Search Results - "TOMIMOTO, MITSUMI"

TAK-599, a novel N-Phosphono type prodrug of anti-MRSA cephalosporin T-91825: synthesis, physicochemical and pharmacological properties by Ishikawa, Tomoyasu, Matsunaga, Nobuyuki, Tawada, Hiroyuki, Kuroda, Noritaka, Nakayama, Yutaka, Ishibashi, Yukio, Tomimoto, Mitsumi, Ikeda, Yukihiro, Tagawa, Yoshihiko, Iizawa, Yuji, Okonogi, Kenji, Hashiguchi, Shohei, Miyake, Akio

“…Crystalline 1 (TAK-599) is a novel N-phosphono prodrug of anti-methicillin-resistant Staphylococcus aureus (MRSA) cephalosporin 2a (T-91825) that has high…”
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Synthesis of Carumonam (AMA-1080) and a Related Compound Starting from (2R, 3R)-Epoxysuccinic Acid by SENDAI, MICHIYUKI, HASHIGUCHI, SHOHEI, TOMIMOTO, MITSUMI, KISHIMOTO, SHOJI, MATSUO, TAISUKE, OCHIAI, MICHIHIKO

“…In the course of the chemical modification of sulfazecin, several 4-carbamoyl-2-azetidinone-1-sulfonic acid derivatives were synthesized with the aim of…”
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Synthesis of sulfazecin-type 2-azetidinones with a carbon substituent at the 4-position by Kishimoto, S, Sendai, M, Hashiguchi, S, Tomimoto, M, Satoh, Y, Matsuo, T, Kondo, M, Ochiai, M

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Chemical modification of sulfazecin. Synthesis of 4-(substituted methyl)-2-azetidinone-1-sulfonic acid derivatives by Sendai, M, Hashiguchi, S, Tomimoto, M, Kishimoto, S, Matsuo, T, Kondo, M, Ochiai, M

“…In expectation of improving the antibacterial activity of sulfazecin by chemical modification at the 3- and 4-positions, a number of…”
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Chemical Modification of Sulfazecin. Synthesis of 4-Methoxycarbonyl-2-azetidinone-1-sulfonic Acid Derivatives by KISHIMOTO, SHOJI, SENDAI, MICHIYUKI, TOMIMOTO, MITSUMI, HASHIGUCHI, SHOHEI, MATSUO, TAISUKE, OCHIAI, MICHIHIKO

“…In the course of the chemical modification of sulfazecin, 3-[2-(2-aminothiazol-4-yl)-(Z)-2-(substituted oxyimino)…”
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Studies on the Syntheses of N-Heterocyclic Compounds. IV. Hypocholesterolemic 1, 2, 4-Oxadiazole Derivatives. (2) by YURUGI, SHOJIRO, MIYAKE, AKIO, TOMIMOTO, MITSUMI, MATSUMURA, HARUKI, IMAI, YOSHIO

“…The derivatives of 3-[4-(1-ethoxycarbonyl-1-methylethoxy) phenyl]-5-(3-pyridyl)-1, 2, 4-oxadiazole (I), which showed considerable hypocholesterolemic…”
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Studies on the Syntheses of N-Heterocyclic Compounds. II. Pyrimido[4, 5-e]-, Pyridazino[3, 4-e]- and Pyrido[4, 3-e]-1, 2, 3, 5-tetrahydro[1, 4]oxazepine-5-one by YURUGI, SHOJIRO, HIEDA, MASARU, FUSHIMI, TOMIYOSHI, TOMIMOTO, MITSUMI

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Studies on the Syntheses of N-Heterocyclic Compounds. XXVIII. Syntheses of Pyrido [3, 4-d] pyridazine Derivatives. (4) by OMURA, KIYOSHI, TADA, NORIO, TOMIMOTO, MITSUMI, USUI, YOSHIRO, OKA, YOSHIKAZU, YURUGI, SHOJIRO

“…A variety of 7, 8-disubstituted 1, 4-dimorpholinopyrido [3, 4-d] pyridazine derivatives were synthesized in connection with the structure-activity…”
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Studies on the Syntheses of N-Heterocyclic Compounds. V. 2-Aryl-5, 8-dichloropyrimido [4, 5-d] pyridazine by YURUGI, SHOJIRO, HIEDA, MASARU, FUSHIMI, TOMIYOSHI, KAWAMATSU, YUTAKA, SUGIHARA, HIROSADA, TOMIMOTO, MITSUMI

“…2-Substituted-5, 6, 7, 8-tetrahydropyrimido [4, 5-d] pyridazine-5, 8-diones (6) having a variety of substituents at 2-position were synthesized. Chlorination…”
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Studies on the syntheses of N-heterocyclic compounds. XXVI. Syntheses of pyrido(3,4-d)pyridazine derivatives. III by OKA, YOSHIKAZU, ITOH, KATSUMI, MIYAKE, AKIO, TADA, NORIO, OMURA, KIYOSHI, TOMIMOTO, MITSUMI, YURUGI, SHOJIRO

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Studies on the syntheses of N-heterocyclic compounds. XXV. Syntheses of pyrido(3,4-d)pyridazine derivatives. II by OKA, YOSHIKAZU, OMURA, KIYOSHI, MIYAKE, AKIO, ITOH, KATSUMI, TOMIMOTO, MITSUMI, TADA, NORIO, YURUGI, SHOJIRO

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Studies on the Syntheses of N-Heterocyclic Compounds. VII. 2-Aryl-5, 8-disubstitutedpyrimido [4, 5-d] pyridazine by YURUGI, SHOJIRO, HIEDA, MASARU, FUSHIMI, TOMIYOSHI, KAWAMATSU, YUTAKA, SUGIHARA, HIROSADA, TOMIMOTO, MITSUMI

“…When 2-aryl-5, 8-dichloropyrimido [4, 5-d] pyridazine (1) was reacted with a variety of nucleophiles, such as amines, sodium methoxide, sodium azide, sodium…”
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Studies on the Syntheses of N-Heterocyclic Compounds. XXV. Syntheses of Pyrido [3, 4-d] pyridazine Derivatives. (2) by OKA, YOSHIKAZU, OMURA, KIYOSHI, MIYAKE, AKIO, ITOH, KATSUMI, TOMIMOTO, MITSUMI, TADA, NORIO, YURUGI, SHOJIRO

“…Investigations on the preparative methods and some chemical modifications of the previously reported potent diuretic, 1, 4-dimorpholino-7-phenylpyrido [3, 4-d]…”
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Studies on the Syntheses of N-Heterocyclic Compounds. XXVI. Syntheses of Pyrido [3, 4-d] pyridazine Derivatives. (3) by OKA, YOSHIKAZU, ITOH, KATSUMI, MIYAKE, AKIO, TADA, NORIO, OMURA, KIYOSHI, TOMIMOTO, MITSUMI, YURUGI, SHOJIRO

“…A new synthetic route to 1, 4-dimorpholino-7-phenylpyrido [3, 4-d] pyridazine (1), a potent diuretic, has been investigated. Chlorination and the subsequent…”
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