Search Results - "TOOLE, A"

The impact of public basic research on industrial innovation: Evidence from the pharmaceutical industry by Toole, Andrew A.

“…• Generalizes case study findings on public biomedical research and drug innovation. • Finds that public basic research contributes significantly to industry…”
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Delay and secrecy: Does industry sponsorship jeopardize disclosure of academic research? by Czarnitzki, Dirk, Grimpe, Christoph, Toole, Andrew A

“…The viability of modern open science norms and practices depend on public disclosure of new knowledge, methods, and materials. Aggregate data from the OECD…”
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PATENT PROTECTION, MARKET UNCERTAINTY, AND R&D INVESTMENT by Czarnitzki, Dirk, Toole, Andrew A.

“…The main reason governments grant patent protection is to spur innovation. However, the size of the R&D stimulus from patent protection is far from clear…”
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The Evolving Institutional Structure of Public and Private Agricultural Research by Fuglie, Keith O., Toole, Andrew A.

“…Over the past several decades, the private sector has assumed a larger role in developing improved technology for food and agriculture. Private companies fund…”
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Exploring the Relationship Between Scientist Human Capital and Firm Performance: The Case of Biomedical Academic Entrepreneurs in the SBIR Program by Toole, Andrew A, Czarnitzki, Dirk

“…There is an emerging debate in the scholarly literature regarding the extent to which academic human capital contributes to firm performance. This debate…”
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Digestibility of gluten proteins is reduced by baking and enhanced by starch digestion by Smith, Frances, Pan, Xiaoyan, Bellido, Vincent, Toole, Geraldine A, Gates, Fred K, Wickham, Martin S. J, Shewry, Peter R, Bakalis, Serafim, Padfield, Philip, Mills, E. N. Clare

“…SCOPE: Resistance of proteins to gastrointestinal digestion may play a role in determining immune‐mediated adverse reactions to foods. However, digestion…”
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Homologs of the LapD-LapG c-di-GMP Effector System Control Biofilm Formation by Bordetella bronchiseptica by Ambrosis, Nicolás, Boyd, Chelsea D, O Toole, George A, Fernández, Julieta, Sisti, Federico

“…Biofilm formation is important for infection by many pathogens. Bordetella bronchiseptica causes respiratory tract infections in mammals and forms biofilm…”
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Desmoglein 3 promotes cancer cell migration and invasion by regulating activator protein 1 and protein kinase C-dependent-Ezrin activation by Brown, L, Waseem, A, Cruz, I N, Szary, J, Gunic, E, Mannan, T, Unadkat, M, Yang, M, Valderrama, F, O′Toole, E A, Wan, H

“…Desmoglein 3 (Dsg3), the pemphigus vulgaris antigen, has recently been shown to be upregulated in squamous cell carcinoma (SCC) and has been identified as a…”
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An integrated study of grain development of wheat (cv. Hereward) by Shewry, Peter R., Mitchell, Rowan A.C., Tosi, Paola, Wan, Yongfang, Underwood, Claudia, Lovegrove, Alison, Freeman, Jackie, Toole, Geraldine A., Mills, E.N. Clare, Ward, Jane L.

“…We have carried out a detailed study of grain development of wheat cv. Hereward in order to provide a reference source for researchers and to obtain new…”
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Is public R&D a complement or substitute for private R&D? A review of the econometric evidence by David, Paul A., Hall, Bronwyn H., Toole, Andrew A.

“…Is public R&D spending complementary and thus “additional” to private R&D spending, or does it substitute for and tend to “crowd out” private R&D? Conflicting…”
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Light-driven cycling of dimethylsulfide (DMS) in the Sargasso Sea: Closing the loop by Toole, Dierdre A., Siegel, David A.

“…The factors driving dimethylsulfide (DMS) cycling in oligotrophic environments are isolated using a time‐series of DMS sampled in the Sargasso Sea. The…”
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Business R&D and the Interplay of R&D Subsidies and Product Market Uncertainty by Czarnitzki, Dirk, Toole, Andrew A.

“…This paper examines the effect of product market uncertainty and government research and development (R&D) subsidies on firm-level R&D investment. Using a…”
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Procoagulant activity in gynaecological cancer patients; the effect of surgery and chemotherapy by Abu Saadeh, F, Langhe, R, Galvin, D.M, O Toole, S.A, O'Donnell, D.M, Gleeson, N, Norris, L.A

“…Abstract Background Gynaecological cancers are associated with high rates of venous thromboembolism (VTE). Studies on ambulatory cancer patients do not support…”
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Does Public Scientific Research Complement Private Investment in Research and Development in the Pharmaceutical Industry? by Toole, Andrew A.

“…This paper analyzes how pharmaceutical research and development (R&D) investment responds to publicly supported biomedical research performed mainly at…”
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Involving patients in healthcare research is well documented but can it work in lab-based research? by Connor, Adele E, Hughes, Claire, Schäfer, Lea, McNally, Lorraine, Raw, Deirdre O, Bahramian, Katayoun, Carr, Bridget, Dunne, Ingrid Halligan, Lysaght, Joanne, Toole, Sharon A. O, Simpson, Jeremy C, Perry, Antoinette S

“…Abstract Public and Patient Involvement in research is becoming a requirement on most research funding applications; this includes both healthcare and…”
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A light-driven, one-dimensional dimethylsulfide biogeochemical cycling model for the Sargasso Sea by Toole, Dierdre A., Siegel, David A., Doney, Scott C.

“…We evaluate the extent to which dimethylsulfide (DMS) cycling in an open‐ocean environment can be constrained and parameterized utilizing emerging evidence for…”
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Low-Dose Single Agent Weekly Carboplatin (2 AUC/M2 ) Is an Adequate Radiosensitizer in the Treatment of Oropharyngeal Cancer by Held, M.R, Aref, A, Szpunar, S, Leonard, R, Toole, A, Agnone, E, Chuba, P

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Biological Consumption of Dimethylsulfide (DMS) and Its Importance in DMS Dynamics in the Ross Sea, Antarctica by del Valle, Daniela A., Kieber, David J., Toole, Dierdre A., Brinkley, Jordan, Kiene, Ronald P.

“…We studied the biological consumption of dimethylsulfide (DMS) and its role in controlling DMS concentrations in the Ross Sea, Antarctica, during the spring…”
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Dissolved DMSO production via biological and photochemical oxidation of dissolved DMS in the Ross Sea, Antarctica by del Valle, Daniela A., Kieber, David J., Toole, Dierdre A., Bisgrove, John, Kiene, Ronald P.

“…Dimethylsulfoxide (DMSO) is an important degradation product of the climate-influencing gas dimethylsulfide (DMS). In the Ross Sea, Antarctica, dissolved DMSO…”
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How does initial public financing influence private incentives for follow-on investment in early-stage technologies? by Toole, Andrew A, Turvey, Calum

“…One common rationale supporting public financing programs for small firms is that initial public investment creates incentives for follow-on private…”
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