Search Results - "TOMAS, Alejandra"

EGF receptor trafficking: consequences for signaling and cancer by Tomas, Alejandra, Futter, Clare E, Eden, Emily R

“…Highlights • EGF receptor endocytic traffic can regulate signaling and cell survival. • Signaling from activated EGFR occurs at the endosome as well as the…”
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The Interplay of Glucagon-Like Peptide-1 Receptor Trafficking and Signalling in Pancreatic Beta Cells by Marzook, Amaara, Tomas, Alejandra, Jones, Ben

“…The glucagon-like peptide 1 receptor (GLP-1R) is a class B G protein-coupled receptor (GPCR) which mediates the effects of GLP-1, an incretin hormone secreted…”
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Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics by Ast, Julia, Arvaniti, Anastasia, Fine, Nicholas H. F., Nasteska, Daniela, Ashford, Fiona B., Stamataki, Zania, Koszegi, Zsombor, Bacon, Andrea, Jones, Ben J., Lucey, Maria A., Sasaki, Shugo, Brierley, Daniel I., Hastoy, Benoit, Tomas, Alejandra, D’Agostino, Giuseppe, Reimann, Frank, Lynn, Francis C., Reissaus, Christopher A., Linnemann, Amelia K., D’Este, Elisa, Calebiro, Davide, Trapp, Stefan, Johnsson, Kai, Podewin, Tom, Broichhagen, Johannes, Hodson, David J.

“…The glucagon-like peptide-1 receptor (GLP1R) is a class B G protein-coupled receptor (GPCR) involved in metabolism. Presently, its visualization is limited to…”
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Targeting GLP-1 receptor trafficking to improve agonist efficacy by Jones, Ben, Buenaventura, Teresa, Kanda, Nisha, Chabosseau, Pauline, Owen, Bryn M., Scott, Rebecca, Goldin, Robert, Angkathunyakul, Napat, Corrêa Jr, Ivan R., Bosco, Domenico, Johnson, Paul R., Piemonti, Lorenzo, Marchetti, Piero, Shapiro, A. M. James, Cochran, Blake J., Hanyaloglu, Aylin C., Inoue, Asuka, Tan, Tricia, Rutter, Guy A., Tomas, Alejandra, Bloom, Stephen R.

“…Glucagon-like peptide-1 receptor (GLP-1R) activation promotes insulin secretion from pancreatic beta cells, causes weight loss, and is an important…”
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Biomimetic electromechanical stimulation to maintain adult myocardial slices in vitro by Watson, Samuel A., Duff, James, Bardi, Ifigeneia, Zabielska, Magdalena, Atanur, Santosh S., Jabbour, Richard J., Simon, André, Tomas, Alejandra, Smolenski, Ryszard T., Harding, Sian E., Perbellini, Filippo, Terracciano, Cesare M.

“…Adult cardiac tissue undergoes a rapid process of dedifferentiation when cultured outside the body. The in vivo environment, particularly constant…”
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DRP1 levels determine the apoptotic threshold during embryonic differentiation through a mitophagy-dependent mechanism by Pernaute, Barbara, Pérez-Montero, Salvador, Sánchez Nieto, Juan Miguel, Di Gregorio, Aida, Lima, Ana, Lawlor, Katerina, Bowling, Sarah, Liccardi, Gianmaria, Tomás, Alejandra, Meier, Pascal, Sesaki, Hiromi, Rutter, Guy A., Barbaric, Ivana, Rodríguez, Tristan A.

“…The changes that drive differentiation facilitate the emergence of abnormal cells that need to be removed before they contribute to further development or the…”
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Simplified lower eyelid reconstruction algorithm after basal cell carcinoma surgery: A retrospective series of patients by Redondo, Pedro, Barrio, Jesús, Salido‐Vallejo, Rafael, Tomás‐Velázquez, Alejandra

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Stress-specific p38 MAPK activation is sufficient to drive EGFR endocytosis but not its nuclear translocation by Tomas, Alejandra, Jones, Sylwia, Vaughan, Simon O, Hochhauser, Daniel, Futter, Clare E

“…EGF receptor (EGFR) endocytosis is induced by stress in a manner dependent on the p38 MAPK family. Ligand and stresses such as X-rays, reportedly promote…”
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Alpelisib decreases nevocytes of congenital melanocytic nevi by Tomás-Velázquez, Alejandra, López-Gutiérrez, Juan Carlos, de Andrea, Carlos, Reyes-Múgica, Miguel, Salgado, Claudia M, Redondo, Pedro

“…Multiple, large or giant congenital melanocytic nevi (CMN) are uncommon and affected patients can show progressive growth and thickening, associate…”
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Agonist-induced membrane nanodomain clustering drives GLP-1 receptor responses in pancreatic beta cells by Buenaventura, Teresa, Bitsi, Stavroula, Laughlin, William E, Burgoyne, Thomas, Lyu, Zekun, Oqua, Affiong I, Norman, Hannah, McGlone, Emma R, Klymchenko, Andrey S, Corrêa, Jr, Ivan R, Walker, Abigail, Inoue, Asuka, Hanyaloglu, Aylin, Grimes, Jak, Koszegi, Zsombor, Calebiro, Davide, Rutter, Guy A, Bloom, Stephen R, Jones, Ben, Tomas, Alejandra

“…The glucagon-like peptide-1 receptor (GLP-1R), a key pharmacological target in type 2 diabetes (T2D) and obesity, undergoes rapid endocytosis after stimulation…”
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Focal Adhesion Remodeling Is Crucial for Glucose-Stimulated Insulin Secretion and Involves Activation of Focal Adhesion Kinase and Paxillin by RONDAS, Dieter, TOMAS, Alejandra, HALBAN, Philippe A

“…Actin cytoskeleton remodeling is known to be involved in glucose-stimulated insulin secretion (GSIS). We have observed glucose-stimulated changes at the β-cell…”
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Moesin and cortactin control actin-dependent multivesicular endosome biogenesis by Muriel, Olivia, Tomas, Alejandra, Scott, Cameron C, Gruenberg, Jean

“…We used in vivo and in vitro strategies to study the mechanisms of multivesicular endosome biogenesis. We found that, whereas annexinA2 and ARP2/3 mediate…”
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WASH and Tsg101/ALIX-dependent diversion of stress-internalized EGFR from the canonical endocytic pathway by Tomas, Alejandra, Vaughan, Simon O., Burgoyne, Thomas, Sorkin, Alexander, Hartley, John A., Hochhauser, Daniel, Futter, Clare E.

“…Stress exposure triggers ligand-independent EGF receptor (EGFR) endocytosis, but its post-endocytic fate and role in regulating signalling are unclear. We show…”
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Variation in responses to incretin therapy: Modifiable and non-modifiable factors by Austin, Gregory O, Tomas, Alejandra

“…Type 2 diabetes (T2D) and obesity have reached epidemic proportions. Incretin therapy is the second line of treatment for T2D, improving both blood glucose…”
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OSBP-mediated PI(4)P-cholesterol exchange at endoplasmic reticulum-secretory granule contact sites controls insulin secretion by Panagiotou, Styliani, Tan, Kia Wee, Nguyen, Phuoc My, Müller, Andreas, Oqua, Affiong Ika, Tomas, Alejandra, Wendt, Anna, Eliasson, Lena, Tengholm, Anders, Solimena, Michele, Idevall-Hagren, Olof

“…Insulin is packaged into secretory granules that depart the Golgi and undergo a maturation process that involves changes in the protein and lipid composition…”
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Ligand-Specific Factors Influencing GLP-1 Receptor Post-Endocytic Trafficking and Degradation in Pancreatic Beta Cells by Fang, Zijian, Chen, Shiqian, Manchanda, Yusman, Bitsi, Stavroula, Pickford, Philip, David, Alessia, Shchepinova, Maria M, Corrêa, Jr, Ivan R, Hodson, David J, Broichhagen, Johannes, Tate, Edward W, Reimann, Frank, Salem, Victoria, Rutter, Guy A, Tan, Tricia, Bloom, Stephen R, Tomas, Alejandra, Jones, Ben

“…The glucagon-like peptide-1 receptor (GLP-1R) is an important regulator of blood glucose homeostasis. Ligand-specific differences in membrane trafficking of…”
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In vivo and in vitro characterization of GL0034, a novel long‐acting glucagon‐like peptide‐1 receptor agonist by Jones, Ben, Burade, Vinod, Akalestou, Elina, Manchanda, Yusman, Ramchunder, Zenouska, Carrat, Gaëlle, Nguyen‐Tu, Marie‐Sophie, Marchetti, Piero, Piemonti, Lorenzo, Leclerc, Isabelle, Thennati, Rajamannar, Vilsboll, Tina, Thorens, Bernard, Tomas, Alejandra, Rutter, Guy A.

“…Aims To describe the in vitro characteristics and antidiabetic in vivo efficacy of the novel glucagon‐like peptide‐1 receptor agonist (GLP‐1RA) GL0034…”
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GRK2 regulates GLP-1R-mediated early phase insulin secretion in vivo by Arcones, Alba C, Vila-Bedmar, Rocío, Mirasierra, Mercedes, Cruces-Sande, Marta, Vallejo, Mario, Jones, Ben, Tomas, Alejandra, Mayor, Jr, Federico, Murga, Cristina

“…Insulin secretion from the pancreatic β-cell is finely modulated by different signals to allow an adequate control of glucose homeostasis. Incretin hormones…”
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A case of unilateral linear capillaritis by Rodriguez‐Garijo, Nuria, Tomas‐Velazquez, Alejandra, Estenaga, Angela, Antoñanzas, Javier, Idoate, Miguel Angel, Espana, Agustin

“…Unilateral linear capillaritis is a rare variant of the pigmented purpuric dermatoses that can be misdiagnosed due to confusion with other cutaneous diseases…”
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Receptor Activity-Modifying Protein 2 (RAMP2) alters glucagon receptor trafficking in hepatocytes with functional effects on receptor signalling by McGlone, Emma Rose, Manchanda, Yusman, Jones, Ben, Pickford, Phil, Inoue, Asuka, Carling, David, Bloom, Stephen R., Tan, Tricia, Tomas, Alejandra

“…Receptor Activity-Modifying Protein 2 (RAMP2) is a chaperone protein which allosterically binds to and interacts with the glucagon receptor (GCGR). The aims of…”
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