Search Results - "TOMASINI, Richard"

Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions by Olivares, Orianne, Mayers, Jared R., Gouirand, Victoire, Torrence, Margaret E., Gicquel, Tristan, Borge, Laurence, Lac, Sophie, Roques, Julie, Lavaut, Marie-Noëlle, Berthezène, Patrice, Rubis, Marion, Secq, Veronique, Garcia, Stéphane, Moutardier, Vincent, Lombardo, Dominique, Iovanna, Juan Lucio, Tomasini, Richard, Guillaumond, Fabienne, Vander Heiden, Matthew G., Vasseur, Sophie

“…Tissue architecture contributes to pancreatic ductal adenocarcinoma (PDAC) phenotypes. Cancer cells within PDAC form gland-like structures embedded in a…”
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Cholesterol uptake disruption, in association with chemotherapy, is a promising combined metabolic therapy for pancreatic adenocarcinoma by Guillaumond, Fabienne, Bidaut, Ghislain, Ouaissi, Mehdi, Servais, Stéphane, Gouirand, Victoire, Olivares, Orianne, Lac, Sophie, Borge, Laurence, Roques, Julie, Gayet, Odile, Pinault, Michelle, Guimaraes, Cyrille, Nigri, Jérémy, Loncle, Céline, Lavaut, Marie-Noëlle, Garcia, Stéphane, Tailleux, Anne, Staels, Bart, Calvo, Ezequiel, Tomasini, Richard, Iovanna, Juan Lucio, Vasseur, Sophie

“…The malignant progression of pancreatic ductal adenocarcinoma (PDAC) is accompanied by a profound desmoplasia, which forces proliferating tumor cells to…”
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Strengthened glycolysis under hypoxia supports tumor symbiosis and hexosamine biosynthesis in pancreatic adenocarcinoma by Guillaumond, Fabienne, Leca, Julie, Olivares, Orianne, Lavaut, Marie-Noëlle, Vidal, Nicolas, Berthezène, Patrice, Dusetti, Nelson Javier, Loncle, Céline, Calvo, Ezequiel, Turrini, Olivier, lovanna, Juan Lucio, Tomasini, Richard, Vasseur, Sophie

“…Pancreatic ductal adenocarcinoma is one of the most intractable and fatal cancer. The decreased blood vessel density displayed by this tumor not only favors…”
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The p53 family: guardians of maternal reproduction by Melino, Gerry, Levine, Arnold J, Tomasini, Richard, McKeon, Frank D, Mak, Tak W

“…The p53 family of transcription factors have diverse roles during development and in cancer. However, there is increasing evidence that their ancestral…”
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Cancer-associated fibroblast-derived annexin A6+ extracellular vesicles support pancreatic cancer aggressiveness by Leca, Julie, Martinez, Sébastien, Lac, Sophie, Nigri, Jérémy, Secq, Véronique, Rubis, Marion, Bressy, Christian, Sergé, Arnauld, Lavaut, Marie-Noelle, Dusetti, Nelson, Loncle, Céline, Roques, Julie, Pietrasz, Daniel, Bousquet, Corinne, Garcia, Stéphane, Granjeaud, Samuel, Ouaissi, Mehdi, Bachet, Jean Baptiste, Brun, Christine, Iovanna, Juan L, Zimmermann, Pascale, Vasseur, Sophie, Tomasini, Richard

“…The intratumoral microenvironment, or stroma, is of major importance in the pathobiology of pancreatic ductal adenocarcinoma (PDA), and specific conditions in…”
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Pharmacological targeting of the protein synthesis mTOR/4E‐BP1 pathway in cancer‐associated fibroblasts abrogates pancreatic tumour chemoresistance by Duluc, Camille, Moatassim‐Billah, Siham, Chalabi‐Dchar, Mounira, Perraud, Aurélie, Samain, Rémi, Breibach, Florence, Gayral, Marion, Cordelier, Pierre, Delisle, Marie‐Bernadette, Bousquet‐Dubouch, Marie‐Pierre, Tomasini, Richard, Schmid, Herbert, Mathonnet, Muriel, Pyronnet, Stéphane, Martineau, Yvan, Bousquet, Corinne

“…Pancreatic ductal adenocarcinoma (PDAC) is extremely stroma‐rich. Cancer‐associated fibroblasts (CAFs) secrete proteins that activate survival and promote…”
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FAK activity in cancer‐associated fibroblasts is a prognostic marker and a druggable key metastatic player in pancreatic cancer by Zaghdoudi, Sonia, Decaup, Emilie, Belhabib, Ismahane, Samain, Rémi, Cassant‐Sourdy, Stéphanie, Rochotte, Julia, Brunel, Alexia, Schlaepfer, David, Cros, Jérome, Neuzillet, Cindy, Strehaiano, Manon, Alard, Amandine, Tomasini, Richard, Rajeeve, Vinothini, Perraud, Aurélie, Mathonnet, Muriel, Pearce, Oliver MT, Martineau, Yvan, Pyronnet, Stéphane, Bousquet, Corinne, Jean, Christine

“…Cancer‐associated fibroblasts (CAFs) are considered the most abundant type of stromal cells in pancreatic ductal adenocarcinoma (PDAC), playing a critical role…”
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TAp73 depletion accelerates aging through metabolic dysregulation by Rufini, Alessandro, Niklison-Chirou, Maria Victoria, Inoue, Satoshi, Tomasini, Richard, Harris, Isaac S, Marino, Arianna, Federici, Massimo, Dinsdale, David, Knight, Richard A, Melino, Gerry, Mak, Tak Wah

“…Aging is associated with impaired scavenging of reactive oxygen species (ROS). Here, we show that TAp73, a p53 family member, protects against aging by…”
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Oncogene-Induced Senescence Limits the Progression of Pancreatic Neoplasia through Production of Activin A by Zhao, Yajie, Wu, Zhichong, Chanal, Marie, Guillaumond, Fabienne, Goehrig, Delphine, Bachy, Sophie, Principe, Moitza, Ziverec, Audrey, Flaman, Jean-Michel, Collin, Guillaume, Tomasini, Richard, Pasternack, Arja, Ritvos, Olli, Vasseur, Sophie, Bernard, David, Hennino, Ana, Bertolino, Philippe

“…Pancreatic ductal adenocarcinoma (PDAC) is a deadly and aggressive cancer. Understanding mechanisms that drive preneoplastic pancreatic lesions is necessary to…”
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Sympathetic axonal sprouting induces changes in macrophage populations and protects against pancreatic cancer by Guillot, Jérémy, Dominici, Chloé, Lucchesi, Adrien, Nguyen, Huyen Thi Trang, Puget, Angélique, Hocine, Mélanie, Rangel-Sosa, Martha M., Simic, Milesa, Nigri, Jérémy, Guillaumond, Fabienne, Bigonnet, Martin, Dusetti, Nelson, Perrot, Jimmy, Lopez, Jonathan, Etzerodt, Anders, Lawrence, Toby, Pudlo, Pierre, Hubert, Florence, Scoazec, Jean-Yves, van de Pavert, Serge A., Tomasini, Richard, Chauvet, Sophie, Mann, Fanny

“…Neuronal nerve processes in the tumor microenvironment were highlighted recently. However, the origin of intra-tumoral nerves remains poorly known, in part…”
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Macrophages reprogramming driven by cancer-associated fibroblasts under FOLFIRINOX treatment correlates with shorter survival in pancreatic cancer by Hussain, Zainab, Bertran, Thomas, Finetti, Pascal, Lohmann, Eugenie, Mamessier, Emilie, Bidaut, Ghislain, Bertucci, François, Rego, Moacyr, Tomasini, Richard

“…Pancreatic ductal adenocarcinoma (PDAC) remains a clinically challenging cancer, mainly due to limited therapeutic options and the presence of a highly…”
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Tumor protein 53-induced nuclear protein 1 expression is repressed by miR-155, and its restoration inhibits pancreatic tumor development by Gironella, Meritxell, Seux, Mylène, Xie, Min-Jue, Cano, Carla, Tomasini, Richard, Gommeaux, Julien, Garcia, Stephane, Nowak, Jonathan, Yeung, Man Lung, Jeang, Kuan-Teh, Chaix, Amandine, Fazli, Ladan, Motoo, Yoshiharu, Wang, Qing, Rocchi, Palma, Russo, Antonio, Gleave, Martin, Dagorn, Jean-Charles, Iovanna, Juan L, Carrier, Alice, Pébusque, Marie-Josèphe, Dusetti, Nelson J

“…Pancreatic cancer is a disease with an extremely poor prognosis. Tumor protein 53-induced nuclear protein 1 (TP53INP1) is a proapoptotic stress-induced p53…”
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TAp73 is required for spermatogenesis and the maintenance of male fertility by Inoue, Satoshi, Tomasini, Richard, Rufini, Alessandro, Elia, Andrew J., Agostini, Massimiliano, Amelio, Ivano, Cescon, Dave, Dinsdale, David, Zhou, Lily, Harris, Isaac S., Lac, Sophie, Silvester, Jennifer, Li, Wanda Y., Sasaki, Masato, Haight, Jillian, Brüstle, Anne, Wakeham, Andrew, Mckerlie, Colin, Jurisicova, Andrea, Melino, Gerry, Mak, Tak W.

“…The generation of viable sperm proceeds through a series of coordinated steps, including germ cell self-renewal, meiotic recombination, and terminal…”
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Activated fibroblasts enhance cancer cell migration by microvesicles-mediated transfer of Galectin-1 by Toti, Alessandra, Santi, Alice, Pardella, Elisa, Nesi, Ilaria, Tomasini, Richard, Mello, Tommaso, Paoli, Paolo, Caselli, Anna, Cirri, Paolo

“…Cancer-associated fibroblasts (CAFs) are one of the main components of the stromal compartment in the tumor microenvironment (TME) and the crosstalk between…”
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DECONbench: a benchmarking platform dedicated to deconvolution methods for tumor heterogeneity quantification by Decamps, Clémentine, Arnaud, Alexis, Petitprez, Florent, Ayadi, Mira, Baurès, Aurélia, Armenoult, Lucile, Alcala, N., Arnaud, A., Avila Cobos, F., Batista, Luciana, Batto, A.-F., Blum, Y., Chuffart, F., Cros, J., Decamps, C., Dirian, L., Doncevic, D., Durif, G., Bahena Hernandez, S. Y., Jakobi, M., Jardillier, R., Jeanmougin, M., Jedynak, P., Jumentier, B., Kakoichankava, A., Kondili, Maria, Liu, J., Maie, T., Marécaille, J., Merlevede, J., Meylan, M., Nazarov, P., Newar, K., Nyrén, K., Petitprez, F., Novella Rausell, C., Richard, M., Scherer, M., Sompairac, N., Waury, K., Xie, T., Zacharouli, M.-A., Escalera, Sergio, Guyon, Isabelle, Nicolle, Rémy, Tomasini, Richard, de Reyniès, Aurélien, Cros, Jérôme, Blum, Yuna, Richard, Magali

“…Abstract Background Quantification of tumor heterogeneity is essential to better understand cancer progression and to adapt therapeutic treatments to patient…”
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Cadherin-1 and cadherin-3 cooperation determines the aggressiveness of pancreatic ductal adenocarcinoma by Siret, Carole, Dobric, Aurélie, Martirosyan, Anna, Terciolo, Chloé, Germain, Sébastien, Bonier, Renaté, Dirami, Thassadite, Dusetti, Nelson, Tomasini, Richard, Rubis, Marion, Garcia, Stéphane, Iovanna, Juan, Lombardo, Dominique, Rigot, Véronique, André, Frédéric

“…Background: Pancreatic ductal adenocarcinoma (PDAC) is characterised by an extensive tissue invasion and an early formation of metastasis. Alterations in the…”
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TAp73 regulates the spindle assembly checkpoint by modulating BubR1 activity by Tomasini, Richard, Tsuchihara, Katsuya, Tsuda, Chiharu, Lau, Suzanne K, Wilhelm, Margareta, Ruffini, Alessandro, Tsao, Ming-sound, Iovanna, Juan L, Jurisicova, Andrea, Melino, Gerry, Mak, Tak W

“…The role of various p73 isoforms in tumorigenesis has been controversial. However, as we have recently shown, the generation of TAp73-deficient (TAp73⁻/⁻) mice…”
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Pancreatic preneoplastic lesions plasma signatures and biomarkers based on proteome profiling of mouse models by Ligat, Laetitia, Saint-Laurent, Nathalie, El-Mrani, Aïcha, Gigoux, Véronique, Al Saati, Talal, Tomasini, Richard, Nigri, Jérémy, Dejean, Sébastien, Pont, Frédéric, Baer, Romain, Guillermet-Guibert, Julie, Cordelier, Pierre, Lopez, Frédéric, Dufresne, Marlène

“…Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies with a mortality that is almost identical to incidence. Because…”
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Peritumoral adipose tissue lipolysis activates the lymphatic system to promote PDAC-associated cachexia by Fabienne, De Toni, Jeremy, Nigri, Richard, Tomasini, Jean, Galitzky, Anne, Bouloumié, Barbara, Garmy-Susini

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Dendritic cell-based vaccination: powerful resources of immature dendritic cells against pancreatic adenocarcinoma by Collignon, Aurélie, Silvy, Françoise, Robert, Stéphane, Trad, Malika, Germain, Sébastien, Nigri, Jérémy, André, Frédéric, Rigot, Véronique, Tomasini, Richard, Bonnotte, Bernard, Lombardo, Dominique, Mas, Eric, Beraud, Evelyne

“…Pancreatic adenocarcinoma (PAC) has a poor prognosis. One treatment approach, investigated here, is to reinforce antitumor immunity. Dendritic cells (DCs) are…”
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