Search Results - "TOPLEY, Nicholas"

The Pathophysiology of the Peritoneal Membrane by DEVUYST, Olivier, MARGETTS, Peter J, TOPLEY, Nicholas

“…The development of peritoneal dialysis (PD) as a successful therapy has and still depends on experimental models to test and understand critical pieces of…”
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Barriers and facilitators to physical activity: A comparative analysis of transplant athletes competing in high intensity sporting events with other transplant recipients by Rienties, Bart, Duncan, Elaine, Judd, Perry, Oakley, Ben, Pengel, Liset H M, Roelen, Keetie, Topley, Nicholas

“…There is widespread recognition that many transplant recipients struggle to become and remain physically active. However, some transplant recipients do…”
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Independent Effects of Systemic and Peritoneal Inflammation on Peritoneal Dialysis Survival by LAMBIE, Mark, CHESS, James, DORVAL, Marc, SUMMERS, Angela, WILLIAMS, John D, BANKART, John, DAVIES, Simon J, TOPLEY, Nicholas, DONOVAN, Kieron L, YONG LIM KIM, JUN YOUNG DO, HI BAHL LEE, HYUNJIN NOH, WILLIAMS, Paul F, WILLIAMS, Andrew J, DAVISON, Sara

“…Systemic inflammation, as evidenced by elevated inflammatory cytokines, is a feature of advanced renal failure and predicts worse survival. Dialysate IL-6…”
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IL-6 Regulates Neutrophil Trafficking during Acute Inflammation via STAT3 by Fielding, Ceri A, McLoughlin, Rachel M, McLeod, Louise, Colmont, Chantal S, Najdovska, Meri, Grail, Dianne, Ernst, Matthias, Jones, Simon A, Topley, Nicholas, Jenkins, Brendan J

“…The successful resolution of inflammation is dependent upon the coordinated transition from the initial recruitment of neutrophils to a more sustained…”
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Pathogen-Specific Local Immune Fingerprints Diagnose Bacterial Infection in Peritoneal Dialysis Patients by LIN, Chan-Yu, ROBERTS, Gareth W, KIFT-MORGAN, Ann, DONOVAN, Kieron L, TOPLEY, Nicholas, EBERL, Matthias

“…Accurate and timely diagnosis of bacterial infection is crucial for effective and targeted treatment, yet routine microbiological identification is inefficient…”
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Peritoneal Protein Clearance Is a Function of Local Inflammation and Membrane Area Whereas Systemic Inflammation and Comorbidity Predict Survival of Incident Peritoneal Dialysis Patients by Yu, Zanzhe, Lambie, Mark, Chess, James, Williams, Andrew, Do, Jun-Young, Topley, Nicholas, Davies, Simon J

“…It is not clear whether the association of increased peritoneal protein clearance (PPCl) with worse survival on peritoneal dialysis (PD) is a consequence of…”
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Therapeutic Targeting of IL-6 Trans Signaling Counteracts STAT3 Control of Experimental Inflammatory Arthritis by Nowell, Mari A, Williams, Anwen S, Carty, Sarah A, Scheller, Jurgen, Hayes, Anthony J, Jones, Gareth W, Richards, Peter J, Slinn, Simon, Ernst, Matthias, Jenkins, Brendan J, Topley, Nicholas, Rose-John, Stefan, Jones, Simon A

“…Cytokine control of the synovial infiltrate is a central process in the development of inflammatory arthritis. In this study, we combine genetic approaches and…”
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The Euro-Balance Trial: The effect of a new biocompatible peritoneal dialysis fluid (balance) on the peritoneal membrane by Williams, John D., Topley, Nicholas, Craig, Kathrine J., Mackenzie, Ruth K., Pischetsrieder, Monika, Lage, Cristina, Passlick-deetjen, Jutta

“…The Euro-Balance Trial: The effect of a new biocompatible peritoneal dialysis fluid (balance) on the peritoneal membrane. Although peritoneal dialysis (PD) is…”
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IL‐10 differentially controls the infiltration of inflammatory macrophages and antigen‐presenting cells during inflammation by Liao, Chia‐Te, Rosas, Marcela, Davies, Luke C., Giles, Peter J., Tyrrell, Victoria J., O'Donnell, Valerie B., Topley, Nicholas, Humphreys, Ian R., Fraser, Donald J., Jones, Simon A., Taylor, Philip R.

“…The inflammatory activation and recruitment of defined myeloid populations is essential for controlling the bridge between innate and adaptive immunity and…”
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Human neutrophil clearance of bacterial pathogens triggers anti-microbial γδ T cell responses in early infection by Davey, Martin S, Lin, Chan-Yu, Roberts, Gareth W, Heuston, Sinéad, Brown, Amanda C, Chess, James A, Toleman, Mark A, Gahan, Cormac G M, Hill, Colin, Parish, Tanya, Williams, John D, Davies, Simon J, Johnson, David W, Topley, Nicholas, Moser, Bernhard, Eberl, Matthias

“…Human blood Vγ9/Vδ2 T cells, monocytes and neutrophils share a responsiveness toward inflammatory chemokines and are rapidly recruited to sites of infection…”
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IL-6 Trans-Signaling via STAT3 Directs T Cell Infiltration in Acute Inflammation by McLoughlin, Rachel M., Jenkins, Brendan J., Grail, Dianne, Williams, Anwen S., Fielding, Ceri A., Parker, Clare R., Ernst, Matthias, Topley, Nicholas, Jones, Simon A., Marrack, Philippa

“…Interleukin (IL)-6 signaling through its soluble receptor (IL-6 trans-signaling) directs transition between innate and acquired immune responses by…”
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TLR activation enhances C5a‐induced pro‐inflammatory responses by negatively modulating the second C5a receptor, C5L2 by Raby, Anne‐Catherine, Holst, Benjamin, Davies, James, Colmont, Chantal, Laumonnier, Yves, Coles, Barbara, Shah, Sanjoy, Hall, Judith, Topley, Nicholas, Köhl, Jörg, Morgan, B. Paul, Labéta, Mario O.

“…TLR and complement activation ensures efficient clearance of infection. Previous studies documented synergism between TLRs and the receptor for the…”
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Esterified eicosanoids are acutely generated by 5-lipoxygenase in primary human neutrophils and in human and murine infection by Clark, Stephen R., Guy, Christopher J., Scurr, Martin J., Taylor, Philip R, Kift-Morgan, Ann P., Hammond, Victoria J., Thomas, Christopher P., Coles, Barbara, Roberts, Gareth W., Eberl, Matthias, Jones, Simon A., Topley, Nicholas, Kotecha, Sailesh, O'Donnell, Valerie B.

“…5-Lipoxygenase (5-LOX) plays key roles in infection and allergic responses. Herein, four 5-LOX–derived lipids comprising 5-hydroxyeicosatetraenoic acid (HETE)…”
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The soluble interleukin 6 receptor: mechanisms of production and implications in disease by JONES, SIMON A., HORIUCHI, SANKICHI, TOPLEY, NICHOLAS, YAMAMOTO, NAOKI, FULLER, GERALD M.

“…ABSTRACT Interleukin 6 (IL‐6) performs a prominent role during disease and has been described as both a pro‐ and anti‐inflammatory cytokine. A key feature in…”
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IL-6 and Its Soluble Receptor Orchestrate a Temporal Switch in the Pattern of Leukocyte Recruitment Seen during Acute Inflammation by Hurst, Suzanne M, Wilkinson, Thomas S, McLoughlin, Rachel M, Jones, Suzanne, Horiuchi, Sankichi, Yamamoto, Naoki, Rose-John, Stefan, Fuller, Gerald M, Topley, Nicholas, Jones, Simon A

“…During acute inflammation, leukocyte recruitment is characterized by an initial infiltration of neutrophils, which are later replaced by a more sustained…”
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Soluble TLR2 Reduces Inflammation without Compromising Bacterial Clearance by Disrupting TLR2 Triggering by Raby, Anne-Catherine, Le Bouder, Emmanuel, Colmont, Chantal, Davies, James, Richards, Peter, Coles, Barbara, George, Christopher H, Jones, Simon A, Brennan, Paul, Topley, Nicholas, Labeta, Mario O

“…TLR overactivation may lead to end organ damage and serious acute and chronic inflammatory conditions. TLR responses must therefore be tightly regulated to…”
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12/15-Lipoxygenase Regulates the Inflammatory Response to Bacterial Products In Vivo by Dioszeghy, Vincent, Rosas, Marcela, Maskrey, Benjamin H, Colmont, Chantal, Topley, Nicholas, Chaitidis, Pavlos, Kuhn, Hartmut, Jones, Simon A, Taylor, Philip R, O'Donnell, Valerie B

“…The peritoneal macrophage (Mphi) is the site of greatest 12/15-lipoxygenase (12/15-LOX) expression in the mouse; however, its immunoregulatory role in this…”
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Human peritoneal mesothelial cells respond to bacterial ligands through a specific subset of Toll-like receptors by Colmont, Chantal S., Raby, Anne-Catherine, Dioszeghy, Vincent, LeBouder, Emmanuel, Foster, Thomas L., Jones, Simon A., Labéta, Mario O., Fielding, Ceri A., Topley, Nicholas

“…Background. Bacterial infection remains a major cause of morbidity and mortality in peritoneal dialysis (PD) patients worldwide. Previous studies have…”
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Peritoneal inflammation precedes encapsulating peritoneal sclerosis: results from the GLOBAL Fluid Study by Lambie, Mark R., Chess, James, Summers, Angela M., Williams, Paul Ford, Topley, Nicholas, Davies, Simon J.

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Soluble IL-6 Receptor Governs IL-6 Activity in Experimental Arthritis: Blockade of Arthritis Severity by Soluble Glycoprotein 130 by Nowell, Mari A, Richards, Peter J, Horiuchi, Sankichi, Yamamoto, Naoki, Rose-John, Stefan, Topley, Nicholas, Williams, Anwen S, Jones, Simon A

“…Studies in IL-6-deficient (IL-6(-/-)) mice highlight that IL-6 contributes to arthritis progression. However, the molecular mechanism controlling its activity…”
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