Search Results - "TORPY, D. J"

Septic Shock and Sepsis: A Comparison of Total and Free Plasma Cortisol Levels by Ho, J. T., Al-Musalhi, H., Chapman, M. J., Quach, T., Thomas, P. D., Bagley, C. J., Lewis, J. G., Torpy, D. J.

“…Context: Severe systemic infection leads to hypercortisolism. Reduced cortisol binding proteins may accentuate the free cortisol elevations seen in systemic…”
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Multicenter Australian Trial of Islet Transplantation: Improving Accessibility and Outcomes by O'Connell, P. J., Holmes‐Walker, D. J., Goodman, D., Hawthorne, W. J., Loudovaris, T., Gunton, J. E., Thomas, H. E., Grey, S. T., Drogemuller, C. J., Ward, G. M., Torpy, D. J., Coates, P. T., Kay, T. W.

“…Whilst initial rates of insulin independence following islet transplantation are encouraging, long‐term function using the Edmonton Protocol remains a concern…”
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Depletion of high-affinity corticosteroid-binding globulin corresponds to illness severity in sepsis and septic shock; clinical implications by Nenke, M.A., Rankin, W., Chapman, M.J., Stevens, N.E., Diener, K.R., Hayball, J. D., Lewis, J.G., Torpy, D.J.

“…Summary Objective Corticosteroid‐binding globulin (CBG) is cleaved by neutrophil elastase converting the high‐affinity (haCBG) conformation of CBG to a…”
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A 42-year-old man presented with adrenal incidentaloma due to non-classic congenital adrenal hyperplasia with a novel CYP21A2 mutation by Falhammar, H., Torpy, D. J.

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CBG Santiago: A Novel CBG Mutation by Torpy, D. J, Lundgren, B. Ardesjö, Ho, J. T, Lewis, J. G, Scott, H. S, Mericq, V

“…Context: Corticosteroid-binding globulin (CBG; SERPIN A6) gene mutations are rare; only four mutations have been described, often in association with fatigue…”
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Corticosteroid-binding globulin gene polymorphisms: clinical implications and links to idiopathic chronic fatigue disorders by Torpy, D. J., Ho, J. T.

“…Summary Corticosteroid‐binding globulin (CBG) binds cortisol with high affinity, facilitating transport of cortisol in blood, although tissue‐specific…”
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Characteristics of plasma NOx levels in severe sepsis: high interindividual variability and correlation with illness severity, but lack of correlation with cortisol levels by HO, J. T, CHAPMAN, M. J, O'CONNOR, S, LAM, S, EDWARDS, J, LUDBROOK, G, LEWIS, J. G, TORPY, D. J

“…Objectives Nitric oxide (NO) concentrations are elevated in sepsis and their vasodilatory action may contribute to the development of hyperdynamic circulatory…”
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Systematic review: adrenal insufficiency secondary to swallowed topical corticosteroids in eosinophilic oesophagitis by Philpott, H., Dougherty, M. K., Reed, C. C., Caldwell, M., Kirk, D., Torpy, D. J., Dellon, E. S.

“…Summary Background Swallowed topical corticosteroids are prescribed for eosinophilic oesophagitis (EoE), but there is a theoretical risk of adrenal…”
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Adrenal Insufficiency in Australia: Is it Possible that the Use of Lower Dose, Short-Acting Glucocorticoids has Increased the Risk of Adrenal Crises? by Rushworth, R L, Torpy, D J

“…Morbidity from adrenal insufficiency (AI) in Australia is poorly described. The objective of this study was to evaluate AI morbidity patterns in adults between…”
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Corticosteroid-Binding Globulin: A Review of Basic and Clinical Advances by Meyer, E J, Nenke, M A, Rankin, W, Lewis, J G, Torpy, D J

“…Corticosteroid-binding globulin (CBG, transcortin) is the primary cortisol binding protein. It is a non-inhibitory serine protease inhibitor, capable of…”
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Modern Hydrocortisone Replacement Regimens in Adrenal Insufficiency Patients and the Risk of Adrenal Crisis by Rushworth, R L, Torpy, D J

“…The aim of this study was to examine the incidence of adrenal crises (AC) and the prescription of short-acting glucocorticoids (GC) in different geographic…”
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Familial hyperaldosteronism type II : Description of a large kindred and exclusion of the aldosterone synthase (CYP11B2) gene by TORPY, D. J, GORDON, R. D, JING PING LIN, HUGGARD, P. R, TAYMANS, S. E, STOWASSER, M, CHROUSOS, G. P, STRATAKIS, C. A

“…Familial hyperaldosteronism type II (FH-II) is characterized by autosomal dominant inheritance and hypersecretion of aldosterone due to adrenocortical…”
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Greater replication and differentiation of preadipocytes in inherited corticosteroid-binding globulin deficiency by Joyner, J M, Hutley, L J, Bachmann, A W, Torpy, D J, Prins, J B

“…Glucocorticoids are pivotal for adipose tissue development. Rodent studies suggest that corticosteroid-binding globulin (CBG) modulates glucocorticoid action…”
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The Emerging Role of Copeptin by Jalleh, R, Torpy, D J

“…Direct measurement of the nonapeptide vasopressin has been limited by analyte instability ex vivo and in vivo rapid degradation, low serum concentrations…”
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Evidence of Reduced CBG Cleavage in Abdominal Obesity: A Potential Factor in Development of the Metabolic Syndrome by Nenke, M A, Lewis, J G, Rankin, W, Torpy, D J

“…Corticosteroid-binding globulin (CBG) is involved in the regulation of cortisol delivery. Neutrophil elastase-mediated cleavage of high to low affinity CBG…”
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Acute and delayed effects of a single-dose injection of interleukin-6 on thyroid function in healthy humans by Torpy, D.J., Tsigos, C., Lotsikas, A.J., Defensor, R., Chrousos, G.P., Papanicolaou, D.A.

“…Interleukin-6 (IL-6) is produced in response to inflammatory and noninflammatory stress and acts as the principal regulator of the acute-phase protein…”
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Pregnancy-associated corticosteroid-binding globulin: high resolution separation of glycan isoforms by Mitchell, E, Torpy, D J, Bagley, C J

“…Corticosteroid-binding globulin (CBG) is a glycoprotein that functions as a specific carrier of cortisol in the circulation. CBG contains six sites for…”
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Leptin and interleukin-6 in sepsis by Torpy, D J, Bornstein, S R, Chrousos, G P

“…Both leptin and interleukin-6 (IL-6) are hypersecreted in acute critical illness, such as sepsis. Leptin is produced by adipocytes, it inhibits appetite and…”
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Interactions between the hypothalamic-pituitary-adrenal axis and the female reproductive system : Clinical implications by CHROUSOS, G. P, TORPY, D. J, GOLD, P. W

“…The hypothalamic-pituitary-adrenal axis exerts profound, multilevel inhibitory effects on the female reproductive system. Corticotropin-releasing hormone (CRH)…”
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ARMC5 is not implicated in familial hyperaldosteronism type II (FH-II) by De Sousa, S M C, Stowasser, M, Feng, J, Schreiber, A W, Wang, P, Hahn, C N, Gordon, R D, Torpy, D J, Scott, H S, Gagliardi, L

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