Search Results - "TOONE, J"

Inferring air–water temperature relationships from river and catchment properties by Johnson, M. F, Wilby, R. L, Toone, J. A

“…Water temperature (Tw) is a key determinant of freshwater ecosystem status and cause for concern under a changing climate. Hence, there is growing interest in…”
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Drug design from the cryptic inhibitor envelope by Lee, Chul-Jin, Liang, Xiaofei, Wu, Qinglin, Najeeb, Javaria, Zhao, Jinshi, Gopalaswamy, Ramesh, Titecat, Marie, Sebbane, Florent, Lemaitre, Nadine, Toone, Eric J., Zhou, Pei

“…Conformational dynamics plays an important role in enzyme catalysis, allosteric regulation of protein functions and assembly of macromolecular complexes…”
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In Situ Growth of a Stoichiometric Peg-Like Conjugate at a Protein's N-terminus with Significantly Improved Pharmacokinetics by Gao, Weiping, Liu, Wenge, Mackay, J. Andrew, Zalutsky, Michael R., Toone, Eric J., Chilkoti, Ashutosh, Demain, Arnold L.

“…The challenge in the synthesis of protein-polymer conjugates for biological applications is to synthesize a stoichiometric (typically 1:1) conjugate of the…”
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The Cluster Glycoside Effect by Lundquist, Joseph J, Toone, Eric J

“…Lundquist and Toone review the cluster glycoside effect, considering first the construction of multivalent saccharides, next the various assays used to…”
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Photo-activated psoralen binds the ErbB2 catalytic kinase domain, blocking ErbB2 signaling and triggering tumor cell apoptosis by Xia, Wenle, Gooden, David, Liu, Leihua, Zhao, Sumin, Soderblom, Erik J, Toone, Eric J, Beyer, Jr, Wayne F, Walder, Harold, Spector, Neil L

“…Photo-activation of psoralen with UVA irradiation, referred to as PUVA, is used in the treatment of proliferative skin disorders. The anti-proliferative…”
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Nocturnal river water temperatures: Spatial and temporal variations by Wilby, R.L., Johnson, M.F., Toone, J.A.

“…Nocturnal water temperature (Tw) affects the behaviour of aquatic biota and metabolism of whole rivers. However, night-time water temperature (nTw) is poorly…”
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Derivatives of Plant Phenolic Compound Affect the Type III Secretion System of Pseudomonas aeruginosa via a GacS-GacA Two-Component Signal Transduction System by YAMAZAKI, Akihiro, JIN LI, QUAN ZENG, KHOKHANI, Devanshi, HUTCHINS, William C, YOST, Angela C, BIDDLE, Eulandria, TOONE, Eric J, XIN CHEN, YANG, Ching-Hong

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Curative Treatment of Severe Gram-Negative Bacterial Infections by a New Class of Antibiotics Targeting LpxC by Lemaître, Nadine, Liang, Xiaofei, Najeeb, Javaria, Lee, Chul-Jin, Titecat, Marie, Leteurtre, Emmanuelle, Simonet, Michel, Toone, Eric J, Zhou, Pei, Sebbane, Florent

“…The infectious diseases caused by multidrug-resistant bacteria pose serious threats to humankind. It has been suggested that an antibiotic targeting LpxC of…”
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Improving upon Nature: Active Site Remodeling Produces Highly Efficient Aldolase Activity toward Hydrophobic Electrophilic Substrates by Cheriyan, Manoj, Toone, Eric J, Fierke, Carol A

“…The substrate specificity of enzymes is frequently narrow and constrained by multiple interactions, limiting the use of natural enzymes in biocatalytic…”
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Natural history of nonketotic hyperglycinemia in 65 patients by HOOVER-FONG, J. E, SHAH, S, VAN HOVE, J. L. K, APPLEGARTH, D, TOONE, J, HAMOSH, A

“…Glycine encephalopathy, also known as nonketotic hyperglycinemia (NKH), is an autosomal recessive disorder caused by a defect in the glycine cleavage system…”
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A Small-Molecule Inhibitor of Isoprenylcysteine Carboxyl Methyltransferase with Antitumor Activity in Cancer Cells by Winter-Vann, Ann M., Baron, Rudi A., Wong, Waihay, dela Cruz, June, York, John D., Gooden, David M., Bergo, Martin O., Young, Stephen G., Toone, Eric J., Casey, Patrick J., Glomset, John A.

“…Many key regulatory proteins, including members of the Ras family of GTPases, are modified at their C terminus by a process termed prenylation. This processing…”
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Lipooligosaccharide is required for the generation of infectious elementary bodies in Chlamydia trachomatis by Nguyen, Bidong D, Cunningham, Doreen, Liang, Xiaofei, Chen, Xin, Toone, Eric J, Raetz, Christian R.H, Zhou, Pei, Valdivia, Raphael H

“…Lipopolysaccharides (LPS) and lipooligosaccharides (LOS) are the main lipid components of bacterial outer membranes and are essential for cell viability in…”
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Glycine encephalopathy (nonketotic hyperglycinaemia): Review and update by Applegarth, D. A., Toone, J. R.

“…This article summarizes data and issues covered in the workshop on Glycine Encephalopathy using headings that cover important topics in our present knowledge…”
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On the Meaning of Affinity:  Cluster Glycoside Effects and Concanavalin A by Dimick, Sarah M, Powell, Steven C, McMahon, Stephen A, Moothoo, Davina N, Naismith, James H, Toone, Eric J

“…The inhibition of protein−carbohydrate interaction provides a powerful therapeutic strategy for the treatment of myriad human diseases. To date, application of…”
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Soft-Lithographic Approach to Functionalization and Nanopatterning Oxide-Free Silicon by Shestopalov, Alexander A., Morris, Carleen J., Vogen, Briana N., Hoertz, Amanda, Clark, Robert L., Toone, Eric J.

“…We report a simple, reliable high-throughput method for patterning passivated silicon with reactive organic monolayers and demonstrate selective…”
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Identification and Inhibitory Properties of a Novel Ca2+/Calmodulin Antagonist by Colomer, Josep, Schmitt, Allison A, Toone, Eric J, Means, Anthony R

“…We developed a high-throughput yeast-based assay to screen for chemical inhibitors of Ca2+/calmodulin-dependent kinase pathways. After screening two small…”
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Incidence of Inborn Errors of Metabolism in British Columbia, 1969-1996 by Applegarth, Derek A, Toone, Jennifer R, Lowry, RT{section}; and R. Brian

“…To determine how many children with specific types of inborn errors of metabolism are born each year in British Columbia, Canada. This population provides a…”
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Isocaloric carbohydrate versus carbohydrate-protein ingestion and cycling time-trial performance by Toone, Rebecca J, Betts, James A

“…This study was designed to compare the effects of energy-matched carbohydrate (CHO) and carbohydrate-protein (CHO-PRO) supplements on cycling time-trial…”
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Multivalency Effects in Protein−Carbohydrate Interaction:  The Binding of the Shiga-like Toxin 1 Binding Subunit to Multivalent C-Linked Glycopeptides by Lundquist, Joseph J, Debenham, Sheryl D, Toone, Eric J

“…A series of monovalent and bivalent glycopeptides displaying a C-linked analogue of the Pk trisaccharide, the in vivo ligand for the pentavalent Shiga-like…”
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S−N Dissociation Energies of S-Nitrosothiols:  On the Origins of Nitrosothiol Decomposition Rates by Bartberger, Michael D, Mannion, Joseph D, Powell, Steven C, Stamler, Jonathan S, Houk, K. N, Toone, Eric J

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