Search Results - "TORRES, Rhoda"
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Use of a Trapping Agent for Simultaneous Capturing and High-Throughput Screening of Both “Soft” and “Hard” Reactive Metabolites
Published in Analytical chemistry (Washington) (01-06-2007)“…Glutathione (GSH) has been widely used for in vitro trapping and subsequently detecting reactive metabolites using liquid chromatography−mass spectrometry. A…”
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Isobaric metabolite interferences and the requirement for close examination of raw data in addition to stringent chromatographic separations in liquid chromatography/tandem mass spectrometric analysis of drugs in biological matrix
Published in Rapid communications in mass spectrometry (15-07-2008)“…In addition to matrix effects, common interferences observed in liquid chromatography/tandem mass spectrometry (LC/MS/MS) analyses can be caused by the…”
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BIOACTIVATION OF 4-METHYLPHENOL (p-CRESOL) VIA CYTOCHROME P450-MEDIATED AROMATIC OXIDATION IN HUMAN LIVER MICROSOMES
Published in Drug metabolism and disposition (01-12-2005)“…It has previously been proposed that 4-methylphenol ( p -cresol) is metabolically activated by oxidation of the methyl group to form a reactive quinone…”
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Metabolism and Bioactivation of 3-Methylindole by Human Liver Microsomes
Published in Chemical research in toxicology (01-01-2007)“…Metabolism and bioactivation of 3-methylindole (3MI) were investigated in human liver microsomes. The metabolism of two deuterium-labeled analogues of 3MI…”
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Rapid detection and characterization of minor reactive metabolites using stable-isotope trapping in combination with tandem mass spectrometry
Published in Rapid communications in mass spectrometry (01-01-2005)“…Stable‐isotope trapping combined with mass spectrometry (MS) neutral loss scanning has recently been developed as a high‐throughput method for the in vitro…”
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