Search Results - "TOMITA, Tsutomu"

Three Cases of Unprovoked Venous Thromboembolism with Prothrombin p.Arg596Gln Variant and a Literature Review of Antithrombin Resistance by Tsuji, Akihiro, Miyata, Toshiyuki, Sekine, Akihiro, Neki, Reiko, Kokame, Koichi, Tomita, Tsutomu, Kashima, Yumi, Asano, Ryotaro, Ueda, Jin, Aoki, Tatsuo, Ogo, Takeshi

“…Antithrombin resistance (ATR) is a newly identified strong genetic predisposition to venous thromboembolism (VTE) caused by genetic variations in prothrombin…”
Get full text

Comparative studies of hair shaft components between healthy and diseased donors by Ota, Atsuko, Kitamura, Hiroaki, Sugimoto, Keigo, Ogawa, Miho, Dohmae, Naoshi, Okuno, Hiroki, Takahashi, Kazuya, Ikeda, Kazutaka, Tomita, Tsutomu, Matsuoka, Naoki, Matsuishi, Kunitaka, Inokuma, Tetsuro, Nagano, Tohru, Takeo, Makoto, Tsuji, Takashi

“…Globally, the rapid aging of the population is predicted to become even more severe in the second half of the 21st century. Thus, it is expected to establish a…”
Get full text

Exploring the genetic diversity of the Japanese population: Insights from a large-scale whole genome sequencing analysis by Kawai, Yosuke, Watanabe, Yusuke, Omae, Yosuke, Miyahara, Reiko, Khor, Seik-Soon, Noiri, Eisei, Kitajima, Koji, Shimanuki, Hideyuki, Gatanaga, Hiroyuki, Hata, Kenichiro, Hattori, Kotaro, Iida, Aritoshi, Ishibashi-Ueda, Hatsue, Kaname, Tadashi, Kanto, Tatsuya, Matsumura, Ryo, Miyo, Kengo, Noguchi, Michio, Ozaki, Kouichi, Sugiyama, Masaya, Takahashi, Ayako, Tokuda, Haruhiko, Tomita, Tsutomu, Umezawa, Akihiro, Watanabe, Hiroshi, Yoshida, Sumiko, Goto, Yu-Ichi, Maruoka, Yutaka, Matsubara, Yoichi, Niida, Shumpei, Mizokami, Masashi, Tokunaga, Katsushi

“…The Japanese archipelago is a terminal location for human migration, and the contemporary Japanese people represent a unique population whose genomic diversity…”
Get full text

Seipin is necessary for normal brain development and spermatogenesis in addition to adipogenesis by Ebihara, Chihiro, Ebihara, Ken, Aizawa-Abe, Megumi, Mashimo, Tomoji, Tomita, Tsutomu, Zhao, Mingming, Gumbilai, Valentino, Kusakabe, Toru, Yamamoto, Yuji, Aotani, Daisuke, Yamamoto-Kataoka, Sachiko, Sakai, Takeru, Hosoda, Kiminori, Serikawa, Tadao, Nakao, Kazuwa

“…Seipin, encoded by BSCL2 gene, is a protein whose physiological functions remain unclear. Mutations of BSCL2 cause the most-severe form of congenital…”
Get full text

Effect of tofogliflozin on cardiac and vascular endothelial function in patients with type 2 diabetes and heart diseases: A pilot study by Tochiya, Mayu, Makino, Hisashi, Tamanaha, Tamiko, Matsuo, Miki, Hishida, Ai, Koezuka, Ryo, Ohata, Yoko, Tomita, Tsutomu, Son, Choel, Miyamoto, Yoshihiro, Yasuda, Satoshi, Hosoda, Kiminori

“…Recent studies have shown that sodium–glucose cotransporter 2 inhibitors decrease the risk of heart failure in patients with type 2 diabetes. However, the…”
Get full text

Relevant use of Klotho in FGF19 subfamily signaling system in vivo by Tomiyama, Ken-ichi, Maeda, Ryota, Urakawa, Itaru, Yamazaki, Yuji, Tanaka, Tomohiro, Ito, Shinji, Nabeshima, Yoko, Tomita, Tsutomu, Odori, Shinji, Hosoda, Kiminori, Nakao, Kazuwa, Imura, Akihiro, Nabeshima, Yo-ichi

“…α-Klotho (α-Kl) and its homolog, β-Klotho (β-Kl) are key regulators of mineral homeostasis and bile acid/cholesterol metabolism, respectively. FGF15/…”
Get full text

Adipocyte-specific expression of C-type natriuretic peptide suppresses lipid metabolism and adipocyte hypertrophy in adipose tissues in mice fed high-fat diet by Bae, Cho-Rong, Hino, Jun, Hosoda, Hiroshi, Son, Cheol, Makino, Hisashi, Tokudome, Takeshi, Tomita, Tsutomu, Hosoda, Kiminori, Miyazato, Mikiya, Kangawa, Kenji

“…C-type natriuretic peptide (CNP) is expressed in diverse tissues, including adipose and endothelium, and exerts its effects by binding to and activating its…”
Get full text

Bazedoxifene Ameliorates Homocysteine-Induced Apoptosis and Accumulation of Advanced Glycation End Products by Reducing Oxidative Stress in MC3T3-E1 Cells by Kanazawa, Ippei, Tomita, Tsutomu, Miyazaki, Shun, Ozawa, Eiji, Yamamoto, Luis A., Sugimoto, Toshitsugu

“…Elevated plasma homocysteine (Hcy) level increases the risk of osteoporotic fracture by deteriorating bone quality. However, little is known about the effects…”
Get full text

Effect of Keishibukuryogan, a Japanese Traditional Kampo Prescription, on Improvement of Microcirculation and Oketsu and Induction of Endothelial Nitric Oxide: A Live Imaging Study by Aoyagi, Kazumasa, Matsui, Hirofumi, Hirayama, Aki, Tomita, Tsutomu

“…Oketsu is a characteristic condition that plays an important role in Kampo, Japanese traditional medicine, and includes multiple aspects of hemodynamic…”
Get full text

Overexpression of C-type Natriuretic Peptide in Endothelial Cells Protects against Insulin Resistance and Inflammation during Diet-induced Obesity by Bae, Cho-Rong, Hino, Jun, Hosoda, Hiroshi, Arai, Yuji, Son, Cheol, Makino, Hisashi, Tokudome, Takeshi, Tomita, Tsutomu, Kimura, Toru, Nojiri, Takashi, Hosoda, Kiminori, Miyazato, Mikiya, Kangawa, Kenji

“…The endogenous peptide C-type natriuretic peptide (CNP) binds its receptor, guanylyl cyclase B (GCB), and is expressed by endothelial cells in diverse tissues…”
Get full text

Morphological and functional adaptation of pancreatic islet blood vessels to insulin resistance is impaired in diabetic db/db mice by Okajima, Yuka, Matsuzaka, Takashi, Miyazaki, Shun, Motomura, Kaori, Ohno, Hiroshi, Sharma, Rahul, Shimura, Takuya, Istiqamah, Nurani, Han, Song-Iee, Mizunoe, Yuhei, Osaki, Yoshinori, Iwasaki, Hitoshi, Yatoh, Shigeru, Suzuki, Hiroaki, Sone, Hirohito, Miyamoto, Takafumi, Aita, Yuichi, Takeuchi, Yoshinori, Sekiya, Motohiro, Yahagi, Naoya, Nakagawa, Yoshimi, Tomita, Tsutomu, Shimano, Hitoshi

“…The pancreatic islet vasculature is of fundamental importance to the β-cell response to obesity-associated insulin resistance. To explore islet vascular…”
Get more information

Serum proteomic identification and validation of two novel atherosclerotic aortic aneurysm biomarkers, profilin 1 and complement factor D by Murakami, Yusuke, Nishigori, Mitsuhiro, Yagi, Hiroaki, Osaki, Tsukasa, Wakabayashi, Masaki, Shirai, Manabu, Son, Cheol, Iba, Yutaka, Minatoya, Kenji, Kusano, Kengo, Tomita, Tsutomu, Ishibashi-Ueda, Hatsue, Matsuda, Hitoshi, Minamino, Naoto

“…Effective diagnostic biomarkers for aortic aneurysm (AA) that are detectable in blood tests are required because early detection and rupture risk assessment of…”
Get full text

Mitochondrial reactive oxygen species accelerate gastric cancer cell invasion by Tamura, Masato, Matsui, Hirofumi, Tomita, Tsutomu, Sadakata, Hisato, Indo, Hiroko P., Majima, Hideyuki J., Kaneko, Tsuyoshi, Hyodo, Ichinosuke

“…Tumor invasion is the most important factor to decide patient’s prognosis. The relation between reactive oxygen species and tumor invasion is mainly reported…”
Get full text

Prevalence and Atypical Clinical Characteristics of NOTCH3 Mutations Among Patients Admitted for Acute Lacunar Infarctions by Okada, Takashi, Washida, Kazuo, Irie, Kenichi, Saito, Satoshi, Noguchi, Michio, Tomita, Tsutomu, Koga, Masatoshi, Toyoda, Kazunori, Okazaki, Shuhei, Koizumi, Takashi, Mizuta, Ikuko, Mizuno, Toshiki, Ihara, Masafumi

“…Objectives Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common hereditary small vessel…”
Get full text

A Prospective Longitudinal Study on the Relationship Between Glucose Fluctuation and Cognitive Function in Type 2 Diabetes: PROPOSAL Study Protocol by Matsubara, Masaki, Makino, Hisashi, Washida, Kazuo, Matsuo, Miki, Koezuka, Ryo, Ohata, Yoko, Tamanaha, Tamiko, Honda-Kohmo, Kyoko, Noguchi, Michio, Tomita, Tsutomu, Son, Cheol, Nakai, Michikazu, Nishimura, Kunihiro, Miyamoto, Yoshihiro, Ihara, Masafumi, Hosoda, Kiminori

“…Introduction Although the risk of dementia among patients with type 2 diabetes mellitus (T2DM) is double that of those without T2DM, the mechanism remains to…”
Get full text

Diabetic microvascular complications predicts non‐heart failure with reduced ejection fraction in type 2 diabetes by Tochiya, Mayu, Makino, Hisashi, Tamanaha, Tamiko, Omura‐Ohata, Yoko, Matsubara, Masaki, Koezuka, Ryo, Noguchi, Michio, Tomita, Tsutomu, Asaumi, Yasuhide, Miyamoto, Yoshihiro, Yasuda, Satoshi, Hosoda, Kiminori

“…Aims The relationship between diabetic microvascular complications and the incidence of two types of heart failure—heart failure with reduced ejection fraction…”
Get full text

The G-Protein-Coupled Long-Chain Fatty Acid Receptor GPR40 and Glucose Metabolism by Tomita, Tsutomu, Hosoda, Kiminori, Fujikura, Junji, Inagaki, Nobuya, Nakao, Kazuwa

“…Free fatty acids (FFAs) play a pivotal role in metabolic control and cell signaling processes in various tissues. In particular, FFAs are known to augment…”
Get full text

Genetic and Pharmacological Inhibition of Rho-associated Kinase II Enhances Adipogenesis by Noguchi, Michio, Hosoda, Kiminori, Fujikura, Junji, Fujimoto, Muneya, Iwakura, Hiroshi, Tomita, Tsutomu, Ishii, Takako, Arai, Naoki, Hirata, Masakazu, Ebihara, Ken, Masuzaki, Hiroaki, Itoh, Hiroshi, Narumiya, Shuh, Nakao, Kazuwa

“…Rho-associated kinase (ROCK) regulates reorganization of actin cytoskeleton. During adipogenesis, the structure of filamentous actin is converted from long…”
Get full text

Kangen-karyu raises surface body temperature through oxidative stress modification by Hirayama, Aki, Okamoto, Takuya, Kimura, Satomi, Nagano, Yumiko, Matsui, Hirofumi, Tomita, Tsutomu, Oowada, Shigeru, Aoyagi, Kazumasa

“…Kangen-karyu, a prescription containing six herbs, has been shown to achieve its pharmacological effect through oxidative stress-dependent pathways in animal…”
Get full text

Glucagon-like Peptide-1 analogues and delipidation of coronary atheroma in statin-treated type 2 diabetic patients with coronary artery disease: The prespecified sub-analysis of the OPTIMAL randomized clinical trial by Kataoka, Yu, Kitahara, Satoshi, Funabashi, Sayaka, Makino, Hisashi, Matsubara, Masaki, Matsuo, Miki, Omura-Ohata, Yoko, Koezuka, Ryo, Tochiya, Mayu, Tamanaha, Tamiko, Tomita, Tsutomu, Honda-Kohmo, Kyoko, Noguchi, Michio, Murai, Kota, Sawada, Kenichiro, Iwai, Takamasa, Matama, Hideo, Honda, Satoshi, Fujino, Masashi, Nakao, Kazuhiro, Yoneda, Shuichi, Takagi, Kensuke, Otsuka, Fumiyuki, Asaumi, Yasuhide, Hosoda, Kiminori, Nicholls, Stephen J., Yasuda, Satoshi, Noguchi, Teruo

“…Randomized clinical trials have demonstrated the ability of glucagon-like peptide-1 analogues (GLP-1RAs) to reduce atherosclerotic cardiovascular disease…”
Get full text