Search Results - "TOMLINSON, Ian P"

The effects of mutational processes and selection on driver mutations across cancer types by Temko, Daniel, Tomlinson, Ian P. M., Severini, Simone, Schuster-Böckler, Benjamin, Graham, Trevor A.

“…Epidemiological evidence has long associated environmental mutagens with increased cancer risk. However, links between specific mutation-causing processes and…”
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Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase by Frezza, Christian, Zheng, Liang, Folger, Ori, Rajagopalan, Kartik N., MacKenzie, Elaine D., Jerby, Livnat, Micaroni, Massimo, Chaneton, Barbara, Adam, Julie, Hedley, Ann, Kalna, Gabriela, Tomlinson, Ian P. M., Pollard, Patrick J., Watson, Dave G., Deberardinis, Ralph J., Shlomi, Tomer, Ruppin, Eytan, Gottlieb, Eyal

“…Drug targets for kidney cancer Inherited mutations in fumarate hydratase (FH), an enzyme in the tricarboxylic acid cycle — which links many of the metabolic…”
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Mitochondrial tumour suppressors: a genetic and biochemical update by Gottlieb, Eyal, Tomlinson, Ian P. M

“…Since the discovery 5 years ago that the D-subunit of succinate dehydrogenase (SDHD) can behave as a classic tumour suppressor, other nuclear-encoded…”
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Prognostic significance of POLE proofreading mutations in endometrial cancer by Church, David N, Stelloo, Ellen, Nout, Remi A, Valtcheva, Nadejda, Depreeuw, Jeroen, ter Haar, Natalja, Noske, Aurelia, Amant, Frederic, Tomlinson, Ian P M, Wild, Peter J, Lambrechts, Diether, Jürgenliemk-Schulz, Ina M, Jobsen, Jan J, Smit, Vincent T H B M, Creutzberg, Carien L, Bosse, Tjalling

“…Current risk stratification in endometrial cancer (EC) results in frequent over- and underuse of adjuvant therapy, and may be improved by novel biomarkers. We…”
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Chromosomal Instability Confers Intrinsic Multidrug Resistance by LEE, Alvin J. X, ENDESFELDER, David, KSCHISCHO, Maik, SWANTON, Charles, ROWAN, Andrew J, WALTHER, Axel, BIRKBAK, Nicolai J, ANDREW FUTREAL, P, DOWNWARD, Julian, SZALLASI, Zoltan, TOMLINSON, Ian P. M, HOWELL, Michael

“…Aneuploidy is associated with poor prognosis in solid tumors. Spontaneous chromosome missegregation events in aneuploid cells promote chromosomal instability…”
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Evaluation of PIK3CA Mutation As a Predictor of Benefit From Nonsteroidal Anti-Inflammatory Drug Therapy in Colorectal Cancer by DOMINGO, Enric, CHURCH, David N, SIEBER, Oliver, RAMAMOORTHY, Rajarajan, YANAGISAWA, Yoko, JOHNSTONE, Elaine, DAVIDSON, Brian, KERR, David J, TOMLINSON, Ian P. M, MIDGLEY, Rachel

“…Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) protect against colorectal cancer (CRC) and are associated with reduced disease recurrence and…”
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Colorectal Cancer Cell Lines Are Representative Models of the Main Molecular Subtypes of Primary Cancer by MOURADOV, Dmitri, SLOGGETT, Clare, O'CONNOR, Liam, WILDING, Jennifer L, BICKNELL, David, TOMLINSON, Ian P. M, BODMER, Walter F, MARIADASON, John M, SIEBER, Oliver M, JORISSEN, Robert N, LOVE, Christopher G, SHAN LI, BURGESS, Antony W, ARANGO, Diego, STRAUSBERG, Robert L, BUCHANAN, Daniel, WORMALD, Samuel

“…Human colorectal cancer cell lines are used widely to investigate tumor biology, experimental therapy, and biomarkers. However, to what extent these…”
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Replication stress links structural and numerical cancer chromosomal instability by Burrell, Rebecca A., McClelland, Sarah E., Endesfelder, David, Groth, Petra, Weller, Marie-Christine, Shaikh, Nadeem, Domingo, Enric, Kanu, Nnennaya, Dewhurst, Sally M., Gronroos, Eva, Chew, Su Kit, Rowan, Andrew J., Schenk, Arne, Sheffer, Michal, Howell, Michael, Kschischo, Maik, Behrens, Axel, Helleday, Thomas, Bartek, Jiri, Tomlinson, Ian P., Swanton, Charles

“…A mechanism to explain chromosomal instability (CIN) in colorectal cancer is demonstrated; three new CIN-suppressor genes ( PIGN , MEX3C and ZNF516 ) encoded…”
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Measuring single cell divisions in human tissues from multi-region sequencing data by Werner, Benjamin, Case, Jack, Williams, Marc J., Chkhaidze, Ketevan, Temko, Daniel, Fernández-Mateos, Javier, Cresswell, George D., Nichol, Daniel, Cross, William, Spiteri, Inmaculada, Huang, Weini, Tomlinson, Ian P. M., Barnes, Chris P., Graham, Trevor A., Sottoriva, Andrea

“…Both normal tissue development and cancer growth are driven by a branching process of cell division and mutation accumulation that leads to intra-tissue…”
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The importance of p53 pathway genetics in inherited and somatic cancer genomes by Stracquadanio, Giovanni, Wang, Xuting, Wallace, Marsha D., Grawenda, Anna M., Zhang, Ping, Hewitt, Juliet, Zeron-Medina, Jorge, Castro-Giner, Francesc, Tomlinson, Ian P., Goding, Colin R., Cygan, Kamil J., Fairbrother, William G., Thomas, Laurent F., Sætrom, Pål, Gemignani, Federica, Landi, Stefano, Schuster-Böckler, Benjamin, Bell, Douglas A., Bond, Gareth L.

“…Key Points In this Analysis, we explore the possibility that commonly inherited genetic variants in the p53 pathway play a significant part in susceptibility…”
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Genetically predicted physical activity levels are associated with lower colorectal cancer risk: a Mendelian randomisation study by Zhang, Xiaomeng, Theodoratou, Evropi, Li, Xue, Farrington, Susan M., Law, Philip J., Broderick, Peter, Walker, Marion, Klimentidis, Yann C., Rees, Jessica M. B., Houlston, Richard S., Tomlinson, Ian P. M., Burgess, Stephen, Campbell, Harry, Dunlop, Malcolm G., Timofeeva, Maria

“…Background We conducted a Mendelian randomisation (MR) study to investigate whether physical activity (PA) causes a reduction of colorectal cancer risk and to…”
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Phenome-wide association study (PheWAS) of colorectal cancer risk SNP effects on health outcomes in UK Biobank by Zhang, Xiaomeng, Li, Xue, He, Yazhou, Law, Philip J., Farrington, Susan M., Campbell, Harry, Tomlinson, Ian P. M., Houlston, Richard S., Dunlop, Malcolm G., Timofeeva, Maria, Theodoratou, Evropi

“…Background Associations between colorectal cancer (CRC) and other health outcomes have been reported, but these may be subject to biases, or due to limitations…”
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Common genetic variants at the 11q13.3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 expression by Schödel, Johannes, Bardella, Chiara, Sciesielski, Lina K, Brown, Jill M, Pugh, Chris W, Buckle, Veronica, Tomlinson, Ian P, Ratcliffe, Peter J, Mole, David R

“…Johannes Schödel and colleagues report the identification of a distant transcriptional enhancer of CCND1 at the recently identified renal cell carcinoma…”
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Genomic Evolution and Transcriptional Changes in the Evolution of Prostate Cancer into Neuroendocrine and Ductal Carcinoma Types by Rao, Srinivasa R, Protheroe, Andrew, Cerundolo, Lucia, Maldonado-Perez, David, Browning, Lisa, Lamb, Alastair D, Bryant, Richard J, Mills, Ian G, Woodcock, Dan J, Hamdy, Freddie C, Tomlinson, Ian P M, Verrill, Clare

“…Prostate cancer is typically of acinar adenocarcinoma type but can occasionally present as neuroendocrine and/or ductal type carcinoma. These are associated…”
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KRAS Mutation Is Associated with Lung Metastasis in Patients with Curatively Resected Colorectal Cancer by TIE, Jeanne, LIPTON, Lara, PICK, Adrian W, KNIGHT, Simon, CARNE, Peter W. G, BERRY, Roger, POLGLASE, Adrian, MCMURRICK, Paul, QI ZHAO, BUSAM, Dana, STRAUSBERG, Robert L, DOMINGO, Enric, DESAI, Jayesh, TOMLINSON, Ian P. M, MIDGLEY, Rachel, KERR, David, SIEBER, Oliver M, GIBBS, Peter, JORISSEN, Robert N, CHRISTIE, Michael, DRUMMOND, Katharine J, THOMSON, Benjamin N. J, USATOFF, Valery, EVANS, Peter M

“…Oncogene mutations contribute to colorectal cancer development. We searched for differences in oncogene mutation profiles between colorectal cancer metastases…”
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A Polymorphic p53 Response Element in KIT Ligand Influences Cancer Risk and Has Undergone Natural Selection by Zeron-Medina, Jorge, Wang, Xuting, Repapi, Emmanouela, Campbell, Michelle R., Su, Dan, Castro-Giner, Francesc, Davies, Benjamin, Peterse, Elisabeth F.P., Sacilotto, Natalia, Walker, Graeme J., Terzian, Tamara, Tomlinson, Ian P., Box, Neil F., Meinshausen, Nicolai, De Val, Sarah, Bell, Douglas A., Bond, Gareth L.

“…The ability of p53 to regulate transcription is crucial for tumor suppression and implies that inherited polymorphisms in functional p53-binding sites could…”
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Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status by Bardella, Chiara, El-Bahrawy, Mona, Frizzell, Norma, Adam, Julie, Ternette, Nicola, Hatipoglu, Emine, Howarth, Kimberley, O'Flaherty, Linda, Roberts, Ian, Turner, Gareth, Taylor, Jennifer, Giaslakiotis, Konstantinos, Macaulay, Valentine M, Harris, Adrian L, Chandra, Ashish, Lehtonen, Heli J, Launonen, Virpi, Aaltonen, Lauri A, Pugh, Christopher W, Mihai, Radu, Trudgian, David, Kessler, Benedikt, Baynes, John W, Ratcliffe, Peter J, Tomlinson, Ian P, Pollard, Patrick J

“…Germline mutations in the FH gene encoding the Krebs cycle enzyme fumarate hydratase predispose to hereditary leiomyomatosis and renal cell cancer (HLRCC)…”
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Novel Breast Cancer Susceptibility Locus at 9q31.2: Results of a Genome-Wide Association Study by FLETCHER, Olivia, JOHNSON, Nichola, COUPLAND, Ben, BRODERICK, Peter, SCHOEMAKER, Minouk, JONES, Michael, WILLIAMSON, Jill, CHILCOTT-BURNS, Sarah, TOMCZYK, Katarzyna, SIMPSON, Gemma, JACOBS, Kevin B, CHANOCK, Stephen J, ORR, Nick, HUNTER, David J, TOMLINSON, Ian P, SWERDLOW, Anthony, ASHWORTH, Alan, ROSS, Gillian, DOS SANTOS SILVA, Isabel, LATHROP, Mark, HOULSTON, Richard S, PETO, Julian, HOSKING, Fay J, GIBSON, Lorna J, WALKER, Kate, ZELENIKA, Diana, GUT, Ivo, HEATH, Simon, PALLES, Claire

“…Genome-wide association studies have identified several common genetic variants associated with breast cancer risk. It is likely, however, that a substantial…”
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Oncogenic IDH1 Mutations Promote Enhanced Proline Synthesis through PYCR1 to Support the Maintenance of Mitochondrial Redox Homeostasis by Hollinshead, Kate E.R., Munford, Haydn, Eales, Katherine L., Bardella, Chiara, Li, Chunjie, Escribano-Gonzalez, Cristina, Thakker, Alpesh, Nonnenmacher, Yannic, Kluckova, Katarina, Jeeves, Mark, Murren, Robert, Cuozzo, Federica, Ye, Dan, Laurenti, Giulio, Zhu, Wei, Hiller, Karsten, Hodson, David J., Hua, Wei, Tomlinson, Ian P., Ludwig, Christian, Mao, Ying, Tennant, Daniel A.

“…Since the discovery of mutations in isocitrate dehydrogenase 1 (IDH1) in gliomas and other tumors, significant efforts have been made to gain a deeper…”
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Author Correction: The effects of mutational processes and selection on driver mutations across cancer types by Temko, Daniel, Tomlinson, Ian P. M., Severini, Simone, Schuster-Böckler, Benjamin, Graham, Trevor A.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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