Search Results - "TOSHNER, Mark R"

The pulmonary endothelium in acute respiratory distress syndrome: insights and therapeutic opportunities by Millar, Fraser R, Summers, Charlotte, Griffiths, Mark J, Toshner, Mark R, Proudfoot, Alastair G

“…The pulmonary endothelium is a dynamic, metabolically active layer of squamous endothelial cells ideally placed to mediate key processes involved in lung…”
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Plasma Metabolomics Implicates Modified Transfer RNAs and Altered Bioenergetics in the Outcomes of Pulmonary Arterial Hypertension by Rhodes, Christopher J, Ghataorhe, Pavandeep, Wharton, John, Rue-Albrecht, Kevin C, Hadinnapola, Charaka, Watson, Geoffrey, Bleda, Marta, Haimel, Matthias, Coghlan, Gerry, Corris, Paul A, Howard, Luke S, Kiely, David G, Peacock, Andrew J, Pepke-Zaba, Joanna, Toshner, Mark R, Wort, S John, Gibbs, J Simon R, Lawrie, Allan, Gräf, Stefan, Morrell, Nicholas W, Wilkins, Martin R

“…Pulmonary arterial hypertension (PAH) is a heterogeneous disorder with high mortality. We conducted a comprehensive study of plasma metabolites using…”
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Long-term use of sildenafil in inoperable chronic thromboembolic pulmonary hypertension by Suntharalingam, Jay, Treacy, Carmen M, Doughty, Natalie J, Goldsmith, Kimberley, Soon, Elaine, Toshner, Mark R, Sheares, Karen K, Hughes, Rodney, Morrell, Nicholas W, Pepke-Zaba, Joanna

“…There are currently no licensed medical therapies for inoperable chronic thromboembolic pulmonary hypertension (CTEPH). In this double-blind,…”
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Decreased time constant of the pulmonary circulation in chronic thromboembolic pulmonary hypertension by MacKenzie Ross, Robert V, Toshner, Mark R, Soon, Elaine, Naeije, Robert, Pepke-Zaba, Joanna

“…This study analyzed the relationship between pulmonary vascular resistance (PVR) and pulmonary arterial compliance (Ca) in patients with idiopathic pulmonary…”
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StratosPHere 2: study protocol for a response-adaptive randomised placebo-controlled phase II trial to evaluate hydroxychloroquine and phenylbutyrate in pulmonary arterial hypertension caused by mutations in BMPR2 by Deliu, Nina, Das, Rajenki, May, Angelique, Newman, Joseph, Steele, Jo, Duckworth, Melissa, Jones, Rowena J, Wilkins, Martin R, Toshner, Mark R, Villar, Sofia S

“…Pulmonary arterial hypertension is a life-threatening progressive disorder characterised by high blood pressure (hypertension) in the arteries of the lungs…”
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Limitations of resting haemodynamics in chronic thromboembolic disease without pulmonary hypertension by Swietlik, Emilia Maria, Ruggiero, Alessandro, Fletcher, Andrew J, Taboada, Dolores, Knightbridge, Emily, Harlow, Louise, Harvey, Ian, Screaton, Nicholas, Cannon, John E, Sheares, Karen K K, Ng, Choo, Jenkins, David P, Pepke-Zaba, Joanna, Toshner, Mark R

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Impaired Natural Killer Cell Phenotype and Function in Idiopathic and Heritable Pulmonary Arterial Hypertension by ORMISTON, Mark L, CHIWEN CHANG, SOUTHWOOD, Mark, PEPKE-ZABA, Joanna, EXLEY, Andrew, TREMBATH, Richard C, COLUCCI, Francesco, WILLS, Mark, TROWSDALE, John, MORRELL, Nicholas W, LONG, Lu L, SOON, Elaine, JONES, Des, MACHADO, Rajiv, TREACY, Carmen, TOSHNER, Mark R, CAMPBELL, Kate, RIDING, Alex

“…Beyond their role as innate immune effectors, natural killer (NK) cells are emerging as important regulators of angiogenesis and vascular remodeling. Pulmonary…”
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Approaches to treat pulmonary arterial hypertension by targeting BMPR2: from cell membrane to nucleus by Dunmore, Benjamin J, Jones, Rowena J, Toshner, Mark R, Upton, Paul D, Morrell, Nicholas W

“…Abstract Pulmonary arterial hypertension (PAH) is estimated to affect between 10 and 50 people per million worldwide. The lack of cure and devastating nature…”
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Pulmonary arterial size and response to sildenafil in chronic thromboembolic pulmonary hypertension by Toshner, Mark R., MB ChB, Gopalan, Deepa, MB ChB, Suntharalingam, Jay, MB ChB, Treacy, Carmen, Soon, Elaine, MB ChB, Sheares, Karen K., MB ChB, Morrell, Nicholas W., MB ChB, Screaton, Nicholas, MB ChB, Pepke-Zaba, Joanna, MD

“…Background Relative area change (RAC) of the proximal pulmonary artery is a measurement of pulmonary artery distensibility and has been shown to correlate with…”
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Prevalence and clinical significance of conduction disease in patients with idiopathic pulmonary arterial hypertension by Reddy, Sathineni Ashwin, Nethercott, Sarah L., Teh, Wen, De Bie, Eckart MDD, Pepke-Zaba, Joanna, Toshner, Mark R., Martin, Claire A.

“…Anatomical and physiological changes in the right heart as a direct consequence of the upstream pressure overload characteristic of idiopathic pulmonary…”
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Natural history of chronic thromboembolic pulmonary disease with no or mild pulmonary hypertension by Reddy, Sathineni A, Swietlik, Emilia M, Robertson, Lucy, Michael, Alice, Boyle, Sonja, Polwarth, Gary, Screaton, Nick J, Ruggiero, Alessandro, Nethercott, Sarah L, Taboada, Dolores, Sheares, Karen K, Hadinnapola, Charaka, Cannon, John E, Bunclark, Katherine, Jenkins, David, Ng, Choo, Toshner, Mark R, Pepke-Zaba, Joanna

“…We describe baseline characteristics, disease progression and mortality in chronic thromboembolic pulmonary disease patients as a function of mean pulmonary…”
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The lysosomal inhibitor, chloroquine, increases cell surface BMPR-II levels and restores BMP9 signalling in endothelial cells harbouring BMPR-II mutations by Dunmore, Benjamin J, Drake, Kylie M, Upton, Paul D, Toshner, Mark R, Aldred, Micheala A, Morrell, Nicholas W

“…Pulmonary arterial hypertension (PAH) is characterized by dysregulated pulmonary artery endothelial cell (PAEC) proliferation, apoptosis and permeability…”
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Joint patient and clinician priority setting to identify 10 key research questions regarding the long-term sequelae of COVID-19 by Houchen-Wolloff, Linzy, Poinasamy, Krisnah, Holmes, Kate, Tarpey, Maryrose, Hastie, Claire, Raihani, Kelly, Rogers, Natalie, Smith, Nikki, Adams, Dawn, Burgess, Paul, Clark, Jean, Cranage, Clare, Desai, Mahadev, Geary, Nicola, Gill, Rhyan, Mangwani, Jitendra, Staunton, Lily, Berry, Colin, Bolton, Charlotte E, Chalder, Trudie, Chalmers, James, De Soyza, Anthony, Elneima, Omer, Geddes, John, Heller, Simon, Ho, Ling-Pei, Jacob, Joseph, McAuley, Hamish, Parmar, Aarti, Quint, Jennifer K, Raman, Betty, Rowland, Matthew, Singapuri, Amisha, Singh, Sally J, Thomas, David, Toshner, Mark R, Wain, Louise V, Horsley, Alex Robert, Marks, Michael, Brightling, Christopher E, Evans, Rachael A

“…Given the large numbers of people infected and high rates of ongoing morbidity, research is clearly required to address the needs of adult survivors of…”
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EmPHasis-10 health-related quality of life score predicts outcomes in patients with idiopathic and connective tissue disease-associated pulmonary arterial hypertension: results from a UK multicentre study by Lewis, Robert A, Armstrong, Iain, Bergbaum, Carmel, Brewis, Melanie J, Cannon, John, Charalampopoulos, Athanasios, Church, A Colin, Coghlan, J Gerry, Davies, Rachel J, Dimopoulos, Konstantinos, Elliot, Charlie, Gibbs, J Simon R, Gin-Sing, Wendy, Haji, Gulam, Hameed, Abdul G, Howard, Luke S, Johnson, Martin K, Kempny, Aleksander, Kiely, David G, Lo Giudice, Francesco, McCabe, Colm, Peacock, Andrew J, Peleyeju, Oyinkansola, Pepke-Zaba, Joanna, Polwarth, Gary, Price, Laura, Sabroe, Ian, Schreiber, Benjamin E, Sheares, Karen, Taboada, Dolores, Thompson, A A Roger, Toshner, Mark R, Wanjiku, Ivy, Wort, S John, Yorke, Janelle, Condliffe, Robin

“…Health-related quality of life (HRQoL) scores assess symptom burden in pulmonary arterial hypertension (PAH) but data regarding their role in prognostication…”
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Traffic exposures, air pollution and outcomes in pulmonary arterial hypertension: a UK cohort study analysis by Sofianopoulou, Eleni, Kaptoge, Stephen, Gräf, Stefan, Hadinnapola, Charaka, Treacy, Carmen M, Church, Colin, Coghlan, Gerry, Gibbs, J Simon R, Haimel, Matthias, Howard, Luke S, Johnson, Martin, Kiely, David G, Lawrie, Allan, Lordan, James, MacKenzie Ross, Robert V, Martin, Jennifer M, Moledina, Shahin, Newnham, Michael, Peacock, Andrew J, Price, Laura C, Rhodes, Christopher J, Suntharalingam, Jay, Swietlik, Emilia M, Toshner, Mark R, Wharton, John, Wilkins, Martin R, Wort, Stephen J, Pepke-Zaba, Joanna, Condliffe, Robin, Corris, Paul A, Di Angelantonio, Emanuele, Provencher, Steeve, Morrell, Nicholas W

“…While traffic and air pollution exposure is associated with increased mortality in numerous diseases, its association with disease severity and outcomes in…”
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Deprivation and prognosis in patients with pulmonary arterial hypertension: missing the effect of deprivation on a rare disease? by Sofianopoulou, Eleni, Church, Colin, Coghlan, Gerry, Howard, Luke, Johnson, Martin, Kiely, David G, Lawrie, Allan, Lordan, James, Wilkins, Martin R, Wort, Stephen J, Morrell, Nicholas W, Toshner, Mark R

“…In this journal, P ellino et al. [1] presented a survival analysis to assess how deprivation affects prognosis in patients with pulmonary arterial hypertension…”
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Generation and Culture of Blood Outgrowth Endothelial Cells from Human Peripheral Blood by Ormiston, Mark L, Toshner, Mark R, Kiskin, Fedir N, Huang, Christopher J Z, Groves, Emily, Morrell, Nicholas W, Rana, Amer A

“…Historically, the limited availability of primary endothelial cells from patients with vascular disorders has hindered the study of the molecular mechanisms…”
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Hepatic Shunting of Eggs and Pulmonary Vascular Remodeling in Bmpr2(+/-) Mice with Schistosomiasis by Crosby, Alexi, Soon, Elaine, Jones, Frances M, Southwood, Mark R, Haghighat, Leila, Toshner, Mark R, Raine, Tim, Horan, Ian, Yang, Peiran, Moore, Stephen, Ferrer, Elisabet, Wright, Penny, Ormiston, Mark L, White, R James, Haight, Deborah A, Dunne, David W, Morrell, Nicholas W

“…Schistosomiasis is a major cause of pulmonary arterial hypertension (PAH). Mutations in the bone morphogenetic protein type-II receptor (BMPR-II) are the…”
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Unexplained iron deficiency in idiopathic and heritable pulmonary arterial hypertension by Soon, Elaine, Treacy, Carmen M, Toshner, Mark R, MacKenzie-Ross, Robert, Manglam, Vijay, Busbridge, Mark, Sinclair-McGarvie, Mark, Arnold, Jayantha, Sheares, Karen K, Morrell, Nicholas W, Pepke-Zaba, Joanna

“…Anaemia is common in left heart failure and is associated with a poorer outcome. Many patients with pulmonary arterial hypertension (PAH) are anaemic or…”
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Reply to "Letter to the editor: 'Pulsatile pulmonary artery pressure: are fluid-filled catheters accurate in pulmonary hypertension?'" by Mackenzie Ross, Robert V, Toshner, Mark R, Soon, Elaine, Naeije, Robert, Pepke-Zaba, Joanna

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