Search Results - "TOSSI, Alessandro"

Antimicrobial Peptides as Anti-Infective Agents in Pre-Post-Antibiotic Era? by Rončević, Tomislav, Puizina, Jasna, Tossi, Alessandro

“…Resistance to antibiotics is one of the main current threats to human health and every year multi-drug resistant bacteria are infecting millions of people…”
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The human cathelicidin LL-37 — A pore-forming antibacterial peptide and host-cell modulator by Xhindoli, Daniela, Pacor, Sabrina, Benincasa, Monica, Scocchi, Marco, Gennaro, Renato, Tossi, Alessandro

“…The human cathelicidin hCAP18/LL-37 has become a paradigm for the pleiotropic roles of peptides in host defence. It has a remarkably wide functional repertoire…”
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Proline-rich antimicrobial peptides: converging to a non-lytic mechanism of action by Scocchi, Marco, Tossi, Alessandro, Gennaro, Renato

“…Proline-rich antimicrobial peptides are a group of cationic host defense peptides of vertebrates and invertebrates characterized by a high content of proline…”
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The Dolphin Proline-Rich Antimicrobial Peptide Tur1A Inhibits Protein Synthesis by Targeting the Bacterial Ribosome by Mardirossian, Mario, Pérébaskine, Natacha, Benincasa, Monica, Gambato, Stefano, Hofmann, Sven, Huter, Paul, Müller, Claudia, Hilpert, Kai, Innis, C Axel, Tossi, Alessandro, Wilson, Daniel N

“…Proline-rich antimicrobial peptides (PrAMPs) internalize into susceptible bacteria using specific transporters and interfere with protein synthesis and…”
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DADP: the database of anuran defense peptides by NOVKOVIC, Mario, SIMUNIC, Juraj, BOJOVIC, Viktor, TOSSI, Alessandro, JURETIC, Davor

“…Anuran tissues, and especially skin, are a rich source of bioactive peptides and their precursors. We here present a manually curated database of antimicrobial…”
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Human β-Defensin 3 Inhibits Cell Wall Biosynthesis in Staphylococci by Sass, Vera, Schneider, Tanja, Wilmes, Miriam, Körner, Christian, Tossi, Alessandro, Novikova, Natalia, Shamova, Olga, Sahl, Hans-Georg

“…Human β-defensin 3 (hBD3) is a highly charged (+11) cationic host defense peptide, produced by epithelial cells and neutrophils. hBD3 retains antimicrobial…”
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Native oligomerization determines the mode of action and biological activities of human cathelicidin LL-37 by Xhindoli, Daniela, Pacor, Sabrina, Guida, Filomena, Antcheva, Nikolinka, Tossi, Alessandro

“…LL-37 is a multifunctional component of innate immunity, with a membrane-directed antimicrobial activity and receptor-mediated pleiotropic effects on host…”
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Natural and Synthetic Halogenated Amino Acids-Structural and Bioactive Features in Antimicrobial Peptides and Peptidomimetics by Mardirossian, Mario, Rubini, Marina, Adamo, Mauro F A, Scocchi, Marco, Saviano, Michele, Tossi, Alessandro, Gennaro, Renato, Caporale, Andrea

“…The 3D structure and surface characteristics of proteins and peptides are crucial for interactions with receptors or ligands and can be modified to some extent…”
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Silver Nanoparticles Functionalized With Antimicrobial Polypeptides: Benefits and Possible Pitfalls of a Novel Anti-infective Tool by Zharkova, Maria S, Golubeva, Olga Yu, Orlov, Dmitriy S, Vladimirova, Elizaveta V, Dmitriev, Alexander V, Tossi, Alessandro, Shamova, Olga V

“…Silver nanoparticles (AgNPs) and antimicrobial peptides or proteins (AMPs/APs) are both considered as promising platforms for the development of novel…”
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Myticalins: A Novel Multigenic Family of Linear, Cationic Antimicrobial Peptides from Marine Mussels (Mytilus spp.) by Leoni, Gabriele, De Poli, Andrea, Mardirossian, Mario, Gambato, Stefano, Florian, Fiorella, Venier, Paola, Wilson, Daniel N, Tossi, Alessandro, Pallavicini, Alberto, Gerdol, Marco

“…The application of high-throughput sequencing technologies to non-model organisms has brought new opportunities for the identification of bioactive peptides…”
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Influence of Bacterial Biofilm Polysaccharide Structure on Interactions with Antimicrobial Peptides: A Study on Klebsiella pneumoniae by Bellich, Barbara, Lagatolla, Cristina, Tossi, Alessandro, Benincasa, Monica, Cescutti, Paola, Rizzo, Roberto

“…Balneotherapy is a clinically effective complementary approach in the treatment of low-grade inflammation- and stress-related pathologies. The biological…”
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Mixed Fluorinated/Hydrogenated Self‐Assembled Monolayer‐Protected Gold Nanoparticles: In Silico and In Vitro Behavior by Marson, Domenico, Guida, Filomena, Şologan, Maria, Boccardo, Silvia, Pengo, Paolo, Perissinotto, Fabio, Iacuzzi, Valentina, Pellizzoni, Elena, Polizzi, Stefano, Casalis, Loredana, Pasquato, Lucia, Pacor, Sabrina, Tossi, Alessandro, Posocco, Paola

“…Gold nanoparticles (AuNPs) covered with mixtures of immiscible ligands present potentially anisotropic surfaces that can modulate their interactions at complex…”
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Parallel identification of novel antimicrobial peptide sequences from multiple anuran species by targeted DNA sequencing by Rončević, Tomislav, Gerdol, Marco, Spazzali, Francesca, Florian, Fiorella, Mekinić, Stjepan, Tossi, Alessandro, Pallavicini, Alberto

“…Antimicrobial peptides (AMPs) are multifunctional effector molecules that often combine direct antimicrobial activities with signaling or immunomodulatory…”
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Characterization of Cetacean Proline-Rich Antimicrobial Peptides Displaying Activity against ESKAPE Pathogens by Sola, Riccardo, Mardirossian, Mario, Beckert, Bertrand, Sanghez De Luna, Laura, Prickett, Dennis, Tossi, Alessandro, Wilson, Daniel N, Scocchi, Marco

“…Proline-rich antimicrobial peptides (PrAMPs) may be a valuable weapon against multi-drug resistant pathogens, combining potent antimicrobial activity with low…”
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Relating Molecular Dynamics Simulations to Functional Activity for Gly-Rich Membranolytic Helical Kiadin Peptides by Rončević, Tomislav, Maleš, Matko, Sonavane, Yogesh, Guida, Filomena, Pacor, Sabrina, Tossi, Alessandro, Zoranić, Larisa

“…Kiadins are in silico designed peptides with a strong similarity to PGLa-H, a tandem sequence of PGLa-H (KIAKVALKAL) and with single, double or quadruple…”
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Redesigning Arenicin-1, an Antimicrobial Peptide from the Marine Polychaeta Arenicola marina , by Strand Rearrangement or Branching, Substitution of Specific Residues, and Backbone Linearization or Cyclization by Orlov, Dmitriy S, Shamova, Olga V, Eliseev, Igor E, Zharkova, Maria S, Chakchir, Oleg B, Antcheva, Nikolinka, Zachariev, Sotir, Panteleev, Pavel V, Kokryakov, Vladimir N, Ovchinnikova, Tatiana V, Tossi, Alessandro

“…Arenicin-1, a β-sheet antimicrobial peptide isolated from the marine polychaeta coelomocytes, has a potent, broad-spectrum microbicidal activity and also shows…”
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Cathelicidins—a rich seam of antimicrobial peptides waiting for exploitation by Tossi, Alessandro, Gerdol, Marco, Caporale, Andrea, Pacor, Sabrina, Mardirossian, Mario, Scocchi, Marco, Prickett, Michael D., Manzini, Giorgio, Gennaro, Renato

“…Cathelicidins are a ubiquitous family of host defence antimicrobial peptides in vertebrate animals. Unlike other antimicrobial peptide families, it is defined…”
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Broad-Spectrum Activity against Bacterial Mastitis Pathogens and Activation of Mammary Epithelial Cells Support a Protective Role of Neutrophil Cathelicidins in Bovine Mastitis by Tomasinsig, Linda, De Conti, Gennyfer, Skerlavaj, Barbara, Piccinini, Renata, Mazzilli, Maria, D'Este, Francesca, Tossi, Alessandro, Zanetti, Margherita

“…Cathelicidins are peptide components of the innate immune system of mammals. Apart from exerting a direct antibiotic activity, they can also trigger specific…”
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Structural aspects of plant antimicrobial peptides by Padovan, Lara, Scocchi, Marco, Tossi, Alessandro

“…Antimicrobial peptides exert an important role in plant defence and their structure/activity relationship against pathogens is widely described. Although the…”
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Computational Design of Highly Selective Antimicrobial Peptides by Juretić, Davor, Vukičević, Damir, Ilić, Nada, Antcheva, Nikolinka, Tossi, Alessandro

“…We have created a structure-selectivity database (AMPad) of frog-derived, helical antimicrobial peptides (AMPs), in which the selectivity was determined as a…”
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