Search Results - "TOUQUI, Lhousseine"

Cationic antimicrobial peptides: alternatives and/or adjuvants to antibiotics active against methicillin-resistant Staphylococcus aureus and multidrug-resistant Pseudomonas aeruginosa by Geitani, Regina, Ayoub Moubareck, Carole, Touqui, Lhousseine, Karam Sarkis, Dolla

“…Methicillin-resistant Staphylococcus aureus and multidrug-resistant Pseudomonas aeruginosa are becoming difficult to treat with antibiotics whereas Cationic…”
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Pulmonary bacteriophage therapy on Pseudomonas aeruginosa cystic fibrosis strains: first steps towards treatment and prevention by Morello, Eric, Saussereau, Emilie, Maura, Damien, Huerre, Michel, Touqui, Lhousseine, Debarbieux, Laurent

“…Multidrug-resistant bacteria are the cause of an increasing number of deadly pulmonary infections. Because there is currently a paucity of novel antibiotics,…”
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Type IIA Secreted Phospholipase A2 in Host Defense against Bacterial Infections by van Hensbergen, Vincent P., Wu, Yongzheng, van Sorge, Nina M., Touqui, Lhousseine

“…The enzyme type IIA secreted phospholipase A2 (sPLA2-IIA) is crucial for mammalian innate host defense against bacterial pathogens. Most studies have…”
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Modulation of the immune response by the Pseudomonas aeruginosa type-III secretion system by Jouault, Albane, Saliba, Alessandra Mattos, Touqui, Lhousseine

“…is an opportunistic pathogen that can cause critical cellular damage and subvert the immune response to promote its survival. Among the numerous virulence…”
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Expression and Roles of Antimicrobial Peptides in Innate Defense of Airway Mucosa: Potential Implication in Cystic Fibrosis by Geitani, Regina, Moubareck, Carole Ayoub, Xu, Zhengzhong, Karam Sarkis, Dolla, Touqui, Lhousseine

“…The treatment of respiratory infections is associated with the dissemination of antibiotic resistance in the community and clinical settings. Development of…”
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Modulation of Airway Expression of the Host Bactericidal Enzyme, sPLA2-IIA, by Bacterial Toxins by Wu, Yongzheng, Pernet, Erwan, Touqui, Lhousseine

“…Host molecules with antimicrobial properties belong to a large family of mediators including type-IIA secreted phospholipase A2 (sPLA2-IIA). The latter is a…”
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Role of Host and Bacterial Lipids in Pseudomonas aeruginosa Respiratory Infections by Constantino-Teles, Pamella, Jouault, Albane, Touqui, Lhousseine, Saliba, Alessandra Mattos

“…The opportunistic pathogen Pseudomonas aeruginosa is one of the most common agents of respiratory infections and has been associated with high morbidity and…”
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Novel Anti-Inflammatory Approaches for Cystic Fibrosis Lung Disease: Identification of Molecular Targets and Design of Innovative Therapies by Mitri, Christie, Xu, Zhengzhong, Bardin, Pauline, Corvol, Harriet, Touqui, Lhousseine, Tabary, Olivier

“…Cystic fibrosis (CF) is the most common genetic disorder among Caucasians, estimated to affect more than 70,000 people in the world. Severe and persistent…”
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Bacteria-driven peribronchial lymphoid neogenesis in bronchiectasis and cystic fibrosis by Frija-Masson, Justine, Martin, Clémence, Regard, Lucile, Lothe, Marie-Noëlle, Touqui, Lhousseine, Durand, Aurélie, Lucas, Bruno, Damotte, Diane, Alifano, Marco, Fajac, Isabelle, Burgel, Pierre-Régis

“…We aimed to characterise lymphoid neogenesis in bronchiectasis and cystic fibrosis (CF) lungs and to examine the role of bacterial infection.Lymphoid…”
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Pseudomonas aeruginosa Production of Hydrogen Cyanide Leads to Airborne Control of Staphylococcus aureus Growth in Biofilm and In Vivo Lung Environments by Létoffé, Sylvie, Wu, Yongzheng, Darch, Sophie E., Beloin, Christophe, Whiteley, Marvin, Touqui, Lhousseine, Ghigo, Jean-Marc

“…Diverse bacterial volatile compounds alter bacterial stress responses and physiology, but their contribution to population dynamics in polymicrobial…”
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Airway surface liquid acidification initiates host defense abnormalities in Cystic Fibrosis by Simonin, Juliette, Bille, Emmanuelle, Crambert, Gilles, Noel, Sabrina, Dreano, Elise, Edwards, Aurélie, Hatton, Aurélie, Pranke, Iwona, Villeret, Bérengère, Cottart, Charles-Henry, Vrel, Jean-Patrick, Urbach, Valérie, Baatallah, Nesrine, Hinzpeter, Alexandre, Golec, Anita, Touqui, Lhousseine, Nassif, Xavier, Galietta, Luis J. V, Planelles, Gabrielle, Sallenave, Jean-Michel, Edelman, Aleksander, Sermet-Gaudelus, Isabelle

“…Cystic fibrosis (CF) is caused by defective Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein. Morbidity is mainly due to early airway…”
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Contribution of intramacrophage stages to Pseudomonas aeruginosa infection outcome in zebrafish embryos: insights from mgtC and oprF mutants by Hajjar, Hélène, Berry, Laurence, Wu, Yongzheng, Touqui, Lhousseine, Vergunst, Annette C., Blanc-Potard, Anne-Béatrice

“…Pseudomonas aeruginosa often colonizes immunocompromised patients, causing acute and chronic infections. This bacterium can reside transiently inside cultured…”
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Pseudomonas aeruginosa LPS or flagellin are sufficient to activate TLR-dependent signaling in murine alveolar macrophages and airway epithelial cells by Raoust, Eloïse, Balloy, Viviane, Garcia-Verdugo, Ignacio, Touqui, Lhousseine, Ramphal, Reuben, Chignard, Michel

“…The human lung is exposed to a large number of airborne pathogens as a result of the daily inhalation of 10,000 liters of air. Innate immunity is thus…”
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Role of human group IIA secreted phospholipase A2 in malaria pathophysiology: Insights from a transgenic mouse model by Dacheux, Mélanie, Chaouch, Soraya, Joy, Alonso, Labat, Amandine, Payré, Christine, Petit-Paitel, Agnès, Bihl, Franck, Lagrange, Isabelle, Grellier, Philippe, Touqui, Lhousseine, Lambeau, Gérard, Deregnaucourt, Christiane

“…We previously showed that injection of recombinant human group IIA secreted phospholipase A2 (hGIIA sPLA2) to Plasmodium chabaudi-infected mice lowers…”
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Staphylococcus aureus Adenosine Inhibits sPLA2-IIA-Mediated Host Killing in the Airways by Pernet, Erwan, Brunet, Jérémy, Guillemot, Laurent, Chignard, Michel, Touqui, Lhousseine, Wu, Yongzheng

“…Staphylococcus aureus is a common cause of bacterial infections in respiratory diseases. It secretes molecules to dampen host immunity, and the recently…”
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Secreted Group IIA Phospholipase A₂ Protects Humans Against the Group B Streptococcus: Experimental and Clinical Evidence by Movert, Elin, Wu, Yongzheng, Lambeau, Gérard, Kahn, Fredrik, Touqui, Lhousseine, Areschoug, Thomas

“…Group streptococcus (GBS) is a leading neonatal pathogen and a growing cause of invasive disease in the elderly, with clinical manifestations such as pneumonia…”
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The Ancestral N-Terminal Domain of Big Defensins Drives Bacterially Triggered Assembly into Antimicrobial Nanonets by Loth, Karine, Vergnes, Agnès, Barreto, Cairé, Voisin, Sébastien N, Meudal, Hervé, Da Silva, Jennifer, Bressan, Albert, Belmadi, Nawal, Bachère, Evelyne, Aucagne, Vincent, Cazevielle, Chantal, Marchandin, Hélène, Rosa, Rafael Diego, Bulet, Philippe, Touqui, Lhousseine, Delmas, Agnès F, Destoumieux-Garzón, Delphine

“…Big defensins, ancestors of β-defensins, are composed of a β-defensin-like C-terminal domain and a globular hydrophobic ancestral N-terminal domain. This…”
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Mouse models of cystic fibrosis: Phenotypic analysis and research applications by Wilke, Martina, Buijs-Offerman, Ruvalic M, Aarbiou, Jamil, Colledge, William H, Sheppard, David N, Touqui, Lhousseine, Bot, Alice, Jorna, Huub, De Jonge, Hugo R, Scholte, Bob J

“…Abstract Genetically modified mice have been studied for more than fifteen years as models of cystic fibrosis (CF). The large amount of experimental data…”
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Human peroxiredoxin 6 is essential for malaria parasites and provides a host-based drug target by Wagner, Matthias Paulus, Formaglio, Pauline, Gorgette, Olivier, Dziekan, Jerzy Michal, Huon, Christèle, Berneburg, Isabell, Rahlfs, Stefan, Barale, Jean-Christophe, Feinstein, Sheldon I., Fisher, Aron B., Ménard, Didier, Bozdech, Zbynek, Amino, Rogerio, Touqui, Lhousseine, Chitnis, Chetan E.

“…The uptake and digestion of host hemoglobin by malaria parasites during blood-stage growth leads to significant oxidative damage of membrane lipids. Repair of…”
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Microbial Protein Binding to gC1qR Drives PLA2G1B-Induced CD4 T-Cell Anergy by Pothlichet, Julien, Meola, Annalisa, Bugault, Florence, Jeammet, Louise, Savitt, Anne G, Ghebrehiwet, Berhane, Touqui, Lhousseine, Pouletty, Philippe, Fiore, Frédéric, Sauvanet, Alain, Thèze, Jacques

“…The origin of the impaired CD4 T-cell response and immunodeficiency of HIV-infected patients is still only partially understood. We recently demonstrated that…”
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