Search Results - "TOTH, Lisa N"

Application of Stable Isotope Methodology in the Evaluation of the Pharmacokinetics of (S,S)-3-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine Hydrochloride in Rats by YAMAZAKI, Shinji, TOTH, Lisa N, KIMOTO, Emi, BOWER, Janice, SKAPTASON, Judith, ROMERO, David, HEATH, Timothy G

“…The primary objective of this study was to demonstrate the use of stable isotope (SI)-labeled compound as an approach for pharmacokinetic analysis such as…”
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COMPARISON OF PREDICTION METHODS FOR IN VIVO CLEARANCE OF (S,S)-3-[3-(METHYLSULFONYL)PHENYL]-1-PROPYLPIPERIDINE HYDROCHLORIDE, A DOPAMINE D2 RECEPTOR ANTAGONIST, IN HUMANS by YAMAZAKI, Shinji, TOTH, Lisa N, BLACK, Meredith L, DUNCAN, J. Neil

“…The purpose of this study is to investigate reliable prediction methods for in vivo pharmacokinetics and the likelihood of drug interactions with several…”
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Structure-Based Design of HIV Protease Inhibitors:  Sulfonamide-Containing 5,6-Dihydro-4-hydroxy-2-pyrones as Non-Peptidic Inhibitors by Thaisrivongs, Suvit, Skulnick, Harvey I, Turner, Steve R, Strohbach, Joseph W, Tommasi, Ruben A, Johnson, Paul D, Aristoff, Paul A, Judge, Thomas M, Gammill, Ronald B, Morris, Jeanette K, Romines, Karen R, Chrusciel, Robert A, Hinshaw, Roger R, Chong, Kong-Teck, Tarpley, W. Gary, Poppe, Susan M, Slade, David E, Lynn, Janet C, Horng, Miao-Miao, Tomich, Paul K, Seest, Eric P, Dolak, Lester A, Howe, W. Jeffrey, Howard, Gina M, Schwende, Francis J, Toth, Lisa N, Padbury, Guy E, Wilson, Grace J, Shiou, Lihua, Zipp, Gail L, Wilkinson, Karen F, Rush, Bob D, Ruwart, Mary J, Koeplinger, Kenneth A, Zhao, Zhiyang, Cole, Serena, Zaya, Renee M, Kakuk, Thomas J, Janakiraman, Musiri N, Watenpaugh, Keith D

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Structure-Based Design of HIV Protease Inhibitors: 4-Hydroxycoumarins and 4-Hydroxy-2-pyrones as Non-peptidic Inhibitors by Thaisrivongs, Suvit, Tomich, Paul K, Watenpaugh, Keith D, Chong, Kong-Teck, Howe, W. Jeffrey, Yang, Chih-Ping, Strohbach, Joseph W, Turner, Steve R, McGrath, James P

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Use of Medium-Sized Cycloalkyl Rings To Enhance Secondary Binding: Discovery of a New Class of Human Immunodeficiency Virus (HIV) Protease Inhibitors by Romines, Karen R, Watenpaugh, Keith D, Tomich, Paul K, Howe, W. Jeffrey, Morris, Jeanette K, Lovasz, Kristine D, Mulichak, Anne M, Finzel, Barry C, Lynn, Janet C

“…A unique strategy for the enhancement of secondary binding of an inhibitor to an enzyme has been demonstrated in the design of new human immunodeficiency virus…”
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Synthesis and pharmacological evaluation of sulfone substituted HIV protease inhibitors by Schwartz, Theresa M., Bundy, Gordon L., Strohbach, Joseph W., Thaisrivongs, Suvit, Johnson, Paul D., Skulnick, Harvey I., Tomich, Paul K., Lynn, Janet C., Chong, Kong Teck, Hinshaw, Roger R., Raub, Thomas J., Padbury, Guy E., Toth, Lisa N.

“…The sulfonamide substituted pyranones ( 1) have recently been shown to be potent HIV protease inhibitors. We prepared a series of sulfone substituted analogs…”
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