, G, Schiffrin, E L

“…OBJECTIVES—The aim of this study was to determine molecular mechanisms whereby c-Src regulates angiotensin II (Ang II)-mediated NAD(P)H oxidase-derived ·O2 in…”
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Aldosterone and Angiotensin II Synergistically Stimulate Migration in Vascular Smooth Muscle Cells Through c-Src–Regulated Redox-Sensitive RhoA Pathways by Montezano, A C, Callera, G E, Yogi, A, He, Y, Tostes, R C, He, G, Schiffrin, E L, Touyz, R M

“…OBJECTIVE—Synergistic interactions between aldosterone (Aldo) and angiotensin II (Ang II) have been implicated in vascular inflammation, fibrosis, and…”
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p47phox Associates With the Cytoskeleton Through Cortactin in Human Vascular Smooth Muscle Cells: Role in NAD(P)H Oxidase Regulation by Angiotensin II by Touyz, R M, Yao, G, Quinn, M T, Pagano, P J, Schiffrin, E L

“…OBJECTIVE—We tested the hypothesis that p47phox associates with the actin cytoskeleton, enabling site-directed activation of NAD(P)H oxidase, and assessed…”
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Angiotensin II induces Fat1 expression/activation and vascular smooth muscle cell migration via Nox1-dependent reactive oxygen species generation by Bruder-Nascimento, T, Chinnasamy, P, Riascos-Bernal, D.F, Cau, S.B, Callera, G.E, Touyz, R.M, Tostes, R.C, Sibinga, N.E.S

“…Abstract Fat1 is an atypical cadherin that controls vascular smooth muscle cell (VSMC) proliferation and migration. Nicotinamide adenine dinucleotide phosphate…”
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Antioxidant Effects of Vitamins C and E Are Associated With Altered Activation of Vascular NADPH Oxidase and Superoxide Dismutase in Stroke-Prone SHR by Chen, Xin, Touyz, Rhian M, Park, Jeong Bae, Schiffrin, Ernesto L

“…Ascorbic acid (vitamin C) and α-tocopherol (vitamin E) have antioxidant properties that could improve redox-sensitive vascular changes associated with…”
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Correction of arterial structure and endothelial dysfunction in human essential hypertension by the angiotensin receptor antagonist losartan by SCHIFFRIN, E. L, JEONG BAE PARK, INTENGAN, H. D, TOUYZ, R. M

“…Structural and functional alterations of the vasculature may contribute to complications of hypertension. Because angiotensin II may be pivotal in some of…”
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Mitogen-Activated Protein/Extracellular Signal-Regulated Kinase Inhibition Attenuates Angiotensin II-Mediated Signaling and Contraction in Spontaneously Hypertensive Rat Vascular Smooth Muscle Cells by Touyz, R.M, El Mabrouk, M, He, G, Wu, X-H, Schiffrin, E.L

“…This study investigates the role of extracellular signal-regulated kinases (ERKs) in angiotensin II (Ang II)-generated intracellular second messengers…”
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Anti‐atherosclerotic effect of the angiotensin 1–7 mimetic AVE0991 is mediated by inhibition of perivascular and plaque inflammation in early atherosclerosis by Skiba, D S, Nosalski, R, Mikolajczyk, T P, Siedlinski, M, Rios, F J, Montezano, A C, Jawien, J, Olszanecki, R, Korbut, R, Czesnikiewicz‐Guzik, M, Touyz, R M, Guzik, T J

“…Background and Purpose Inflammation plays a key role in atherosclerosis. The protective role of angiotensin 1–7 (Ang‐(1–7)) in vascular pathologies suggested…”
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Endothelin-1, but not Ang II, Activates MAP Kinases Through c-Src–Independent Ras-Raf–Dependent Pathways in Vascular Smooth Muscle Cells by Yogi, A, Callera, G E, Montezano, A C.I, Aranha, A B, Tostes, R C, Schiffrin, E L, Touyz, R M

“…OBJECTIVE—Endothelin-1 (ET-1) and angiotensin II (Ang II) activate common signaling pathways to promote changes in vascular reactivity, remodeling,…”
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Ang II-Stimulated Superoxide Production Is Mediated via Phospholipase D in Human Vascular Smooth Muscle Cells by Touyz, Rhian M, Schiffrin, Ernesto L

“…Intracellular signaling events that mediate the long-term effects of Ang II in vascular smooth muscle cells are unclear, but oxidative stress may play an…”
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Tail-Cuff Versus Radiotelemetry to Measure Blood Pressure in Mice and Rats by Harrison, D G, Bader, M, Lerman, L O, Fink, G, Karumanchi, S A, Reckelhoff, J F, Sequeira-Lopez, M L S, Touyz, R M

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Reactive Oxygen Species, Vascular Oxidative Stress, and Redox Signaling in Hypertension: What Is the Clinical Significance? by Touyz, Rhian M

“…Metabolism of oxygen by cells generates potentially deleterious reactive oxygen species (ROS). Under normal conditions the rate and magnitude of oxidant…”
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Liquorice alert by Takami, K, Touyz, L. Z. G, Touyz, R. M

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Role of magnesium in the pathogenesis of hypertension by Touyz, R.M.

“…Human essential hypertension is a complex, multifactorial, quantitative trait under polygenic control. Although the exact etiology is unknown, the fundamental…”
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Reactive oxygen species in vascular biology: implications in hypertension by Touyz, R M, Schiffrin, E L

“…Reactive oxygen species (ROS), including superoxide (*O2-), hydrogen peroxide (H2O2), and hydroxyl anion (OH-), and reactive nitrogen species, such as nitric…”
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Magnesium supplementation attenuates, but does not prevent, development of hypertension in spontaneously hypertensive rats by Touyz, R.M, Milne, F.J

“…This study evaluated the effects of magnesium supplementation on the development of hypertension in spontaneously hypertensive rats (SHR) and assesses the…”
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