Search Results - "TOTI, FLORENCE"

Cellular Mechanisms Underlying the Formation of Circulating Microparticles by Morel, Olivier, Jesel, Laurence, Freyssinet, Jean-Marie, Toti, Florence

“…Microparticles (MPs) derived from platelets, monocytes, endothelial cells, red blood cells, and granulocytes may be detected in low concentrations in normal…”
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Long-term cardiovascular complications following sepsis: is senescence the missing link? by Merdji, Hamid, Schini-Kerth, Valérie, Meziani, Ferhat, Toti, Florence

“…Among the long-term consequences of sepsis (also termed “post-sepsis syndrome”) the increased risk of unexplained cardiovascular complications, such as…”
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Angiotensin II-induced upregulation of SGLT1 and 2 contributes to human microparticle-stimulated endothelial senescence and dysfunction: protective effect of gliflozins by Park, Sin-Hee, Belcastro, Eugenia, Hasan, Hira, Matsushita, Kensuke, Marchandot, Benjamin, Abbas, Malak, Toti, Florence, Auger, Cyril, Jesel, Laurence, Ohlmann, Patrick, Morel, Olivier, Schini-Kerth, Valérie B

“…Sodium-glucose cotransporter 2 (SGLT2) inhibitors reduced cardiovascular risk in type 2 diabetes patients independently of glycemic control. Although…”
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Angiotensin II‐induced redox‐sensitive SGLT1 and 2 expression promotes high glucose‐induced endothelial cell senescence by Khemais‐Benkhiat, Sonia, Belcastro, Eugenia, Idris‐Khodja, Noureddine, Park, Sin‐Hee, Amoura, Lamia, Abbas, Malak, Auger, Cyril, Kessler, Laurence, Mayoux, Eric, Toti, Florence, Schini‐Kerth, Valérie B.

“…High glucose (HG)‐induced endothelial senescence and dysfunction contribute to the increased cardiovascular risk in diabetes. Empagliflozin, a selective sodium…”
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DNA‐bound elastase of neutrophil extracellular traps degrades plasminogen, reduces plasmin formation, and decreases fibrinolysis: proof of concept in septic shock plasma by Cruz, Dayana Barbosa da, Helms, Julie, Aquino, Lluvia Ramírez, Stiel, Laure, Cougourdan, Lucas, Broussard, Cedric, Chafey, Philippe, Riès‐Kautt, Madeleine, Meziani, Ferhat, Toti, Florence, Gaussem, Pascale, Anglés‐Cano, Eduardo

“…Activation of platelets and neutrophils in septic shock results in the formation of microvascular clots containing an intricate scaffold of fibrin with…”
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Formation of procoagulant microparticles and properties by Freyssinet, Jean-Marie, Toti, Florence

“…Abstract The platelet procoagulant response consists of providing a catalytic surface where vitamin K-dependent clotting factors can interact with cofactors to…”
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Evidence of Netosis in Septic Shock-Induced Disseminated Intravascular Coagulation by Delabranche, Xavier, Stiel, Laure, Severac, François, Galoisy, Anne-Cécile, Mauvieux, Laurent, Zobairi, Fatiha, Lavigne, Thierry, Toti, Florence, Anglès-Cano, Eduardo, Meziani, Ferhat, Boisramé-Helms, Julie

“…INTRODUCTION:Neutrophils extracellular traps (NETs) have recently emerged as a new potential link between inflammation, immunity, and thrombosis and could play…”
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Early Detection of Disseminated Intravascular Coagulation During Septic Shock: A Multicenter Prospective Study by Delabranche, Xavier, Quenot, Jean-Pierre, Lavigne, Thierry, Mercier, Emmanuelle, François, Bruno, Severac, François, Grunebaum, Lélia, Mehdi, Madah, Zobairi, Fatiha, Toti, Florence, Meziani, Ferhat, Boisramé-Helms, Julie

“…OBJECTIVES:Inadequate stratification of septic shock patients may result in inappropriate treatment allocation in randomized clinical trials, especially…”
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Porphyromonas gingivalis triggers the shedding of inflammatory endothelial microvesicles that act as autocrine effectors of endothelial dysfunction by Bugueno, Isaac Maximiliano, Zobairi El-Ghazouani, Fatiha, Batool, Fareeha, El Itawi, Hanine, Anglès-Cano, Eduardo, Benkirane-Jessel, Nadia, Toti, Florence, Huck, Olivier

“…A link between periodontitis and atherothrombosis has been highlighted. The aim of this study was to determine the influence of Porphyromonas gingivalis on…”
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Microparticles are new biomarkers of septic shock-induced disseminated intravascular coagulopathy by Delabranche, Xavier, Boisramé-Helms, Julie, Asfar, Pierre, Berger, Asaël, Mootien, Yoganaden, Lavigne, Thierry, Grunebaum, Lélia, Lanza, François, Gachet, Christian, Freyssinet, Jean-Marie, Toti, Florence, Meziani, Ferhat

“…Purpose Septic shock-induced disseminated intravascular coagulopathy (DIC) contributes to multiple organ failure. Mechanisms governing vascular responses to…”
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Distinguishing Plasmin-Generating Microvesicles: Tiny Messengers Involved in Fibrinolysis and Proteolysis by Plawinski, Laurent, Cras, Audrey, Hernández Lopez, José Rubicel, de la Peña, Aurora, Van der Heyden, Angéline, Belle, Catherine, Toti, Florence, Anglés-Cano, Eduardo

“…A number of stressors and inflammatory mediators (cytokines, proteases, oxidative stress mediators) released during inflammation or ischemia stimulate and…”
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Septic shock as a trigger of arterial stress-induced premature senescence: A new pathway involved in the post sepsis long-term cardiovascular complications by Merdji, Hamid, Kassem, Mohamad, Chomel, Louise, Clere-Jehl, Raphaël, Helms, Julie, Kurihara, Kei, Chaker, Ahmed Bey, Auger, Cyril, Schini-Kerth, Valérie, Toti, Florence, Meziani, Ferhat

“…Major adverse cardiovascular events among sepsis survivors is an emerging health issue. Because endothelial senescence leads to vascular dysfunction and…”
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Bench-to-bedside review: circulating microparticles--a new player in sepsis? by Meziani, Ferhat, Delabranche, Xavier, Asfar, Pierre, Toti, Florence

“…In sepsis, inflammation and thrombosis are both the cause and the result of interactions between circulating (for example, leukocytes and platelets),…”
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Replicative senescence promotes prothrombotic responses in endothelial cells: Role of NADPH oxidase- and cyclooxygenase-derived oxidative stress by Silva, Grazielle Caroline, Abbas, Malak, Khemais-Benkhiat, Sonia, Burban, Melanie, Ribeiro, Thais Porto, Toti, Florence, Idris-Khodja, Noureddine, Côrtes, Steyner F., Schini-Kerth, Valérie B.

“…Endothelial senescence has been suggested to promote endothelial dysfunction in age-related vascular disorders. This study evaluated the prothrombotic…”
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Neutrophil Fluorescence: A New Indicator of Cell Activation During Septic Shock–Induced Disseminated Intravascular Coagulation by Stiel, Laure, Delabranche, Xavier, Galoisy, Anne-Cécile, Severac, François, Toti, Florence, Mauvieux, Laurent, Meziani, Ferhat, Boisramé-Helms, Julie

“…OBJECTIVE:To investigate the contribution of neutrophil activation as innate immune cells during septic shock–induced disseminated intravascular coagulation…”
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Oral Intake of EPA:DHA 6:1 by Middle-Aged Rats for One Week Improves Age-Related Endothelial Dysfunction in Both the Femoral Artery and Vein: Role of Cyclooxygenases by Gaertner, Sébastien, Auger, Cyril, Farooq, Muhammad A, Pollet, Brigitte, Khemais-Benkhiat, Sonia, Niazi, Zahid R, Schrevens, Sophie, Park, Sin-Hee, Toti, Florence, Stephan, Dominique, Schini-Kerth, Valérie B

“…In humans, aging is associated with endothelial dysfunction and an increased risk of venous thromboembolism. Although intake of eicosapentaenoic acid (EPA) and…”
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Cellular damage, platelet activation, and inflammatory response after pulmonary vein isolation: A randomized study comparing radiofrequency ablation with cryoablation by Herrera Siklódy, Claudia, MD, Arentz, Thomas, MD, Minners, Jan, MD, PhD, Jesel, Laurence, MD, Stratz, Christian, MD, Valina, Christian M., MD, Weber, Reinhold, MD, Kalusche, Dietrich, MD, FHRS, Toti, Florence, PhD, Morel, Olivier, MD, PhD, Trenk, Dietmar, PhD

“…Background Experimental data suggest that use of cryoablation in pulmonary vein isolation (PVI) is associated with less cell damage and less thrombus formation…”
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Differential influence of tacrolimus and sirolimus on mitochondrial-dependent signaling for apoptosis in pancreatic cells by Constantinescu, Andrei Alexandru, Abbas, Malak, Kassem, Mohamad, Gleizes, Céline, Kreutter, Guillaume, Schini-Kerth, Valerie, Mitrea, Ioan Liviu, Toti, Florence, Kessler, Laurence

“…To examine and compare the mitochondria-related cellular mechanisms by which tacrolimus (TAC) or sirolimus (SIR) immunosuppressive drugs alter the pancreatic…”
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Thrombomodulin favors leukocyte microvesicle fibrinolytic activity, reduces NETosis and prevents septic shock-induced coagulopathy in rats by Helms, Julie, Clere-Jehl, Raphaël, Bianchini, Elsa, Le Borgne, Pierrick, Burban, Mélanie, Zobairi, Fatiha, Diehl, Jean-Luc, Grunebaum, Lelia, Toti, Florence, Meziani, Ferhat, Borgel, Delphine

“…Background Septic shock-induced disseminated intravascular coagulation is responsible for increased occurrence of multiple organ dysfunction and mortality…”
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Once versus twice daily injection of enoxaparin for thromboprophylaxis in bariatric surgery: effects on antifactor Xa activity and procoagulant microparticles. A randomized controlled study by Steib, Annick, M.D., Ph.D, Degirmenci, Su-Emmanuelle, M.D, Junke, Etienne, M.D, Asehnoune, Karim, M.D., Ph.D, Figier, Martine, M.D, Pericard, Christophe, M.D, Rohr, Serge, M.D., Ph.D, Letessier, Eric, M.D., Ph.D, Brunaud, Laurent, M.D., Ph.D, Vix, Michel, M.D, Zobairi, Fatiha, Grunebaum, Lelia, M.D, Toti, Florence, Ph.D

“…Abstract Background The optimal scheme of thromboprophylaxis in bariatric surgery remains uncertain, because clinical practice is different between countries…”
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