Search Results - "TOUGH, T. W"

CD40 expression by human monocytes : regulation by cytokines and activation of monocytes by the ligand for CD40 by ALDERSON, M. R, ARMITAGE, R. J, TOUGH, T. W, STROCKBINE, L, FANSLOW, W. C, SPRIGGS, M. K

“…CD40 is a member of the tumor necrosis factor (TNF) receptor family of cell surface proteins and was originally described as a B cell restricted antigen…”
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Fas transduces activation signals in normal human T lymphocytes by ALDERSON, M. R, ARMITAGE, R. J, MARASKOVSKY, E, TOUGH, T. W, ROUX, E, SCHOOLEY, K, RAMSDELL, F, LYNCH, D. H

“…The Fas gene encodes a cell surface molecule that is a member of the the nerve growth factor/tumor necrosis factor receptor family of proteins and can mediate…”
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Interleukin 7 induces cytokine secretion and tumoricidal activity by human peripheral blood monocytes by ALDERSON, M. R, TOUGH, T. W, ZIEGLER, S. F, GRABSTEIN, K. H

“…Peripheral blood monocytes can be induced by stimuli such as bacterial lipopolysaccharide (LPS) to secrete an array of cytokines. We have studied the effects…”
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Molecular and biological characterization of a ligand for CD27 defines a new family of cytokines with homology to tumor necrosis factor by Goodwin, R G, Alderson, M R, Smith, C A, Armitage, R J, VandenBos, T, Jerzy, R, Tough, T W, Schoenborn, M A, Davis-Smith, T, Hennen, K

“…CD27 is a surface antigen found on T and B cells that has homology to a family of molecules including the receptors for tumor necrosis factor (TNF) and nerve…”
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gld/gld mice are unable to express a functional ligand for Fas by Ramsdell, F, Seaman, M S, Miller, R E, Tough, T W, Alderson, M R, Lynch, D H

“…Mice homozygous for either the lpr or gld genes develop phenotypically identical autoimmune disorders. The gene responsible for the pathology in lpr/lpr mice…”
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CD40 ligand is a T cell growth factor by Armitage, R J, Tough, T W, Macduff, B M, Fanslow, W C, Spriggs, M K, Ramsdell, F, Alderson, M R

“…CD40 ligand (CD40L) is a 33-kDa type II membrane glycoprotein induced on T cells upon activation. CD40L has previously been shown to induce proliferation of…”
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Induction of macrophage inflammatory protein-1 beta gene expression in human monocytes by lipopolysaccharide and IL-7 by Ziegler, SF, Tough, TW, Franklin, TL, Armitage, RJ, Alderson, MR

“…HuMIP-1 beta is a member of a gene family of inflammatory cytokines whose expression is induced by proinflammatory and mitogenic stimuli. The gene was rapidly…”
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Fas ligand mediates activation-induced cell death in human T lymphocytes by Alderson, M R, Tough, T W, Davis-Smith, T, Braddy, S, Falk, B, Schooley, K A, Goodwin, R G, Smith, C A, Ramsdell, F, Lynch, D H

“…A significant proportion of previously activated human T cells undergo apoptosis when triggered through the CD3/T cell receptor complex, a process termed…”
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Molecular and biological characterization of human 4-1BB and its ligand by Alderson, M R, Smith, C A, Tough, T W, Davis-Smith, T, Armitage, R J, Falk, B, Roux, E, Baker, E, Sutherland, G R, Din, W S

“…4-1BB was originally described as a cDNA expressed by activated murine T cells and subsequently demonstrated to encode a member of the tumor necrosis factor…”
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Regulation of human monocyte cell-surface and soluble CD23 (Fc epsilon RII) by granulocyte-macrophage colony-stimulating factor and IL-3 by Alderson, MR, Tough, TW, Ziegler, SF, Armitage, RJ

“…We have investigated the regulation of expression of cell-surface and soluble CD23 (sCD23) by purified human peripheral blood monocytes and in cultures of…”
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Regulation of apoptosis and T cell activation by Fas-specific mAb by Alderson, M R, Tough, T W, Braddy, S, Davis-Smith, T, Roux, E, Schooley, K, Miller, R E, Lynch, D H

“…Fas was initially described as a molecule expressed on the surface of certain cell lines that could mediate programmed cell death (apoptosis) subsequent to…”
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Alternative forms of the human G-CSF receptor function in growth signal transduction by Ziegler, S F, Davis, T, Schneringer, J A, Franklin, T L, Tough, T W, Teepe, M, Larsen, A, Williams, D E, Smith, C A

“…Two forms of the human granulocyte colony-stimulating factor (G-CSF) receptor (HuG-CSFR), differing only at the carboxyl terminus, were recently identified by…”
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Synergistic effects of IL-4 and either GM-CSF or IL-3 on the induction of CD23 expression by human monocytes: regulatory effects of IFN-alpha and IFN-gamma by Alderson, M R, Armitage, R J, Tough, T W, Ziegler, S F

“…CD23 expression by B cells and monocytes can be regulated by cytokines including IL-4, IFN-gamma and IFN-alpha. We recently reported that GM-CSF and IL-3 are…”
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Induction of macrophage inflammatory protein-1β gene expression in human monocytes by lipolysaccharide and IL-7 by ZIEGLER, S. F, TOUGH, T. W, FRANKLIN, T. L, ARMITAGE, R. J, ALDERSON, M. R

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Molecular and biological characterization of a ligand for CD27 defines a new family of cytokines with homology to tumor necrosis factor by Goodwin, R G, Alderson, M R, Smith, CA, Armitage, R J, VandenBos, T, Jerzy, R, Tough, T W, Schoenborn, MA, Davis-Smith, T, Hennen, K, Falk, B, Ceeman, D, Baker, E, Sutherland, G R, Giri, J G

“…CD27 is a surface antigen found on T and B cells that has homology to a family of molecules including the receptors for tumor necrosis factor (TNF) and nerve…”
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