Search Results - "TOPPET, M"

Hydroxyurea for Treatment of Severe Sickle Cell Anemia: A Pediatric Clinical Trial by Ferster, A., Vermylen, C., Cornu, G., Buyse, M., Corazza, F., Devalck, C., Fondu, P., Toppet, M., Sariban, E.

“…Hydroxyurea (HU) enhances the synthesis of fetal hemoglobin (HbF) and can improve the clinical course of some adult patients with sickle cell anemia (SCA). In…”
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Stereoselective transformation of pyrazinones into substituted analogues of cis-5-amino-6-oxo-2-piperidinemethanol and cis-5-amino-2-piperidinemethanol by Rogiers, Joeri, De Borggraeve, Wim M, Toppet, Suzanne M, Compernolle, Frans, Hoornaert, Georges J

“…Various analogues of cis-5-amino-6-oxo-2-piperidinemethanol and cis-5-amino-2-piperidinemethanol have been prepared via Diels–Alder reaction of substituted…”
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Rôle déterminant de la prise en charge médicosociale dans le pronostic des affections hématologiques de l'enfant by TOPPET, M

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Synthesis of a conformationally restricted dipeptide analogue and its evaluation as a β-turn mimic by De Borggraeve, Wim M, Rombouts, Frederik J.R, Van der Eycken, Erik V, Toppet, Suzanne M, Hoornaert, Georges J

“…Dichloropyrazinone 3 was converted into a conformationally restricted dipeptide analogue 8 by means of a Diels–Alder strategy. The β-turn characteristics of…”
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Development of a Functionalizable External β-Turn Mimic Based on a cis-Fused 1,7-Naphthyridine Scaffold by Rombouts, Frederik J. R., Borggraeve, Wim M. De, Delaere, David, Froeyen, Matheus, Toppet, Suzanne M., Compernolle, Frans, Hoornaert, Georges J.

“…An intramolecular Diels−Alder strategy using 2(1H)‐pyrazinones was applied to generate a substituted perhydro‐1,7‐naphthyridine ring system that served as a…”
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Synthesis and conformational analysis of Substance P antagonist analogues based on a 1,7-naphthyridine scaffold by Rombouts, Frederik J.R, Van den Bossche, Jeroen, Toppet, Suzanne M, Compernolle, Frans, Hoornaert, Georges J

“…Two analogues of formerly described piperidine-based Substance P antagonists have been synthesised using an intramolecular Diels–Alder reaction of…”
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Intramolecular Diels–Alder reactions of N-alkenyl-2(1 H)-pyrazinones: generation of a novel type of cis-1,7-naphthyridine by Rombouts, Frederik J.R, De Borggraeve, Wim, Toppet, Suzanne M, Compernolle, Frans, Hoornaert, Georges J

“…The intramolecular Diels–Alder reaction of three 1-(ω-alkenyl)-2(1 H)-pyrazinones was investigated. Cycloaddition was shown to proceed for 1-(4-pentenyl)- and…”
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Acute torsion of a wandering spleen in a child: preoperative diagnosis by ultrasonography and computed tomography by Saadaoui, Hassen, Toppet, Véronique M., Hubloux, Guido, Horth, Martin, Cadière, Guy B., Spehl, Marianne R.

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Corticosteroids in primary tuberculosis with bronchial obstruction by Toppet, M, Malfroot, A, Derde, M P, Toppet, V, Spehl, M, Dab, I

“…The usefulness of prednisolone in combination with the modern potent antituberculous drugs has been studied in 29 children with primary lung tuberculosis and…”
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OESOPHAGEAL MOTILITY DISORDERS IN CORNELIA DE LANGE SYNDROME ORIGINAL FEATURE OR OESOPHAGITIS RELATED ABNORMALITIES? by Scaillon, M., De LAET, M. H., Toppet, M., Cadranel, S.

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Growth failure, encephalopathy, and endocrine dysfunctions in two siblings, one with 5-oxoprolinase deficiency by COHEN, L. H. F, VAMOS, E, HEINRICHS, C, TOPPET, M, COURTENS, W, KUMPS, A, MARDENS, Y, CARLSSON, B, GRILLNER, L, LARSSON, A

“…Two female siblings, born to consanguineous parents, presented with a similar phenotype characterized by severe growth and developmental failure, dysmorphic…”
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Cycloaddition of 3-Amino-5-chloro-2(1H)-pyrazinones and Olefins:  Ring Transformation into 3-Amino- or 6-Cyano-Substituted 2-Pyridinone Systems by Vandenberghe, Stef M, Buysens, Kris J, Meerpoel, Lieven, Loosen, Patrick K, Toppet, Suzanne M, Hoornaert, Georges J

“…The cycloadducts formed from the Diels−Alder reaction of 3-amino-5-chloro-2(1H)-pyrazinones with methyl acrylate in toluene are subject to two alternative…”
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Tuberculosis in children : a 13-year follow up of 1714 patients in a Belgian home care centre by TOPPET, M, MALFROOT, A, HOFMAN, B, CASIMIR, G, CANTRAINE, F, DAB, I

“…From May 1970 to September 1983, 1714 children with different forms of primary tuberculosis were referred to the paediatric home care centre (Enfants soignés…”
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Vasopressin and gonadotropin deficiency in a boy with the ectrodactyly-ectodermal dysplasia-clefting syndrome by Van Maldergem, L, Gillerot, Y, Vamos, E, Toppet, M, Watillon, P, Van Vliet, G

“…A boy presented with ectrodactyly (lobster claw deformity), bilateral cleft lip and palate, semilobar holoprosencephaly and microcephaly, associated with…”
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Interleukin-2 and soluble interleukin-2 receptor levels in children with active pulmonary tuberculosis and atypical mycobacterial adenitis by Nyabenda, J, Turneer, M, Waelbroeck, A, Duvivier, A, Toppet, M

“…Interleukin-2 (IL-2) level was measured in sera and in supernatants of Purified Protein Derivatives of Tuberculin (PPD) stimulated peripheral blood mononuclear…”
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Five years of experience with hydroxyurea in children and young adults with sickle cell disease by Ferster, Alina, Tahriri, Parvine, Vermylen, Christiane, Sturbois, Geneviève, Corazza, Francis, Fondu, Pierre, Devalck, Christine, Dresse, Marie F., Feremans, Walter, Hunninck, Kathleen, Toppet, Michele, Philippet, Pierre, Van Geet, Chris, Sariban, Eric

“…The short-term beneficial effect of hydroxyurea (HU) in sickle cell disease (SCD) has been proven by randomized studies in children and adults. The Belgian…”
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The determinant role of an accurate medicosocial approach in the prognosis of pediatric blood diseases by Toppet, M

“…The care of infancy and childhood blood diseases implies a comprehensive medicosocial approach. This is a prerequisite for regular follow-up, for satisfactory…”
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Neutrophil dysfunctions in thalassaemia major: the role of cell iron overload by Cantinieaux, B, Hariga, C, Ferster, A, De Maertelaere, E, Toppet, M, Fondu, P

“…The susceptibility to infections was recorded in 13 patients with beta thalassaemia major (T.P.). The following parameters were also investigated in their…”
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Factor VIII inhibitor in mild haemophilia by Capel, P, Toppet, M, van Remoortel, E, Fondu, P

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Diels–Alder reactions with pyridine o-quinodimethanes generated from pyridine sulfolenes by Cappelle, Steven L, Vogels, Ilse A, Govaerts, Tom C, Toppet, Suzanne M, Compernolle, Frans, Hoornaert, Georges J

“…An efficient route has been developed for the synthesis of polysubstituted 6,6-dioxo-6,7-dihydrothieno[3,4- b]pyridines 3 , which serve as excellent precursors…”
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